{"id":719,"date":"2023-11-29T11:17:23","date_gmt":"2023-11-29T03:17:23","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=719"},"modified":"2023-11-29T11:17:23","modified_gmt":"2023-11-29T03:17:23","slug":"%e8%80%81%e6%8c%9d%e5%8d%97%e5%a1%94%e6%81%a9%e8%a5%bf%e5%9c%b0%e5%b9%b3enasidenib%e4%b8%ad%e6%96%87%e8%af%b4%e6%98%8e%e4%b9%a6","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=719","title":{"rendered":"\u8001\u631d\u5357\u5854\u6069\u897f\u5730\u5e73(Enasidenib)\u4e2d\u6587\u8bf4\u660e\u4e66"},"content":{"rendered":"

\"\u8001\u631d\u5357\u5854\u6069\u897f\u5730\u5e73(Enasidenib)\u4e2d\u6587\u8bf4\u660e\u4e66\"<\/p>\n

\u6069\u897f\u5730\u5e73(Enasidenib)<\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/strong>\u6069\u897f\u5730\u5e73<\/p>\n

\u5546\u54c1\u540d\uff1a<\/strong>Idhifa<\/p>\n

\u5236\u836f\u5546\uff1a<\/strong>Louang Namtha Pharm\/\u8001\u631d\u5357\u5854\u5236\u836f<\/p>\n

\u89c4\u683c\uff1a<\/strong>50mg\/30\u7c92\/\u76d2<\/p>\n

\u5168\u90e8\u540d\u79f0\uff1a<\/strong>\u6069\u897f\u5730\u5e73\uff0cIdhifa\uff0cEnasidenib<\/p>\n

\u9002\u5e94\u75c7<\/strong><\/p>\n

Enasidenib\u662f\u4e00\u79cd\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-2\u6291\u5236\u5242\u9002\u7528\u4e3a\u6210\u5e74\u60a3\u8005\u6709\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5(AML)\u7684\u6cbb\u7597\u5f53\u88abFDA-\u6279\u51c6\u7684\u6d4b\u8bd5\u68c0\u6d4b\u5230\u6709\u4e00\u4e2a\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-2(IDH2)\u7a81\u53d8\u3002<\/p>\n

\u7528\u6cd5\u7528\u91cf<\/strong><\/p>\n

100 mg\u53e3\u670d\u6bcf\u59291\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u63a5\u53d7\u6bd2\u6027\u3002<\/p>\n

1.\u5b8c\u5168\u6309\u7167\u60a8\u7684\u533b\u751f\u544a\u8bc9\u60a8\u7684\u65b9\u5f0f\u670d\u7528Idhifa\u3002<\/p>\n

2.\u6bcf\u5929\u540c\u4e00\u65f6\u95f4\u670d\u7528\u4e00\u6b21Idhifa\u3002<\/p>\n

3.\u6574\u7247\u541e\u4e0bIdhifa\u836f\u7247\u3002\u4e0d\u8981\u5480\u56bc\u6216\u63b0\u5f00\u836f\u7247\u3002<\/p>\n

4.\u75288\u76ce\u53f8(\u4e00\u676f)\u7684\u6c34\u541e\u4e0bIdhifa\u3002<\/p>\n

5.Idhifa\u53ef\u4ee5\u4e0e\u98df\u7269\u540c\u65f6\u670d\u7528\u3002<\/p>\n

6.\u5982\u679c\u60a8\u5728\u670d\u7528\u4e00\u5242Idhifa\u540e\u9519\u8fc7\u4e86\u4e00\u5242Idhifa\u6216\u4ea7\u751f\u5455\u5410\u53cd\u5e94\uff0c\u8bf7\u5728\u5f53\u5929\u5c3d\u5feb\u670d\u7528\u4e00\u5242Idhifa\u3002\u7136\u540e\u5728\u7b2c\u4e8c\u5929\u8ba1\u5212\u65f6\u95f4\u5185\u670d\u7528\u4e0b\u4e00\u5242\u3002\u4e0d\u53ef\u4e3a\u4e86\u8865\u6f0f\u670d\u7684\u91cf\u800c\u540c\u65f6\u670d\u7528\u4e24\u5242\u3002<\/p>\n

6.\u60a8\u7684\u533b\u751f\u5e94\u8be5\u5728\u60a8\u5f00\u59cb\u4f7f\u7528Idhifa\u6cbb\u7597\u524d\u505a\u4e00\u6b21\u8840\u6db2\u68c0\u67e5\uff0c\u68c0\u67e5\u60a8\u7684\u8840\u7403\u6570\uff0c\u5e76\u81f3\u5c11\u6bcf\u4e24\u5468\u68c0\u67e5\u4e00\u6b21\uff0c\u81f3\u5c11\u5728\u6cbb\u7597\u7684\u524d\u4e09\u4e2a\u6708\u68c0\u67e5\u4e00\u6b21\u526f\u4f5c\u7528\u3002<\/p>\n

\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879<\/strong><\/p>\n

\u80da\u80ce-\u80ce\u513f\u6bd2\u6027\uff1aIdhifa\u53ef\u80fd\u81f4\u80ce\u513f\u5371\u5bb3\u5f53\u7ed9\u4e88\u4e00\u4f4d\u598a\u5a20\u5987\u5973\u3002\u5fe0\u544a\u5bf9\u80ce\u513f\u6f5c\u5728\u98ce\u9669\u3002<\/p>\n

1.\u5e38\u89c1\u7684\u6069\u897f\u5730\u5e73Idhifa(Enasidenib)\u526f\u4f5c\u7528\u6709\u6076\u5fc3\u3001\u8179\u6cfb\u3001\u5455\u5410\u3001\u80c6\u7ea2\u7d20\u6c34\u5e73\u5347\u9ad8\u548c\u98df\u6b32\u964d\u4f4e\u7b49\u3002<\/p>\n

2.\u7981\u5fcc\uff1a\u6000\u5b55\u6216\u54fa\u4e73\u671f\u5973\u6027\u4e0d\u5e94\u670d\u7528\u6069\u897f\u5730\u5e73Idhifa(Enasidenib)\uff0c\u56e0\u4e3a\u5b83\u53ef\u80fd\u4f1a\u5bf9\u53d1\u80b2\u4e2d\u7684\u80ce\u513f\u6216\u65b0\u751f\u5a74\u513f\u9020\u6210\u4f24\u5bb3\u3002<\/p>\n

3.\u8b66\u544a\uff1a\u6069\u897f\u5730\u5e73Idhifa(Enasidenib)\u7684\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u9700\u6ce8\u610f\u5206\u5316\u7efc\u5408\u5f81\u7684\u98ce\u9669(\u53d1\u70ed\u3001\u547c\u5438\u56f0\u96be\u548c\u591a\u4e2a\u5668\u5b98\u529f\u80fd\u969c\u788d\u7b49)\uff0c\u5982\u679c\u672a\u7ecf\u6cbb\u7597\uff0c\u53ef\u80fd\u4f1a\u662f\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n

\u4e0d\u826f\u53cd\u5e94<\/strong><\/p>\n

>10%:<\/p>\n

1\u3001\u5185\u5206\u6ccc\u548c\u4ee3\u8c22\uff1a\u8840\u6e05\u9499\u964d\u4f4e(74%)\uff0c\u8840\u6e05\u94be\u51cf\u5c11(41%)<\/p>\n

2\u3001\u80c3\u80a0\u9053\uff1a\u6076\u5fc3(50%)\u3001\u8179\u6cfb(43%)\u3001\u98df\u6b32\u4e0b\u964d(34%)\u3001\u5455\u5410(34%)\u3001\u98df\u6b32\u4e0d\u632f(12%)<\/p>\n

3\u3001\u8840\u6db2\u548c\u80bf\u7624\uff1a\u78f7\u6c34\u5e73\u5f02\u5e38(27%;\u22653\u7ea7\uff1a8%;\u964d\u4f4e)\u3001\u5206\u5316\u7efc\u5408\u5f81(14%)\u3001\u767d\u7ec6\u80de\u589e\u591a(12%;\u22653\u7ea7\uff1a6%;\u975e\u4f20\u67d3\u6027)<\/p>\n

4\u3001\u809d\u810f\uff1a\u8840\u6e05\u80c6\u7ea2\u7d20\u5347\u9ad8(81%)<\/p>\n

1% -10%:<\/p>\n

1\u3001\u8840\u6db2\u548c\u80bf\u7624\uff1a\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81(6%)<\/p>\n

2\u3001\u547c\u5438\u7cfb\u7edf\uff1a\u6025\u6027\u547c\u5438\u7a98\u8feb(\u226410%)\uff0c\u80ba\u6c34\u80bf(\u226410%)<\/p>\n

\u7981\u5fcc<\/strong><\/p>\n

\u6000\u5b55\u6216\u54fa\u4e73\u671f\u5973\u6027\u4e0d\u5e94\u670d\u7528\u6069\u897f\u5730\u5e73(Idhifa\/ Enasidenib)\uff0c\u56e0\u4e3a\u5b83\u53ef\u80fd\u4f1a\u5bf9\u53d1\u80b2\u4e2d\u7684\u80ce\u513f\u6216\u65b0\u751f\u5a74\u513f\u9020\u6210\u4f24\u5bb3\u3002<\/p>\n

\u4f5c\u7528\u673a\u5236<\/p>\n

\u6069\u897f\u5730\u5e73Idhifa(Enasidenib)\u662f\u4e00\u79cd\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u91762(IDH2)\u6291\u5236\u5242\u3002\u4e09\u7fa7\u9178\u5faa\u73af(TCA cycle)\u5bf9\u4e8e\u8bb8\u591a\u7684\u751f\u5316\u4fe1\u53f7\u901a\u8def\u81f3\u5173\u91cd\u8981\uff0c IDH2\u662f\u4e09\u7fa7\u9178\u5faa\u73af\u4e2d\u7684\u5173\u952e\u9176\uff0c\u8be5\u86cb\u767d\u7684\u67d0\u4e9b\u7a81\u53d8\u5f62\u5f0f(R140Q, R172S,R172K)\u5bfc\u81f4\u7279\u5f02\u6027\u4ee3\u8c22\u4ea7\u72692-\u7f9f\u57fa\u620a\u4e8c\u9178(2-hydroxyglutarate,2-HG)\u5347\u9ad8\uff0c\u6069\u897f\u5730\u5e73\u53ef\u964d\u4f4e2-HG\u7684\u542b\u91cf\u4ece\u800c\u8bf1\u5bfc\u767d\u8840\u75c5\u7ec6\u80de\u5206\u5316\u3002<\/p>\n

 <\/p>\n

\u8d2e\u85cf<\/strong><\/p>\n

1.\u572868\u00b0F\u523077\u00b0F(20\u00b0C\u523025 \u00b0C)\u7684\u5ba4\u6e29\u4e0b\u4fdd\u5b58Idhifa.<\/p>\n

2.\u5c06IDHIFA\u4fdd\u5b58\u5728\u539f\u59cb\u5bb9\u5668\u4e2d\u3002<\/p>\n

3.\u4fdd\u6301\u5e72\u71e5\u5242\u653e\u5728\u74f6\u5185\u5e76\u7d27\u95ed\u5bb9\u5668\uff0c\u907f\u514d\u836f\u7247\u5438\u6f6e\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6069\u897f\u5730\u5e73(Enasidenib) \u901a\u7528\u540d\uff1a\u6069\u897f\u5730\u5e73 \u5546\u54c1\u540d\uff1aIdhifa \u5236\u836f\u5546\uff1aLouang Namtha Pharm\/\u8001\u631d\u5357\u5854\u5236\u836f \u89c4\u683c\uff1a50mg\/30\u7c92\/\u76d2 \u5168\u90e8\u540d\u79f0\uff1a\u6069\u897f\u5730\u5e73\uff0cIdhifa\uff0cEnasidenib \u9002\u5e94\u75c7 Enasid […]<\/p>\n","protected":false},"author":1,"featured_media":720,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[262,261],"topic":[],"class_list":["post-719","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-xueygs","tag-262","tag-261"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=719"}],"version-history":[{"count":1,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/719\/revisions"}],"predecessor-version":[{"id":721,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/719\/revisions\/721"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/720"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=719"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}