{"id":73,"date":"2023-09-18T14:44:48","date_gmt":"2023-09-18T06:44:48","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=73"},"modified":"2023-09-18T14:45:11","modified_gmt":"2023-09-18T06:45:11","slug":"%e8%bf%88%e5%85%b0%e5%90%89%e4%b8%89%e4%bb%a3%e4%b8%99%e9%80%9a%e6%b2%99%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=73","title":{"rendered":"\u8fc8\u5170\u5409\u4e09\u4ee3(\u4e19\u901a\u6c99\uff09"},"content":{"rendered":"\n
\n
\"\"<\/figure>\n<\/figure>\n\n\n\n

\u3010\u836f\u54c1\u540d\u79f0\u3011
\u5546\u54c1\u540d\u79f0\uff1a\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u7247(\u4e19\u901a\u6c99)(\u5409\u4e09\u4ee3)
\u3010\u4e3b\u8981\u6210\u4efd\u3011<\/p>\n\n\n\n

\u672c\u54c1\u4e3a\u590d\u65b9\u5236\u5242\uff0c\u5176\u7ec4\u4efd\u4e3a\uff1a\u6bcf\u7247\u542b 400 mg \u7d22\u78f7\u5e03\u97e6\u548c 100 mg \u7ef4\u5e15\u4ed6\u97e6\u3002
\u3010\u9002\u5e94\u75c7\/\u529f\u80fd\u4e3b\u6cbb\u3011<\/p>\n\n\n\n

\u672c\u54c1\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6162\u6027\u4e19\u578b\u809d\u708e\u75c5\u6bd2 (HCV) \u611f\u67d3\uff08\u53c2\u89c1\u3010\u7528\u6cd5\u7528\u91cf\u3011\u3001\u3010\u6ce8\u610f\u4e8b\u9879\u3011\u548c\u3010\u836f\u7406\u6bd2\u7406\u3011\uff09\u3002
\u3010\u89c4\u683c\u578b\u53f7\u3011<\/p>\n\n\n\n

28s(\u6bcf\u7247\u542b400mg\u7d22\u78f7\u5e03\u97e6\u548c100mg\u7ef4\u5e15\u4ed6\u97e6)
\u3010\u7528\u6cd5\u7528\u91cf\u3011<\/p>\n\n\n\n

Epclusa \u7684\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u65e5\u4e00\u6b21\uff0c\u6bcf\u6b21\u53e3\u670d\u4e00\u7247\uff0c\u968f\u98df\u7269\u6216\u4e0d\u968f\u98df\u7269\u670d\u7528\uff08\u53c2\u89c1\u3010\u836f\u4ee3\u52a8\u529b\u5b66\u3011\uff09\u3002\u8be6\u60c5\u8bf7\u89c1\u8bf4\u660e\u4e66\u3002
\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/p>\n\n\n\n

\u5b89\u5168\u6027\u7279\u5f81\u603b\u7ed3\uff1a Epclusa \u7684\u5b89\u5168\u6027\u8bc4\u4f30\u57fa\u4e8e\u57fa\u56e0\u578b 1\u30012\u30013\u30014\u30015 \u6216 6 HCV \u611f\u67d3\u60a3\u8005\uff08\u60a3\u6216\u672a\u60a3\u4ee3\u507f\u671f\u809d\u786c\u5316\uff09\u7684\u6c47\u603b 3 \u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5305\u62ec\u63a5\u53d7 12 \u5468 Epclusa \u6cbb\u7597\u7684 1,035 \u540d\u60a3\u8005\u3002 \u5bf9\u4e8e\u63a5\u53d7 12 \u5468 Epclusa \u6cbb\u7597\u7684\u60a3\u8005\uff0c\u56e0\u4e0d\u826f\u4e8b\u4ef6\u800c\u6c38\u4e45\u505c\u6b62\u6cbb\u7597\u7684\u60a3\u8005\u6bd4\u4f8b\u4e3a 0.2%\uff0c\u51fa\u73b0\u4efb\u4f55\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u6bd4\u4f8b\u4e3a 3.2%\u3002<\/p>\n\n\n\n

\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5934\u75db\u3001\u75b2\u52b3\u548c\u6076\u5fc3\u662f\u5728\u63a5\u53d7 12 \u5468 Epclusa \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u62a5\u544a\u7684\u6700\u5e38\u89c1\uff08\u53d1\u751f\u7387 \u2265 10%\uff09\u7684\u6cbb\u7597\u5f15\u53d1\u4e0d\u826f\u4e8b\u4ef6\u3002\u4e0a\u8ff0\u53ca\u5176\u4ed6\u4e0d\u826f\u4e8b\u4ef6\u5728\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e0e\u63a5\u53d7 Epclusa \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u7684\u62a5\u544a\u9891\u7387\u76f8\u4f3c\u3002<\/p>\n\n\n\n

\u5931\u4ee3\u507f\u671f\u809d\u786c\u5316\u60a3\u8005\uff1a \u5df2\u5728\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u4e2d\u8bc4\u4f30\u4e86 Epclusa \u7684\u5b89\u5168\u6027\u7279\u5f81\uff0c\u5728\u8be5\u7814\u7a76\u4e2d CPT B \u7ea7\u809d\u786c\u5316\u60a3\u8005\u63a5\u53d7\u4e86 12 \u5468 Epclusa \u6cbb\u7597(n = 90)\u300112 \u5468 Epclusa + RBV \uff08\u5229\u5df4\u97e6\u6797\uff09\u6cbb\u7597 (n = 87) \u6216 24 \u5468 Epclusa \u6cbb\u7597 (n = 90)\u3002\u7814\u7a76\u89c2\u5bdf\u5230\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e0e\u5931\u4ee3\u507f\u671f\u809d\u75c5\u7684\u9884\u8ba1\u4e34\u5e8a\u540e\u9057\u75c7\u6216\u5f53\u60a3\u8005\u63a5\u53d7Epclusa\u4e0e\u5229\u5df4\u97e6\u6797\u8054\u5408\u7528\u836f\u65f6\uff0c\u5229\u5df4\u97e6\u6797\u7684\u5df2\u77e5\u6bd2\u6027\u7279\u5f81\u4e00\u81f4\u3002 \u5728\u63a5\u53d7 12 \u5468 Epclusa + RBV \uff08\u5229\u5df4\u97e6\u6797\uff09\u6cbb\u7597\u7684 87 \u540d\u60a3\u8005\u4e2d\uff0c\u5206\u522b\u6709 23% \u548c 7% \u7684\u60a3\u8005\u5728\u6cbb\u7597\u671f\u95f4\u7684\u8840\u7ea2\u86cb\u767d\u4e0b\u964d\u81f3\u4f4e\u4e8e 10 mg\/dL \u548c 8.5 mg\/dL\u300215% \u7684\u63a5\u53d7 12 \u5468 Epclusa + RBV \u6cbb\u7597\u7684\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u800c\u505c\u7528\u4e86\u5229\u5df4\u97e6\u6797\u3002<\/p>\n\n\n\n

\u9009\u5b9a\u4e0d\u826f\u53cd\u5e94\u7684\u8bf4\u660e \u5fc3\u5f8b\u5931\u5e38 \u5f53\u7d22\u78f7\u5e03\u97e6\u4e0e\u5176\u4ed6\u76f4\u63a5\u4f5c\u7528\u6297\u75c5\u6bd2\u836f\u7269\u8054\u5408\uff0c\u5e76\u5408\u7528\u836f\u7269\u80fa\u7898\u916e\u548c\/\u6216\u964d\u4f4e\u5fc3\u7387\u7684\u5176\u4ed6\u836f\u54c1\u65f6\uff0c\u89c2\u5bdf\u5230\u4e25\u91cd\u5fc3\u52a8\u8fc7\u7f13\u548c\u5fc3\u810f\u4f20\u5bfc\u963b\u6ede\u60c5\u51b5\uff08\u53c2\u89c1\u3010\u6ce8\u610f\u4e8b\u9879\u3011\u548c\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011\uff09\u3002<\/p>\n\n\n\n

\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\u7684\u62a5\u544a \u836f\u54c1\u88ab\u6279\u51c6\u4e0a\u5e02\u540e\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\u7684\u62a5\u544a\u5341\u5206\u91cd\u8981\u3002\u5982\u6b64\u53ef\u6301\u7eed\u76d1\u6d4b\u4f7f\u7528\u8be5\u836f\u54c1\u7684\u83b7\u76ca\/\u98ce\u9669\u5e73\u8861\u3002\u5728\u4e2d\u56fd\uff0c\u8981\u6c42\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u4eba\u5458\u901a\u8fc7\u56fd\u5bb6\u62a5\u544a\u7cfb\u7edf\u62a5\u544a\u4efb\u4f55\u7591\u4f3c\u4e0d\u826f\u53cd\u5e94\u3002
\u3010\u7981 \u5fcc\u3011<\/p>\n\n\n\n

\u5bf9\u6d3b\u6027\u6210\u5206\u6216\u4efb\u4e00\u8d4b\u5f62\u5242\u51fa\u73b0\u8d85\u654f\u53cd\u5e94\u3002 \u4e0e\u5f3a\u6548P-gp\u8bf1\u5bfc\u5242\u548c\u5f3a\u6548CYP\u8bf1\u5bfc\u5242\u8054\u7528\u5f3a\u6548 P-\u7cd6\u86cb\u767d(P-gp)\u8bf1\u5bfc\u5242\u6216\u5f3a\u6548\u7ec6\u80de\u8272\u7d20P450(CYP)\u8bf1\u5bfc\u5242\u7c7b\u836f\u54c1\uff08\u5229\u798f\u5e73\u3001\u5229\u798f\u5e03\u76ef\u5723\u7ea6\u7ff0\u8349 [Hypericumperforatum]\u3001\u5361\u9a6c\u897f\u5e73\u3001\u82ef\u5df4\u6bd4\u59a5\u548c\u82ef\u59a5\u82f1\uff09\u3002\u8054\u5408\u7528\u836f\u4f1a\u663e\u8457\u964d\u4f4e\u7d22\u78f7\u5e03\u97e6\u6216\u7ef4\u5e15\u4ed6\u97e6\u7684\u8840\u6d46\u6d53\u5ea6\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4 Epclusa\u5931\u53bb\u7597\u6548\uff08\u53c2\u89c1\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011\uff09\u3002
\u3010\u6ce8\u610f\u4e8b\u9879\u3011<\/p>\n\n\n\n

\u8b66\u544a\uff1aHCV\u548cHBV\u5408\u5e76\u611f\u67d3\u60a3\u8005\u4e2d\u7684\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u518d\u6fc0\u6d3b\u98ce\u9669 \u5728\u5f00\u59cb EPCLUSA\u6cbb\u7597\u524d\u5bf9\u6240\u6709\u60a3\u8005\u8fdb\u884c\u5f53\u524d\u6216\u65e2\u5f80\u4e59\u578b\u809d\u708e\u75c5\u6bd2(HBV)\u611f\u67d3\u8ff9\u8c61\u68c0\u6d4b\u3002\u5df2\u5728\u6b63\u63a5\u53d7\u6216\u5df2\u5b8c\u6210HCV\u76f4\u63a5\u4f5c\u7528\u6297\u75c5\u6bd2\u836f\u7269\u6cbb\u7597\u53ca\u672a\u63a5\u53d7HBV\u6297\u75c5\u6bd2\u6cbb\u7597\u7684HCV\/HBV\u5408\u5e76\u611f\u67d3\u60a3\u8005\u4e2d\u62a5\u544a\u4e86HBV\u518d\u6fc0\u6d3b\u3002\u4e00\u4e9b\u75c5\u4f8b\u5bfc\u81f4\u4e86\u66b4\u53d1\u6027\u809d\u708e\u3001\u809d\u8870\u7aed\u548c\u6b7b\u4ea1\u3002\u5728HCV\u6cbb\u7597\u548c\u6cbb\u7597\u540e\u968f\u8bbf\u671f\u95f4\u76d1\u6d4bHCV\/HBV\u5408\u5e76\u611f\u67d3\u60a3\u8005\u662f\u5426\u51fa\u73b0\u809d\u708e\u53d1\u4f5c\u6216HBV\u518d\u6fc0\u6d3b\u3002\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u5bf9HBV\u611f\u67d3\u5b9e\u65bd\u9002\u5f53\u7684\u60a3\u8005\u7ba1\u7406\u3002 Epclusa\u4e0d\u5e94\u4e0e\u542b\u7d22\u78f7\u5e03\u97e6\u7684\u5176\u4ed6\u836f\u54c1\u540c\u65f6\u7ed9\u836f\u3002\u8be6\u60c5\u8bf7\u89c1\u8bf4\u660e\u4e66\u3002
\u3010\u513f\u7ae5\u7528\u836f\u3011<\/p>\n\n\n\n

\u5c1a\u672a\u786e\u5b9aEpclusa\u5728\u513f\u7ae5\u53ca18\u5c81\u4ee5\u4e0b\u9752\u5c11\u5e74\u4e2d\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002\u5c1a\u65e0\u53ef\u7528\u6570\u636e\u3002
\u3010\u8001\u5e74\u60a3\u8005\u7528\u836f\u3011<\/p>\n\n\n\n

Epclusa\u7684\u4e34\u5e8a\u7814\u7a76\u7eb3\u5165\u4e86156\u540d\u5e74\u9f84\u4e3a65\u5c81\u53ca\u4ee5\u4e0a\u7684\u60a3\u8005\uff08\u53603\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u60a3\u8005\u603b\u6570\u768412%\uff09\u3002\u5728\u5404\u6cbb\u7597\u7ec4\u95f4\uff0c\u226565\u5c81\u7684\u60a3\u8005\u7684\u5e94\u7b54\u7387\u4e0e<65\u5c81\u60a3\u8005\u7684\u5e94\u7b54\u7387\u76f8\u4f3c\u3002
\u3010\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7528\u836f\u3011<\/p>\n\n\n\n

\u598a\u5a20\uff1a \u5c1a\u65e0\u5b55\u5987\u4f7f\u7528\u7d22\u78f7\u5e03\u97e6\u3001\u7ef4\u5e15\u4ed6\u97e6\u6216Epclusa\u7684\u6570\u636e\u6216\u6b64\u7c7b\u6570\u636e\u975e\u5e38\u6709\u9650\uff08\u4e0d\u8db3300\u4f8b\u598a\u5a20\u7ed3\u5c40\uff09\u3002\u7d22\u78f7\u5e03\u97e6\u5173\u4e8e\u751f\u6b96\u6bd2\u6027\uff0c\u52a8\u7269\u7814\u7a76\u672a\u8868\u660e\u5b58\u5728\u76f4\u63a5\u6216\u95f4\u63a5\u6709\u5bb3\u5f71\u54cd\uff08\u53c2\u89c1\u3010\u836f\u7406\u6bd2\u7406\u3011\uff09\u3002\u76f8\u5bf9\u4e8e\u63a8\u8350\u4e34\u5e8a\u5242\u91cf\u4e0b\u7684\u4eba\u7c7b\u66b4\u9732\u91cf\uff0c\u65e0\u6cd5\u5145\u5206\u4f30\u8ba1\u5927\u9f20\u4e2d\u6240\u8fbe\u5230\u7684\u7d22\u78f7\u5e03\u97e6\u66b4\u9732\u8fb9\u754c\uff08\u53c2\u89c1\u3010\u836f\u7406\u6bd2\u7406\u3011\uff09\u3002 \u7ef4\u5e15\u4ed6\u97e6\uff1a \u52a8\u7269\u7814\u7a76\u5df2\u8868\u660e\u53ef\u80fd\u4e0e\u751f\u6b96\u6bd2\u6027\u76f8\u5173\uff08\u53c2\u89c1\u3010\u836f\u7406\u6bd2\u7406\u3011\uff09\u3002<\/p>\n\n\n\n

\u4f5c\u4e3a\u4e00\u79cd\u9884\u9632\u63aa\u65bd\uff0c\u598a\u5a20\u671f\u95f4\u4e0d\u5efa\u8bae\u4f7f\u7528 Epclusa\u3002<\/p>\n\n\n\n

\u54fa\u4e73\uff1a \u5c1a\u4e0d\u6e05\u695a\u7d22\u78f7\u5e03\u97e6\u3001\u7d22\u78f7\u5e03\u97e6\u7684\u4ee3\u8c22\u7269\u6216\u7ef4\u5e15\u4ed6\u97e6\u662f\u5426\u4f1a\u5206\u6ccc\u5230\u4eba\u4e73\u4e2d\u3002\u52a8\u7269\u5b9e\u9a8c\u6240\u5f97\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u663e\u793a\u7ef4\u5e15\u4ed6\u97e6\u548c\u7d22\u78f7\u5e03\u97e6\u7684\u4ee3\u8c22\u4ea7\u7269\u901a\u8fc7\u4e73\u6c41\u6392\u51fa\u3002\u4e0d\u80fd\u6392\u9664\u5bf9\u4e8e\u65b0\u751f\u513f\/\u5a74\u513f\u7684\u98ce\u9669\u3002\u56e0\u6b64\uff0c\u54fa\u4e73\u671f\u95f4\u4e0d\u5e94\u4f7f\u7528Epclusa\u3002<\/p>\n\n\n\n

\u751f\u80b2\u529b\uff1a \u5c1a\u65e0Epclusa\u5f71\u54cd\u4eba\u7c7b\u751f\u80b2\u529b\u7684\u76f8\u5173\u6570\u636e\u3002\u52a8\u7269\u7814\u7a76\u672a\u8868\u660e\u7d22\u78f7\u5e03\u97e6\u6216\u7ef4\u5e15\u4ed6\u97e6\u5bf9\u751f\u80b2\u529b\u4ea7\u751f\u6709\u5bb3\u5f71\u54cd\u3002\u5982\u679c\u5229\u5df4\u97e6\u6797\u4e0eEpclusa\u8054\u5408\u4f7f\u7528\uff0c\u5219\u53c2\u8003\u5229\u5df4\u97e6\u6797\u7684\u5904\u65b9\u4fe1\u606f\uff0c\u4e86\u89e3\u5173\u4e8e\u598a\u5a20\u3001\u907f\u5b55\u548c\u54fa\u4e73\u7684\u8be6\u7ec6\u5efa\u8bae\u3002
\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011<\/p>\n\n\n\n

\u7531\u4e8eEpclusa\u542b\u7d22\u78f7\u5e03\u97e6\u548c\u7ef4\u5e15\u4ed6\u97e6\uff0c\u5355\u72ec\u4f7f\u7528\u8fd9\u4e9b\u6d3b\u6027\u7269\u8d28\u65f6\u53d1\u73b0\u7684\u4efb\u4f55\u76f8\u4e92\u4f5c\u7528\u5747\u53ef\u80fd\u5728\u4f7f\u7528 Epclusa\u65f6\u53d1\u751f\u3002\u8be6\u60c5\u8bf7\u89c1\u8bf4\u660e\u4e66\u3002
\u3010\u836f\u7269\u8fc7\u91cf\u3011<\/p>\n\n\n\n

\u7d22\u78f7\u5e03\u97e6\u548c\u7ef4\u5e15\u4ed6\u97e6\u7684\u6600\u9ad8\u8bb0\u5f55\u5242\u91cf\u5206\u522b\u4e3a\u5355\u6b21\u7ed9\u836f1,200mg\u548c\u5355\u6b21\u7ed9\u836f500mg\u3002\u5728\u8fd9\u4e9b\u5065\u5eb7\u5fd7\u613f\u8005\u7814\u7a76\u4e2d\uff0c\u672a\u5728\u8fd9\u4e9b\u5242\u91cf\u6c34\u5e73\u4e0b\u89c2\u5bdf\u5230\u4e0d\u826f\u4f5c\u7528\uff0c\u4e14\u4e0d\u826f\u4e8b\u4ef6\u7684\u62a5\u544a\u9891\u7387\u548c\u4e25\u91cd\u7a0b\u5ea6\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u4f3c\u3002\u5c1a\u4e0d\u6e05\u695a\u66f4\u9ad8\u5242\u91cf\/\u66b4\u9732\u91cf\u7684\u5f71\u54cd\u3002 \u5c1a\u672a\u63d0\u4f9b\u9488\u5bf9Epclusa\u836f\u7269\u8fc7\u91cf\u7684\u7279\u5b9a\u89e3\u6bd2\u5242\u3002\u5982\u679c\u53d1\u751f\u836f\u7269\u8fc7\u91cf\uff0c\u5fc5\u987b\u76d1\u6d4b\u60a3\u8005\u662f\u5426\u6709\u6bd2\u6027\u8ff9\u8c61\u3002\u6cbb\u7597Epclusa\u836f\u7269\u8fc7\u91cf\u65f6\u9700\u8981\u91c7\u53d6\u4e00\u822c\u652f\u6301\u6027\u63aa\u65bd\uff0c\u5305\u62ec\u76d1\u6d4b\u751f\u547d\u4f53\u5f81\u4ee5\u53ca\u89c2\u5bdf\u60a3\u8005\u7684\u4e34\u5e8a\u72b6\u6001\u3002\u8840\u6db2\u900f\u6790\u53ef\u4ee5\u6709\u6548\u5730\u6e05\u9664\u7d22\u78f7\u5e03\u97e6\u7684\u4e3b\u8981\u5faa\u73af\u4ee3\u8c22\u4ea7\u7269GS-331007\uff0c\u63d0\u53d6\u7387\u4e3a53%\u3002\u7531\u4e8e\u7ef4\u5e15\u4ed6\u97e6\u4e0e\u8840\u6d46\u86cb\u767d\u7684\u7ed3\u5408\u7387\u8f83\u9ad8\uff0c\u56e0\u6b64\u8840\u6db2\u900f\u6790\u4e0d\u592a\u53ef\u80fd\u663e\u8457\u6e05\u9664\u7ef4\u5e15\u4ed6\u97e6\u3002
\u3010\u836f\u7406\u6bd2\u7406\u3011<\/p>\n\n\n\n

\u836f\u7406\u4f5c\u7528\uff1a \u672c\u54c1\u4e3a\u7d22\u78f7\u5e03\u97e6\u4e0e\u7ef4\u5e15\u4ed6\u97e6\u7ec4\u6210\u7684\u590d\u65b9\u5236\u5242\u3002\u7d22\u78f7\u5e03\u97e6\u662f\u4e19\u809d\u975e\u7ed3\u6784\u86cb\u767d5B\u4f9d\u8d56\u6027RNA\u805a\u5408\u9176\u6291\u5236\u5242\uff0c\u662f\u4e00\u79cd\u6838\u82f7\u9178\u836f\u7269\u524d\u4f53\uff0c\u4ee3\u8c22\u4ea7\u7269GS-461203\uff08\u5c3f\u82f7\u7c7b\u4f3c\u7269\u4e09\u78f7\u9178\u76d0\uff09\u53ef\u88abNS5B\u805a\u5408\u9176\u5d4c\u5165HCVRNA\u800c\u7ec8\u6b62\u590d\u5236\u3002GS-461203\u65e2\u4e0d\u662f\u4eba\u7c7bDNA\u548cRNA\u805a\u5408\u9176\u6291\u5236\u5242\uff0c\u4e5f\u4e0d\u662f\u7ebf\u7c92\u4f53RNA\u805a\u5408\u9176\u7684\u6291\u5236\u5242\u3002<\/p>\n\n\n\n

\u6bd2\u7406\u7814\u7a76\uff1a \u7d22\u78f7\u5e03\u97e6\u9057\u4f20\u6bd2\u6027\uff1a\u7d22\u78f7\u5e03\u97e6Ames\u8bd5\u9a8c\u3001\u4eba\u5916\u5468\u8840\u6dcb\u5df4\u7ec6\u80de\u67d3\u8272\u4f53\u7578\u53d8\u8bd5\u9a8c\u3001\u5c0f\u9f20\u5fae\u6838\u8bd5\u9a8c\u7ed3\u679c\u5747\u4e3a\u9634\u6027\u3002<\/p>\n\n\n\n

\u751f\u6b96\u6bd2\u6027\uff1a\u7d22\u78f7\u5e03\u97e6\u5728\u5242\u91cf\u4e3a20\u3001100\u3001500mg\/kg\/\u65e5\u65f6\uff0c\u5bf9\u5927\u9f20\u80da\u80ce-\u80ce\u4ed4\u53d1\u80b2\u6216\u751f\u80b2\u529b\u672a\u89c1\u5f71\u54cd\uff0c500mg\/kg\/\u65e5\u5242\u91cf\u4e0b\u4e3b\u8981\u5faa\u73af\u4ee3\u8c22\u4ea7\u7269\uff08GS-331007\uff09\u7684\u66b4\u9732\u91cf\u7ea6\u4e3a\u4eba\u4e34\u5e8a\u5242\u91cf\u4e0b\u66b4\u9732\u91cf\u76848\u500d\u3002\u7d22\u78f7\u5e03\u97e6\u5bf9\u5927\u9f20\uff08500mg\/kg\/\u65e5\uff09\u548c\u5154\uff08300mg\/kg\/\u65e5\uff09\u672a\u89c1\u81f4\u7578\u4f5c\u7528\u3002GS-331007\u5728\u598a\u5a20\u5927\u9f20\u548c\u598a\u5a20\u5154\u4f53\u5185\u7684\u66b4\u9732\u91cf\u968f\u7ed9\u836f\u65f6\u95f4\u7684\u589e\u52a0\u800c\u589e\u52a0\uff0c\u5206\u522b\u76f8\u5f53\u4e8e\u4eba\u4e34\u5e8a\u5242\u91cf\u66b4\u9732\u76845\uff5e10\u500d\u548c12\uff5e28\u500d\u3002GS-331007\u53ef\u901a\u8fc7\u4e73\u6c41\u5206\u6ccc\uff0c\u5bf9\u80ce\u4ed4\u672a\u89c1\u5f71\u54cd\u3002<\/p>\n\n\n\n

\u81f4\u764c\u6027\uff1a\u5728\u5c0f\u9f20\u548c\u5927\u9f202\u5e74\u81f4\u764c\u6027\u8bd5\u9a8c\u4e2d\uff0c\u96cc\u3001\u96c4\u5c0f\u9f20\u7ed9\u4e88\u7d22\u78f7\u5e03\u97e6\u5242\u91cf\u5206\u522b\u8fbe600mg\/kg\/\u65e5\u3001200mg\/kg\/\u65e5\uff0c\u96cc\u3001\u96c4\u5927\u9f20\u7684\u7ed9\u836f\u5242\u91cf750mg\/kg\/\u65e5\uff0c\u672a\u89c1\u81f4\u764c\u6027\u3002GS-331007\u5728\u5c0f\u9f20\u4f53\u5185\u7684\u66b4\u9732\u91cf\u5206\u522b\u76f8\u5f53\u4e8e\u4eba\u4e34\u5e8a\u5242\u91cf\u66b4\u9732\u76843\u500d\uff08\u96c4\uff09\u548c15\u500d\uff08\u96cc\uff09\uff0c\u5728\u5927\u9f20\u4f53\u5185\u7684\u66b4\u9732\u91cf\u5206\u522b\u76f8\u5f53\u4e8e\u4eba\u7ed9\u836f\u5242\u91cf\u66b4\u9732\u91cf\u76847\u500d\uff08\u96c4\uff09\u548c9\u500d\uff08\u96cc\uff09\u3002\u8be6\u60c5\u8bf7\u89c1\u8bf4\u660e\u4e66\u3002
\u3010\u836f\u4ee3\u52a8\u529b\u5b66\u3011<\/p>\n\n\n\n

\u5438\u6536\uff1a \u5728\u5065\u5eb7\u6210\u5e74\u53d7\u8bd5\u8005\u548c\u6162\u6027\u4e19\u809d\u60a3\u8005\u4e2d\u8bc4\u4f30\u4e86\u7d22\u78f7\u5e03\u97e6\u3001GS-331007 \u548c\u7ef4\u5e15\u4ed6\u97e6\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u6027\u3002\u7ecf\u53e3\u7ed9\u4e88 Epclusa \u540e\uff0c\u7d22\u78f7\u5e03\u97e6\u5438\u6536\u8fc5\u901f\uff0c\u5728\u7ed9\u836f\u540e 1 \u5c0f\u65f6\u89c2\u6d4b\u5230\u4e2d\u4f4d\u8840\u6d46\u6d53\u5ea6\u5cf0\u503c\u3002\u5728\u7ed9\u836f\u540e 3 \u5c0f\u65f6\u89c2\u6d4b\u5230 GS-331007 \u7684\u4e2d\u4f4d\u8840\u6d46\u6d53\u5ea6\u5cf0\u503c\u3002\u5728\u7ed9\u836f\u540e3 \u5c0f\u65f6\u89c2\u6d4b\u5230\u7ef4\u5e15\u4ed6\u97e6\u7684\u4e2d\u4f4d\u6d53\u5ea6\u5cf0\u503c\u3002\u57fa\u4e8e\u5bf9 HCV \u611f\u67d3\u60a3\u8005\u8fdb\u884c\u7684\u4eba\u7fa4\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\uff0c\u7d22\u78f7\u5e03\u97e6 (n = 982)\u3001GS-331007(n = 1,428) \u548c\u7ef4\u5e15\u4ed6\u97e6 (n = 1,425) \u7684\u7a33\u6001 AUC \u5206\u522b\u4e3a 1,260\u300113,970 \u548c0-242,970 ng h\/mL\u3002\u7d22\u78f7\u5e03\u97e6\u3001GS-331007 \u548c\u7ef4\u5e15\u4ed6\u97e6\u7684\u7a33\u6001 C \u5206\u522b\u4e3a 566\u3001868 \u548cmax259 ng\/mL\u3002\u7d22\u78f7\u5e03\u97e6\u548c GS-331007 \u7684 AUC \u548c C \u5728\u5065\u5eb7\u6210\u5e74\u53d7\u8bd5\u8005\u4e2d\u4e0e\u5728 HCV0-24 max\u611f\u67d3\u60a3\u8005\u4e2d\u76f8\u4f3c\u3002HCV \u611f\u67d3\u60a3\u8005\u7684\u7ef4\u5e15\u4ed6\u97e6 AUC \u548c C \u5206\u522b\u6bd4\u5065\u5eb7\u53d7\u8bd5\u80050-24 max(n = 331) \u4f4e 37% \u548c 41%\u3002<\/p>\n\n\n\n

\u98df\u7269\u5f71\u54cd\uff1a \u76f8\u5bf9\u4e8e\u7a7a\u8179\u6761\u4ef6\uff0c\u968f\u4e2d\u5ea6\u8102\u80aa\u9910\uff08~600kcal\uff0c30%\u8102\u80aa\uff09\u6216\u9ad8\u8102\u80aa\u9910\uff08~800kcal\uff0c50%\u8102\u80aa\uff09\u5355\u6b21\u7ed9\u4e88Epclusa\u540e\uff0c\u7ef4\u5e15\u4ed6\u97e6AUC\u5206\u522b\u589e\u52a0\u4e8634%\u548c21%\uff0c\u7ef4\u5e15\u4ed60-inf\u97e6C\u5206\u522b\u589e\u52a0\u4e8631%\u548c5%\u3002\u4e2d\u5ea6\u6216\u9ad8\u8102\u80aa\u9910\u5206\u522b\u4f7f\u7d22\u78f7\u5e03\u97e6AUC\u589e\u52a0\u4e8660%max0-inf\u548c78%\uff0c\u4f46\u672a\u663e\u8457\u5f71\u54cd\u7d22\u78f7\u5e03\u97e6C\u3002\u4e2d\u5ea6\u6216\u9ad8\u8102\u80aa\u9910\u6ca1\u6709\u6539\u53d8GS-331007AUC\uff0cmax0-inf\u4f46\u4f7fC\u5206\u522b\u589e\u52a0\u4e8625%\u548c37%\u3002\u968f\u98df\u7269\u6216\u4e0d\u968f\u98df\u7269\u670d\u7528Epclusa\u7684HCV\u611f\u67d3\u60a3\u8005max\u57283\u671f\u7814\u7a76\u4e2d\u7684\u5e94\u7b54\u7387\u76f8\u4f3c\u3002\u53ef\u5728\u4e0d\u8003\u8651\u98df\u7269\u7684\u60c5\u51b5\u4e0b\u7ed9\u4e88Epclusa\u3002<\/p>\n\n\n\n

\u5206\u5e03\uff1a \u7d22\u78f7\u5e03\u97e6\u4e0e\u4eba\u8840\u6d46\u86cb\u767d\u7684\u7ed3\u5408\u7387\u7ea6\u4e3a 61-65%\uff0c\u5728 1 \u03bcg\/mL \u81f3 20 \u03bcg\/mL \u7684\u8303\u56f4\u5185\uff0c\u7ed3\u5408\u7387\u4e0e\u836f\u7269\u6d53\u5ea6\u65e0\u5173\u3002\u5728\u4eba\u8840\u6d46\u4e2d\uff0cGS-331007 \u7684\u86cb\u767d\u7ed3\u5408\u7387\u6781\u4f4e\u3002\u5411\u5065\u5eb7\u53d7\u8bd5\u8005\u535514 14\u6b21\u7ed9\u4e88 400 mg [ C]-\u7d22\u78f7\u5e03\u97e6\u540e\uff0c[ C]-\u653e\u5c04\u6027\u7684\u8840\u6db2\u4e0e\u8840\u6d46\u4e4b\u6bd4\u7ea6\u4e3a 0.7\u3002\u7ef4\u5e15\u4ed6\u97e6\u7684\u4eba\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7387 > 99.5%\uff0c\u836f\u7269\u6d53\u5ea6\u4e3a 0.09 \u03bcg\/mL \u81f3 1.8 \u03bcg\/mL \u65f6\uff0c\u6b64\u7ed3\u5408\u7387\u4e0d14 14\u53d7\u836f\u7269\u6d53\u5ea6\u5f71\u54cd\u3002\u5411\u5065\u5eb7\u53d7\u8bd5\u8005\u5355\u6b21\u7ed9\u4e88 100 mg [ C]-\u7ef4\u5e15\u4ed6\u97e6\u540e\uff0c[ C]-\u653e\u5c04\u6027\u7684\u8840\u6db2\u4e0e\u8840\u6d46\u4e4b\u6bd4\u8303\u56f4\u4e3a 0.52 \u81f3 0.67\u3002
\u3010\u8d2e \u85cf\u3011<\/p>\n\n\n\n

30\u00b0C\u4ee5\u4e0b\u4fdd\u5b58
\u3010\u5305 \u88c5\u3011<\/p>\n\n\n\n

28\u7247\/\u76d2\u3002
\u3010\u6709 \u6548 \u671f\u3011<\/p>\n\n\n\n

24 \u6708<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u836f\u54c1\u540d\u79f0\u3011\u5546\u54c1\u540d\u79f0\uff1a\u7d22\u78f7\u5e03\u97e6\u7ef4\u5e15\u4ed6\u97e6\u7247(\u4e19\u901a\u6c99)(\u5409\u4e09\u4ee3)\u3010\u4e3b\u8981\u6210\u4efd\u3011 \u672c\u54c1\u4e3a\u590d\u65b9\u5236\u5242\uff0c\u5176\u7ec4\u4efd\u4e3a\uff1a\u6bcf\u7247\u542b 400 mg \u7d22\u78f7\u5e03\u97e6\u548c 100 mg \u7ef4\u5e15\u4ed6\u97e6\u3002\u3010\u9002\u5e94\u75c7\/\u529f\u80fd\u4e3b\u6cbb\u3011 \u672c\u54c1\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u6162\u6027\u4e19\u578b\u809d\u708e\u75c5\u6bd2 (HCV) \u611f\u67d3\uff08\u53c2\u89c1\u3010\u7528 […]<\/p>\n","protected":false},"author":1,"featured_media":74,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"topic":[],"class_list":["post-73","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/73","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=73"}],"version-history":[{"count":1,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/73\/revisions"}],"predecessor-version":[{"id":75,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/73\/revisions\/75"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/74"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=73"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=73"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=73"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=73"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}