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\"\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa(TAF\u7279\u62c9\u82ac)\"<\/figure>\n\n\n\n

\u3010\u9002\u5e94\u75c7\u3011<\/p>\n\n\n\n

\u3000\u3000\u5bcc\u9a6c\u9178\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\u7247\u9002\u4e8e\u6cbb\u7597\u6210\u4eba\u548c\u9752\u5c11\u5e74\uff08\u5e74\u9f84 12 \u5c81\u53ca\u4ee5\u4e0a\uff0c\u4f53\u91cd\u81f3\u5c11\u4e3a 35 kg\uff09\u6162\u6027\u4e59\u578b\u809d\u708e\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u97e6\u7acb\u5f97\u7528\u6cd5\u7528\u91cf\u3011<\/p>\n\n\n\n

\u3000\u3000\u5e94\u5f53\u7531\u5177\u5907\u6162\u6027\u4e59\u578b\u809d\u708e\u7ba1\u7406\u7ecf\u9a8c\u7684\u533b\u751f\u5f00\u59cb\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u3000\u3000\u6210\u4eba\u548c\u9752\u5c11\u5e74\uff08\u5e74\u9f84\u4e3a 12 \u5c81\u53ca\u4ee5\u4e0a\u4e14\u4f53\u91cd\u81f3\u5c11\u4e3a 35 kg\uff09\uff1a<\/p>\n\n\n\n

\u3000\u3000\u6bcf\u65e5\u4e00\u6b21\uff0c\u4e00\u6b21\u4e00\u7247\u3002\u53e3\u670d\u3002\u9700\u968f\u98df\u7269\u670d\u7528\u3002<\/p>\n\n\n\n

\u3000\u3000\u6f0f\u670d\u5242\u91cf<\/p>\n\n\n\n

\u3000\u3000\u5982\u679c\u6f0f\u670d\u4e00\u5242\u5bcc\u9a6c\u9178\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\u7247\u4e14\u5df2\u8d85\u8fc7\u901a\u5e38\u670d\u836f\u65f6\u95f4\u4e0d\u8db3 18 \u5c0f\u65f6\uff0c\u5219\u60a3\u8005\u5e94\u5c3d\u5feb\u670d\u7528\u4e00\u5242\uff0c\u5e76\u6062\u590d\u6b63\u5e38\u7ed9\u836f\u65f6\u95f4\u3002\u5982\u679c\u5df2\u8d85\u8fc7\u901a\u5e38\u670d\u836f\u65f6\u95f4 18 \u5c0f\u65f6\u4ee5\u4e0a\uff0c\u5219\u60a3\u8005\u4e0d\u5e94\u670d\u7528\u6f0f\u670d\u836f\u7269\uff0c\u4ec5\u5e94\u6062\u590d\u6b63\u5e38\u7ed9\u836f\u65f6\u95f4\u3002<\/p>\n\n\n\n

\u3000\u3000\u5982\u679c\u60a3\u8005\u5728\u670d\u7528\u5bcc\u9a6c\u9178\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\u7247\u540e 1 \u5c0f\u65f6\u5185\u5455\u5410\uff0c\u5219\u8be5\u60a3\u8005\u5e94\u518d\u670d\u7528\u4e00\u7247\u3002 \u5982\u679c\u60a3\u8005\u5728\u670d\u7528\u5bcc\u9a6c\u9178\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\u7247\u540e\u8d85\u8fc7 1 \u5c0f\u65f6\u5455\u5410\uff0c\u5219\u8be5\u60a3\u8005\u65e0\u9700\u518d\u670d\u7528\u4e00\u7247\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u7279\u6b8a\u4eba\u7fa4\u3011<\/p>\n\n\n\n

\u3000\u3000\u8001\u5e74\u4eba<\/p>\n\n\n\n

\u3000\u3000\u65e0\u9700\u9488\u5bf9\u5e74\u9f84\u4e3a 65 \u5c81\u53ca\u4ee5\u4e0a\u7684\u60a3\u8005\u8fdb\u884c\u5bcc\u9a6c\u9178\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\u7247\u5242\u91cf\u8c03\u6574\u3002<\/p>\n\n\n\n

\u3000\u3000\u80be\u529f\u80fd\u635f\u5bb3<\/p>\n\n\n\n

\u3000\u3000\u5bf9\u4e8e\u808c\u9150\u6e05\u9664\u7387 (CrCl) \u4f30\u8ba1\u503c \u2265 15 mL\/min \u7684\u6210\u4eba\u6216\u9752\u5c11\u5e74\uff08\u5e74\u9f84\u81f3\u5c11\u4e3a12\u5c81\uff0c\u5e76\u4e14\u4f53\u91cd\u81f3\u5c11\u4e3a 35 kg\uff09\u6216CrCl < 15 mL\/min\u4e14\u6b63\u5728\u63a5\u53d7\u8840\u6db2\u900f\u6790\u7684\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5bcc\u9a6c\u9178\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\u7247\u5242\u91cf\u3002 \u5728\u8fdb\u884c\u8840\u6db2\u900f\u6790\u5f53\u5929\uff0c\u5e94\u5728\u8840\u6db2\u900f\u6790\u6cbb\u7597\u5b8c\u6210\u540e\u7ed9\u4e88\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\u7247\u3002<\/p>\n\n\n\n

\u3000\u3000\u5bf9\u4e8eCrCl < 15 mL\/min\u4e14\u672a\u63a5\u53d7\u8840\u6db2\u900f\u6790\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u4e0d\u7528\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff08TAF\uff09\u3002<\/p>\n\n\n\n

\u3000\u3000\u809d\u529f\u80fd\u635f\u5bb3<\/p>\n\n\n\n

\u3000\u3000\u5728\u6709\u5931\u4ee3\u507f(Child-Pugh B\u6216C)\u809d\u53d7\u635f\u60a3\u8005\u4e2d\u5efa\u8bae\u4e0d\u7528\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff08TAF\uff09\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u8b66\u544a\u4e0e\u6ce8\u610f\u4e8b\u9879\u3011<\/p>\n\n\n\n

\u3000\u3000HBV\u548cHIV-1\u5171\u611f\u67d3\uff1a\u5efa\u8bae\u4e0d\u5355\u72ec\u4f7f\u7528\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff08TAF\uff09\u4e3aHIV-1\u611f\u67d3\u7684\u6cbb\u7597\u3002\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u53ef\u80fd\u53d1\u751fHIV-1\u8010\u836f\u6027\u3002<\/p>\n\n\n\n

\u3000\u3000\u65b0\u53d1\u4f5c\u6216\u6076\u5316\u7684\u80be\u53d7\u635f\uff1a\u5efa\u8bae\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff08TAF\uff09\u6cbb\u7597\u4e59\u578b\u809d\u8bc4\u4f30\u8840\u6e05\u808c\u9150\uff0c\u8840\u6e05\u78f7\uff0c\u4f30\u7b97\u808c\u9150\u6e05\u9664\u7387\uff0c\u5c3f\u7cd6\uff0c\u548c\u5c3f\u86cb\u767d\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/p>\n\n\n\n

\u3000\u3000\u4f7f\u7528Hepbest\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94(\u53d1\u751f\u7387\u5927\u4e8e\u6216\u7b49\u4e8e5%\uff0c\u6240\u6709\u7ea7\u522b)\u662f\u5934\u75db\uff0c\u8179\u75db\uff0c\u75b2\u4e4f\uff0c\u54b3\u55fd\uff0c\u6076\u5fc3\uff0c\u548c\u80cc\u75db\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011<\/p>\n\n\n\n

\u3000\u3000\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff08TAF\uff09\u662f\u4e00\u79cdP-\u7cd6\u86cb\u767d(P-gp)\u548cBCRP\u7684\u5e95\u7269\u3002\u5f3a\u70c8\u5f71\u54cdP-gp\u548cBCRP\u6d3b\u6027\u836f\u7269\u53ef\u80fd\u5bfc\u81f4\u5728\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff08TAF\uff09\u5438\u6536\u4e2d\u53d8\u5316<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u9002\u5e94\u75c7\u3011 \u3000\u3000\u5bcc\u9a6c\u9178\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\u7247\u9002\u4e8e\u6cbb\u7597\u6210\u4eba\u548c\u9752\u5c11\u5e74\uff08\u5e74\u9f84 12 \u5c81\u53ca\u4ee5\u4e0a\uff0c\u4f53\u91cd\u81f3\u5c11\u4e3a 35 kg\uff09\u6162\u6027\u4e59\u578b\u809d\u708e\u3002 \u3000\u3000\u3010\u97e6\u7acb\u5f97\u7528\u6cd5\u7528\u91cf\u3011 \u3000\u3000\u5e94\u5f53\u7531\u5177\u5907\u6162\u6027\u4e59\u578b\u809d\u708e\u7ba1\u7406\u7ecf\u9a8c\u7684\u533b\u751f\u5f00\u59cb\u6cbb\u7597\u3002 \u3000\u3000\u6210\u4eba\u548c\u9752\u5c11\u5e74\uff08\u5e74\u9f84\u4e3a 12 \u5c81\u53ca\u4ee5\u4e0a\u4e14\u4f53 […]<\/p>\n","protected":false},"author":1,"featured_media":77,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"topic":[],"class_list":["post-76","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ganaiyaoping"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/76","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=76"}],"version-history":[{"count":2,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/76\/revisions"}],"predecessor-version":[{"id":392,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/76\/revisions\/392"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/77"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=76"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=76"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=76"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=76"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}