{"id":736,"date":"2023-12-28T15:58:44","date_gmt":"2023-12-28T07:58:44","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=736"},"modified":"2023-12-28T15:58:44","modified_gmt":"2023-12-28T07:58:44","slug":"atezolizumab-%e9%98%bf%e7%89%b9%e7%8f%a0%e5%8d%95%e6%8a%97%ef%bc%8c%e9%98%bf%e6%9b%bf%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97-%e6%b3%b0%e5%9c%a3%e5%a5%87","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=736","title":{"rendered":"Atezolizumab \u963f\u7279\u73e0\u5355\u6297\uff0c\u963f\u66ff\u5229\u73e0\u5355\u6297 \u6cf0\u5723\u5947"},"content":{"rendered":"

 <\/p>\n

\"Atezolizumab

Atezolizumab \u963f\u7279\u73e0\u5355\u6297\uff0c\u963f\u66ff\u5229\u73e0\u5355\u6297 \u6cf0\u5723\u5947<\/p><\/div>\n

\u836f\u54c1\u6982\u8ff0<\/h3>\n
\n

Atezolizumab\u4e8e2016\u5e745\u670818\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c2020\u5e745\u6708\uff0c\u8be5\u836f\u83b7\u5f97\u7f8e\u56fdFDA\u6269\u5c55\u9002\u5e94\u75c7\u6279\u51c6\uff0c\u7528\u4e8e\u5355\u836f\u4e00\u7ebf\u6cbb\u7597PD-L1\u9ad8\u8868\u8fbe\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u7684\u80bf\u7624\u4e0d\u643a\u5e26EGFR\u6216ALK\u57fa\u56e0\u53d8\u5f02\u3002\u5728\u4e2d\u56fd\uff0c\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e8e\u4eca\u5e742\u6708\u83b7\u6279\u8054\u5408\u5316\u7597\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u5e7f\u6cdb\u671f\u7684\u5c0f\u7ec6\u80de\u80ba\u764c\uff1b\u5176\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u4e0a\u5e02\u7533\u8bf7\u5df2\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002

\u7f8e\u56fdFDA\u6279\u51c6\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u9002\u5e94\u8bc1\u8fd8\u5305\u62ec\uff1a\u5c3f\u8def\u4e0a\u76ae\u764c\u3001NSCLC\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u3002\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u83b7\u6279\u8fd9\u4e9b\u9002\u5e94\u8bc1\uff0c\u53ef\u5728\u4e0e\u60a3\u8005\u5145\u5206\u6c9f\u901a\u7684\u60c5\u51b5\u4e0b\u3001\u6309\u7167\u6bcf\u4e2a\u7624\u80bf\u6279\u51c6\u7684\u7528\u6cd5\u6b63\u786e\u4f7f\u7528\u3002

Atezolizumab\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u4f5c\u4e3a\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u914d\u4f53\uff08PD-L1\uff09\u963b\u65ad\u5242\uff0c\u80fd\u4e0e\u80bf\u7624\u7ec6\u80de\u4e0a\u7684PD-L1\u7ed3\u5408\uff0c\u5e76\u963b\u65ad\u5176\u4e0eT\u7ec6\u80de\u53ca\u6297\u539f\u9012\u5448\u7ec6\u80dePD-1\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u89e3\u9664PD-1\/PD-L1\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\uff0c\u4fc3\u8fdbT\u7ec6\u80de\u653b\u51fb\u80bf\u7624\u7ec6\u80de\u3002

\u4e00\u9879\u540d\u4e3aIMpower130\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u5bf9\u7167\u30013\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u663e\u793a\uff0c\u8054\u5408\u5316\u7597\u836f<\/a>\u7269(\u901a\u7528\u540d:\u963f\u7279\u73e0\u5355\u6297\uff0c\u5546\u54c1\u540d:TECENTRIQ)]\u663e\u8457\u5ef6\u957f\u4e86\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u603b\u751f\u5b58\u671f(OS)\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u3002
\u00a0
\u5171\u6709723\u540d\u4e4b\u524d\u672a\u63a5\u53d7\u5316\u7597\u7684\u2173\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u88ab\u7eb3\u5165\u7814\u7a76\u3002\u6309\u71672:1\u7684\u968f\u673a\u6bd4\u4f8b\uff0c\u5c06\u5176\u5206\u4e3a\u963f\u7279\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\u548c\u5355\u7eaf\u5316\u7597\u7ec4\u3002\u4e24\u7ec4\u60a3\u8005\u5206\u522b\u63a5\u53d7Atruzumab\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u5361\u94c2\u548c\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u5361\u94c2\u6cbb\u7597\u3002
\u00a0
\u7ed3\u679c\u663e\u793a\uff0c\u8054\u5408\u5316\u7597\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f(OS)\u6bd4\u5355\u7eaf\u5316\u7597\u7ec4([)\u957f5.3\u4e2a\u6708\uff0c\u5206\u522b\u4e3a18.6\u4e2a\u6708\u548c13.9\u4e2a\u6708(\u5fc3\u73870.80\uff0c95%\u53ef\u4fe1\u533a\u95f40.64-0.99\uff0cP=0.0384)]\uff1b\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u5ef6\u957f\u4e860.7\u4e2a\u6708\uff0c[\u5ef6\u957f\u4e867.2\u4e2a\u6708\uff0c\u800c\u5bf9\u7167\u7ec4\u5ef6\u957f\u4e866.5\u4e2a\u6708(\u5fc3\u73870.75\uff0c95%\u53ef\u4fe1\u533a\u95f40.63-0.91\uff0cp=0.0024)\uff0c\u7ec4\u95f4\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002
\u00a0
\u57fa\u4e8eIMpower130\u7684\u9633\u6027\u7814\u7a76\u7ed3\u679c\uff0c2019\u5e7412\u67083\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u963f\u7279\u73e0\u5355\u6297\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u7d2b\u6749\u9187\u548c\u5361\u94c2\u4e00\u7ebf\u6cbb\u7597\u65e0EGFR\u6216ALK\u57fa\u56e0\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSqNSCLC)\u6210\u4eba\u60a3\u8005\u3002
\u00a0
\u8fd9\u662f2019\u5e74T\u836f\u54c1\u7684\u7b2c\u4e09\u6b21\u6279\u51c6\u3002\u81ea2016\u5e745\u670818\u65e5\u9996\u6b21\u83b7\u5f97\u6279\u51c6\u4ee5\u6765\uff0c\u836f\u7269T\u5df2\u88ab\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c<\/a>(TNBC)\u548c\u80ba\u764c\u3002\u5176\u4e2d\uff0c\u836f\u7269T\u5728\u80ba\u764c\u6cbb\u7597\u9886\u57df\u5177\u6709\u6700\u88ab\u8ba4\u53ef\u7684\u9002\u5e94\u75c7\uff0c\u5e76\u4e14\u90fd\u662f\u4e00\u7ebf\u548c\u4e8c\u7ebf\u7597\u6cd5\u3002

2020\u5e7410\u670828\u65e5\uff0c\u7f57\u6c0f\u5ba3\u5e03\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u5176\u80bf\u7624\u514d\u75ab\u521b\u65b0\u836f\u7269\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08\u5546\u54c1\u540d\uff1a\u6cf0\u5723\u5947\u00ae\uff0cTecentriq\u00ae\uff09\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cT+A\u201d\u8054\u5408\u7597\u6cd5\uff09\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u3002

2021\u5e744\u670829\u65e5\uff0c\u6211\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u963f\u7279\u73e0\u5355\u6297\u7684\u65b0\u9002\u5e94\u75c7\uff0c\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597PD-L1\u8868\u8fbe\u6c34\u5e73\u9ad8\uff08TC\u226550%\uff09\u6216IC\u226510%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u60a3\u8005\u7684EGFR\u53caALK\u7a81\u53d8\u4e3a\u9634\u6027\u3002
<\/p>\n

2021 \u5e74 6 \u6708 22 \u65e5\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5b98\u7f51\u663e\u793a\uff0c\u514d\u75ab\u836f\u7269 PD-L1 \u6297\u4f53\u963f\u66ff\u5229\u73e0\u5355\u6297\u65b0\u9002\u5e94\u75c7\u6b63\u5f0f\u83b7\u6279\u3002\u6b64\u6b21\u83b7\u6279\u7684\u9002\u5e94\u75c7\u4e3a\uff1a\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u5316\u7597\u7528\u4e8e\u65e0 EGFR \u7a81\u53d8\u548c\u65e0 ALK \u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002

2021\u5e7410\u6708\uff0c\u7f57\u6c0f\u96c6\u56e2\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40 (FDA)\u00a0\u6279\u51c6\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08Atezolizumab\uff0c\u6cf0\u5723\u5947\u5373T\u836f\uff09\u65b0\u9002\u5e94\u75c7\uff01\u4f5c\u4e3a\u624b\u672f\u548c\u94c2\u7c7b\u5316\u7597\u540e\u7684\u8f85\u52a9\u6cbb\u7597\uff0c\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u8868\u8fbe PD-L1\u22651% \u7684\u6210\u4eba II-IIIA \u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c (NSCLC)\u3002

2022\u5e743\u670818\u65e5\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6b63\u5f0f\u6279\u51c6\u4e86\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08\u5546\u54c1\u540d\uff1a\u6cf0\u5723\u5947\uff09\u5355\u836f\u7528\u4e8e\u68c0\u6d4b\u8bc4\u4f30\u4e3a\u22651%\u80bf\u7624\u7ec6\u80de\uff08TC\uff09PD-L1\u67d3\u8272\u9633\u6027\u3001\u7ecf\u624b\u672f\u5207\u9664\u3001\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u5316\u7597\u4e4b\u540e\u7684II-IIIA\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002\u8fd9\u662f\u4e2d\u56fd\u83b7\u6279\u7684\u9996\u4e2aNSCLC\u672f\u540e\u8f85\u52a9\u514d\u75ab\u6cbb\u7597\u9002\u5e94\u75c7\u3002

2022\u5e7412\u67089\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08Atezolizumab\uff09\u7528\u4e8e\u60a3\u6709\u65e0\u6cd5\u5207\u9664\u6216\u8f6c\u79fb\u6027\u817a\u6ce1\u72b6\u8f6f\u7ec4\u7ec7\u8089\u7624\uff08ASPS\uff09\u7684\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\uff082\u5c81\u4ee5\u4e0a\uff09\u3002<\/p>\n<\/div>\n

\u7b80\u8981\u8bf4\u660e\u4e66<\/h3>\n
\n\n\n\n\n\n\n\n\n
\u963f\u66ff\u5229\u73e0\u5355\u6297 atezolizumab(\u6cf0\u5723\u5947 Tecentriq\u00a0)\u8bf4\u660e\u4e66<\/td>\n<\/tr>\n
\u836f\u7269\uff1a<\/td>\n\u963f\u66ff\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u00a0atezolizumab<\/td>\n<\/tr>\n
\u9776\u70b9\uff1a<\/td>\nPD-1\/PD-L1<\/td>\n<\/tr>\n
\u6cbb\u7597\uff1a<\/td>\n\u9002\u7528\u4e8e\u6709\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u7684\u6cbb\u7597\u60a3\u8005<\/td>\n<\/tr>\n
\u53c2\u8003\u7528\u6cd5\u7528\u91cf\uff1a<\/td>\n\u6bcf3\u5468\u7ed9\u4e881200mg\uff0c\u4e00\u6b21\u9759\u8109\u8f93\u6ce8\u5386\u65f660\u5206\u949f\uff0c\u9759\u8109\u8f93\u6ce8\u524d\u9700\u7a00\u91ca\u3002<\/td>\n<\/tr>\n
\u4e0d\u826f\u53cd\u5e94\uff1a<\/td>\n\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94(\u226520%\u7684\u60a3\u8005)\u5305\u62ec\uff1a\u75b2\u4e4f\uff0c\u98df\u6b32\u51cf\u9000\uff0c\u6076\u5fc3\uff0c\u5c3f\u8def\u611f\u67d3\uff0c\u53d1\u70ed\u548c\u4fbf\u79d8\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u66f4\u591a\u54a8\u8be2\uff0c \u8bf7\u5fae\uff1alkhong77<\/h3>\n","protected":false},"excerpt":{"rendered":"

  \u836f\u54c1\u6982\u8ff0 Atezolizumab\u4e8e2016\u5e745\u670818\u65e5\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c2020\u5e745\u6708\uff0c\u8be5\u836f\u83b7\u5f97\u7f8e\u56fdFDA\u6269\u5c55\u9002\u5e94\u75c7\u6279\u51c6\uff0c\u7528\u4e8e\u5355\u836f\u4e00\u7ebf\u6cbb\u7597PD-L1\u9ad8\u8868\u8fbe\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u7684\u80bf\u7624\u4e0d\u643a\u5e26EGF […]<\/p>\n","protected":false},"author":1,"featured_media":737,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[273,272,271],"topic":[],"class_list":["post-736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-feiaiyaoping","tag-273","tag-272","tag-271"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=736"}],"version-history":[{"count":1,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/736\/revisions"}],"predecessor-version":[{"id":738,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/736\/revisions\/738"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/737"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=736"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}