{"id":701,"date":"2023-11-28T20:11:16","date_gmt":"2023-11-28T12:11:16","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=701"},"modified":"2023-11-28T20:16:47","modified_gmt":"2023-11-28T12:16:47","slug":"%e9%98%bf%e8%a5%bf%e7%b1%b3%e5%b0%bc%e4%bd%bf%e7%94%a8%e6%8c%87%e5%8d%97%e8%af%b4%e6%98%8e%e4%b9%a6%e5%8f%82%e8%80%83","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=701","title":{"rendered":"\u963f\u897f\u7c73\u5c3c\u4f7f\u7528\u6307\u5357\u8bf4\u660e\u4e66\u53c2\u8003"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-702\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231128200037.png\" alt=\"\u963f\u897f\u7c73\u5c3c\u4f7f\u7528\u6307\u5357\u8bf4\u660e\u4e66\u53c2\u8003\" width=\"516\" height=\"435\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231128200037.png 801w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231128200037-768x647.png 768w\" sizes=\"auto, (max-width: 516px) 100vw, 516px\" \/><\/p>\n<p>\u3010\u6982\u62ec\u3011<\/p>\n<p>\u963f\u897f\u7c73\u5c3c\u9002\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u4ee5\u4e0b\u75be\u75c5\u7684\u6210\u4eba\u60a3\u8005:<\/p>\n<p>1\u3001\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5(Ph+ CML)\uff0c\u6162\u6027\u671f(CP)\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e24\u79cd\u6216\u4e24\u79cd\u4ee5\u4e0a\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242(tki)\u6cbb\u7597\u3002<\/p>\n<p>2\u3001\u51fa\u73b0T315I\u7a81\u53d8\u7684CP\u4e2dPh+ CML\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u9002\u5e94\u75c7\u3011<\/p>\n<p>\u9002\u7528\u4e8e\u6cbb\u7597\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ CML\uff09\u6162\u6027\u671f\uff08CP\uff09\u6210\u5e74\u60a3\u8005\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u89c4\u683c\u3011<\/p>\n<p>40mg\/\u7247\uff0c60\u7247\/\u76d2\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u8d2e\u5b58\u3011<\/p>\n<p>\u8d2e\u5b58\u4e8e20\u00b0C\u00a0\uff5e25\u00b0C (68\u00b0C\u00a0\uff5e77\u00b0F)\uff1b\u5141\u8bb8\u8303\u56f4\u4e3a15\uff5e30\u00b0C (59\u201386\u00b0F)\u6e29\u5ea6\u6761\u4ef6\u4e0b\u77ed\u9014\u8fd0\u8f93\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u7528\u6cd5\u7528\u91cf\u3011<\/p>\n<p>1\u3001\u5148\u524d\u63a5\u53d7\u8fc7\u4e24\u6b21\u6216\u591a\u6b21tki\u6cbb\u7597\u7684Ph+ CML-CP\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf<\/p>\n<p>Asciminib\u7684\u63a8\u8350\u5242\u91cf\u4e3a80 mg\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u6bcf\u5929\u670d\u836f\u65f6\u95f4\u5927\u81f4\u76f8\u540c\uff0c\u621640 mg\u53e3\u670d\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u95f4\u9694\u7ea612\u5c0f\u65f6\u3002\u63a8\u8350\u5242\u91cf\u7684Asciminib\u53ef\u5728\u4e0d\u8fdb\u98df\u7684\u60c5\u51b5\u4e0b\u53e3\u670d\u3002\u81f3\u5c11\u5728\u670d\u7528Asciminib\u524d2\u5c0f\u65f6\u548c\u670d\u7528Asciminib\u540e1\u5c0f\u65f6\u5185\u907f\u514d\u8fdb\u98df\u3002<\/p>\n<p>\u53ea\u8981\u89c2\u5bdf\u5230\u4e34\u5e8a\u83b7\u76ca\u6216\u76f4\u5230\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\uff0c\u5c31\u7ee7\u7eed\u4f7f\u7528Asciminib\u6cbb\u7597\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>2\u30012T315I\u7a81\u53d8\u7684Ph+ CML-CP\u60a3\u8005\u7684\u63a8\u8350\u5242\u91cf<\/p>\n<p>Asciminib\u7684\u63a8\u8350\u5242\u91cf\u4e3a200 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u95f4\u9694\u7ea612\u5c0f\u65f6\u3002\u63a8\u8350\u5242\u91cf\u7684Asciminib\u53ef\u5728\u4e0d\u8fdb\u98df\u7684\u60c5\u51b5\u4e0b\u53e3\u670d\u3002\u81f3\u5c11\u5728\u670d\u7528Asciminib\u524d2\u5c0f\u65f6\u548c\u670d\u7528Asciminib\u540e1\u5c0f\u65f6\u5185\u907f\u514d\u8fdb\u98df\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>3\u3001\u6f0f\u670d\u5242\u91cf<\/p>\n<p>\u6bcf\u65e5\u4e00\u6b21\u7ed9\u836f\u65b9\u6848:\u5982\u679c\u9519\u8fc7Asciminib\u5242\u91cf\u8d85\u8fc7\u7ea612\u5c0f\u65f6\uff0c\u5219\u8df3\u8fc7\u8be5\u5242\u91cf\uff0c\u5e76\u6309\u8ba1\u5212\u670d\u7528\u4e0b\u4e00\u5242\u91cf\u3002<\/p>\n<p>\u6bcf\u65e5\u4e24\u6b21\u7ed9\u836f\u65b9\u6848:\u5982\u679c\u9519\u8fc7Asciminib\u5242\u91cf\u8d85\u8fc7\u7ea66\u5c0f\u65f6\uff0c\u5219\u8df3\u8fc7\u8be5\u5242\u91cf\u5e76\u6309\u8ba1\u5212\u670d\u7528\u4e0b\u4e00\u5242\u91cf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>4\u3001\u5242\u91cf\u8c03\u6574<\/p>\n<p>\u5148\u524d\u63a5\u53d7\u8fc7\u4e24\u79cd\u6216\u591a\u79cdtki\u6cbb\u7597\u7684Ph+ CML-CP\u60a3\u8005\u7684\u5242\u91cf\u8c03\u6574\u4e3a\u4e86\u7ba1\u7406\u4e0d\u826f\u53cd\u5e94\uff0c\u6309\u88681\u6240\u8ff0\u51cf\u5c11Asciminib\u5242\u91cf\u3002<\/p>\n<p>T315I\u7a81\u53d8\u7684Ph+ CML-CP\u60a3\u8005\u7684\u5242\u91cf\u8c03\u6574<\/p>\n<p>\u4e3a\u63a7\u5236\u4e0d\u826f\u53cd\u5e94\uff0c\u6309\u88681\u6240\u8ff0\u51cf\u5c11Asciminib\u5242\u91cf\u3002<\/p>\n<p>\u88681:\u4e0d\u826f\u53cd\u5e94Asciminib\u7684\u63a8\u8350\u51cf\u91cf<\/p>\n<table>\n<tbody>\n<tr>\n<td valign=\"top\" width=\"189\">\u5242\u91cf\u51cf\u5c11<\/td>\n<td valign=\"top\" width=\"330\">\u4e4b\u524d\u63a5\u53d7\u8fc7\u4e24\u6b21\u6216\u591a\u6b21tki\u6cbb\u7597\u7684CP-CML\u60a3\u8005\u7684\u5242\u91cf<\/td>\n<td valign=\"top\" width=\"415\">\u51fa\u73b0T315I\u7a81\u53d8\u7684Ph+ CML-CP\u60a3\u8005\u7684\u5242\u91cf<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"189\">\u7b2c\u4e00<\/td>\n<td valign=\"top\" width=\"330\">\u00b7 40 mg\uff0c\u6bcf\u65e5\u4e00\u6b21\u6216<\/p>\n<p>\u00b7 20\u6beb\u514b\uff0c\u6bcf\u65e5\u4e24\u6b21<\/td>\n<td valign=\"top\" width=\"415\">160\u6beb\u514b\uff0c\u6bcf\u65e5\u4e24\u6b21<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"189\">\u540e\u7eed\u8fd8\u539f<\/td>\n<td valign=\"top\" width=\"330\">\u5bf9\u4e8e\u65e0\u6cd5\u8010\u53d740 mg\u6bcf\u65e5\u4e00\u6b21\u621620 mg\u6bcf\u65e5\u4e24\u6b21\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u6c38\u4e45\u505c\u7528Asciminib\u3002<\/td>\n<td valign=\"top\" width=\"415\">\u5bf9\u4e8e\u65e0\u6cd5\u8010\u53d7160 mg\u6bcf\u65e5\u4e24\u6b21\u7684\u60a3\u8005\uff0c\u6c38\u4e45\u505c\u7528Asciminib\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u88682\u663e\u793a\u4e86\u7528\u4e8e\u7ba1\u7406\u9009\u5b9a\u4e0d\u826f\u53cd\u5e94\u7684\u5efa\u8bae\u5242\u91cf\u8c03\u6574\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/p>\n<p>\u88682:\u4e3a\u7ba1\u7406\u4e0d\u826f\u53cd\u5e94\u800c\u4fee\u6539Asciminib\u5242\u91cf<\/p>\n<table>\n<tbody>\n<tr>\n<td valign=\"top\" width=\"284\">\u9006\u53cd\u5e94<\/td>\n<td valign=\"top\" width=\"651\">\u5242\u91cf\u8c03\u6574<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" valign=\"top\" width=\"935\">\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u548c\/\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7[\u53c2\u89c1\u201c\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879\u201d]<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"284\">ANC\u5c0f\u4e8e1.0 x 109\/L\u548c\/\u6216PLT\u5c0f\u4e8e50 x 109\/L<\/td>\n<td valign=\"top\" width=\"651\">\u6263\u7559Asciminib\uff0c\u76f4\u81f3\u6eb6\u89e3\u81f3ANC\u5927\u4e8e\u6216\u7b49\u4e8e1 x 109\/L\u548c\/\u6216PLT\u5927\u4e8e\u6216\u7b49\u4e8e50 x 109\/L\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5982\u679c\u89e3\u51b3:<\/p>\n<p>a\u30012\u5468\u5185:\u6309\u8d77\u59cb\u5242\u91cf\u6062\u590dAsciminib\u3002<\/p>\n<p>b\u30012\u5468\u540e:\u6062\u590d\u6309\u51cf\u5c11\u5242\u91cf\u670d\u7528Asciminib\u3002<\/p>\n<p>\u5bf9\u4e8e\u590d\u53d1\u6027\u4e25\u91cd\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u548c\/\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0c\u6682\u505cAsciminib\u6cbb\u7597\uff0c\u76f4\u81f3\u6d88\u9000\u81f3ANC\u5927\u4e8e\u6216\u7b49\u4e8e1 x 109\/L\u4e14PLT\u5927\u4e8e\u6216\u7b49\u4e8e50\u00d7109\/L\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590d\u3002<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" valign=\"top\" width=\"935\">\u65e0\u75c7\u72b6\u6dc0\u7c89\u9176\u548c\/\u6216\u8102\u80aa\u9176\u5347\u9ad8[\u53c2\u89c1\u201c\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879\u201d]<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"284\">\u6d77\u62d4\u9ad8\u5ea6\u5927\u4e8e2.0 x ULN<\/td>\n<td valign=\"top\" width=\"651\">\u6263\u7559Asciminib\uff0c\u76f4\u81f3\u6d53\u5ea6\u964d\u81f31.5x ULN\u4ee5\u4e0b\u3002<\/p>\n<p>\u5982\u679c\u89e3\u51b3:<\/p>\n<p>a\u3001\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dAsciminib\u3002<\/p>\n<p>\u5982\u679c\u4e8b\u4ef6\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u518d\u6b21\u53d1\u751f\uff0c\u5219\u6c38\u4e45\u505c\u7528Asciminib\u3002<\/p>\n<p>\u5982\u679c\u672a\u89e3\u51b3:<\/p>\n<p>b\u3001\u6c38\u4e45\u505c\u7528Asciminib\u3002\u8fdb\u884c\u8bca\u65ad\u6d4b\u8bd5\u4ee5\u6392\u9664\u80f0\u817a\u708e\u3002<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" valign=\"top\" width=\"935\">\u975e\u8840\u6db2\u5b66\u4e0d\u826f\u53cd\u5e94[\u53c2\u89c1\u201c\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879\u201d]<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" width=\"284\">31\u7ea7\u6216\u4ee5\u4e0a<\/td>\n<td valign=\"top\" width=\"651\">&nbsp;<\/p>\n<p>\u6682\u505cAsciminib\uff0c\u76f4\u81f3\u6062\u590d\u81f31\u7ea7\u6216\u4ee5\u4e0b\u3002\u5982\u679c\u89e3\u51b3:<\/p>\n<p>\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dAsciminib\u3002<\/p>\n<p>\u5982\u679c\u672a\u89e3\u51b3:<\/p>\n<p>\u6c38\u4e45\u505c\u7528Asciminib\u3002<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" valign=\"top\" width=\"935\">\u7b80\u79f0:ANC\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\uff1bPLT\uff0c\u8840\u5c0f\u677f\uff1bULN\uff0c\u6b63\u5e38\u4e0a\u9650\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/p>\n<p>1\u3001\u9aa8\u9ad3\u6291\u5236<\/p>\n<p>\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684\u60a3\u8005\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u548c\u8d2b\u8840\u3002\u5728356\u540d\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u670998\u540d(28%)\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0c\u5206\u522b\u670924\u540d(7%)\u548c42\u540d(12%)\u60a3\u8005\u62a5\u544a\u67093\u7ea7\u62164\u7ea7\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u3002\u57283\u7ea7\u62164\u7ea7\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u60a3\u8005\u4e2d\uff0c\u4e8b\u4ef6\u9996\u6b21\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a6\u5468(\u8303\u56f4:0.1\u81f364\u5468)\u3002\u572898\u4f8b\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u60a3\u8005\u4e2d\uff0c7\u4f8b(2%)\u60a3\u8005\u6c38\u4e45\u505c\u7528sceblux\uff0c45\u4f8b(13%)\u60a3\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u6682\u65f6\u505c\u7528LuciAsc(Asciminib)\u3002<\/p>\n<p>\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u768469\u4f8b(19%)\u60a3\u8005\u51fa\u73b0\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0c\u5206\u522b\u670926\u4f8b(7%)\u548c30\u4f8b(8%)\u60a3\u8005\u62a5\u544a3\u7ea7\u548c4\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3002\u57283\u7ea7\u62164\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u60a3\u8005\u4e2d\uff0c\u4e8b\u4ef6\u9996\u6b21\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a6\u5468(\u8303\u56f4:0.1\u81f3180\u5468)\u3002\u572869\u4f8b\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u60a3\u8005\u4e2d\uff0c4\u4f8b(1.1%)\u60a3\u8005\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)\uff0c34\u4f8b(10%)\u60a3\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u6682\u65f6\u505c\u7528LuciAsc(Asciminib)\u3002<\/p>\n<p>\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u768446\u540d(13%)\u60a3\u8005\u53d1\u751f\u8d2b\u8840\uff0c\u5176\u4e2d19\u540d(5%)\u60a3\u8005\u53d1\u751f3\u7ea7\u8d2b\u8840\u3002\u57283\u7ea7\u62164\u7ea7\u8d2b\u8840\u60a3\u8005\u4e2d\uff0c\u4e8b\u4ef6\u9996\u6b21\u53d1\u751f\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a30\u5468(\u8303\u56f4:0.4\u81f3207\u5468)\u3002\u572846\u4f8b\u8d2b\u8840\u60a3\u8005\u4e2d\uff0c\u67092\u4f8b(0.6%)\u60a3\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u800c\u6682\u65f6\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u4e0d\u826f\u53cd\u5e94\u201d]\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5728\u524d3\u4e2a\u6708\u7684\u6cbb\u7597\u4e2d\uff0c\u6bcf\u4e24\u5468\u8fdb\u884c\u4e00\u6b21\u5168\u8840\u7ec6\u80de\u8ba1\u6570\uff0c\u4e4b\u540e\u6bcf\u6708\u6216\u6839\u636e\u4e34\u5e8a\u6307\u793a\u8fdb\u884c\u4e00\u6b21\u3002\u76d1\u6d4b\u60a3\u8005\u9aa8\u9ad3\u6291\u5236\u7684\u4f53\u5f81\u548c\u75c7\u72b6\u3002<\/p>\n<p>\u6839\u636e\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u548c\/\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u51cf\u5c11\u5242\u91cf\u3001\u6682\u65f6\u505c\u7528\u6216\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u5242\u91cf\u548c\u7528\u6cd5\u201d]\u3002<\/p>\n<p>2\u3001\u80f0\u817a\u6bd2\u6027<\/p>\n<p>\u5728\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684356\u4f8b\u60a3\u8005\u4e2d\uff0c\u67099\u4f8b(2.5%)\u53d1\u751f\u80f0\u817a\u708e\uff0c\u5176\u4e2d4\u4f8b(1.1%)\u53d1\u751f3\u7ea7\u80f0\u817a\u708e\u3002\u6240\u6709\u80f0\u817a\u708e\u75c5\u4f8b\u5747\u53d1\u751f\u5728I\u671f\u7814\u7a76(X2101)\u4e2d\u3002\u57289\u4f8b\u80f0\u817a\u708e\u60a3\u8005\u4e2d\uff0c2\u4f8b(0.6%)\u60a3\u8005\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)\uff0c4\u4f8b(1.1%)\u60a3\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u6682\u65f6\u505c\u7528LuciAsc(Asciminib)\u3002\u5728\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684356\u4f8b\u60a3\u8005\u4e2d\uff0c76\u4f8b(21%)\u51fa\u73b0\u65e0\u75c7\u72b6\u7684\u8840\u6e05\u8102\u80aa\u9176\u548c\u6dc0\u7c89\u9176\u5347\u9ad8\uff0c\u5176\u4e2d36\u4f8b(10%)\u548c8\u4f8b(2.2%)\u60a3\u8005\u5206\u522b\u51fa\u73b03\u7ea7\u548c4\u7ea7\u80f0\u9176\u5347\u9ad8\u3002\u572876\u4f8b\u80f0\u9176\u5347\u9ad8\u7684\u60a3\u8005\u4e2d\uff0c\u67098\u4f8b(2.2%)\u60a3\u8005\u56e0\u4e0d\u826f\u53cd\u5e94\u800c\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u4e0d\u826f\u53cd\u5e94\u201d]\u3002<\/p>\n<p>\u5728LuciAsc(Asciminib)\u6cbb\u7597\u671f\u95f4\u6216\u6309\u7167\u4e34\u5e8a\u6307\u793a\u6bcf\u6708\u8bc4\u4f30\u8840\u6e05\u8102\u80aa\u9176\u548c\u6dc0\u7c89\u9176\u6c34\u5e73\u3002\u76d1\u6d4b\u60a3\u8005\u80f0\u817a\u6bd2\u6027\u7684\u4f53\u5f81\u548c\u75c7\u72b6\u3002\u5bf9\u6709\u80f0\u817a\u708e\u75c5\u53f2\u7684\u60a3\u8005\u8fdb\u884c\u66f4\u9891\u7e41\u7684\u76d1\u6d4b\u3002\u5982\u679c\u8102\u80aa\u9176\u548c\u6dc0\u7c89\u9176\u5347\u9ad8\u4f34\u6709\u8179\u90e8\u75c7\u72b6\uff0c\u5219\u6682\u65f6\u505c\u7528LuciAsc(Asciminib)\uff0c\u5e76\u8003\u8651\u8fdb\u884c\u9002\u5f53\u7684\u8bca\u65ad\u8bd5\u9a8c\u4ee5\u6392\u9664\u80f0\u817a\u708e[\u53c2\u89c1\u201c\u5242\u91cf\u548c\u7528\u6cd5\u201d]\u3002<\/p>\n<p>\u6839\u636e\u8102\u80aa\u9176\u548c\u6dc0\u7c89\u9176\u5347\u9ad8\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u51cf\u5c11\u5242\u91cf\u3001\u6682\u65f6\u505c\u7528\u6216\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u5242\u91cf\u548c\u7528\u6cd5\u201d]\u3002<\/p>\n<p>3\u3001\u9ad8\u8840\u538b<\/p>\n<p>\u5728\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684356\u540d\u60a3\u8005\u4e2d\uff0c\u670968\u540d(19%)\u53d1\u751f\u9ad8\u8840\u538b\uff0c\u5206\u522b\u670932\u540d(9%)\u548c1\u540d(0.3%)\u60a3\u8005\u62a5\u544a\u67093\u7ea7\u62164\u7ea7\u9ad8\u8840\u538b\u30023\u7ea7\u62164\u7ea7\u9ad8\u8840\u538b\u60a3\u8005\u9996\u6b21\u53d1\u75c5\u7684\u4e2d\u4f4d\u65f6\u95f4\u4e3a14\u5468(\u8303\u56f4:0.1\u81f3156\u5468)\u3002\u572868\u4f8b\u9ad8\u8840\u538b\u60a3\u8005\u4e2d\uff0c\u67093\u4f8b(0.8%)\u60a3\u8005\u7531\u4e8e\u4e0d\u826f\u53cd\u5e94\u800c\u6682\u65f6\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u4e0d\u826f\u53cd\u5e94\u201d]\u3002<\/p>\n<p>\u5728LuciAsc(Asciminib)\u6cbb\u7597\u671f\u95f4\uff0c\u6839\u636e\u4e34\u5e8a\u6307\u793a\uff0c\u4f7f\u7528\u6807\u51c6\u6297\u9ad8\u8840\u538b\u6cbb\u7597\u76d1\u6d4b\u548c\u7ba1\u7406\u9ad8\u8840\u538b\uff1b\u5bf9\u4e8e3\u7ea7\u6216\u66f4\u9ad8\u7684\u9ad8\u8840\u538b\uff0c\u6839\u636e\u9ad8\u8840\u538b\u7684\u6301\u7eed\u60c5\u51b5\uff0c\u6682\u65f6\u505c\u7528\u3001\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u5242\u91cf\u4e0e\u7528\u6cd5\u201d]\u3002<\/p>\n<p>4\u3001\u8d85\u654f\u53cd\u5e94<\/p>\n<p>\u5728\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684356\u540d\u60a3\u8005\u4e2d\uff0c\u6709115\u540d(32%)\u53d1\u751f\u8d85\u654f\u53cd\u5e94\uff0c6\u540d(1.7%)\u60a3\u8005\u62a5\u544a\u67093\u7ea7\u62164\u7ea7\u8d85\u654f\u53cd\u5e94[\u53c2\u89c1\u201c\u4e0d\u826f\u53cd\u5e94\u201d(6.1)]\u3002\u53cd\u5e94\u5305\u62ec\u76ae\u75b9\u3001\u6c34\u80bf\u548c\u652f\u6c14\u7ba1\u75c9\u631b\u3002\u76d1\u6d4b\u60a3\u8005\u7684\u8d85\u654f\u53cd\u5e94\u4f53\u5f81\u548c\u75c7\u72b6\uff0c\u5e76\u6839\u636e\u4e34\u5e8a\u6307\u793a\u5f00\u59cb\u9002\u5f53\u6cbb\u7597\uff1b\u5bf9\u4e8e3\u7ea7\u6216\u66f4\u9ad8\u7684\u8d85\u654f\u53cd\u5e94\uff0c\u6839\u636e\u8d85\u654f\u53cd\u5e94\u7684\u6301\u7eed\u60c5\u51b5\uff0c\u6682\u65f6\u505c\u6b62\u3001\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u5242\u91cf\u4e0e\u7ed9\u836f\u201d]\u3002<\/p>\n<p>5\u3001\u5fc3\u8840\u7ba1\u6bd2\u6027<\/p>\n<p>\u5728\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684356\u540d\u60a3\u8005\u4e2d\uff0c\u5206\u522b\u670946\u540d(13%)\u548c9\u540d(2.5%)\u51fa\u73b0\u5fc3\u8840\u7ba1\u6bd2\u6027(\u5305\u62ec\u7f3a\u8840\u6027\u5fc3\u810f\u548cCNS\u75be\u75c5\u3001\u52a8\u8109\u8840\u6813\u5f62\u6210\u548c\u6813\u585e\u75be\u75c5)\u548c\u5fc3\u529b\u8870\u7aed[\u53c2\u89c1\u201c\u4e0d\u826f\u53cd\u5e94\u201d(6.1)]\u300212\u4f8b(3.4%)\u60a3\u8005\u62a5\u544a\u4e863\u7ea7\u5fc3\u8840\u7ba1\u6bd2\u6027\uff0c5\u4f8b(1.4%)\u60a3\u8005\u62a5\u544a\u4e863\u7ea7\u5fc3\u529b\u8870\u7aed\u30022\u4f8b(0.6%)\u60a3\u8005\u53d1\u751f4\u7ea7\u5fc3\u8840\u7ba1\u6bd2\u6027\uff0c3\u4f8b(0.8%)\u60a3\u8005\u53d1\u751f\u6b7b\u4ea1\u30023\u4f8b(0.8%)\u60a3\u8005\u56e0\u5fc3\u8840\u7ba1\u6bd2\u6027\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)\uff0c1\u4f8b(0.3%)\u60a3\u8005\u56e0\u5fc3\u529b\u8870\u7aed\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)\u3002\u5fc3\u8840\u7ba1\u6bd2\u6027\u53d1\u751f\u4e8e\u5df2\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u6216\u98ce\u9669\u56e0\u7d20\u548c\/\u6216\u4e4b\u524d\u63a5\u89e6\u8fc7\u591a\u79cdtki\u7684\u60a3\u8005\u3002<\/p>\n<p>\u5728356\u540d\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u670924\u540d\u53d1\u751f\u5fc3\u5f8b\u5931\u5e38(\u5305\u62ecQTc\u5ef6\u957f)\uff0c\u5176\u4e2d8\u540d(2%)\u60a3\u8005\u62a5\u544a\u67093\u7ea7\u5fc3\u5f8b\u5931\u5e38\u3002\u5728\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684356\u540d\u60a3\u8005\u4e2d\uff0c\u67093\u540d(0.8%)\u51fa\u73b0QTc\u5ef6\u957f\uff0c1\u540d(0.3%)\u60a3\u8005\u62a5\u544a\u51fa\u73b03\u7ea7QTc\u5ef6\u957f[\u53c2\u89c1\u201c\u4e0d\u826f\u53cd\u5e94\u201d]\u3002<\/p>\n<p>\u76d1\u6d4b\u6709\u5fc3\u8840\u7ba1\u5371\u9669\u56e0\u7d20\u53f2\u7684\u60a3\u8005\u7684\u5fc3\u8840\u7ba1\u4f53\u5f81\u548c\u75c7\u72b6\u3002\u6839\u636e\u4e34\u5e8a\u6307\u793a\u5f00\u59cb\u9002\u5f53\u6cbb\u7597\uff1b\u5bf9\u4e8e3\u7ea7\u6216\u66f4\u9ad8\u5fc3\u8840\u7ba1\u6bd2\u6027\uff0c\u6839\u636e\u5fc3\u8840\u7ba1\u6bd2\u6027\u7684\u6301\u7eed\u6027\uff0c\u6682\u65f6\u505c\u6b62\u3001\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528LuciAsc(Asciminib)[\u53c2\u89c1\u201c\u5242\u91cf\u4e0e\u7ed9\u836f\u201d]\u3002<\/p>\n<p>6\u3001\u80da\u80ce-\u80ce\u4ed4\u6bd2\u6027<\/p>\n<p>\u6839\u636e\u52a8\u7269\u7814\u7a76\u7684\u7ed3\u679c\u53ca\u5176\u4f5c\u7528\u673a\u5236\uff0cLuciAsc(Asciminib)\u5728\u5bf9\u5b55\u5987\u7ed9\u836f\u65f6\u4f1a\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\u3002\u5728\u52a8\u7269\u751f\u6b96\u7814\u7a76\u4e2d\uff0c\u5728\u5668\u5b98\u53d1\u751f\u671f\u95f4\u5bf9\u598a\u5a20\u5927\u9f20\u548c\u5154\u7ed9\u4e88\u963f\u897f\u7c73\u5c3c\u4f1a\u5bfc\u81f4\u4e0d\u826f\u53d1\u80b2\u7ed3\u5c40\uff0c\u5305\u62ec\u6bcd\u4f53\u66b4\u9732\u91cf(AUC)\u7b49\u4e8e\u6216\u5c0f\u4e8e\u63a8\u8350\u5242\u91cf\u65f6\u60a3\u8005\u7684\u80da\u80ce-\u80ce\u4ed4\u6b7b\u4ea1\u7387\u548c\u7578\u5f62\u3002\u5982\u679c\u5728\u598a\u5a20\u671f\u95f4\u4f7f\u7528LuciAsc(Asciminib)\u6216\u5982\u679c\u60a3\u8005\u5728\u670d\u7528LuciAsc(Asciminib)\u671f\u95f4\u6000\u5b55\uff0c\u5219\u544a\u77e5\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5b55\u5987\u548c\u96cc\u6027\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u98ce\u9669\u3002\u5728\u5f00\u59cbLuciAsc(Asciminib)\u6cbb\u7597\u524d\uff0c\u9a8c\u8bc1\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u96cc\u6027\u7684\u598a\u5a20\u72b6\u6001\u3002\u6709\u751f\u6b96\u6f5c\u529b\u7684\u96cc\u6027\u5e94\u5728LuciAsc(Asciminib)\u6cbb\u7597\u671f\u95f4\u548c\u6700\u540e\u4e00\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u4f7f\u7528\u6709\u6548\u907f\u5b55\u65b9\u6cd5[\u53c2\u89c1\u201c\u7279\u5b9a\u4eba\u7fa4\u4e2d\u7684\u4f7f\u7528\u201d]\u3002<\/p>\n<p>\u3010\u7279\u6b8a\u4eba\u7fa4\u7528\u836f\u3011<\/p>\n<p>1\u3001\u6000\u5b55<\/p>\n<p>\u6839\u636e\u52a8\u7269\u7814\u7a76\u7684\u7ed3\u679c\u548c\u4f5c\u7528\u673a\u5236\uff0c\u5bf9\u5b55\u5987\u7ed9\u836f\u65f6\uff0cLuciAsc(Asciminib)\u53ef\u9020\u6210\u80da\u80ce-\u80ce\u4ed4\u4f24\u5bb3\u3002\u6ca1\u6709\u5173\u4e8e\u5b55\u5987\u4f7f\u7528LuciAsc(Asciminib)\u8bc4\u4f30\u836f\u7269\u76f8\u5173\u98ce\u9669\u7684\u53ef\u7528\u6570\u636e\u3002<\/p>\n<p>\u5728\u598a\u5a20\u5927\u9f20\u548c\u5154\u4e2d\u8fdb\u884c\u7684\u52a8\u7269\u751f\u6b96\u7814\u7a76\u8868\u660e\uff0c\u5728\u5668\u5b98\u53d1\u751f\u8fc7\u7a0b\u4e2d\u53e3\u670d\u963f\u897f\u7c73\u5c3c\u4f1a\u8bf1\u53d1\u7ed3\u6784\u5f02\u5e38\u3001\u80da\u80ce-\u80ce\u4ed4\u6b7b\u4ea1\u7387\u548c\u751f\u957f\u53d8\u5316\u3002<\/p>\n<p>\u544a\u77e5\u5b55\u5987\u548c\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u98ce\u9669\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>2\u3001\u54fa\u4e73\u671f<\/p>\n<p>\u76ee\u524d\u8fd8\u6ca1\u6709\u5173\u4e8eLuciAsc(Asciminib)\u6216\u5176\u4ee3\u8c22\u4ea7\u7269\u5728\u4eba\u4e73\u4e2d\u7684\u5b58\u5728\u3001\u5bf9\u6bcd\u4e73\u5582\u517b\u513f\u7ae5\u7684\u5f71\u54cd\u6216\u4ea7\u5976\u91cf\u7684\u6570\u636e\u3002<\/p>\n<p>\u7531\u4e8e\u6bcd\u4e73\u5582\u517b\u7684\u5a74\u513f\u53ef\u80fd\u51fa\u73b0\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u5987\u5973\u5728\u670d\u7528LuciAsc(Asciminib)\u6cbb\u7597\u671f\u95f4\u548c\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\u4e0d\u8981\u8fdb\u884c\u6bcd\u4e73\u5582\u517b\u3002<\/p>\n<p>3\u3001\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u7537\u6027\u548c\u5973\u6027<\/p>\n<p>\u6839\u636e\u52a8\u7269\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u5f53\u5bf9\u5b55\u5987\u7ed9\u836f\u65f6\uff0cLuciAsc(Asciminib)\u53ef\u5bfc\u81f4\u80da\u80ce-\u80ce\u4ed4\u4f24\u5bb3[\u53c2\u89c1\u201c\u5728\u7279\u5b9a\u4eba\u7fa4\u4e2d\u7684\u4f7f\u7528\u201d]\u3002<\/p>\n<p>\u5728\u5f00\u59cbLuciAsc(Asciminib)\u6cbb\u7597\u524d\uff0c\u9a8c\u8bc1\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u96cc\u6027\u7684\u598a\u5a20\u72b6\u6001\u3002<\/p>\n<p>\u5728LuciAsc(Asciminib)\u6cbb\u7597\u671f\u95f4\u548c\u672b\u6b21\u7ed9\u836f\u540e1\u5468\u5185\uff0c\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\u5e94\u4f7f\u7528\u6709\u6548\u907f\u5b55\u65b9\u6cd5\u3002<\/p>\n<p>\u6839\u636e\u52a8\u7269\u7814\u7a76\u7ed3\u679c\uff0cLuciAsc(Asciminib)\u53ef\u80fd\u4f1a\u635f\u5bb3\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\u7684\u751f\u80b2\u80fd\u529b\u3002\u8fd9\u79cd\u6548\u5e94\u5bf9\u751f\u80b2\u529b\u7684\u53ef\u9006\u6027\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>4\u3001\u513f\u7ae5\u7528\u836f<\/p>\n<p>\u5c1a\u672a\u786e\u5b9aLuciAsc(Asciminib)\u5728\u513f\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002<\/p>\n<p>5\u3001\u8001\u5e74\u7528\u836f<\/p>\n<p>\u603b\u4f53\u800c\u8a00\uff0c\u4e0e\u5e74\u8f7b\u60a3\u8005\u76f8\u6bd4\uff0c\u672a\u89c2\u5bdf\u523065\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\u670d\u7528LuciAsc(Asciminib)\u7684\u5b89\u5168\u6027\u6216\u7597\u6548\u5b58\u5728\u5dee\u5f02\u300275\u5c81\u53ca\u4ee5\u4e0a\u7684\u60a3\u8005\u4eba\u6570\u4e0d\u8db3\u4ee5\u8bc4\u4f30\u5b89\u5168\u6027\u6216\u7597\u6548\u662f\u5426\u5b58\u5728\u5dee\u5f02\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>6\u3001\u80be\u529f\u80fd\u635f\u5bb3<\/p>\n<p>\u5bf9\u4e8e\u8f7b\u5ea6\u81f3\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u5bb3(\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u4f30\u8ba1\u503c[eGFR] 15\u81f389 mL\/min\/1.73 m2)\u4e14\u65e0\u9700\u63a5\u53d7LuciAsc(Asciminib)\u900f\u6790\u7684\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/p>\n<p>7\u3001\u809d\u529f\u80fd\u635f\u5bb3<\/p>\n<p>\u5bf9\u4e8e\u63a5\u53d7LuciAsc(Asciminib)\u6cbb\u7597\u7684\u8f7b\u5ea6[\u603b\u80c6\u7ea2\u7d20\u2264\u6b63\u5e38\u4e0a\u9650(ULN)\u548c\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176(AST) &gt; ULN\u6216\u603b\u80c6\u7ea2\u7d20&gt; 1\u81f31.5\u500dULN\u548c\u4efb\u4f55AST]\u81f3\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u5bb3(\u603b\u80c6\u7ea2\u7d20&gt; 3\u500dULN\u548c\u4efb\u4f55AST)\u7684\u60a3\u8005\uff0c\u65e0\u9700\u8c03\u6574\u5242\u91cf\u3002<\/p>\n<p>\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011<\/p>\n<p>&nbsp;<\/p>\n<p>\u67d0\u4e9bCYP3A4\u5e95\u7269<\/p>\n<p>\u963f\u897f\u7c73\u5c3c\u662f\u4e00\u79cdCYP3A4\u6291\u5236\u5242\u3002\u540c\u65f6\u4f7f\u7528LuciAsc(Asciminib)\u4f1a\u589e\u52a0CYP3A4\u5e95\u7269\u7684Cmax\u548cAUC\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0\u8fd9\u4e9b\u5e95\u7269\u7684\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002<\/p>\n<p>\u5bc6\u5207\u76d1\u6d4b\u63a5\u53d780 mg\u6bcf\u65e5\u603b\u5242\u91cfLuciAsc(Asciminib)\u8054\u5408\u4f7f\u7528\u67d0\u4e9bCYP3A4\u5e95\u7269\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5176\u4e2d\u6700\u5c0f\u7684\u6d53\u5ea6\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u907f\u514d\u6bcf\u65e5\u4e24\u6b21\u5c06200mg SCE mblix\u4e0e\u67d0\u4e9bCYP3A4\u5e95\u7269\u8054\u5408\u7ed9\u836f\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6700\u5c0f\u7684\u6d53\u5ea6\u53d8\u5316\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>CYP2C9\u5e95\u7269<\/p>\n<p>\u963f\u897f\u7c73\u5c3c\u662f\u4e00\u79cdCYP2C9\u6291\u5236\u5242\u3002\u540c\u65f6\u4f7f\u7528LuciAsc(Asciminib)\u4f1a\u589e\u52a0CYP2C9\u5e95\u7269\u7684Cmax\u548cAUC\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0\u8fd9\u4e9b\u5e95\u7269\u7684\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002<\/p>\n<p>\u907f\u514d\u6bcf\u65e5\u603b\u5242\u91cf\u4e3a80 mg\u7684LuciAsc(Asciminib)\u4e0e\u67d0\u4e9bCYP2C9\u5e95\u7269\u8054\u5408\u7ed9\u836f\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6700\u5c0f\u7684\u6d53\u5ea6\u53d8\u5316\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u5982\u679c\u8054\u5408\u7528\u836f\u4e0d\u53ef\u907f\u514d\uff0c\u8bf7\u6309\u7167\u5176\u5904\u65b9\u4fe1\u606f\u4e2d\u7684\u5efa\u8bae\u51cf\u5c11CYP2C9\u5e95\u7269\u5242\u91cf\u3002<\/p>\n<p>\u907f\u514d\u6bcf\u65e5\u4e24\u6b21200mg LuciAsc(Asciminib)\u4e0e\u654f\u611fCYP2C9\u5e95\u7269\u548c\u67d0\u4e9bCYP2C9\u5e95\u7269\u8054\u5408\u7ed9\u836f\uff0c\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0c\u6700\u5c0f\u7684\u6d53\u5ea6\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u5982\u679c\u8054\u5408\u7528\u836f\u4e0d\u53ef\u907f\u514d\uff0c\u5219\u8003\u8651\u4f7f\u7528\u975eCYP2C9\u5e95\u7269\u7684\u66ff\u4ee3\u7597\u6cd5\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u67d0\u4e9bP-gp\u5e95\u7269<\/p>\n<p>\u963f\u897f\u7c73\u5c3c\u662f\u4e00\u79cdP-gp\u6291\u5236\u5242\u3002\u540c\u65f6\u4f7f\u7528LuciAsc(Asciminib)\u4f1a\u589e\u52a0P-gp\u5e95\u7269\u7684\u8840\u6d46\u6d53\u5ea6\uff0c\u8fd9\u53ef\u80fd\u4f1a\u589e\u52a0\u8fd9\u4e9b\u5e95\u7269\u7684\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002<\/p>\n<p>\u5bc6\u5207\u76d1\u6d4b\u6240\u6709\u63a8\u8350\u5242\u91cf\u7684LuciAsc(Asciminib)\u8054\u5408P-gp\u5e95\u7269\u6cbb\u7597\u60a3\u8005\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5176\u4e2d\u6700\u5c0f\u7684\u6d53\u5ea6\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u7684\u6bd2\u6027\u3002<\/p>\n<h2><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6982\u62ec\u3011 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