{"id":706,"date":"2023-11-28T20:43:00","date_gmt":"2023-11-28T12:43:00","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=706"},"modified":"2023-11-28T20:43:00","modified_gmt":"2023-11-28T12:43:00","slug":"%e3%80%90%e6%96%b0%e6%96%b9%e6%b3%95%e3%80%91%e8%88%92%e6%b2%83%e6%9b%bf%e5%b0%bc%e7%89%87-%e6%bd%9c%e5%9c%a8%e5%90%8c%e7%b1%bb%e6%9c%80%e4%bd%b3%e8%82%ba%e7%99%8c%e9%9d%b6%e5%90%91","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=706","title":{"rendered":"\u3010\u65b0\u65b9\u6cd5\u3011\u8212\u6c83\u66ff\u5c3c\u7247\u2014\u2014\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\u80ba\u764c\u9776\u5411\u836f"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-707 \" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231128203519.png\" alt=\"\u8212\u6c83\u66ff\u5c3c\u7247\u2014\u2014\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\u80ba\u764c\u9776\u5411\u836f\" width=\"469\" height=\"295\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231128203519.png 821w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231128203519-768x483.png 768w\" sizes=\"auto, (max-width: 469px) 100vw, 469px\" \/><\/p>\n<p>\u80ba\u764c\u662f\u6211\u56fd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u5176\u4e2dEGFR\u662fNSCLC\u6700\u5e38\u89c1\u7684\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u3002EGFR Exon20ins\u7a81\u53d8\u662fEGFR\u7f55\u89c1\u7a81\u53d8\u7c7b\u578b\uff0c\u7ea6\u5360EGFR\u7a81\u53d8\u768412%\uff0c\u56e0\u5176\u7a7a\u95f4\u6784\u578b\u7279\u6b8a\uff0c\u5f02\u8d28\u6027\u5f3a\uff0c\u4e00\u76f4\u4ee5\u6765\u7f3a\u4e4f\u5b89\u5168\u6709\u6548\u7684\u9776\u5411\u6cbb\u7597\u624b\u6bb5\uff0c\u60a3\u8005\u751f\u5b58\u83b7\u76ca\u77ed\uff0c\u662f\u4e9f\u9700\u89e3\u51b3\u7684\u4e34\u5e8a\u75db\u70b9\u3002<\/p>\n<section>\n<section>\n<section>2023\u5e748\u670823\u65e5\uff0c\u6211\u56fd<strong>\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u80ba\u764c\u9776\u5411\u836f\u8212\u6c83\u54f2<sup>\u00ae<\/sup>\uff08\u901a\u7528\u540d\uff1a\u8212\u6c83\u66ff\u5c3c\u7247\uff09\u4e8e8\u670822\u65e5\u6b63\u5f0f\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6<\/strong>\uff0c\u7528\u4e8e\u65e2\u5f80\u7ecf\u542b\u94c2\u5316\u7597\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u6216\u4e0d\u8010\u53d7\u542b\u94c2\u5316\u7597\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff0920\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff0c\u6210\u4e3a<strong>\u9996\u6b3e\u9488\u5bf9EGFR exon20ins\u7a81\u53d8\u578b\u665a\u671f NSCLC\u7684\u56fd\u521b\u65b0\u836f<\/strong>\u3002\u6b64\u524d\uff0c\u8212\u6c83\u54f2<sup>\u00ae<\/sup>\u51ed\u501f\u5353\u8d8a\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u6210\u4e3a\u80ba\u764c\u9886\u57df\u9996\u4e2a\u4e14\u76ee\u524d\u552f\u4e00\u83b7\u4e2d\u3001\u7f8e\u53cc\u201c\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u201d\u7684\u56fd\u521b1\u7c7b\u65b0\u836f\uff0c\u5176\u4e0a\u5e02\u7533\u8bf7\u88abNMPA\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u3002<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\u8212\u6c83\u54f2<sup>\u00ae<\/sup>\u662f\u4e00\u6b3e\u9488\u5bf9\u591a\u79cdEGFR\u7a81\u53d8\u4e9a\u578b\u7684\u9ad8\u9009\u62e9\u6027EGFR\u9776\u5411\u836f\u7269\uff0c\u6b64\u6b21\u83b7\u6279\u4e3b\u8981\u57fa\u4e8e\u4e2d\u56fd\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff08\u609f\u7a7a6 \uff0cWU-KONG6\uff09\uff0c\u8be5\u7814\u7a76\u662f\u4e00\u9879\u9488\u5bf9\u542b\u94c2\u5316\u7597\u8fdb\u5c55\u6216\u4e0d\u8010\u53d7\u7684EGFR exon20ins\u665a\u671fNSCLC\u60a3\u8005\u7684\u5355\u81c2\u3001\u591a\u4e2d\u5fc3II\u671f\u6ce8\u518c\u7814\u7a76\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e3a\u72ec\u7acb\u5f71\u50cf\u8bc4\u4f30\u59d4\u5458\u4f1a\uff08IRC\uff09\u8bc4\u4f30\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u7814\u7a76\u7ed3\u679c\u57282023\u5e74ASCO\u5e74\u4f1a\u4e0a\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u516c\u5e03\u3002<\/p>\n<\/section>\n<\/section>\n<section>\n<section>\u5728\u63a5\u53d7\u8212\u6c83\u54f2<sup>\u00ae<\/sup>\u6cbb\u7597\u768497\u4f8b\u7597\u6548\u5206\u6790\u4eba\u7fa4\u4e2d\uff0c<\/p>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\u7ecfIRC\u786e\u8ba4\u7684ORR\u8fbe<strong>60.8%<\/strong>\uff0c\u7a81\u7834\u73b0\u6709\u6cbb\u7597\u74f6\u9888<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\u5b89\u5168\u6027\u4e0e\u4f20\u7edfEGFR TKI\u76f8\u4f3c\uff0c\u6574\u4f53\u8010\u53d7\u6027\u597d\uff0c\u4e34\u5e8a\u53ef\u7ba1\u7406\u53ef\u6062\u590d<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><span class=\"wx_text_underline\">\u8212\u6c83\u54f2<sup>\u00ae<\/sup><\/span><strong><span class=\"wx_text_underline\">\u9ad8\u6548\u4f4e\u6bd2\uff0c\u65e0\u8bba\u662f\u7597\u6548\u8fd8\u662f\u5b89\u5168\u6027\u5747\u4e3a\u540c\u7c7b\u6f5c\u5728\u6700\u4f73<\/span><\/strong><span class=\"wx_text_underline\">\uff0c\u6709\u671b\u6210\u4e3aEGFR exon20ins\u7a81\u53d8\u665a\u671fNSCLC\u60a3\u8005\u66f4\u4f18\u6cbb\u7597\u9009\u62e9\uff0c\u91cd\u5851EGFR exon20ins\u7a81\u53d8\u665a\u671fNSCLC\u7684\u6cbb\u7597\u683c\u5c40\u3002<\/span><\/p>\n<section>\n<section>\n<section>\n<section>\u8212\u6c83\u54f2<sup>\u00ae<\/sup>\u662f\u9996\u6b3e\u9488\u5bf9EGFR 20\u53f7\u5916\u663e\u5b50\u63d2\u5165\uff08EGFR exon20ins\uff09\u7a81\u53d8\u578b\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u56fd\u521b\u65b0\u836f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\u9ad8\u6548\u4f4e\u6bd2\uff0c\u6f5c\u5728\u540c\u7c7b\u6700\u4f73<\/p>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09<strong>60.8%<\/strong>\uff0c\u8ba9\u60a3\u8005\u80bf\u7624\u8d1f\u8377\u663e\u8457\u7f29\u5c0f\uff0c\u4eab\u53d7\u9ad8\u8d28\u91cf\u751f\u5b58\u83b7\u76ca<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\u5b89\u5168\u6027\u826f\u597d\uff0c\u4e0d\u826f\u53cd\u5e94\u4e34\u5e8a\u53ef\u7ba1\u7406\u53ef\u6062\u590d<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\u8212\u6c83\u54f2<sup>\u00ae<\/sup>\u5168\u7ebf\u5e03\u5c40EGFR\u7a81\u53d8NSCLC\uff0c\u5168\u7403\u5173\u952e\u6027\u4e34\u5e8a\u7814\u7a76\u52a0\u901f\u63a8\u8fdb<\/p>\n<section>\u8212\u6c83\u66ff\u5c3c\u7247\u8bf4\u660e\u4e66<\/section>\n<section>\u672c\u54c1\u4e3a\u9644\u6761\u4ef6\u6279\u51c6\u4e0a\u5e02\u3002\u8bf7\u4ed4\u7ec6\u9605\u8bfb\u8bf4\u660e\u4e66\u5e76\u5728\u533b\u5e08\u6216\u836f\u5e08\u6307\u5bfc\u4e0b\u4f7f\u7528\u3002<\/section>\n<section>\u3010\u836f\u54c1\u540d\u79f0\u3011<\/section>\n<section>\u901a\u7528\u540d\u79f0\uff1a\u8212\u6c83\u66ff\u5c3c\u7247<\/section>\n<section>\u5546\u54c1\u540d\u79f0\uff1a\u8212\u6c83\u54f2\u00ae<\/section>\n<section>\u82f1\u6587\u540d\u79f0\uff1aSunvozertinib Tablets<\/section>\n<section>\u6c49\u8bed\u62fc\u97f3\uff1aShuwotini Pian<\/section>\n<section>\u3010\u6210\u4efd\u3011<\/section>\n<section>\u672c\u54c1\u6d3b\u6027\u6210\u4efd\u4e3a\u8212\u6c83\u66ff\u5c3c\u3002<\/section>\n<section>\u5316\u5b66\u540d\u79f0\uff1a(R)-N-(2-((3-\u4e8c\u7532\u6c28\u57fa)\u5421\u54af\u70f7-1-\u57fa)-5-((2-((2-\u7f9f\u57fa\u4e19\u70f7-2-\u57fa)-4-((4-\u6c1f-5-\u6c2f-\u82ef\u57fa)\u6c28\u57fa)\u5627\u5576-2-\u57fa)\u6c28\u57fa)-4-\u7532\u6c27\u57fa)\u82ef\u57fa)\u4e19\u70ef\u9170\u80fa<\/section>\n<section>\u5316\u5b66\u7ed3\u6784\u5f0f\uff1a<\/section>\n<section>\u5206\u5b50\u5f0f\uff1aC29H35ClFN7O3<\/section>\n<section>\u5206\u5b50\u91cf\uff1a584.09<\/section>\n<section>\u8f85\u6599\uff1a\u4e73\u7cd6\u3001\u5fae\u6676\u7ea4\u7ef4\u7d20\u3001\u80f6\u6001\u4e8c\u6c27\u5316\u7845\u3001\u4ea4\u8054\u7fa7\u7532\u7ea4\u7ef4\u7d20\u94a0\u3001\u7f9f\u4e19\u7ea4\u7ef4\u7d20\u3001\u786c\u8102\u9178\u9541\u3001\u8584\u819c\u5305\u8863\u9884\u6df7\u5242\u3002<\/section>\n<section>\n<section>\u3010\u6027\u72b6\u3011<\/section>\n<section>\u672c\u54c1\u4e3a\u9ec4\u8272\u8584\u819c\u8863\u7247\uff0c\u9664\u53bb\u5305\u8863\u540e\u663e\u7c7b\u767d\u8272\u81f3\u6de1\u9ec4\u8272\u3002<\/section>\n<section>\u3010\u9002\u5e94\u75c7\u3011<\/section>\n<section>\u672c\u54c1\u9002\u7528\u4e8e\u65e2\u5f80\u7ecf\u542b\u94c2\u5316\u7597\u6cbb\u7597\u65f6\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u6216\u4e0d\u8010\u53d7\u542b\u94c2\u5316\u7597\uff0c\u5e76\u4e14\u7ecf\u68c0\u6d4b\u786e\u8ba4\u5b58\u5728\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff0920\u00a0\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002<\/section>\n<section>\u672c\u54c1\u57fa\u4e8e\u66ff\u4ee3\u7ec8\u70b9\uff08\u4e00\u9879\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff09\u83b7\u5f97\u9644\u6761\u4ef6\u6279\u51c6\u4e0a\u5e02\u3002\u672c\u54c1\u7684\u5b8c\u5168\u6279\u51c6\u5c06\u53d6\u51b3\u4e8e\u6b63\u5728\u8fdb\u884c\u7684\u786e\u8bc1\u6027\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002<\/section>\n<section>\u3010\u89c4\u683c\u3011<\/section>\n<section>\uff081\uff09150 mg\uff1b\uff082\uff09200 mg<\/section>\n<section>\u3010\u7528\u6cd5\u7528\u91cf\u3011<\/section>\n<section>\u672c\u54c1\u5e94\u7531\u80bf\u7624\u6cbb\u7597\u65b9\u9762\u5bcc\u6709\u7ecf\u9a8c\u7684\u533b\u5e08\u5904\u65b9\u4f7f\u7528\u3002<\/section>\n<section>\u5728\u670d\u7528\u672c\u54c1\u524d\uff0c\u9996\u5148\u9700\u8981\u660e\u786e\u00a0EGFR 20\u00a0\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u7684\u72b6\u6001\u3002\u5e94\u91c7\u7528\u7ecf\u5145\u5206\u9a8c\u8bc1\u7684\u68c0\u6d4b\u65b9\u6cd5\u786e\u8ba4\u5b58\u5728\u00a0EGFR 20\u00a0\u53f7\u5916\u663e\u5b50\u63d2\u5165\u7a81\u53d8\u3002<\/section>\n<section>\n<section>\u63a8\u8350\u5242\u91cf<\/section>\n<section>\u672c\u54c1\u7684\u63a8\u8350\u5242\u91cf\u4e3a\u00a0300 mg\uff082\u00a0\u7247\u00a0150 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