{"id":816,"date":"2026-05-14T12:59:11","date_gmt":"2026-05-14T04:59:11","guid":{"rendered":"https:\/\/www.yaozhiyou.com\/?p=816"},"modified":"2026-05-14T13:00:25","modified_gmt":"2026-05-14T05:00:25","slug":"alk-ros1-%e8%82%ba%e7%99%8c%e3%80%81%e8%82%9d%e7%99%8c%e3%80%81%e4%b9%b3%e8%85%ba%e7%99%8c%e6%b2%bb%e7%96%97%e7%8e%b0%e7%8a%b6%e4%b8%8e%e9%9d%b6%e5%90%91%e8%8d%af%e5%8f%91%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=816","title":{"rendered":"ALK\/ROS1 \u80ba\u764c\u3001\u809d\u764c\u3001\u4e73\u817a\u764c\u6cbb\u7597\u73b0\u72b6\u4e0e\u9776\u5411\u836f\u53d1\u5c55"},"content":{"rendered":"<div>\n<div id=\"attachment_819\" style=\"width: 652px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-819\" class=\"size-full wp-image-819\" title=\"\u5fae\u4fe1\u8054\u7cfb\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/10_\u526f\u672c.jpg\" alt=\"\u5fae\u4fe1\u8054\u7cfb\" width=\"642\" height=\"281\" \/><p id=\"caption-attachment-819\" class=\"wp-caption-text\">\u5fae\u4fe1\u8054\u7cfb<\/p><\/div>\n<\/div>\n<div>\u7cbe\u51c6\u533b\u7597\u65f6\u4ee3\uff0c\u9776\u5411\u6cbb\u7597\u5df2\u6210\u4e3a ALK\/ROS1 \u9633\u6027\u80ba\u764c\u3001\u809d\u764c\u3001\u4e73\u817a\u764c\u7b49\u6076\u6027\u80bf\u7624\u7684\u6838\u5fc3\u6cbb\u7597\u624b\u6bb5\u3002\u4f34\u968f\u5206\u5b50\u8bca\u65ad\u6280\u672f\u8fed\u4ee3\u4e0e\u836f\u7269\u7814\u53d1\u7a81\u7834\uff0c\u9776\u5411\u836f\u6b63\u4ece \u201c\u5355\u4e00\u9776\u70b9\u6291\u5236\u201d \u5411 \u201c\u591a\u9776\u70b9\u8986\u76d6\u3001\u8010\u836f\u653b\u514b\u3001\u8111\u8f6c\u79fb\u53ef\u63a7\u201d \u6f14\u8fdb\uff0c\u663e\u8457\u5ef6\u957f\u60a3\u8005\u751f\u5b58\u671f\u5e76\u63d0\u5347\u751f\u6d3b\u8d28\u91cf\u3002\u672c\u6587\u7cfb\u7edf\u68b3\u7406\u4e09\u5927\u764c\u79cd\u7684\u6cbb\u7597\u73b0\u72b6\uff0c\u6df1\u5ea6\u89e3\u6790\u9776\u5411\u836f\u7814\u53d1\u8fdb\u5c55\u4e0e\u672a\u6765\u8d8b\u52bf\u3002<\/div>\n<div><\/div>\n<h2>\u4e00\u3001ALK\/ROS1 \u9633\u6027\u80ba\u764c\uff1a\u201c\u94bb\u77f3\u7a81\u53d8\u201d \u7684\u7cbe\u51c6\u6cbb\u7597\u7a81\u7834<\/h2>\n<div><\/div>\n<div>\u80ba\u764c\u662f\u5168\u7403\u53d1\u75c5\u7387\u4e0e\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u4e2d<strong>\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09<\/strong> \u5360\u6bd4\u8d85 85%\u3002ALK\uff08\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff09\u4e0e ROS1\uff08c-ros \u8089\u7624\u81f4\u764c\u56e0\u5b50 1\uff09\u878d\u5408\u7a81\u53d8\u867d\u5c5e\u7f55\u89c1\u9776\u70b9\uff08ALK \u9633\u6027\u7387 3%-5%\u3001ROS1 \u9633\u6027\u7387 1%-2%\uff09\uff0c\u4f46\u56e0\u9776\u5411\u836f\u7597\u6548\u663e\u8457\u3001\u751f\u5b58\u671f\u957f\uff0c\u88ab\u79f0\u4e3a \u201c\u94bb\u77f3\u7a81\u53d8\u201d\u3002<\/div>\n<div><\/div>\n<h3>\uff08\u4e00\uff09\u6cbb\u7597\u73b0\u72b6\uff1a\u9776\u5411\u6cbb\u7597\u6210\u4e3a\u4e00\u7ebf\u6807\u51c6\uff0c\u8111\u8f6c\u79fb\u4e0e\u8010\u836f\u4e3a\u6838\u5fc3\u75db\u70b9<\/h3>\n<div><\/div>\n<ol>\n<li><strong>\u4e00\u7ebf\u6cbb\u7597<\/strong>\uff1aALK\/ROS1 \u9633\u6027\u665a\u671f NSCLC \u5df2\u5168\u9762\u8fdb\u5165\u9776\u5411\u65f6\u4ee3\uff0c<strong>\u4e00\u4ee3\u3001\u4e8c\u4ee3\u3001\u4e09\u4ee3 TKI\uff08\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff09<\/strong> \u5f62\u6210\u6e05\u6670\u7528\u836f\u68af\u961f\uff0c\u66ff\u4ee3\u4f20\u7edf\u5316\u7597\u6210\u4e3a\u9996\u9009\u3002<\/li>\n<li><strong>\u6838\u5fc3\u6311\u6218<\/strong>\uff1a\n<ul>\n<li><strong>\u8111\u8f6c\u79fb\u9ad8\u53d1<\/strong>\uff1aALK \u9633\u6027\u60a3\u8005\u521d\u8bca\u8111\u8f6c\u79fb\u7387\u7ea6 30%\uff0c\u6cbb\u7597\u4e2d\u53d1\u751f\u7387\u8d85 60%\uff0c\u4e25\u91cd\u5f71\u54cd\u9884\u540e\uff1b<\/li>\n<li><strong>\u8010\u836f\u4e0d\u53ef\u907f\u514d<\/strong>\uff1a\u4e00\u4ee3 TKI \u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4ec5 10-12 \u4e2a\u6708\uff0c\u8010\u836f\u540e\u6613\u51fa\u73b0 G1202R\u3001L1196M \u7b49\u96be\u6cbb\u7a81\u53d8\uff1b<\/li>\n<li><strong>ROS1 \u6cbb\u7597\u9009\u62e9\u6709\u9650<\/strong>\uff1a\u65e2\u5f80\u836f\u7269\u5bf9 G2032R \u8010\u836f\u7a81\u53d8\u65e0\u6548\uff0c\u8111\u8f6c\u79fb\u63a7\u5236\u7387\u4f4e\u3002<\/li>\n<\/ul>\n<div><\/div>\n<\/li>\n<\/ol>\n<div><\/div>\n<h3>\uff08\u4e8c\uff09\u9776\u5411\u836f\u53d1\u5c55\uff1a\u4e09\u4ee3\u836f\u7269\u5168\u8986\u76d6\uff0c\u56db\u4ee3\u65b0\u836f\u653b\u514b\u8010\u836f<\/h3>\n<div><\/div>\n<h4>1. ALK \u9776\u70b9\uff1a\u4ece\u4e00\u4ee3\u5230\u56db\u4ee3\uff0c\u7597\u6548\u4e0e\u5165\u8111\u80fd\u529b\u6301\u7eed\u5347\u7ea7<\/h4>\n<div><\/div>\n<ul>\n<li>\n<div>\n<p><strong>\u4e00\u4ee3\uff1a\u514b\u5511\u66ff\u5c3c\uff08Crizotinib\uff09<\/strong><\/p>\n<div><\/div>\n<p>\u9996\u4e2a\u83b7\u6279 ALK\/ROS1 \u53cc\u9776\u70b9 TKI\uff0c2013 \u5e74\u8fdb\u5165\u4e2d\u56fd\uff0c\u4e00\u7ebf\u4e2d\u4f4d PFS \u7ea6 10.9 \u4e2a\u6708\uff0c\u53ef\u663e\u8457\u7f29\u5c0f\u80bf\u7624\u3002<strong>\u7f3a\u9677<\/strong>\uff1a\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u7387\u4f4e\uff08&lt;10%\uff09\uff0c\u8111\u8f6c\u79fb\u7597\u6548\u5dee\uff1b\u6613\u8bf1\u53d1 G1202R \u7b49\u8010\u836f\u7a81\u53d8\u3002\u76ee\u524d\u5df2\u7eb3\u5165\u533b\u4fdd\uff0c\u6708\u81ea\u4ed8\u8d39\u7528\u4f4e\u4e8e 2000 \u5143\uff0c\u9002\u7528\u4e8e\u7ecf\u6d4e\u538b\u529b\u5927\u3001\u65e0\u8111\u8f6c\u79fb\u60a3\u8005\u3002<\/p>\n<\/div>\n<div><\/div>\n<p><div id=\"attachment_817\" style=\"width: 400px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-817\" class=\" wp-image-817\" title=\"\u514b\u5511\u66ff\u5c3c\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/12.png\" alt=\"\u514b\u5511\u66ff\u5c3c\" width=\"390\" height=\"347\" \/><p id=\"caption-attachment-817\" class=\"wp-caption-text\">\u514b\u5511\u66ff\u5c3c<\/p><\/div><\/li>\n<li>\n<div>\n<p><strong>\u4e8c\u4ee3\uff1a\u963f\u6765\u66ff\u5c3c\u3001\u585e\u745e\u66ff\u5c3c\u3001\u6069\u6c99\u66ff\u5c3c<\/strong><\/p>\n<div><\/div>\n<p>\u76f8\u8f83\u4e00\u4ee3\uff0c<strong>\u5165\u8111\u80fd\u529b\u4e0e\u8010\u836f\u6027\u663e\u8457\u63d0\u5347<\/strong>\uff0c\u6210\u4e3a\u4e00\u7ebf\u4e3b\u6d41\u9009\u62e9\u3002<\/p>\n<\/div>\n<div><\/div>\n<ul>\n<li><strong>\u963f\u6765\u66ff\u5c3c\uff08Alectinib\uff09<\/strong>\uff1a\u4e00\u7ebf\u4e2d\u4f4d PFS \u8fbe 34.8 \u4e2a\u6708\uff0c5 \u5e74\u751f\u5b58\u7387\u8d85 60%\uff1b\u8111\u8f6c\u79fb\u60a3\u8005\u9885\u5185\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe 81%\uff0c\u662f\u76ee\u524d<strong>\u4e00\u7ebf\u9996\u9009\u836f\u7269<\/strong>\u30022025 \u5e74\u4e2d\u56fd\u9500\u552e\u989d\u8fbe 83.84 \u4ebf\u5143\uff0c\u5360 ALK \u5e02\u573a 32.23%\u3002<\/li>\n<li><strong>\u6069\u6c99\u66ff\u5c3c\uff08Ensartinib\uff09<\/strong>\uff1a\u56fd\u4ea7\u539f\u7814\uff0c\u5bf9\u514b\u5511\u66ff\u5c3c\u8010\u836f\u60a3\u8005 ORR \u8fbe 52%\uff0c\u5165\u8111\u80fd\u529b\u4f18\u5f02\uff0c\u4ef7\u683c\u66f4\u4eb2\u6c11\u3002<\/li>\n<\/ul>\n<div><\/div>\n<\/li>\n<li>\n<div>\n<p><strong>\u4e09\u4ee3\uff1a\u6d1b\u62c9\u66ff\u5c3c\uff08Lorlatinib\uff09<\/strong><\/p>\n<div><\/div>\n<p>\u552f\u4e00\u83b7\u6279\u7684<strong>\u5927\u73af\u7c7b ALK\/ROS1 \u53cc\u9776\u70b9 TKI<\/strong>\uff0c\u88ab\u8a89\u4e3a \u201c\u8010\u836f\u514b\u661f\u201d\u3002<\/p>\n<\/div>\n<div><\/div>\n<ul>\n<li><strong>\u6838\u5fc3\u4f18\u52bf<\/strong>\uff1a\u8986\u76d6\u4e00 \/ \u4e8c\u4ee3\u8010\u836f\u7a81\u53d8\uff08G1202R\u3001I1171N \u7b49\uff09\uff1b\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u7387\u8fbe 75%\uff0c\u8111\u8f6c\u79fb\u60a3\u8005\u9885\u5185\u4e2d\u4f4d PFS \u8d85 30 \u4e2a\u6708\uff1b<\/li>\n<li><strong>\u4e34\u5e8a\u6570\u636e<\/strong>\uff1a\u4e00\u7ebf\u6cbb\u7597 5 \u5e74 PFS \u7387\u8d85 60%\uff0c\u7d2f\u79ef\u751f\u5b58\u671f\u53ef\u8fbe 12.3 \u5e74\uff1b\u540e\u7ebf\u6cbb\u7597 ORR \u8fbe 26.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u8fbe 86.7%\u3002<\/li>\n<\/ul>\n<div>\n<div id=\"attachment_818\" style=\"width: 431px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-818\" class=\" wp-image-818\" title=\"\u6d1b\u62c9\u66ff\u5c3c\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670-1.jpg\" alt=\"\u6d1b\u62c9\u66ff\u5c3c\" width=\"421\" height=\"237\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670-1.jpg 800w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670-1-768x432.jpg 768w\" sizes=\"auto, (max-width: 421px) 100vw, 421px\" \/><p id=\"caption-attachment-818\" class=\"wp-caption-text\">\u6d1b\u62c9\u66ff\u5c3c<\/p><\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<p><strong>\u56db\u4ee3\uff1aTRI-611\uff08\u5206\u5b50\u80f6\u964d\u89e3\u5242\uff09<\/strong><\/p>\n<div><\/div>\n<p>\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u7684<strong>\u7b2c\u56db\u4ee3 ALK \u5206\u5b50\u80f6\u964d\u89e3\u5242<\/strong>\uff0c\u7a81\u7834\u4f20\u7edf TKI \u4f5c\u7528\u673a\u5236\u3002<\/p>\n<\/div>\n<div><\/div>\n<ul>\n<li><strong>\u521b\u65b0\u673a\u5236<\/strong>\uff1a\u4e0d\u4f9d\u8d56\u6fc0\u9176\u6d3b\u6027\u4f4d\u70b9\uff0c\u76f4\u63a5\u964d\u89e3 ALK \u878d\u5408\u86cb\u767d\uff0c\u514b\u670d 30 \u591a\u79cd\u8010\u836f\u7a81\u53d8\uff08\u542b\u590d\u5408\u7a81\u53d8\uff09\uff1b<\/li>\n<li><strong>\u6838\u5fc3\u7a81\u7834<\/strong>\uff1a\u5f3a\u6548\u5165\u8111\uff0c\u6e05\u9664\u9885\u5185\u75c5\u7076\uff1b\u4e0e\u4f20\u7edf TKI \u534f\u540c\u589e\u6548\uff0c\u5ef6\u7f13\u8010\u836f\u3002<\/li>\n<\/ul>\n<div><\/div>\n<\/li>\n<\/ul>\n<div><\/div>\n<h4>2. ROS1 \u9776\u70b9\uff1a\u56fd\u4ea7\u65b0\u836f\u7a81\u56f4\uff0c\u653b\u514b\u8010\u836f\u4e0e\u8111\u8f6c\u79fb<\/h4>\n<div><\/div>\n<ul>\n<li><strong>\u4f20\u7edf\u836f\u7269<\/strong>\uff1a\u514b\u5511\u66ff\u5c3c\u3001\u6069\u66f2\u66ff\u5c3c\u3001\u745e\u666e\u66ff\u5c3c\u4e3a\u4e00\u7ebf\u9009\u62e9\uff0c\u6069\u66f2\u66ff\u5c3c\u5165\u8111\u80fd\u529b\u5f3a\uff0c\u4f46\u5bf9 G2032R \u8010\u836f\u7a81\u53d8\u65e0\u6548\u3002<\/li>\n<li><strong>\u56fd\u4ea7\u7a81\u7834\uff1aJYP0322\uff082026 \u5e74\uff09<\/strong>\n<div><\/div>\n<p>\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u7814\u53d1\uff0c\u53d1\u8868\u4e8e\u300aCancer Cell\u300b\uff0c\u662f<strong>\u5168\u7403\u9996\u4e2a\u9ad8\u6548\u514b\u670d G2032R \u8010\u836f\u7684 ROS1 \u6291\u5236\u5242<\/strong>\u3002<\/p>\n<ul>\n<li><strong>\u7597\u6548<\/strong>\uff1a\u521d\u6cbb\u60a3\u8005 ORR \u8fbe 90%\uff0c\u8010\u836f\u60a3\u8005 ORR \u8fbe 60%\uff1b\u8111\u8f6c\u79fb\u60a3\u8005\u9885\u5185\u7f13\u89e3\u7387\u8d85 80%\uff1b<\/li>\n<li><strong>\u4f18\u52bf<\/strong>\uff1a\u9ad8\u9009\u62e9\u6027\uff0c\u4e2d\u67a2\u795e\u7ecf\u6bd2\u6027\u4f4e\uff0c\u586b\u8865\u56fd\u5185 ROS1 \u8010\u836f\u6cbb\u7597\u7a7a\u767d\u3002<\/li>\n<\/ul>\n<div><\/div>\n<\/li>\n<\/ul>\n<div><\/div>\n<h2>\u4e8c\u3001\u809d\u764c\uff1a\u4ece \u201c\u96be\u6cbb\u201d \u5230 \u201c\u53ef\u63a7\u201d\uff0c\u9776\u5411\u4e0e\u514d\u75ab\u8054\u5408\u7a81\u7834<\/h2>\n<div><\/div>\n<div>\u809d\u764c\uff08\u539f\u53d1\u6027\u809d\u7ec6\u80de\u764c\uff09\u662f\u4e2d\u56fd\u9ad8\u53d1\u6076\u6027\u80bf\u7624\uff0c\u53d1\u75c5\u4e0e\u4e59\u809d\u3001\u4e19\u809d\u3001\u9ec4\u66f2\u9709\u6bd2\u7d20\u5bc6\u5207\u76f8\u5173\uff0c<strong>70% \u60a3\u8005\u521d\u8bca\u5373\u4e3a\u665a\u671f<\/strong>\uff0c\u65e2\u5f80\u751f\u5b58\u671f\u4e0d\u8db3 1 \u5e74\u3002\u8fd1\u5e74\u9776\u5411\u836f\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u8054\u5408\u5e94\u7528\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u665a\u671f\u809d\u764c\u7684\u6cbb\u7597\u683c\u5c40\u3002<\/div>\n<div><\/div>\n<h3>\uff08\u4e00\uff09\u6cbb\u7597\u73b0\u72b6\uff1a\u9776\u5411\u8054\u5408\u514d\u75ab\u6210\u4e3a\u4e00\u7ebf\uff0c\u591a\u9776\u70b9\u836f\u7269\u4e3b\u5bfc<\/h3>\n<div><\/div>\n<ol>\n<li><strong>\u4e00\u7ebf\u6807\u51c6<\/strong>\uff1a<strong>\u963f\u66ff\u5229\u73e0\u5355\u6297 + \u8d1d\u4f10\u73e0\u5355\u6297\uff08T+A \u65b9\u6848\uff09<\/strong> \u4e3a\u5168\u7403\u9996\u9009\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u8fbe 19.2 \u4e2a\u6708\uff1b\u56fd\u4ea7\u65b9\u6848\u5982<strong>\u4fe1\u8fea\u5229\u5355\u6297 + \u8d1d\u4f10\u73e0\u5355\u6297\u7c7b\u4f3c\u7269<\/strong>\u7597\u6548\u76f8\u5f53\uff0c\u66f4\u9002\u5408\u4e2d\u56fd\u60a3\u8005\u3002<\/li>\n<li><strong>\u4e8c\u7ebf\u53ca\u540e\u7ebf<\/strong>\uff1a\u745e\u6208\u975e\u5c3c\u3001\u5361\u535a\u66ff\u5c3c\u3001\u96f7\u83ab\u82a6\u5355\u6297\u7b49\u591a\u9776\u70b9\u836f\u7269\uff0c\u7528\u4e8e\u4e00\u7ebf\u8fdb\u5c55\u540e\u6cbb\u7597\uff0c\u4e2d\u4f4d OS \u5ef6\u957f\u81f3 10-14 \u4e2a\u6708\u3002<\/li>\n<li><strong>\u6838\u5fc3\u7279\u70b9<\/strong>\uff1a\u809d\u764c\u9776\u70b9\u590d\u6742\uff08VEGF\u3001FGFR\u3001c-Met \u7b49\uff09\uff0c<strong>\u65e0\u7edd\u5bf9 \u201c\u9a71\u52a8\u9776\u70b9\u201d<\/strong>\uff0c\u591a\u9776\u70b9\u9776\u5411\u836f\u4e3a\u4e3b\uff0c\u5355\u836f\u7597\u6548\u6709\u9650\uff0c\u8054\u5408\u6cbb\u7597\u6210\u4e3b\u6d41\u3002<\/li>\n<\/ol>\n<div><\/div>\n<h3>\uff08\u4e8c\uff09\u9776\u5411\u836f\u53d1\u5c55\uff1a\u591a\u9776\u70b9\u8986\u76d6\uff0c\u56fd\u4ea7\u521b\u65b0\u5d1b\u8d77<\/h3>\n<div><\/div>\n<h4>1. \u4e00\u7ebf\u9776\u5411\u836f\u7269<\/h4>\n<div><\/div>\n<ul>\n<li><strong>\u7d22\u62c9\u975e\u5c3c\uff08Sorafenib\uff09<\/strong>\uff1a\u9996\u4e2a\u83b7\u6279\u809d\u764c\u9776\u5411\u836f\uff0c2007 \u5e74\u4e0a\u5e02\uff0c\u4e2d\u4f4d OS \u8fbe 10.7 \u4e2a\u6708\uff0c\u5960\u5b9a\u9776\u5411\u6cbb\u7597\u57fa\u7840\u3002<\/li>\n<li><strong>\u4ed1\u4f10\u66ff\u5c3c\uff08Lenvatinib\uff09<\/strong>\uff1a2018 \u5e74\u83b7\u6279\uff0c\u4e00\u7ebf\u4e2d\u4f4d OS \u8fbe 13.6 \u4e2a\u6708\uff0c\u4f18\u4e8e\u7d22\u62c9\u975e\u5c3c\uff1b\u5bf9\u4e59\u809d\u76f8\u5173\u809d\u764c\u7597\u6548\u66f4\u4f18\uff0c\u6210\u4e3a<strong>\u4e00\u7ebf\u9996\u9009\u9776\u5411\u836f<\/strong>\u3002<\/li>\n<\/ul>\n<div><\/div>\n<h4>2. \u4e8c\u7ebf\u53ca\u540e\u7ebf\u9776\u5411\u836f\u7269<\/h4>\n<div><\/div>\n<ul>\n<li><strong>\u745e\u6208\u975e\u5c3c\uff08Regorafenib\uff09<\/strong>\uff1a\u591a\u9776\u70b9\u6291\u5236\u5242\uff0c\u7528\u4e8e\u7d22\u62c9\u975e\u5c3c\u8fdb\u5c55\u540e\uff0c\u4e2d\u4f4d OS \u8fbe 10.6 \u4e2a\u6708\u3002<\/li>\n<li><strong>\u5361\u535a\u66ff\u5c3c\uff08Cabozantinib\uff09<\/strong>\uff1a\u8986\u76d6 VEGF\u3001c-Met\u3001RET \u7b49 9 \u4e2a\u9776\u70b9\uff0c\u8010\u836f\u540e ORR \u8fbe 18%\uff0c\u4e2d\u4f4d OS \u8fbe 11.3 \u4e2a\u6708\u3002<\/li>\n<li><strong>\u56fd\u4ea7\u65b0\u836f<\/strong>\uff1a<strong>\u963f\u5e15\u66ff\u5c3c\u3001\u591a\u7eb3\u975e\u5c3c<\/strong>\uff0c\u4ef7\u683c\u4f4e\u5ec9\uff0c\u7597\u6548\u4e0e\u8fdb\u53e3\u836f\u7269\u76f8\u5f53\uff0c\u5df2\u7eb3\u5165\u533b\u4fdd\uff0c\u5927\u5e45\u63d0\u5347\u53ef\u53ca\u6027\u3002<\/li>\n<\/ul>\n<div><\/div>\n<h4>3. \u7814\u53d1\u8d8b\u52bf\uff1a\u7cbe\u51c6\u9776\u70b9\u7ec6\u5206\u4e0e\u8054\u5408\u6cbb\u7597<\/h4>\n<div><\/div>\n<ul>\n<li><strong>\u7279\u5f02\u6027\u9776\u70b9<\/strong>\uff1a\u9488\u5bf9 FGFR \u878d\u5408\u3001c-Met \u6269\u589e\u3001NTRK \u878d\u5408\u7b49\u7f55\u89c1\u9776\u70b9\u7684\u836f\u7269\uff08\u5982\u5384\u8fbe\u66ff\u5c3c\u3001\u62c9\u7f57\u66ff\u5c3c\uff09\u8fdb\u5165\u4e34\u5e8a\uff0c\u4e3a\u90e8\u5206\u60a3\u8005\u63d0\u4f9b\u7cbe\u51c6\u9009\u62e9\u3002<\/li>\n<li><strong>\u8054\u5408\u65b9\u6848<\/strong>\uff1a\u9776\u5411 + \u514d\u75ab\u3001\u9776\u5411 + \u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u6210\u4e3a\u4e3b\u6d41\uff0c\u5982\u4ed1\u4f10\u66ff\u5c3c + \u5e15\u535a\u5229\u73e0\u5355\u6297\uff0c\u4e2d\u4f4d OS \u8fbe 21.2 \u4e2a\u6708\uff0c\u7a81\u7834\u5355\u836f\u7597\u6548\u74f6\u9888\u3002<\/li>\n<\/ul>\n<div><\/div>\n<h2>\u4e09\u3001\u4e73\u817a\u764c\uff1a\u5206\u578b\u7cbe\u51c6\u5316\uff0c\u9776\u5411\u836f\u8986\u76d6\u5168\u6d41\u7a0b<\/h2>\n<div><\/div>\n<div>\u4e73\u817a\u764c\u662f\u5973\u6027\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e2d\u56fd\u6bcf\u5e74\u65b0\u53d1\u75c5\u4f8b\u8d85 35 \u4e07\uff0c\u6b7b\u4ea1\u7ea6 7.5 \u4e07\u4f8b\u3002\u57fa\u4e8e\u6fc0\u7d20\u53d7\u4f53\uff08ER\/PR\uff09\u3001HER2 \u8868\u8fbe\u72b6\u6001\uff0c\u4e73\u817a\u764c\u5206\u4e3a<strong>HR \u9633\u6027\u3001HER2 \u9633\u6027\u3001\u4e09\u9634\u6027<\/strong>\u4e09\u5927\u4e9a\u578b\uff0c\u9776\u5411\u6cbb\u7597\u5df2\u8986\u76d6\u65b0\u8f85\u52a9\u3001\u8f85\u52a9\u3001\u665a\u671f\u59d1\u606f\u5168\u6d41\u7a0b\u3002<\/div>\n<div><\/div>\n<h3>\uff08\u4e00\uff09\u6cbb\u7597\u73b0\u72b6\uff1a\u5206\u578b\u800c\u6cbb\uff0c\u9776\u5411\u836f\u6210\u4e3a\u5404\u4e9a\u578b\u6838\u5fc3<\/h3>\n<div><\/div>\n<ol>\n<li><strong>HR \u9633\u6027\uff08ER+\/PR+\uff0c\u5360 70%\uff09<\/strong>\uff1a\u5185\u5206\u6ccc\u6cbb\u7597\u8054\u5408<strong>CDK4\/6 \u6291\u5236\u5242<\/strong>\u4e3a\u4e00\u7ebf\u6807\u51c6\uff0c\u4e2d\u4f4d PFS \u8fbe 24-30 \u4e2a\u6708\uff1b\u540e\u7ebf\u9762\u4e34\u5185\u5206\u6ccc\u8010\u836f\uff0c\u9776\u5411\u836f\uff08mTOR \u6291\u5236\u5242\u3001AKT \u6291\u5236\u5242\uff09\u4e3a\u4e3b\u8981\u9009\u62e9\u3002<\/li>\n<li><strong>HER2 \u9633\u6027\uff08\u5360 20%-25%\uff09<\/strong>\uff1a<strong>\u6297 HER2 \u9776\u5411\u836f + \u5316\u7597<\/strong>\u4e3a\u6838\u5fc3\uff0c\u65b0\u8f85\u52a9\u6cbb\u7597\u53ef\u5b9e\u73b0\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff08pCR\uff09\uff0c\u8f85\u52a9\u6cbb\u7597\u964d\u4f4e\u590d\u53d1\u98ce\u9669\uff0c\u665a\u671f\u6cbb\u7597\u663e\u8457\u5ef6\u957f\u751f\u5b58\u671f\u3002<\/li>\n<li><strong>\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff0c\u5360 15%-20%\uff09<\/strong>\uff1a\u65e2\u5f80\u4ee5\u5316\u7597\u4e3a\u4e3b\uff0c\u9884\u540e\u6700\u5dee\uff1b\u8fd1\u5e74<strong>ADC \u836f\u7269\u3001PARP \u6291\u5236\u5242<\/strong>\u7a81\u7834\uff0c\u4e3a BRCA \u7a81\u53d8\u3001PD-L1 \u9633\u6027\u60a3\u8005\u63d0\u4f9b\u65b0\u9009\u62e9\u3002<\/li>\n<\/ol>\n<div><\/div>\n<h3>\uff08\u4e8c\uff09\u9776\u5411\u836f\u53d1\u5c55\uff1aADC \u836f\u7269\u5f15\u9886\uff0c\u56fd\u4ea7\u521b\u65b0\u4e0e\u53cc\u6297\u7a81\u7834<\/h3>\n<div><\/div>\n<h4>1. HER2 \u9633\u6027\u4e73\u817a\u764c\uff1a\u4ece\u5355\u6297\u5230 ADC\uff0c\u7597\u6548\u6301\u7eed\u5347\u7ea7<\/h4>\n<div><\/div>\n<ul>\n<li><strong>\u7ecf\u5178\u5355\u6297<\/strong>\uff1a\u66f2\u59a5\u73e0\u5355\u6297\u3001\u5e15\u59a5\u73e0\u5355\u6297\uff0c\u4e00\u7ebf\u8054\u5408\u5316\u7597\u4e2d\u4f4d OS \u8fbe 50 \u4e2a\u6708\uff0c\u662f 20 \u5e74\u6807\u51c6\u65b9\u6848\u3002<\/li>\n<li><strong>\u5c0f\u5206\u5b50 TKI<\/strong>\uff1a\u62c9\u5e15\u66ff\u5c3c\u3001\u6765\u90a3\u66ff\u5c3c\u3001\u56fe\u5361\u66ff\u5c3c\uff0c\u7528\u4e8e\u66f2\u59a5\u73e0\u5355\u6297\u8010\u836f\u540e\uff0c\u56fe\u5361\u66ff\u5c3c\u5165\u8111\u80fd\u529b\u5f3a\uff0c\u8111\u8f6c\u79fb\u60a3\u8005 OS \u8fbe 18 \u4e2a\u6708\u3002<\/li>\n<li><strong>ADC \u836f\u7269\uff08\u6297\u4f53\u5076\u8054\u836f\u7269\uff09<\/strong>\uff1a<strong>DS-8201\uff08\u5fb7\u66f2\u59a5\u73e0\u5355\u6297\uff09<\/strong> \u4e3a\u5168\u7403\u6807\u6746\uff0c\u540e\u7ebf\u6cbb\u7597 ORR \u8fbe 79%\uff0c\u4e2d\u4f4d OS \u8fbe 28.8 \u4e2a\u6708\uff1b\u56fd\u4ea7<strong>\u7ef4\u8fea\u897f\u59a5\u5355\u6297<\/strong>\u7597\u6548\u76f8\u5f53\uff0c\u4ef7\u683c\u66f4\u4f4e\u3002<\/li>\n<li><strong>\u56fd\u4ea7\u53cc\u9776\u70b9\u65b0\u836f\uff1aTQB2102<\/strong>\uff082025 \u5e74\uff09\uff1a\u540c\u65f6\u9776\u5411 HER2 \u53cc\u8868\u4f4d\uff0c\u65e0\u9700\u8054\u5408\u5316\u7597\uff0c\u5355\u836f ORR \u8fbe 33.3%\uff0c\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\u8fbe 73.1%\uff0c\u4e3a\u8010\u836f\u60a3\u8005\u63d0\u4f9b\u65b0\u9009\u62e9\u3002<\/li>\n<\/ul>\n<div><\/div>\n<h4>2. HR \u9633\u6027\u4e73\u817a\u764c\uff1aCDK4\/6 \u6291\u5236\u5242\u4e3b\u5bfc\uff0c\u8010\u836f\u9776\u5411\u836f\u7a81\u7834<\/h4>\n<div><\/div>\n<ul>\n<li><strong>CDK4\/6 \u6291\u5236\u5242<\/strong>\uff1a\u54cc\u67cf\u897f\u5229\u3001\u745e\u535a\u897f\u5229\u3001\u963f\u8d1d\u897f\u5229\uff0c\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u4e00\u7ebf\u4e2d\u4f4d PFS \u8fbe 2 \u5e74\u4ee5\u4e0a\uff0c\u5df2\u7eb3\u5165\u533b\u4fdd\u3002<\/li>\n<li><strong>\u8010\u836f\u540e\u9776\u5411<\/strong>\uff1amTOR \u6291\u5236\u5242\uff08\u4f9d\u7ef4\u83ab\u53f8\uff09\u3001AKT \u6291\u5236\u5242\uff08\u5361\u5339\u74e6\u585e\u66ff\u5c3c\uff09\u3001HER2 \u4f4e\u8868\u8fbe ADC \u836f\u7269\uff08\u5fb7\u8fbe\u535a\u59a5\u5355\u6297\uff09\uff0c\u7834\u89e3\u5185\u5206\u6ccc\u8010\u836f\u56f0\u5c40\u3002<\/li>\n<\/ul>\n<div><\/div>\n<h4>3. \u4e09\u9634\u6027\u4e73\u817a\u764c\uff1a\u7cbe\u51c6\u9776\u5411\u7a81\u7834\uff0cADC \u4e0e PARP \u6291\u5236\u5242\u6210\u4e3b\u529b<\/h4>\n<div><\/div>\n<ul>\n<li><strong>PARP \u6291\u5236\u5242<\/strong>\uff1a\u5965\u62c9\u5e15\u5229\u3001 talazoparib\uff0c\u7528\u4e8e BRCA \u7a81\u53d8\u60a3\u8005\uff0c\u4e2d\u4f4d PFS \u8fbe 7-10 \u4e2a\u6708\u3002<\/li>\n<li><strong>ADC \u836f\u7269<\/strong>\uff1a<strong>\u6208\u6c99\u59a5\u73e0\u5355\u6297<\/strong>\uff08Trop-2 \u9776\u5411\uff09\uff0c\u540e\u7ebf\u6cbb\u7597 ORR \u8fbe 35%\uff0c\u4e2d\u4f4d OS \u8fbe 12.1 \u4e2a\u6708\uff1b\u56fd\u4ea7<strong>\u5fb7\u8fbe\u535a\u59a5\u5355\u6297<\/strong>2026 \u5e74\u83b7\u6279\uff0c\u7528\u4e8e HR \u9633\u6027 \/ HER2 \u9634\u6027\u540e\u7ebf\u6cbb\u7597\uff0c\u964d\u4f4e 46% \u8fdb\u5c55\u98ce\u9669\u3002<\/li>\n<\/ul>\n<div><\/div>\n<h2>\u56db\u3001\u4e09\u5927\u764c\u79cd\u9776\u5411\u6cbb\u7597\u5171\u6027\u8d8b\u52bf\u4e0e\u672a\u6765\u5c55\u671b<\/h2>\n<div><\/div>\n<h3>\uff08\u4e00\uff09\u5171\u6027\u8d8b\u52bf<\/h3>\n<div><\/div>\n<ol>\n<li><strong>\u7cbe\u51c6\u5316<\/strong>\uff1a\u5206\u5b50\u8bca\u65ad\u6280\u672f\uff08NGS\u3001ctDNA\uff09\u666e\u53ca\uff0c\u4ece \u201c\u7ecf\u9a8c\u6cbb\u7597\u201d \u5411 \u201c\u57fa\u56e0\u5206\u578b\u6307\u5bfc\u201d \u8f6c\u53d8\uff0c\u7f55\u89c1\u9776\u70b9\u60a3\u8005\u83b7\u76ca\u663e\u8457\u3002<\/li>\n<li><strong>\u8010\u836f\u653b\u514b<\/strong>\uff1a\u56db\u4ee3 ALK \u5206\u5b50\u80f6\u964d\u89e3\u5242\u3001ROS1 \u9ad8\u9009\u62e9\u6027\u6291\u5236\u5242\u3001ADC 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