{"id":631,"date":"2023-11-02T19:46:05","date_gmt":"2023-11-02T11:46:05","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=631"},"modified":"2023-11-02T19:46:05","modified_gmt":"2023-11-02T11:46:05","slug":"%e8%be%be%e5%85%8b%e6%9b%bf%e5%b0%bc%ef%bc%88%e8%be%be%e5%8f%af%e6%9b%bf%e5%b0%bc%ef%bc%8c%e5%a4%9a%e6%b3%bd%e6%b6%a6%ef%bc%8cdacomitinib%ef%bc%89%e4%b8%ad%e6%96%87%e8%af%b4%e6%98%8e%e4%b9%a6","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=631","title":{"rendered":"\u8fbe\u514b\u66ff\u5c3c\uff08\u8fbe\u53ef\u66ff\u5c3c\uff0c\u591a\u6cfd\u6da6\uff0cDacomitinib\uff09\u4e2d\u6587\u8bf4\u660e\u4e66"},"content":{"rendered":"

\"\u8fbe\u514b\u66ff\u5c3c\uff08\u8fbe\u53ef\u66ff\u5c3c\uff0c\u591a\u6cfd\u6da6\uff0cDacomitinib\uff09\u4e2d\u6587\u8bf4\u660e\u4e66\"<\/p>\n

\u8fbe\u514b\u66ff\u5c3c(Dacomitinib)\u7b80\u4ecb<\/strong><\/p>\n

\u901a\u7528\u540d\uff1a<\/strong>\u8fbe\u514b\u66ff\u5c3c<\/p>\n

\u5546\u54c1\u540d\uff1a<\/strong>Vizimpro<\/p>\n

\u5168\u90e8\u540d\u79f0\uff1a<\/strong>\u8fbe\u514b\u66ff\u5c3c\uff0c\u8fbe\u53ef\u66ff\u5c3c\uff0c\u591a\u6cfd\u6da6\uff0cDacomitinib\uff0cVizimpro\uff0cDacoMitinib\uff0cDacoplice, PF299804<\/p>\n

Vizimpro\u591a\u6cfd\u6da6\u8fbe\u53ef\u66ff\u5c3c\u9002\u7528\u4e8e\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u5916\u663e\u5b5019\u7f3a\u5931\u6216\u5916\u663e\u5b5021 L858R\u66ff\u4ee3\u7a81\u53d8\u3002<\/p>\n

\u9002\u5e94\u75c7\uff1a<\/strong><\/p>\n

\u9002\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u5177\u6709\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)19\u5916\u663e\u5b50\u7f3a\u5931\u621621\u5916\u663e\u5b50L858R\u9519\u4e49\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u60a3\u8005<\/p>\n

\u7528\u6cd5\u7528\u91cf\uff1a<\/strong><\/p>\n

\u63a8\u8350\u5242\u91cf\u662f\u6bcf\u5929\u53e3\u670d45 mg\uff0c\u76f4\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n

\u53ef\u4ee5\u968f\u9910\u6216\u7a7a\u8179\u670d\u7528\u3002<\/p>\n

\u6bcf\u5929\u56fa\u5b9a\u65f6\u95f4\u670d\u7528Vizimpro\u3002\u5982\u679c\u60a3\u8005\u5455\u5410\u6216\u5242\u91cf\u5c11\u670d\uff0c\u8bf7\u4e0d\u8981\u518d\u989d\u5916\u670d\u7528\u6216\u5f25\u8865\u5c11\u670d\u7684\u5242\u91cf\uff0c\u800c\u5e94\u7ee7\u7eed\u6267\u884c\u4e0b\u4e00\u6b21\u5e94\u670d\u7528\u7684\u5242\u91cf\u3002<\/p>\n

\u4e0d\u826f\u53cd\u5e94\uff1a<\/strong><\/p>\n

>10%:<\/p>\n

\u5fc3\u8840\u7ba1\uff1a\u80f8\u75db(10%)<\/p>\n

\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff1a\u5931\u7720(11%)<\/p>\n

\u76ae\u80a4\u75c5\u5b66\uff1a\u76ae\u75b9(69%-78%)\u3001\u7532\u6c9f\u708e(64%)\u3001\u5e72\u76ae\u75c5(30%)\u3001\u8131\u53d1(23%)\u3001\u7619\u75d2(21%)\u3001\u638c\u8dd6\u7ea2\u80bf(15%)\u3001\u76ae\u708e(11%)<\/p>\n

\u5185\u5206\u6ccc\u4ee3\u8c22\uff1a\u4f4e\u86cb\u767d\u8840\u75c7(44%)\u3001\u9ad8\u8840\u7cd6(36%)\u3001\u4f4e\u9499\u8840\u75c7(33%)\u3001\u4f4e\u94be\u8840\u75c7(29%)\u3001\u4f4e\u94a0\u8840\u75c7(26%)\u3001\u4f53\u91cd\u51cf\u8f7b(26%)\u3001\u4f4e\u9541\u8840\u75c7(22%)<\/p>\n

\u80c3\u80a0\u9053\uff1a\u8179\u6cfb(87%)\u3001\u53e3\u8154\u708e(45%;3\/4\u7ea7\uff1a4%)\u3001\u98df\u6b32\u4e0b\u964d(31%)\u3001\u6076\u5fc3(19%)\u3001\u4fbf\u79d8(13%)\u3001\u53e3\u8154\u7c98\u819c\u6e83\u75a1(12%)<\/p>\n

\u8840\u6db2\u548c\u80bf\u7624\uff1a\u8d2b\u8840(44%;3\/4\u7ea7\uff1a<1%)\uff0c\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11(42%;3\/4\u7ea7\uff1a6%)<\/p>\n

\u809d\uff1a\u8840\u6e05\u4e19\u6c28\u9178\u8f6c\u6c28\u9176\u5347\u9ad8(40%)\uff0c\u8840\u6e05\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\u5347\u9ad8(35%)\uff0c\u8840\u6e05\u78b1\u6027\u78f7\u9178\u9176\u5347\u9ad8(22%)\uff0c\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7(16%)<\/p>\n

\u795e\u7ecf\u808c\u8089\u548c\u9aa8\u9abc\uff1a\u80a2\u4f53\u75bc\u75db(14%)\u3001\u4e4f\u529b(13%)\u3001\u808c\u8089\u9aa8\u9abc\u75bc\u75db(12%)<\/p>\n

\u773c\u79d1\uff1a\u7ed3\u819c\u708e(19%)<\/p>\n

\u80be\uff1a\u808c\u9150\u6e05\u9664\u7387\u589e\u52a0(24%)<\/p>\n

\u547c\u5438\u7cfb\u7edf\uff1a\u54b3\u55fd(21%)\u3001\u9f3b\u90e8\u75c7\u72b6(19%)\u3001\u547c\u5438\u56f0\u96be(13%)\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3(12%)<\/p>\n

1% -10%:<\/p>\n

\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff1a\u75b2\u52b3(9%)<\/p>\n

\u76ae\u80a4\u79d1\uff1a\u76ae\u80a4\u76b2\u88c2(9%)\uff0c\u76ae\u80a4\u8131\u843d(4%-7%)\uff0c\u591a\u6bdb\u75c7(1%)<\/p>\n

\u5185\u5206\u6ccc\u4ee3\u8c22\uff1a\u8131\u6c34(1%)<\/p>\n

\u80c3\u80a0\u9053\uff1a\u5455\u5410(9%)\u3001\u98df\u6b32\u4e0d\u632f(7%)<\/p>\n

\u773c\u79d1\uff1a\u89d2\u819c\u708e(2%)<\/p>\n

\u547c\u5438\u7cfb\u7edf\uff1a\u95f4\u8d28\u6027\u80ba\u75c5(3%)<\/p>\n

<1%\uff1a<\/p>\n

\u4e0a\u5e02\u540e\u6216\u75c5\u4f8b\u62a5\u544a\uff1a\u80ba\u708e<\/p>\n

\u7981\u5fcc\uff1a<\/strong><\/p>\n

\u65e0\u3002<\/p>\n

\u6ce8\u610f\u4e8b\u9879\uff1a<\/strong><\/p>\n

\u95f4\u8d28\u6027\u80ba\u75be\u75c5(ILD)\uff1a\u5728394\u4f8b\u63a5\u53d7VIZIMPRO\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u67090.5%\u53d1\u751f\u4e25\u91cd\u548c\u81f4\u547d\u7684ILD \/\u80ba\u708e;0.3%\u7684\u75c5\u4f8b\u6b7b\u4ea1\u3002\u76d1\u6d4b\u60a3\u8005\u80ba\u90e8\u662f\u5426\u6709ILD \/\u80ba\u708e\u7684\u75c7\u72b6\u3002\u5bf9\u4e8e\u8868\u73b0\u51fa\u53ef\u80fd\u4e3aILD\u7684\u547c\u5438\u9053\u75c7\u72b6\u6076\u5316(\u4f8b\u5982\u547c\u5438\u56f0\u96be\uff0c\u54b3\u55fd\u548c\u53d1\u70e7)\u7684\u60a3\u8005\uff0c\u5e94\u6682\u505cVIZIMPRO\u5e76\u7acb\u5373\u67e5\u8bc1\u662f\u5426\u6709ILD\u3002\u5982\u679c\u786e\u8ba4ILD\uff0c\u5219\u6c38\u4e45\u7ec8\u6b62\u670d\u7528VIZIMPRO \u3002<\/p>\n

\u8179\u6cfb\uff1a\u7528VIZIMPRO\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u4e25\u91cd\u548c\u81f4\u547d\u7684\u8179\u6cfb\u3002394\u540d\u63a5\u53d7VIZIMPRO\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670986%\u51fa\u73b0\u8179\u6cfb\u3002\u636e\u62a5\u9053\uff0c\u670911%\u7684\u60a3\u8005\u60a3\u67093\u62164\u7ea7\u8179\u6cfb\uff0c\u800c\u81f4\u547d\u7684\u75c5\u4f8b\u53600.3%\u3002\u5bf92\u7ea7\u6216\u66f4\u9ad8\u7ea7\u522b\u7684\u8179\u6cfb\uff0c\u5e94\u505c\u6b62\u670d\u7528VIZIMPRO\uff0c\u76f4\u81f3\u6062\u590d\u5230\u5c0f\u4e8e\u6216\u7b49\u4e8e1\u7ea7\u4e25\u91cd\u7a0b\u5ea6\uff0c\u7136\u540e\u6839\u636e\u8179\u6cfb\u7684\u4e25\u91cd\u7a0b\u5ea6\u4ee5\u76f8\u540c\u6216\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dVIZIMPRO\u3002\u8fc5\u901f\u5f00\u59cb\u6b62\u6cfb\u6cbb\u7597(\u6d1b\u54cc\u4e01\u80fa\u6216\u76d0\u9178\u82ef\u4e59\u6c27\u57fa\u5316\u7269\u4e0e\u786b\u9178\u963f\u6258\u54c1)\u3002<\/p>\n

\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\uff1a\u7528VIZIMPRO\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u76ae\u75b9\u548c\u5265\u8131\u6027\u76ae\u80a4\u53cd\u5e94\u3002\u5728394\u4f8b\u63a5\u53d7VIZIMPRO\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u76ae\u75b9\u53d1\u751f\u7387\u8fbe78%\u300221%\u7684\u60a3\u8005\u51fa\u73b03\u62164\u7ea7\u76ae\u75b9\u3002\u67097%\u7684\u60a3\u8005\u51fa\u73b0\u5265\u8131\u6027\u76ae\u80a4\u53cd\u5e94\uff0c1.8%\u7684\u60a3\u8005\u51fa\u73b03\u62164\u7ea7\u5265\u8131\u6027\u76ae\u80a4\u53cd\u5e94\u3002\u5bf9\u4e8e\u6301\u7eed\u76842\u7ea7\u6216\u4efb\u4f553\u7ea7\u62164\u7ea7\u76ae\u80a4\u75c5\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u6682\u505c\u4f7f\u7528VIZIMPRO\uff0c\u76f4\u5230\u6062\u590d\u5230\u5c0f\u4e8e\u6216\u7b49\u4e8e1\u7ea7\u4e25\u91cd\u7a0b\u5ea6\u4e3a\u6b62\uff0c\u7136\u540e\u6839\u636e\u76ae\u80a4\u75c5\u5b66\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u4ee5\u76f8\u540c\u6216\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dVIZIMPRO\u3002\u76ae\u75b9\u548c\u5265\u843d\u6027\u76ae\u80a4\u53cd\u5e94\u7684\u53d1\u751f\u7387\u548c\u4e25\u91cd\u6027\u53ef\u80fd\u4f1a\u968f\u7740\u65e5\u6652\u800c\u589e\u52a0\u3002\u5728\u4f7f\u7528VIZIMPRO\u65f6\uff0c\u6ce8\u610f\u4f7f\u7528\u4fdd\u6e7f\u5242\u548c\u9002\u5f53\u7684\u63aa\u65bd\u6765\u9632\u6b62\u65e5\u6652\u3002\u4e00\u65e6\u53d1\u751f1\u7ea7\u76ae\u75b9\uff0c\u5e94\u5f00\u59cb\u4f7f\u7528\u5c40\u90e8\u6297\u751f\u7d20\u548c\u5c40\u90e8\u7c7b\u56fa\u9187\u6cbb\u7597\u3002\u5bf9\u4e8e2\u7ea7\u6216\u66f4\u4e25\u91cd\u7684\u76ae\u80a4\u75c5\u5b66\u4e0d\u826f\u53cd\u5e94\uff0c\u5e94\u5f00\u59cb\u53e3\u670d\u6297\u751f\u7d20\u3002<\/p>\n

\u80da\u80ce-\u80ce\u513f\u6bd2\u6027\uff1a\u6839\u636e\u52a8\u7269\u7814\u7a76\u7684\u7ed3\u679c\u53ca\u5176\u4f5c\u7528\u673a\u7406\uff0cVIZIMPRO\u5bf9\u5b55\u5987\u7ed9\u836f\u53ef\u5f15\u8d77\u80ce\u513f\u4f24\u5bb3\u3002\u5728\u52a8\u7269\u751f\u6b96\u7814\u7a76\u4e2d\uff0c\u5728\u80ce\u513f\u5668\u5b98\u5f62\u6210\u671f\u95f4\u7ed9\u6000\u5b55\u7684\u5927\u9f20\u53e3\u670d\u8fbe\u53ef\u66ff\u5c3c\uff0c\u5bfc\u81f4\u690d\u5165\u540e\u635f\u5931\u7684\u53d1\u751f\u7387\u589e\u52a0\uff0c\u5e76\u4e14\u80ce\u513f\u4f53\u91cd\u964d\u4f4e\u3002EGFR\u4fe1\u53f7\u4f20\u5bfc\u7684\u7f3a\u4e4f\u5df2\u663e\u793a\u53ef\u5bfc\u81f4\u52a8\u7269\u7684\u80da\u80ce\u81f4\u6b7b\u548c\u51fa\u751f\u540e\u7684\u6b7b\u4ea1\u3002\u5efa\u8bae\u5b55\u5987\u6ce8\u610f\u80ce\u513f\u7684\u6f5c\u5728\u5371\u9669\u3002\u5efa\u8bae\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\u5728\u4f7f\u7528VIZIMPRO\u6cbb\u7597\u671f\u95f4\u5c3d\u91cf\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\uff0c\u76f4\u5230\u6700\u540e\u4e00\u6b21\u670d\u7528\u540e\u81f3\u5c1117\u5929\u3002<\/p>\n

\u8d2e\u85cf\uff1a<\/strong><\/p>\n

\u50a8\u5b58\u4e8e20\u00b0C\u81f325\u00b0C(68\u00b0F\u81f377\u00b0F);\u5141\u8bb8\u572815\u00b0C\u81f330\u00b0C(59\u00b0F\u81f386\u00b0F)\u4e4b\u95f4\u504f\u79fb\u3002<\/p>\n

\u4f5c\u7528\u673a\u5236\uff1a<\/strong><\/p>\n

\u8fbe\u53ef\u66ff\u5c3c\u662f\u4eba\u7c7bEGFR\u5bb6\u65cf\u7684\u6fc0\u9176\u6d3b\u6027(EGFR \/ HER1\uff0cHER2\u548cHER4)\u548c\u67d0\u4e9bEGFR\u6fc0\u6d3b\u7a81\u53d8(\u5916\u663e\u5b5019\u7f3a\u5931\u6216\u5916\u663e\u5b5021 L858R\u53d6\u4ee3\u7a81\u53d8)\u7684\u4e0d\u53ef\u9006\u6291\u5236\u5242\u3002\u5728\u4e34\u5e8a\u76f8\u5173\u6d53\u5ea6\u4e0b\uff0c\u4f53\u5916\u8fbe\u53ef\u66ff\u5c3c\u4e5f\u80fd\u6291\u5236DDR1\uff0cEPHA6\uff0cLCK\uff0cDDR2\u548cMNK1\u7684\u6d3b\u6027\u3002<\/p>\n

\u5728\u643a\u5e26\u7531\u7a81\u53d8\u7684EGFR\u5bb6\u65cf\u7684HER\u5bb6\u65cf\u9776\u6807\u9a71\u52a8\u7684\u76ae\u4e0b\u690d\u5165\u4eba\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u5c0f\u9f20\u4e2d\uff0c\u8fbe\u53ef\u66ff\u5c3c\u663e\u793a\u51fa\u5bf9EGFR\u548cHER2\u81ea\u78f7\u9178\u5316\u4ee5\u53ca\u80bf\u7624\u751f\u957f\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u6291\u5236\u3002\u8fbe\u53ef\u66ff\u5c3c\u5728\u53e3\u670d\u7531EGFR\u6269\u589e\u9a71\u52a8\u7684\u9885\u5185\u4eba\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u53e3\u670d\u7ed9\u836f\u5c0f\u9f20\u4e2d\u4e5f\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n

 <\/p>\n

\u7597\u6548\u4e0e\u5b89\u5168\uff1a<\/strong><\/p>\n

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