{"id":797,"date":"2026-05-12T22:22:26","date_gmt":"2026-05-12T14:22:26","guid":{"rendered":"https:\/\/www.yaozhiyou.com\/?p=797"},"modified":"2026-05-12T22:22:26","modified_gmt":"2026-05-12T14:22:26","slug":"%e9%92%bb%e7%9f%b3%e7%aa%81%e5%8f%98%e7%9a%84-%e7%bb%88%e6%9e%81%e6%ad%a6%e5%99%a8%ef%bd%9c%e5%8a%b3%e6%8b%89%e6%9b%bf%e5%b0%bc%ef%bc%9a%e7%a9%bf%e9%80%8f%e8%a1%80%e8%84%91%e5%b1%8f","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=797","title":{"rendered":"\u94bb\u77f3\u7a81\u53d8\u7684 \u201c\u7ec8\u6781\u6b66\u5668\u201d\uff5c\u52b3\u62c9\u66ff\u5c3c\uff1a\u7a7f\u900f\u8840\u8111\u5c4f\u969c\u3001\u653b\u514b\u8010\u836f\u3001\u5b88\u62a4\u957f\u751f\u5b58"},"content":{"rendered":"<p>\u5982\u679c\u8bf4 ALK \u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u662f\u80ba\u764c\u91cc\u7684 \u201c\u94bb\u77f3\u7a81\u53d8\u201d\u2014\u2014 \u9776\u5411\u836f\u591a\u3001\u7597\u6548\u597d\u3001\u751f\u5b58\u671f\u957f\uff0c\u90a3\u52b3\u62c9\u66ff\u5c3c\uff08\u6d1b\u62c9\u66ff\u5c3c\uff0c\u5546\u54c1\u540d\uff1a\u535a\u745e\u7eb3\uff09\uff0c\u5c31\u662f\u94bb\u77f3\u7a81\u53d8\u91cc\u7684 **\u201c\u7ec8\u6781\u9632\u7ebf\u201d**\u3002<br \/>\n\u5b83\u662f\u7b2c\u4e09\u4ee3 ALK\/ROS1 \u53cc\u9776\u70b9\u9776\u5411\u836f\uff0c\u65e2\u80fd\u89e3\u51b3\u4e00\u4ee3\u3001\u4e8c\u4ee3\u8010\u836f\uff0c\u53c8\u80fd\u5f3a\u529b\u63a7\u5236\u8111\u8f6c\u79fb\uff0c\u66f4\u662f\u76ee\u524d\u552f\u4e00\u8ba9 ALK \u9633\u6027\u60a3\u8005 **5 \u5e74\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u7a81\u7834 60%** \u7684\u9776\u5411\u836f\u3002\u4eca\u5929\u6211\u4eec\u7528\u901a\u4fd7\u8bed\u8a00\uff0c\u628a\u5b83\u8bb2\u900f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-801\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u52b3\u62c92-1.png\" alt=\"\" width=\"661\" height=\"335\" \/><\/p>\n<p>\u4e00\u3001\u52b3\u62c9\u66ff\u5c3c\u662f\u4ec0\u4e48\uff1f\u8c01\u80fd\u7528\uff1f<\/p>\n<p>\u57fa\u672c\u4fe1\u606f<\/p>\n<p>\u901a\u7528\u540d\uff1a\u52b3\u62c9\u66ff\u5c3c\uff08Lorlatinib\uff09\uff0c\u56fd\u5185\u901a\u7528\u540d\uff1a\u6d1b\u62c9\u66ff\u5c3c<\/p>\n<p>\u5546\u54c1\u540d\uff1a\u535a\u745e\u7eb3\uff08Lorbrena\uff09<\/p>\n<p>\u5382\u5bb6\uff1a\u8f89\u745e\uff08\u539f\u7814\uff09<\/p>\n<p>\u9776\u70b9\uff1aALK + ROS1\uff08\u53cc\u9776\u70b9\uff09<\/p>\n<p>\u5b9a\u4f4d\uff1a\u7b2c\u4e09\u4ee3 ALK-TKI\uff0c\u4e13\u6cbb \u201c\u4e00\u4ee3 \/ \u4e8c\u4ee3\u8010\u836f + \u8111\u8f6c\u79fb\u201d<\/p>\n<p>\u9002\u5e94\u75c7\uff08\u7b80\u5355\u8bf4\uff09<\/p>\n<p>ALK \u9633\u6027\u665a\u671f \/ \u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u5305\u62ec\uff1a<\/p>\n<p>\u4e00\u7ebf\u76f4\u63a5\u7528\uff08\u4f18\u5148\u63a8\u8350\uff0c\u7597\u6548\u6700\u5f3a\uff09<\/p>\n<p>\u514b\u5511\u66ff\u5c3c\u8010\u836f\u540e<\/p>\n<p>\u963f\u6765\u66ff\u5c3c \/ \u585e\u745e\u66ff\u5c3c \/ \u5e03\u683c\u66ff\u5c3c\u7b49\u4e8c\u4ee3\u836f\u8010\u836f\u540e<\/p>\n<p>\u5408\u5e76\u8111\u8f6c\u79fb\uff08\u6700\u9002\u5408\uff09\u53c2\u89c1\u4e0b\u56fe\uff1a<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-804\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670-2.png\" alt=\"\" width=\"739\" height=\"731\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670-2.png 1092w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670-2-768x760.png 768w\" sizes=\"auto, (max-width: 739px) 100vw, 739px\" \/><\/p>\n<p>\u4e00\u53e5\u8bdd\uff1a\u53ea\u8981\u662f ALK \u9633\u6027\uff0c\u4e0d\u7ba1\u521d\u6cbb\u8fd8\u662f\u8010\u836f\u3001\u6709\u6ca1\u6709\u8111\u8f6c\u79fb\uff0c\u52b3\u62c9\u66ff\u5c3c\u90fd\u80fd\u4e0a\u3002<\/p>\n<p>\u4e8c\u3001\u4e3a\u4ec0\u4e48\u5b83\u88ab\u79f0\u4e3a \u201c\u8111\u8f6c\u79fb\u514b\u661f\u201d\uff1f<\/p>\n<p>ALK \u80ba\u764c\u7279\u522b\u5bb9\u6613\u8111\u8f6c\u79fb\uff08\u53d1\u751f\u7387\u7ea6 30%\u201360%\uff09\uff0c\u800c\u4e00\u4ee3\u3001\u4e8c\u4ee3\u836f\u666e\u904d\u5165\u8111\u5dee\uff0c\u8111\u8f6c\u79fb\u540e\u5bb9\u6613\u8fdb\u5c55\u3001\u96be\u6cbb\u3002<\/p>\n<p>\u52b3\u62c9\u66ff\u5c3c\u7684\u4e09\u5927\u786c\u6838\u4f18\u52bf\uff1a<\/p>\n<p>1. \u8d85\u5f3a\u5165\u8111\u80fd\u529b\uff08\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u7387\u224875%\uff09<\/p>\n<p>\u8111\u810a\u6db2\u6d53\u5ea6 \u2248 \u8840\u6d46\u6d53\u5ea6\u768475%\uff08\u963f\u6765\u66ff\u5c3c\u4ec5 0.5%\uff09<\/p>\n<p>\u9885\u5185\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u2248 82%<\/p>\n<p>\u9885\u5185\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u2248 92%<\/p>\n<p>\u2192 \u7b80\u5355\u8bf4\uff1a\u80fd\u76f4\u63a5\u6253\u8fdb\u5927\u8111\uff0c\u628a\u8111\u8f6c\u79fb\u75c5\u7076 \u201c\u6253\u6ca1\u201d \u6216\u957f\u671f\u63a7\u5236\u3002<\/p>\n<p>2. \u901a\u6740\u6240\u6709 ALK \u8010\u836f\u7a81\u53d8<\/p>\n<p>\u8986\u76d6\uff1aG1202R\u3001I1171T\u3001L1196M\u7b49\u51e0\u4e4e\u6240\u6709\u4e00 \/ \u4e8c\u4ee3\u8010\u836f\u7a81\u53d8\u3002<\/p>\n<p>\u2192 \u4e8c\u4ee3\u836f\u8010\u836f\u540e\uff0c\u7ea6 90% \u60a3\u8005\u7528\u52b3\u62c9\u66ff\u5c3c\u4ecd\u6709\u6548\u3002<\/p>\n<p>3. \u4e00\u7ebf\u7597\u6548 \u201c\u5929\u82b1\u677f\u201d\uff08CROWN \u7814\u7a76 5 \u5e74\u6570\u636e\uff09<\/p>\n<p>\u4e00\u7ebf 5 \u5e74\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\uff08PFS\uff09\uff1a60%<\/p>\n<p>\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff1a\u672a\u8fbe\u5230\uff08\u8fdc\u8d85\u4e8c\u4ee3\u836f\uff09<\/p>\n<p>5 \u5e74\u603b\u751f\u5b58\u7387\uff08OS\uff09\uff1a73%<\/p>\n<p>\u2192 \u771f\u6b63\u5b9e\u73b0\uff1a\u628a\u665a\u671f\u80ba\u764c\u53d8\u6210\u6162\u6027\u75c5\uff0c\u6d3b\u8fc7 5 \u5e74\u300110 \u5e74\u4e0d\u518d\u662f\u68a6\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-803\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670.jpg\" alt=\"\" width=\"848\" height=\"480\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670.jpg 848w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u56fe\u7247\u53d8\u6e05\u6670-768x435.jpg 768w\" sizes=\"auto, (max-width: 848px) 100vw, 848px\" \/><\/p>\n<p>\u4e09\u4ee3 ALK-TKI \u7ec8\u6781\u5bf9\u6bd4\u8868\uff08\u6d1b\u62c9\u66ff\u5c3c \/ \u52b3\u62c9\u66ff\u5c3c\u3001\u963f\u6765\u66ff\u5c3c\u3001\u585e\u745e\u66ff\u5c3c\u3001\u6069\u6c99\u66ff\u5c3c\u3001\u5e03\u52a0\u66ff\u5c3c\uff09<\/p>\n<p>\u805a\u7126\u5165\u8111\u80fd\u529b\u3001\u6574\u4f53\u7597\u6548\u3001\u526f\u4f5c\u7528\u4e09\u5927\u6838\u5fc3\uff0c\u4e00\u76ee\u4e86\u7136\u3002<\/p>\n<p>\u4e09\u4ee3 ALK \u9776\u5411\u836f\u5bf9\u6bd4\u603b\u8868<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u54c1<\/th>\n<th>\u4ee3\u6b21<\/th>\n<th>\u4e2d\u6587\u540d<\/th>\n<th>\u5165\u533b\u4fdd<\/th>\n<th>\u5165\u8111\u80fd\u529b<\/th>\n<th>\u6838\u5fc3\u4f18\u52bf<\/th>\n<th>\u77ed\u677f<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u514b\u5511\u66ff\u5c3c<\/td>\n<td>\u4e00\u4ee3<\/td>\n<td>\u514b\u5511\u66ff\u5c3c<\/td>\n<td>\u662f<\/td>\n<td>\u5f31<\/td>\n<td>\u4ef7\u683c\u6700\u4f4e\u3001\u57fa\u7840\u4e00\u7ebf<\/td>\n<td>\u5165\u8111\u5dee\u3001\u8010\u836f\u5feb<\/td>\n<\/tr>\n<tr>\n<td>\u585e\u745e\u66ff\u5c3c<\/td>\n<td>\u4e8c\u4ee3<\/td>\n<td>\u585e\u745e\u66ff\u5c3c<\/td>\n<td>\u662f<\/td>\n<td>\u4e2d<\/td>\n<td>\u8010\u836f\u4f4d\u70b9\u8986\u76d6\u5e7f<\/td>\n<td>\u80c3\u80a0\u9053\u526f\u4f5c\u7528\u5927<\/td>\n<\/tr>\n<tr>\n<td>\u963f\u6765\u66ff\u5c3c<\/td>\n<td>\u4e8c\u4ee3<\/td>\n<td>\u963f\u6765\u66ff\u5c3c<\/td>\n<td>\u662f<\/td>\n<td>\u6781\u5f3a<\/td>\n<td>\u4e00\u7ebf\u6807\u51c6\u3001\u63a7\u8111\u6700\u5f3a\u3001\u751f\u5b58\u671f\u6700\u957f<\/td>\n<td>\u4ef7\u683c\u504f\u9ad8\u3001\u90e8\u5206\u4eba\u809d\u9176\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u5e03\u52a0\u66ff\u5c3c<\/td>\n<td>\u4e8c\u4ee3<\/td>\n<td>\u5e03\u52a0\u66ff\u5c3c<\/td>\n<td>\u5426<\/td>\n<td>\u5f3a<\/td>\n<td>\u8010\u514b\u5511\u3001\u8010\u90e8\u5206\u963f\u6765\u3001\u80ba\u6bd2\u6027\u6e29\u548c<\/td>\n<td>\u56fd\u5185\u53ef\u53ca\u6027\u4e00\u822c<\/td>\n<\/tr>\n<tr>\n<td>\u6069\u6c99\u66ff\u5c3c<\/td>\n<td>\u4e8c\u4ee3<\/td>\n<td>\u6069\u6c99\u66ff\u5c3c<\/td>\n<td>\u662f<\/td>\n<td>\u4e2d\u5f3a<\/td>\n<td>\u56fd\u4ea7\u3001\u6027\u4ef7\u6bd4\u9ad8\u3001\u9002\u5408\u540e\u7ebf<\/td>\n<td>\u4e00\u7ebf\u6570\u636e\u504f\u5f31<\/td>\n<\/tr>\n<tr>\n<td>\u4f0a\u9c81\u963f\u514b<\/td>\n<td>\u4e8c\u4ee3<\/td>\n<td>\u4f0a\u9c81\u963f\u514b<\/td>\n<td>\u662f<\/td>\n<td>\u5f3a<\/td>\n<td>\u56fd\u4ea7\u65b0\u836f\u3001\u8986\u76d6\u591a\u79cd\u8010\u836f\u7a81\u53d8<\/td>\n<td>\u4e34\u5e8a\u6570\u636e\u79ef\u7d2f\u504f\u5c11<\/td>\n<\/tr>\n<tr>\n<td>\u6d1b\u62c9\u66ff\u5c3c<\/td>\n<td>\u4e09\u4ee3<\/td>\n<td>\u6d1b\u62c9\u66ff\u5c3c<\/td>\n<td>\u662f<\/td>\n<td>\u9876\u7ea7<\/td>\n<td>\u5168\u8986\u76d6\u8010\u836f\u7a81\u53d8\u3001G1202R \u514b\u661f\u3001\u8111\u8f6c\u79fb\u65e0\u654c<\/td>\n<td>\u8840\u8102\u9ad8\u3001\u60c5\u7eea \/ \u795e\u7ecf\u526f\u4f5c\u7528<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 data-pm-slice=\"0 0 []\">\u4e09\u5927\u7ef4\u5ea6\u91cd\u70b9\u62c6\u89e3<\/h2>\n<h3>1. \u5165\u8111\u80fd\u529b\u6392\u540d\uff08\u4ece\u5f3a\u5230\u5f31\uff09<\/h3>\n<p><strong>\u52b3\u62c9\u66ff\u5c3c \uff1e \u963f\u6765\u66ff\u5c3c \u2248 \u5e03\u52a0\u66ff\u5c3c \uff1e \u6069\u6c99\u66ff\u5c3c \uff1e \u585e\u745e\u66ff\u5c3c<\/strong><\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u6709<strong>\u8111\u819c\u8f6c\u79fb\u3001\u591a\u53d1\u8111\u8f6c\u79fb\u3001\u8111\u8f6c\u79fb\u8fdb\u5c55<\/strong>\uff1a<strong>\u9996\u9009\u52b3\u62c9\u66ff\u5c3c<\/strong><\/section>\n<\/li>\n<li>\n<section>\u666e\u901a\u5355\u53d1 \/ \u5c11\u91cf\u8111\u8f6c\u79fb\uff1a\u963f\u6765\u66ff\u5c3c\u3001\u5e03\u52a0\u66ff\u5c3c\u5b8c\u5168\u591f\u7528<\/section>\n<\/li>\n<\/ul>\n<h3>2. \u6574\u4f53\u7597\u6548\u6392\u540d<\/h3>\n<p><strong>\u52b3\u62c9\u66ff\u5c3c \uff1e \u963f\u6765\u66ff\u5c3c \u2248 \u5e03\u52a0\u66ff\u5c3c \uff1e \u6069\u6c99\u66ff\u5c3c \uff1e \u585e\u745e\u66ff\u5c3c<\/strong><\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u8ffd\u6c42\u6700\u957f\u751f\u5b58\u671f\u3001\u6700\u9ad8\u5b8c\u5168\u7f13\u89e3\u7387\uff1a\u76f4\u63a5\u52b3\u62c9\u66ff\u5c3c<\/section>\n<\/li>\n<li>\n<section>\u666e\u901a\u4e00\u7ebf\u9996\u9009\uff1a\u963f\u6765\u66ff\u5c3c\uff08\u4e34\u5e8a\u6700\u5e38\u7528\u3001\u6700\u7a33\uff09<\/section>\n<\/li>\n<\/ul>\n<h3>3. \u526f\u4f5c\u7528 &amp; \u8010\u53d7\u5ea6\u6392\u540d\uff08\u6700\u597d\u2192\u6700\u5dee\uff09<\/h3>\n<p><strong>\u963f\u6765\u66ff\u5c3c \uff1e \u6069\u6c99\u66ff\u5c3c \uff1e \u52b3\u62c9\u66ff\u5c3c \uff1e \u5e03\u52a0\u66ff\u5c3c \uff1e \u585e\u745e\u66ff\u5c3c<\/strong><\/p>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u963f\u6765\u66ff\u5c3c\uff1a<strong>\u6700\u6e29\u548c\uff0c\u8001\u5e74\u4eba\u3001\u957f\u671f\u5403\u9996\u9009<\/strong><\/section>\n<\/li>\n<li>\n<section>\u52b3\u62c9\u66ff\u5c3c\uff1a\u80a0\u80c3\u8212\u670d\uff0c\u4f46\u8981<strong>\u7ec8\u8eab\u7ba1\u63a7\u8840\u8102<\/strong><\/section>\n<\/li>\n<li>\n<section>\u585e\u745e\u66ff\u5c3c\uff1a\u80c3\u80a0\u9053\u53cd\u5e94\u5927\uff0c\u5f88\u591a\u4eba\u5403\u4e0d\u4e0b\u3001\u6613\u505c\u836f<\/section>\n<\/li>\n<\/ul>\n<hr \/>\n<h2>\u6781\u7b80\u9009\u578b\u53e3\u8bc0<\/h2>\n<ol class=\"list-paddingleft-1\">\n<li><strong>\u6709\u8111\u819c \/ \u591a\u53d1\u8111\u8f6c\u79fb\u3001\u4e8c\u4ee3\u836f\u8010\u836f<\/strong><br \/>\n<section>\u00a0\u2192 \u5fc5\u9009\u00a0<strong>\u52b3\u62c9\u66ff\u5c3c<\/strong><\/section>\n<\/li>\n<li><strong>\u521d\u6cbb\u4e00\u7ebf\u3001\u8ffd\u6c42\u7a33\u59a5\u3001\u8001\u4eba\u957f\u671f\u7528<\/strong><br \/>\n<section>\u00a0\u2192 \u9009\u00a0<strong>\u963f\u6765\u66ff\u5c3c<\/strong><\/section>\n<\/li>\n<li><strong>\u8ffd\u6c42\u6027\u4ef7\u6bd4\u3001\u56fd\u4ea7\u533b\u4fdd<\/strong><br \/>\n<section>\u00a0\u2192 \u9009\u00a0<strong>\u6069\u6c99\u66ff\u5c3c<\/strong><\/section>\n<\/li>\n<li><strong>\u4e0d\u8010\u53d7\u80a0\u80c3\u836f\u3001\u6015\u6076\u5fc3\u8179\u6cfb<\/strong><br \/>\n<section>\u00a0\u2192 \u907f\u5f00\u00a0<strong>\u585e\u745e\u66ff\u5c3c<\/strong><\/section>\n<\/li>\n<\/ol>\n<p>\u4e09\u3001\u7528\u6cd5\u7528\u91cf\uff5c\u600e\u4e48\u5403\u624d\u5bf9\uff1f<\/p>\n<p>\u6807\u51c6\u5242\u91cf\uff1a100mg\uff0c\u6bcf\u65e5 1 \u6b21\uff0c\u7a7a\u8179 \/ \u968f\u9910\u5747\u53ef<\/p>\n<p>\u89c4\u683c\uff1a\u56fd\u5185\u5e38\u89c1 100mg\u00d730 \u7247 \/ \u76d2<\/p>\n<p>\u670d\u7528\u8981\u70b9\uff1a<\/p>\n<p>\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u5403\uff0c\u6f0f\u670d\u4e0d\u8981\u52a0\u500d\uff0c\u7b2c\u4e8c\u5929\u6b63\u5e38\u5403<\/p>\n<p>\u907f\u514d\u67da\u5b50 \/ \u897f\u67da\uff08\u5f71\u54cd\u4ee3\u8c22\uff09<\/p>\n<p>\u809d\u529f\u80fd\u3001\u8840\u8102\u9700\u5b9a\u671f\u76d1\u6d4b<\/p>\n<p>\u56db\u3001\u526f\u4f5c\u7528\uff5c\u4e25\u91cd\u5417\uff1f\u80fd\u8010\u53d7\u5417\uff1f<\/p>\n<p>\u6574\u4f53\u53ef\u63a7\u3001\u53ef\u9006\uff0c\u4e25\u91cd\u53d1\u751f\u7387\u4f4e\uff08\u505c\u836f\u7387\u4ec5 5%\uff09\u3002<\/p>\n<p>\u5e38\u89c1\uff08\u226520%\uff09<\/p>\n<p>\u9ad8\u8102\u8840\u75c7\uff08\u80c6\u56fa\u9187 \/ \u7518\u6cb9\u4e09\u916f\u5347\u9ad8\uff0c\u6700\u5e38\u89c1\uff0c\u9700\u5403\u836f\u63a7\u5236\uff09<\/p>\n<p>\u6c34\u80bf\uff08\u624b\u811a \/ \u773c\u7751\u80bf\uff09<\/p>\n<p>\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\uff08\u624b\u811a\u9ebb\u6728\u3001\u523a\u75db\uff09<\/p>\n<p>\u4f53\u91cd\u589e\u52a0<\/p>\n<p>\u75b2\u52b3\u3001\u4e4f\u529b<\/p>\n<p>\u8f7b\u5ea6\u8ba4\u77e5\u5f71\u54cd\uff08\u6ce8\u610f\u529b\u4e0b\u964d\u3001\u5065\u5fd8\uff0c\u591a\u4e3a\u8f7b\u5ea6\uff09<\/p>\n<p>\u5c11\u89c1\u4f46\u9700\u8b66\u60d5<\/p>\n<p>\u95f4\u8d28\u6027\u80ba\u75c5 \/ \u80ba\u708e\uff08\u54b3\u55fd\u3001\u6c14\u77ed\u3001\u53d1\u70ed\uff0c\u9700\u505c\u836f\u5c31\u533b\uff09<\/p>\n<p>\u623f\u5ba4\u4f20\u5bfc\u963b\u6ede\uff08\u5fc3\u7387\u6162\uff0c\u5b9a\u671f\u67e5\u5fc3\u7535\u56fe\uff09<\/p>\n<p>\u4e25\u91cd\u809d\u635f\u4f24\uff08\u5b9a\u671f\u67e5\u809d\u529f\u80fd\uff09<\/p>\n<p>\u2192 \u4e00\u53e5\u8bdd\uff1a\u526f\u4f5c\u7528\u6bd4\u5316\u7597\u8f7b\u5f97\u591a\uff0c\u591a\u6570\u53ef\u901a\u8fc7\u5403\u836f \/ \u51cf\u91cf\u7ba1\u7406\uff0c\u4e0d\u5f71\u54cd\u957f\u671f\u7528\u836f\u3002<\/p>\n<p>\u4e94\u3001\u4ef7\u683c\u4e0e\u533b\u4fdd\uff5c2026 \u5e74\u6700\u65b0<\/p>\n<p>\u539f\u7814\uff08\u535a\u745e\u7eb3\uff09<\/p>\n<p>\u533b\u4fdd\u524d\uff1a\u7ea6 15800 \u5143 \/ \u76d2\uff08100mg\u00d730 \u7247\uff09<\/p>\n<p>\u533b\u4fdd\u540e\uff08\u4e59\u7c7b\uff0c2025\u20132026 \u534f\u8bae\u671f\uff09\uff1a<\/p>\n<p>\u62a5\u9500\u540e\u81ea\u4ed8\uff1a900\u20133000 \u5143 \/ \u76d2\uff08\u770b\u5730\u533a \/ \u62a5\u9500\u6bd4\u4f8b\uff09<\/p>\n<p>\u9650\uff1aALK \u9633\u6027\u665a\u671f NSCLC<\/p>\n<p>\u4eff\u5236\u836f\uff08\u6d77\u5916\uff0c\u65e0\u56fd\u5185\u4eff\u5236\uff09<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-802\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u5fae\u4fe1\u56fe\u7247_20260512220805_109_34-scaled.jpg\" alt=\"\" width=\"961\" height=\"203\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u5fae\u4fe1\u56fe\u7247_20260512220805_109_34-scaled.jpg 2560w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u5fae\u4fe1\u56fe\u7247_20260512220805_109_34-768x162.jpg 768w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u5fae\u4fe1\u56fe\u7247_20260512220805_109_34-1536x324.jpg 1536w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u5fae\u4fe1\u56fe\u7247_20260512220805_109_34-2048x432.jpg 2048w\" sizes=\"auto, (max-width: 961px) 100vw, 961px\" \/><\/p>\n<p>\u8001\u631d\u5362\u4fee\u65af\uff1a\u7ea6 1500 \u5143 \/ \u76d2<\/p>\n<p>\u8001\u631d\u5927\u718a\uff1a\u7ea6 1600 \u5143 \/ \u76d2<\/p>\n<p>\u5b5f\u52a0\u62c9\u73e0\u5cf0\uff1a\u7ea6 2000 \u5143 \/ \u76d2<\/p>\n<p>\u2192 \u6ce8\u610f\uff1a\u56fd\u5185\u65e0\u6b63\u89c4\u6e20\u9053\uff0c\u4ee3\u8d2d\u98ce\u9669\u9ad8\uff0c\u8c28\u614e\u9009\u62e9\u3002<\/p>\n<p>\u516d\u3001\u4e00\u7ebf vs \u540e\u7ebf\uff5c\u4ec0\u4e48\u65f6\u5019\u7528\u6700\u597d\uff1f<\/p>\n<p>\u4e00\u7ebf\u4f18\u5148\uff08\u6700\u65b0\u6307\u5357\u63a8\u8350\uff09<\/p>\n<p>CROWN \u7814\u7a76\u8bc1\u5b9e\uff1a\u4e00\u7ebf\u52b3\u62c9\u66ff\u5c3c\uff1e\u4e8c\u4ee3\u836f\u5e8f\u8d2f\u52b3\u62c9\u66ff\u5c3c<\/p>\n<p>\u7d2f\u79ef PFS\uff1a12.3 \u5e74 vs 7.4 \u5e74\uff08\u6a21\u578b\u6570\u636e\uff09<\/p>\n<p>\u8111\u8f6c\u79fb\u98ce\u9669\uff1a\u4e00\u7ebf\u52b3\u62c9\u66ff\u5c3c\u53ef\u5927\u5e45\u964d\u4f4e\u8111\u8f6c\u79fb\u53d1\u751f\u7387<\/p>\n<p>\u540e\u7ebf\uff08\u4e00 \/ \u4e8c\u4ee3\u8010\u836f\u540e\uff09<\/p>\n<p>\u6709\u6548\u7387\uff1a\u7ea6 60%\u201370%<\/p>\n<p>\u5c24\u5176\u9002\u5408\uff1aG1202R \u8010\u836f\u3001\u8111\u8f6c\u79fb\u8fdb\u5c55\u60a3\u8005<\/p>\n<p>\u2192 \u7ed3\u8bba\uff1a\u597d\u836f\u5148\u7528\uff0c\u4e00\u7ebf\u52b3\u62c9\u66ff\u5c3c\u662f\u76ee\u524d ALK \u9633\u6027 NSCLC \u7684\u6700\u4f18\u89e3\u3002<\/p>\n<p>\u4e03\u3001\u603b\u7ed3\uff5c\u5199\u7ed9\u60a3\u8005\u7684\u5fc3\u91cc\u8bdd<\/p>\n<p>\u52b3\u62c9\u66ff\u5c3c = \u6700\u5f3a\u5165\u8111 + \u901a\u6740\u8010\u836f + \u8d85\u957f\u751f\u5b58<\/p>\n<p>\u9002\u5408\uff1a\u6240\u6709 ALK \u9633\u6027\u665a\u671f\u80ba\u764c\uff0c\u5c24\u5176\u8111\u8f6c\u79fb\u3001\u8010\u836f\u60a3\u8005<\/p>\n<p>\u533b\u4fdd\u5df2\u8fdb\uff0c\u81ea\u4ed8\u538b\u529b\u5927\u5e45\u4e0b\u964d<\/p>\n<p>\u526f\u4f5c\u7528\u53ef\u63a7\uff0c\u957f\u671f\u751f\u5b58\u4e0d\u662f\u68a6<\/p>\n<p>\u4e0b\u9762\u7ed9\u4f60\u6574\u74065 \u4e2a\u516c\u5f00\u3001\u771f\u5b9e\u7684\u52b3\u62c9\u66ff\u5c3c\uff08\u6d1b\u62c9\u66ff\u5c3c\uff09\u7528\u836f\u6848\u4f8b\uff0c\u8986\u76d6\uff1a\u4e00\u7ebf\u5feb\u901f CR\u3001\u591a\u7ebf\u8010\u836f\uff08\u542b G1202L\uff09\u3001\u8111\u8f6c\u79fb \/ \u8111\u819c\u8f6c\u79fb\u3001\u9ad8\u9f84\u4f53\u5f31\u3001\u5408\u5e76\u7ed3\u6838\u3002\u4fe1\u606f\u6765\u81ea\u56fd\u5185\u533b\u9662\u62a5\u9053 \/ \u671f\u520a\u75c5\u4f8b\uff0c\u53ef\u53c2\u8003\u6027\u5f3a\u3002<\/p>\n<p>\u6848\u4f8b 1\uff1a\u4e00\u7ebf\u6cbb\u7597\uff0c2 \u4e2a\u6708\u8fbe\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09<\/p>\n<p>\u60a3\u8005\uff1a\u5973\uff0c65 \u5c81\uff0c\u2163b \u671f\u80ba\u817a\u764c\uff0cEML4-ALK \u878d\u5408\u9633\u6027\uff0c\u80f8\u819c \/ \u809d \/ \u808b\u9aa8\u591a\u53d1\u8f6c\u79fb\u3002<\/p>\n<p>\u65e2\u5f80\uff1a2022 \u5e74\u672f\u540e\u7528\u6069\u6c99\u66ff\u5c3c\uff08\u4e0d\u8010\u53d7\u76ae\u75b9\u505c\u836f\uff09\uff0c\u540e\u4e2d\u836f\u7ef4\u6301\uff1b2025 \u5e74 6 \u6708\u8fdb\u5c55\u3002<\/p>\n<p>\u65b9\u6848\uff1a\u52b3\u62c9\u66ff\u5c3c 100mg qd \u53e3\u670d\uff082025 \u5e74 7 \u6708\u8d77\uff09\u3002<\/p>\n<p>\u7597\u6548\uff1a<\/p>\n<p>\u7528\u836f 2 \u4e2a\u6708\uff089 \u6708\u590d\u67e5\uff09\uff1a\u80f8\u819c\u7ed3\u8282\u6d88\u5931\uff0c\u6240\u6709\u75c5\u7076\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\uff1b\u6dcb\u5df4\u7ed3\u660e\u663e\u7f29\u5c0f\u3002<\/p>\n<p>\u751f\u6d3b\u8d28\u91cf\uff1a\u4f53\u529b\u6062\u590d\uff0c\u53ef\u6b63\u5e38\u6d3b\u52a8\uff0c\u65e0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n<p>\u5173\u952e\uff1a\u4e00\u7ebf\u7528\u52b3\u62c9\u66ff\u5c3c\uff0c\u8d77\u6548\u6781\u5feb\uff0cCR \u7387\u9ad8\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-799\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/640-1.webp\" alt=\"\" width=\"683\" height=\"265\" \/><\/p>\n<h3 data-pm-slice=\"0 0 []\">\u6848\u4f8b 2\uff1a\u5e74\u8f7b\u60a3\u8005\uff0c\u514b\u5511\u66ff\u5c3c\u2192\u5e03\u52a0\u66ff\u5c3c\u2192\u52b3\u62c9\u66ff\u5c3c\uff08G1202L \u8010\u836f\u7a81\u53d8\uff09<\/h3>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u60a3\u8005\uff1a\u7537\uff0c30 \u5c81\uff0c\u665a\u671f\u80ba\u817a\u764c\uff0c<strong>ALK \u9633\u6027<\/strong>\u3002<\/section>\n<\/li>\n<li>\n<section>\u65e2\u5f80\u7ebf\uff1a<\/section>\n<ol class=\"list-paddingleft-1\">\n<li>\n<section>\u514b\u5511\u66ff\u5c3c\uff1a11 \u4e2a\u6708\uff0c\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u540e\u8fdb\u5c55\u3002<\/section>\n<\/li>\n<li>\n<section>\u5e03\u52a0\u66ff\u5c3c\uff1a12.8 \u4e2a\u6708\uff0c\u7a33\u5b9a\uff08SD\uff09\u540e\u8fdb\u5c55\uff1b\u57fa\u56e0\u68c0\u6d4b\uff1a<strong>ALK G1202L \u65b0\u7a81\u53d8<\/strong>\u3002<\/section>\n<\/li>\n<\/ol>\n<\/li>\n<li>\n<section>\u65b9\u6848\uff1a<strong>\u52b3\u62c9\u66ff\u5c3c 100mg qd<\/strong>\u3002<\/section>\n<\/li>\n<li>\n<section>\u7597\u6548\uff1a\u75be\u75c5\u63a7\u5236<strong>9 \u4e2a\u6708<\/strong>\uff0c\u80bf\u7624\u7f29\u5c0f\uff0c\u75c7\u72b6\u6539\u5584\uff1b\u603b\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09<strong>33.3 \u4e2a\u6708<\/strong>\u3002<\/section>\n<\/li>\n<li>\n<section>\u5173\u952e\uff1a<strong>\u52b3\u62c9\u66ff\u5c3c\u53ef\u514b\u670d G1202L \u7b49\u4e8c\u4ee3\u836f\u8010\u836f\u7a81\u53d8<\/strong>\u3002<\/section>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>\u6848\u4f8b 3\uff1aALK \u9633\u6027\u8111\u819c\u8f6c\u79fb\uff08\u5965\u5e0c\u66ff\u5c3c \/ \u963f\u6765\u66ff\u5c3c \/ \u5e03\u52a0\u66ff\u5c3c\u8010\u836f\uff09<\/h3>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>\u60a3\u8005\uff1a\u5973\uff0c55 \u5c81\uff0c\u4e0d\u5438\u70df\uff0c\u2163 \u671f\u80ba\u817a\u764c\uff0c<strong>ALK \u9633\u6027<\/strong>\uff0c<strong>\u8111\u819c\u8f6c\u79fb<\/strong>\uff08\u5934\u75db\u3001\u5455\u5410\u3001\u610f\u8bc6\u6a21\u7cca\uff09\u3002<\/section>\n<\/li>\n<li>\n<section>\u65e2\u5f80\u7ebf\uff1a<\/section>\n<ol class=\"list-paddingleft-1\">\n<li>\n<section>\u963f\u6765\u66ff\u5c3c\uff1a\u6709\u6548\u540e\u8fdb\u5c55\u3002<\/section>\n<\/li>\n<li>\n<section>\u5e03\u52a0\u66ff\u5c3c\uff1a\u4ecd\u8fdb\u5c55\uff0c\u8111\u819c\u75c7\u72b6\u52a0\u91cd\u3002<\/section>\n<\/li>\n<\/ol>\n<\/li>\n<li>\n<section>\u65b9\u6848\uff1a<strong>\u52b3\u62c9\u66ff\u5c3c 100mg qd<\/strong>\uff08\u8111\u810a\u6db2\u6e17\u900f\u7387\u9ad8\uff09\u3002<\/section>\n<\/li>\n<li>\n<section>\u7597\u6548\uff1a<\/section>\n<ul class=\"list-paddingleft-1\">\n<li>\n<section>1 \u5468\uff1a\u5934\u75db \/ \u5455\u5410\u660e\u663e\u51cf\u8f7b\uff0c\u610f\u8bc6\u6062\u590d\u3002<\/section>\n<\/li>\n<li>\n<section>1 \u4e2a\u6708\uff1a\u8111\u819c\u75c5\u7076\u7f29\u5c0f\uff0c<strong>\u9885\u5185\u7f13\u89e3<\/strong>\uff1b\u5168\u8eab\u75c5\u7076\u7a33\u5b9a\u3002<\/section>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<section>\u5173\u952e\uff1a<strong>\u52b3\u62c9\u66ff\u5c3c\u5165\u8111\u80fd\u529b\u5f3a\uff0c\u662f\u8111\u819c \/ 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class=\"list-paddingleft-1\">\n<li>\n<section>\u80bf\u7624\uff1a\u6301\u7eed<strong>\u90e8\u5206\u7f13\u89e3\uff08PR\uff09<\/strong>\uff0c\u65e0\u8fdb\u5c55\uff0c\u751f\u6d3b\u8d28\u91cf\u6b63\u5e38\u3002<\/section>\n<\/li>\n<li>\n<section>\u7ed3\u6838\uff1a\u9010\u6e10\u63a7\u5236\uff0c\u65e0\u64ad\u6563\uff0c\u65e0\u4e25\u91cd\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002<\/section>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<section>\u5173\u952e\uff1a<strong>\u5408\u5e76\u611f\u67d3\u65f6\uff0c\u52b3\u62c9\u66ff\u5c3c\u53ef\u5728\u4e25\u5bc6\u76d1\u6d4b\u4e0b\u5b89\u5168\u4f7f\u7528<\/strong>\u3002<\/section>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>\u771f\u5b9e\u4e16\u754c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff085 \u4e2a\u6848\u4f8b\u6c47\u603b\uff09<\/h3>\n<ul 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