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\u4f5c\u8005\uff1a\u8bb8\u67ef<\/p>\n\n\n\n

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\u65b0\u578b\u80ba\u764c\u75ab\u82d7Tedopi<\/p>\n\n\n\n

2020\u5e744\u67081\u65e5\uff0c\u6cd5\u56fd\u5236\u836f\u516c\u53f8OSE Immunotherapeutics\u5ba3\u5e03\uff0c\u80bf\u7624\u75ab\u82d7Tedopi\uff08OSE-2101\uff09\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u6210\u529f\uff01\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u4e3a\uff1a\u65e2\u5f80\u63a5\u53d7\u8fc7PD-1\/PD-L1\u514d\u75ab\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\uff0c\u63a5\u53d7\u80bf\u7624\u75ab\u82d7Tedopi\u6cbb\u7597\u540e\uff0c\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c12\u4e2a\u6708\u751f\u5b58\u7387\u63d0\u9ad810\uff05\uff0c1\u5e74\u751f\u5b58\u7387\u8fbe\u523046%\uff0c\u8d85\u8fc7\u4e86\u9884\u8bbe\u768425%\u6307\u6807\u3002<\/p>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

Tedopi\u65b0\u8868\u4f4d\u75ab\u82d7\u4f5c\u7528\u9776\u70b9\u56fe\u7247\u6765\u6e90\uff1aOSE Immunotherapeutics\u516c\u53f8\u5b98\u7f51<\/p>\n\n\n\n

Tedopi\u901a\u8fc7\u4ece5\u79cd\u4e0e\u80bf\u7624\u76f8\u5173\u7684\u6297\u539f\u4e2d\u9009\u62e910\u4e2a\u6700\u4f73\u7684\u6297\u539f\u51b3\u5b9a\u7c07\uff0c\u4f7f\u7528\u9776\u5411\u65b9\u6cd5\u6765\u5bf9\u6297\u80bf\u7624\u5f02\u8d28\u6027\u3002\u53ef\u4ee5\u66f4\u597d\u7684\u523a\u6fc0T\u6dcb\u5df4\u7ec6\u80de\u8bc6\u522b\u548c\u653b\u51fb\u764c\u7ec6\u80de\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u764c\u75c7\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

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\u5b9e\u9a8c\u8bbe\u8ba1<\/strong><\/p>\n\n\n\n

\u8bd5\u9a8c\u5171\u7eb3\u5165\u4e8699\u540dIIIB\u671f\u6216\u8f6c\u79fbIV\u671f\u7684HLA-A2\u9633\u6027NSCLC\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u5168\u90e8\u662f\u7ecf\u8fc7\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5931\u8d25\u540e\uff0c\u9700\u8981\u4e8c\u6216\u4e09\u7ebf\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/p>\n\n\n\n

HLA(human leukocyte antigen \uff0c\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f)\u662f\u4eba\u7c7b\u7684\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\uff08MHC\uff09\u7684\u8868\u8fbe\u4ea7\u7269\u3002HLA-A2\u662f\u764c\u75c7\u60a3\u8005\u6700\u5e38\u89c1\u7684MHC\u7b49\u4f4d\u57fa\u56e0\uff0c\u5df2\u53d1\u73b0\u8bb8\u591a\u4e0e\u8be5\u7b49\u4f4d\u57fa\u56e0\u76f8\u5173\u7684\u80bf\u7624\u7279\u5f02\u6027\u591a\u80bd\u3002<\/p>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

Tedopi\u8bd5\u9a8c\u5c06\u8ff0\u60a3\u8005\u6309\u71672:1\u968f\u673a\u5206\u4e3aTedopi\u75ab\u82d7\u6cbb\u7597\u7ec4\u6216\u5316\u7597\u7ec4\uff08\u57f9\u7f8e\u66f2\u585e\u6216\u591a\u897f\u4ed6\u8d5b\uff09\u3002\u5206\u522b\u63a5\u53d71ml Tedopi\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf3\u5468\u4e00\u6b21\u4e3a\u4e00\u4e2a\u5468\u671f\uff0c\u8fdb\u884c6\u4e2a\u5468\u671f\u540e\uff0c\u4e4b\u540e\u6bcf8\u5468\u4e00\u6b21\uff0c\u6700\u540e\u6bcf12\u5468\u4e00\u6b21\uff1b\u7ed9\u4e88\u591a\u897f\u4ed6\u8d5b75mg\/m2\u6216\u57f9\u7f8e\u66f2\u585e500 mg\/m2\uff0c\u6bcf3\u5468\u4e00\u6b21\u3002<\/p>\n\n\n\n

\u5f80\u671f\u6570\u636e<\/strong><\/p>\n\n\n\n

2019\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a(ACCR)\u5e74\u4f1a\u4e0a\u53d1\u8868\u4e86\u6765\u81eaAtlante-1\u7684\u65e9\u671f\u53d1\u73b0\u3002\u5f53\u65f6\uff0c18\u540d\u60a3\u8005\u767b\u8bb0\u5e76\u63a5\u53d7\u4e86\u6301\u7eed4.9\u4e2a\u6708\u81f312\u4e2a\u6708\u4ee5\u4e0a\u7684OSE-2101\u6cbb\u7597\u30021\u4f8b\u60a3\u8005\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u7f13\u89e3\uff0c2\u4f8b\u60a3\u8005\u75be\u75c5\u7a33\u5b9a\u3002\u6b64\u5916\uff0c\u5b89\u5168\u72b6\u51b5\u5728\u53ef\u63a7\u8303\u56f4\u5185\uff0c\u4ec5\u67091\u540d\u7eb3\u5165\u5206\u6790\u7684\u60a3\u8005\u56e0\u6bd2\u6027\u800c\u9000\u51fa\u3002<\/p>\n\n\n\n

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    \n
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