{"id":742,"date":"2023-12-28T19:23:03","date_gmt":"2023-12-28T11:23:03","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=742"},"modified":"2023-12-28T19:23:03","modified_gmt":"2023-12-28T11:23:03","slug":"entrectinib-%e6%81%a9%e6%9b%b2%e6%9b%bf%e5%b0%bc-%e7%bd%97%e5%9c%a3%e5%85%a8","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=742","title":{"rendered":"Entrectinib \u6069\u66f2\u66ff\u5c3c \u7f57\u5723\u5168"},"content":{"rendered":"
\"Entrectinib

Entrectinib \u6069\u66f2\u66ff\u5c3c \u7f57\u5723\u5168<\/p><\/div>\n

\u836f\u54c1\u6982\u8ff0<\/h3>\n
\n

\u6069\u66f2\u66ff\u5c3c\u662f\u4e00\u79cd\u65b0\u578b\u3001\u53ef\u53e3\u670d\u7684\u3001\u5177\u6709\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6d3b\u6027\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u9776\u5411\u6cbb\u7597\u643a\u5e26NTRK1\/2\/3\u3001ROS1\u548cALK\u57fa\u56e0\u878d\u5408\u7a81\u53d8\u7684\u5b9e\u4f53\u80bf\u7624\uff0c\u662f\u4e34\u5e8a\u4e0a\u552f\u4e00\u4e00\u79cd\u88ab\u8bc1\u660e\u9488\u5bf9\u539f\u53d1\u6027\u548c\u8f6c\u79fb\u6027CNS\u75be\u75c5\u5177\u6709\u7597\u6548\u7684TRK\u6291\u5236\u5242\uff0c\u5e76\u4e14\u6ca1\u6709\u4e0d\u826f\u7684\u8131\u9776\u6d3b\u6027\u3002

\u6069\u66f2\u66ff\u5c3c\u4e8e2019\u5e746\u670819\u65e5\u5728\u65e5\u672c\u6279\u51c6\u4e0a\u5e02\uff0c\u4e8e2019\u5e748\u670815\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u795e\u7ecf\u8425\u517b\u916a\u6c28\u9178\u53d7\u4f53\u6fc0\u9176\uff08NTRK\uff09\u878d\u5408\u9633\u6027\u7684\u665a\u671f\u590d\u53d1\u6027\u5b9e\u4f53\u80bf\u7624\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\uff1b\u4ee5\u53ca\u7528\u4e8e\u6cbb\u7597\u643a\u5e26ROS1\u57fa\u56e0\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/a>\u3002

2022\u5e747\u670829\u65e5\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5b98\u65b9\u516c\u793a\uff1a\u7f57\u6c0f\uff08Roche\uff09\u516c\u53f8\u7684\u6069\u66f2\u66ff\u5c3c\u80f6\u56ca\uff08Rozlytrek\uff0cEntrectinib\uff0cRXDX-101\uff09\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u53ca12\u5c81\u4ee5\u4e0a\u513f\u7ae5\u60a3\u8005\u795e\u7ecf\u8425\u517b\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176\uff08NTRK\uff09\u878d\u5408\u9633\u6027\u3001\u521d\u59cb\u6cbb\u7597\u540e\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u80bf\u7624\u3002

2022\u5e748\u670815\u65e5\uff0c\u7f57\u6c0f\u5236\u836f\u4e2d\u56fd\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u6279\u51c6\u4e86\u7f57\u6c0f\u65d7\u4e0b\u9776\u5411\u6297\u764c\u836f\u7269\u7f57\u5723\u5168\u00ae<\/sup>\uff08\u6069\u66f2\u66ff\u5c3c\/Entrectinib\uff09\u7528\u4e8e\u6cbb\u7597ROS1\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/a>\uff08\u4e0b\u6587\u7b80\u79f0NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002

2023\u5e7412\u670813\u65e5\uff0c\u56fd\u5bb6\u533b\u4fdd\u5c40\u53d1\u5e03\u4e86\u6700\u65b0\u76842024\u7248\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0c\u5176\u4e2d\u6069\u66f2\u66ff\u5c3c\u9996\u6b21\u8fdb\u533b\u4fdd\u3002\u8fdb\u5165\u533b\u4fdd\u9002\u5e94\u75c7\u4e3a\uff1a<\/p>\n

\uff081\uff0912\u5c81\u53ca\u4ee5\u4e0a\uff0c\u7ecf\u5145\u5206\u9a8c3\u4e2a\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u8bca\u65ad\u4e3a\u643a\u5e26\u795e\u7ecf\u8425\u517b\u916a\u6c28\u9178\u53d7\u4f53\u6fc0\u9176(NTRK)\u878d\u5408\u57fa\u56e0\u4e14\u4e0d\u5305\u62ec\u5df2\u77e5\u83b7\u5f97\u6027\u8010\u836f\u7a81\u53d8\u7684\u5b9e\u4f53\u7624\uff1a\u60a3\u6709\u5c40\u90e8 \u665a\u671f\u3001\u8f6c\u79fb\u6027\u75be\u75c5\u6216\u624b\u672f\u5207\u9664\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u5e76\u53d1\u75c7\u7684\u60a3\u8005\uff0c\u6216\u65e0\u6ee1\u610f\u66ff\u4ee3 \u6cbb\u7597\u6216\u65e2\u5f80\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\uff1b<\/span><\/p>\n

\uff082\uff09ROS1\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/a>(NSCLC)\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n<\/div>\n

\u7b80\u8981\u8bf4\u660e\u4e66<\/h3>\n
\n\n\n\n\n\n\n\n\n
Entrectinib \u6069\u66f2\u66ff\u5c3c(Rozlytrek\uff0c\u7f57\u5723\u5168)\u8bf4\u660e\u4e66<\/td>\n<\/tr>\n
\u836f\u7269\uff1a<\/td>\nEntrectinib \u6069\u66f2\u66ff\u5c3c(Rozlytrek\uff0c\u7f57\u5723\u5168)<\/td>\n<\/tr>\n
\u4e2d\u56fd\u4e0a\u5e02\u60c5\u51b5\uff1a<\/td>\n\u5df2\u4e0a\u5e02<\/td>\n<\/tr>\n
\u6cbb\u7597\uff1a<\/td>\n\u7528\u4e8e\u6cbb\u7597\u795e\u7ecf\u8425\u517b\u916a\u6c28\u9178\u53d7\u4f53\u6fc0\u9176\uff08NTRK\uff09\u878d\u5408\u9633\u6027\u7684\u665a\u671f\u590d\u53d1\u6027\u5b9e\u4f53\u80bf\u7624\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\uff1b\u4ee5\u53ca\u7528\u4e8e\u6cbb\u7597\u643a\u5e26ROS1\u57fa\u56e0\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/td>\n<\/tr>\n
\u53c2\u8003\u7528\u6cd5\u7528\u91cf\uff1a<\/td>\n600 mg \u53e3\u670d \u6bcf\u59291\u6b21<\/td>\n<\/tr>\n
\u4e0d\u826f\u53cd\u5e94\uff1a<\/td>\n\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\uff1a\u5473\u89c9\u969c\u788d\u3001\u4e4f\u529b\u3001\u5934\u6655\u3001\u5916\u5468\u6c34\u80bf\u3001\u8179\u6cfb\u3001\u4f53\u91cd\u589e\u52a0\u3001\u8d2b\u8840\u3001\u8840\u808c\u9150\u5347\u9ad8\u3001\u611f\u89c9\u5f02\u5e38\u3001\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u53e3\u5e72\u3001\u8179\u75db\u3001AST\/ALT\/ALP\u5347\u9ad8\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\u3001\u76ae\u75b9\u3001\u5173\u8282\u75db\u3001\u808c\u8089\u75bc\u75db\u3001\u9ad8\u5c3f\u9178\u8840\u75c7\u548c\u89c6\u529b\u6a21\u7cca\u7b49\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u5f53\u7136\u4eff\u5236\u836f\u4ef7\u683c\u5f88\u4fbf\u5b9c\uff0c \u66f4\u591a\u54a8\u8be2\u8bf7\u5fae\u4fe1\uff1alkhong77<\/h3>\n","protected":false},"excerpt":{"rendered":"

\u836f\u54c1\u6982\u8ff0 \u6069\u66f2\u66ff\u5c3c\u662f\u4e00\u79cd\u65b0\u578b\u3001\u53ef\u53e3\u670d\u7684\u3001\u5177\u6709\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6d3b\u6027\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\uff0c\u9776\u5411\u6cbb\u7597\u643a\u5e26NTRK1\/2\/3\u3001ROS1\u548cALK\u57fa\u56e0\u878d\u5408\u7a81\u53d8\u7684\u5b9e\u4f53\u80bf\u7624\uff0c\u662f\u4e34\u5e8a\u4e0a\u552f\u4e00\u4e00\u79cd\u88ab\u8bc1\u660e\u9488\u5bf9\u539f\u53d1\u6027\u548c\u8f6c\u79fb\u6027CNS\u75be\u75c5\u5177\u6709\u7597\u6548\u7684TRK\u6291\u5236\u5242\uff0c\u5e76\u4e14 […]<\/p>\n","protected":false},"author":1,"featured_media":744,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[277,185,186],"topic":[],"class_list":["post-742","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-feiaiyaoping","tag-entrectinib","tag-185","tag-186"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=742"}],"version-history":[{"count":1,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/742\/revisions"}],"predecessor-version":[{"id":745,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/742\/revisions\/745"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/744"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=742"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}