{"id":97,"date":"2023-09-18T15:25:58","date_gmt":"2023-09-18T07:25:58","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=97"},"modified":"2023-09-18T16:01:43","modified_gmt":"2023-09-18T08:01:43","slug":"%e9%98%bf%e6%9d%a5%e6%9b%bf%e5%b0%bc-%e8%89%be%e4%b9%90%e6%9b%bf%e5%b0%bc-%e9%98%bf%e9%9b%b7%e6%9b%bf%e5%b0%bc-%e8%80%81%e6%8c%9d%e4%b8%9c%e7%9b%9f%e5%88%b6%e8%8d%af-alynni","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=97","title":{"rendered":"\u963f\u6765\u66ff\u5c3c\/\u827e\u4e50\u66ff\u5c3c\/\u963f\u96f7\u66ff\u5c3c\/\u8001\u631d\u4e1c\u76df\u5236\u836f-Alynni"},"content":{"rendered":"\n<figure class=\"wp-block-image size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58-300x300.jpg\" alt=\"\" class=\"wp-image-98\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58-300x300.jpg 300w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58-150x150.jpg 150w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58.jpg 560w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u9002\u5e94\u75c7\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/h3>\n\n\n\n<p>\u6307\u793a\u901a\u8fc7FDA\u6279\u51c6\u7684\u6d4b\u8bd5\u68c0\u6d4b\u5230\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\uff0c\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6bcf\u5929\u53e3\u670d2\u6b21(\u6bcf\u65e5\u603b\u5242\u91cf1200 mg)\uff0c\u6bcf\u6b21600 mg(4\u7c92150 mg\u80f6\u56ca) \uff0c\u6bcf\u65e5\u4e24\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u578b\uff1a150mg\u80f6\u56ca<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u91cf\u8c03\u6574<\/h3>\n\n\n\n<p>\u5242\u91cf\u51cf\u5c11\u8ba1\u5212<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8d77\u59cb\u5242\u91cf\uff1a600mg \u6bcf\u6b21\uff0c\u4e00\u5929\u4e24\u6b21<\/li>\n\n\n\n<li>\u9996\u6b21\u5242\u91cf\u51cf\u5c11\uff1a450\u6beb\u514b \u6bcf\u6b21\uff0c\u4e00\u5929\u4e24\u6b21<\/li>\n\n\n\n<li>\u7b2c\u4e8c\u5242\u91cf\u51cf\u5c11\uff1a300\u6beb\u514b \u6bcf\u6b21\uff0c\u4e00\u5929\u4e24\u6b21<\/li>\n\n\n\n<li>\u5982\u679c\u60a3\u8005\u4e0d\u80fd\u8010\u53d7300 mg&nbsp; \u6bcf\u6b21\uff0c\u5219\u505c\u6b62\u4f7f\u7528<\/li>\n<\/ul>\n\n\n\n<p>\u80be\u6bd2\u6027<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>3\u7ea7\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u8840\u6e05\u808c\u9150\u6062\u590d\u81f3\u22641.5xULN\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590d<\/li>\n\n\n\n<li>4\u5e74\u7ea7\uff1a\u6c38\u4e45\u505c\u6b62<\/li>\n<\/ul>\n\n\n\n<p>\u809d\u6bd2\u6027<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ALT\u6216AST\u5347\u9ad8&gt; 5x ULN\uff0c\u603b\u80c6\u7ea2\u7d20\uff08TB\uff09\u22642xULN\uff1a\u6682\u65f6\u505c\u7528\u81f3\u6062\u590d\u81f3\u57fa\u7ebf\u6216\u22643\u500dULN\uff0c\u7136\u540e\u4ee5\u51cf\u91cf\u5242\u91cf\u6062\u590d<\/li>\n\n\n\n<li>ALT\u6216AST\u5347\u9ad8&gt; 3x ULN\uff0c\u7ed3\u80a0\u5347\u9ad8&gt; 2x ULN\uff0c\u65e0\u80c6\u6c41\u6de4\u79ef\u6216\u6eb6\u8840\uff1a\u6c38\u4e45\u505c\u836f<\/li>\n\n\n\n<li>TB\u5347\u9ad8&gt; 3x ULN\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u6062\u590d\u5230\u57fa\u7ebf\u6216\u22641.5xULN\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590d<\/li>\n<\/ul>\n\n\n\n<p>\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\/\u80ba\u708e<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4efb\u4f55\u4e0e\u6cbb\u7597\u76f8\u5173\u7684ILD \/\u80ba\u708e\u7b49\u7ea7\uff1a\u6c38\u4e45\u505c\u836f<\/li>\n<\/ul>\n\n\n\n<p>\u5fc3\u52a8\u8fc7\u7f13<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\n<ul class=\"wp-block-list\">\n<li>\u4fdd\u7559\u76f4\u81f3\u6062\u590d\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560\u6b21\/\u5206<\/li>\n\n\n\n<li>\u5982\u679c\u786e\u5b9a\u5e76\u505c\u6b62\u4f9b\u5e94\u4f34\u968f\u836f\u7269\uff0c\u6216\u8005\u8c03\u6574\u5176\u5242\u91cf\uff0c\u5219\u5728\u6062\u590d\u81f3\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560bpm\u65f6\u6062\u590d\u4ee5\u524d\u5242\u91cf\u7684alectinib<\/li>\n\n\n\n<li>\u5982\u679c\u6ca1\u6709\u786e\u5b9a\u4f9b\u5e94\u7684\u4f34\u968f\u836f\u7269\uff0c\u6216\u8005\u5982\u679c\u4e0d\u505c\u6b62\u6216\u5242\u91cf\u6539\u53d8\u4f9b\u5e94\u7684\u4f34\u968f\u836f\u7269\uff0c\u6062\u590d\u65e0\u75c7\u72b6\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560bpm\u65f6\uff0c\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dalectinib<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u5371\u53ca\u751f\u547d\u7684\u5fc3\u52a8\u8fc7\u7f13\u6216\u7d27\u6025\u5e72\u9884\u8868\u660e\n<ul class=\"wp-block-list\">\n<li>\u5982\u679c\u6ca1\u6709\u786e\u5b9a\u4f9b\u5e94\u7684\u4f34\u968f\u836f\u7269\uff0c\u5219\u6c38\u4e45\u505c\u836f<\/li>\n\n\n\n<li>\u5982\u679c\u786e\u5b9a\u5e76\u505c\u6b62\u4f9b\u5e94\u4f34\u968f\u836f\u7269\uff0c\u6216\u8005\u8c03\u6574\u5176\u5242\u91cf\uff0c\u5219\u5728\u6062\u590d\u81f3\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560bpm\u65f6\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dalectinib\uff0c\u5e76\u6839\u636e\u4e34\u5e8a\u6307\u793a\u8fdb\u884c\u9891\u7e41\u76d1\u6d4b<\/li>\n\n\n\n<li>\u5982\u679c\u518d\u6b21\u53d1\u751f\uff0c\u5c06\u6c38\u4e45\u505c\u6b62<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>CPK\u5347\u9ad8<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CPK&gt; 5x ULN\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u6062\u590d\u81f3\u57fa\u7ebf\u6216\u22642.5xULN\uff0c\u7136\u540e\u4ee5\u76f8\u540c\u5242\u91cf\u6062\u590d<\/li>\n\n\n\n<li>CPK&gt; 10x ULN\u6216\u7b2c\u4e8c\u6b21\u51fa\u73b0&gt; 5x ULN\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u6062\u590d\u81f3\u57fa\u7ebf\u6216\u22642.5xULN\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590d<\/li>\n<\/ul>\n\n\n\n<p>\u80be\u529f\u80fd\u4e0d\u5168<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf<\/li>\n\n\n\n<li>\u4e25\u91cd\uff08CrCl &lt;30 mL \/ min\uff09\u6216ESRD\uff1a\u672a\u7814\u7a76<\/li>\n<\/ul>\n\n\n\n<p>\u809d\u529f\u80fd\u635f\u5bb3<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8f7b\u5ea6\uff08TB\u2264ULN\u548cAST&gt; ULN\u6216TB&gt; 1-1.5x ULN\u548c\u4efb\u4f55AST\uff09\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf<\/li>\n\n\n\n<li>\u4e2d\u5ea6\u81f3\u91cd\u5ea6\uff1a\u672a\u7814\u7a76<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u6ce8\u610f\u4e8b\u9879<\/h3>\n\n\n\n<p>\u5728\u6cbb\u7597\u524d\u5e94\u5bf9\u60a3\u8005\u8fdb\u884c\u6d4b\u8bd5\u5e76\u5448\u73b0ALK\u9633\u6027\u80bf\u7624<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e0d\u5229\u5f71\u54cd<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">&gt; 10\uff05\uff08\u6240\u6709\u7b49\u7ea7\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8d2b\u8840\uff0856\uff05\uff09<\/li>\n\n\n\n<li>AST\u589e\u52a0\uff0851\uff05\uff09<\/li>\n\n\n\n<li>\u78b1\u6027\u78f7\u9178\u9176\u589e\u52a0\uff0847\uff05\uff09<\/li>\n\n\n\n<li>\u589e\u52a0CPK\uff0843\uff05\uff09<\/li>\n\n\n\n<li>\u75b2\u52b3\uff0826-41\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\uff0839\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u8840\u7cd6\uff0836\uff05\uff09<\/li>\n\n\n\n<li>ALT\u589e\u52a0\uff0834\uff05\uff09<\/li>\n\n\n\n<li>\u4fbf\u79d8\uff0834\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u9499\u8840\u75c7\uff0832\uff05\uff09<\/li>\n\n\n\n<li>\u6c34\u80bf\uff0822-30\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94be\u8840\u75c7\uff0829\uff05\uff09<\/li>\n\n\n\n<li>\u808c\u75db\uff0823-29\uff05\uff09<\/li>\n\n\n\n<li>\u808c\u9150\u589e\u52a0\uff0828\uff05\uff09<\/li>\n\n\n\n<li>\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\uff0822\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u78f7\u8840\u75c7\uff0821\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94a0\u8840\u75c7\uff0820\uff05\uff09<\/li>\n\n\n\n<li>\u54b3\u55fd\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u76ae\u75b9\uff0815-18\uff05\uff09<\/li>\n\n\n\n<li>\u6076\u5fc3\uff0814-18\uff05\uff09<\/li>\n\n\n\n<li>\u5934\u75db\uff0817\uff05\uff09<\/li>\n\n\n\n<li>\u8179\u6cfb\uff0812-16\uff05\uff09<\/li>\n\n\n\n<li>\u547c\u5438\u56f0\u96be\uff0816\uff05\uff09<\/li>\n\n\n\n<li>\u80cc\u75db\uff0812\uff05\uff09<\/li>\n\n\n\n<li>\u5455\u5410\uff087-12\uff05\uff09<\/li>\n\n\n\n<li>\u5fc3\u52a8\u8fc7\u7f13\uff0811\uff05\uff09<\/li>\n\n\n\n<li>\u4f53\u91cd\u589e\u52a0\uff0811\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1-10\uff05\uff08\u6240\u6709\u7b49\u7ea7\uff09<\/h3>\n\n\n\n<p>\u89c6\u529b\u969c\u788d\uff0810\uff05\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1-10\uff05\uff083\u5e74\u7ea7\u62164\u5e74\u7ea7\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ALT\u589e\u52a0\uff084.8\uff05\uff09<\/li>\n\n\n\n<li>\u589e\u52a0CPK\uff084.6\uff05\uff09<\/li>\n\n\n\n<li>\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff084.6\uff05\uff09<\/li>\n\n\n\n<li>\u89c6\u529b\u969c\u788d\uff084.6\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94be\u8840\u75c7\uff084\uff05\uff09<\/li>\n\n\n\n<li>\u80be\u529f\u80fd\u635f\u5bb3\uff083.9\uff05\uff09<\/li>\n\n\n\n<li>\u547c\u5438\u56f0\u96be\uff083.6\uff05\uff09<\/li>\n\n\n\n<li>AST\u589e\u52a0\uff083.6\uff05\uff09<\/li>\n\n\n\n<li>Dysgeusia\uff083.3\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u78f7\u8840\u75c7\uff082.8\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\uff082.4\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u8840\u7cd6\uff082\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94a0\u8840\u75c7\uff082\uff05\uff09<\/li>\n\n\n\n<li>\u8d2b\u8840\uff082\uff05\uff09<\/li>\n\n\n\n<li>\u75b2\u52b3\uff081.2\uff05\uff09<\/li>\n\n\n\n<li>\u808c\u75db\uff081.2\uff05\uff09<\/li>\n\n\n\n<li>\u8179\u6cfb\uff081.2\uff05\uff09<\/li>\n\n\n\n<li>\u78b1\u6027\u78f7\u9178\u9176\u589e\u52a0\uff081.2\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">&lt;1\uff05\uff083\u5e74\u7ea7\u62164\u5e74\u7ea7\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6c34\u80bf\uff080.7-0.8\uff05\uff09<\/li>\n\n\n\n<li>\u5934\u75db\uff080.8\uff05\uff09<\/li>\n\n\n\n<li>\u76ae\u75b9\uff080.4-0.7\uff05\uff09<\/li>\n\n\n\n<li>Dysgeusia\uff080.7\uff05\uff09<\/li>\n\n\n\n<li>\u6076\u5fc3\uff080.7\uff05\uff09<\/li>\n\n\n\n<li>\u5455\u5410\uff080.4\uff05\uff09<\/li>\n\n\n\n<li>\u91cd\u91cf\u589e\u52a0\uff080.4\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u9499\u8840\u75c7\uff080.4\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u6ce8\u610f\u4e8b\u9879<\/h3>\n\n\n\n<p>\u636e\u62a5\u9053\u809d\u9176\u5347\u9ad8;&nbsp;\u76d1\u6d4b\u809d\u529f\u80fd\u68c0\u67e5\uff0c\u5305\u62ecALT\uff0cAST\u548c\u603b\u80c6\u7ea2\u7d20\uff0c\u5728\u6cbb\u7597\u7684\u524d2\u4e2a\u6708\u5185\u8fdb\u884cq2\u5468\uff0c\u7136\u540e\u5728\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u8fdb\u884c\uff0c\u5bf9\u53d1\u751f\u8f6c\u6c28\u9176\u548c\u80c6\u7ea2\u7d20\u5347\u9ad8\u7684\u60a3\u8005\u8fdb\u884c\u66f4\u9891\u7e41\u7684\u68c0\u6d4b\uff08\u53c2\u89c1\u5242\u91cf\u8c03\u6574\uff09<\/p>\n\n\n\n<p>\u62a5\u544a\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\u548c\u80ba\u708e;&nbsp;\u53ca\u65f6\u8c03\u67e5\u4efb\u4f55\u51fa\u73b0\u547c\u5438\u9053\u75c7\u72b6\u6076\u5316\uff08\u5982\u547c\u5438\u56f0\u96be\uff0c\u54b3\u55fd\uff0c\u53d1\u70e7\uff09\u7684\u60a3\u8005\uff0c\u5e76\u7acb\u5373\u505c\u6b62\u5bf9\u8bca\u65ad\u4e3aILD 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