{"id":562,"date":"2023-10-30T17:21:22","date_gmt":"2023-10-30T09:21:22","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=562"},"modified":"2023-10-30T17:21:22","modified_gmt":"2023-10-30T09:21:22","slug":"%e7%89%b9%e6%95%88%e8%8d%af%e7%b1%b3%e6%89%98%e5%9d%a6%e5%9c%a8%e6%ac%a7%e7%be%8e%e4%b8%8a%e5%b8%8253%e5%b9%b4%e5%90%8e%ef%bc%8c%e7%bb%88%e5%9c%a8%e4%b8%ad%e5%9b%bd%e6%ad%a3%e5%bc%8f%e8%8e%b7%e6%89%b9","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=562","title":{"rendered":"\u7279\u6548\u836f\u7c73\u6258\u5766\u5728\u6b27\u7f8e\u4e0a\u5e0253\u5e74\u540e\uff0c\u7ec8\u5728\u4e2d\u56fd\u6b63\u5f0f\u83b7\u6279"},"content":{"rendered":"<section>1. \u00a02023\u5e749\u67088\u65e5\uff0c\u4e2d\u56fd\u56fd\u836f\u76d1\u7ba1\u5c40\u5b98\u7f51\u663e\u793a\uff0c\u7528\u4e8e\u6cbb\u7597\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u7c73\u6258\u5766\u7247\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u3002\u8be5\u836f\u7269\u9996\u6b21\u4e0a\u5e02\u4e8e1964\u5e74\u30022022\u5e748\u6708\uff0c\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u60a3\u8005\u5e08\u6c38\u521a\u51fa\u7248\u300a\u65e0\u56fd\u754c\u75c5\u4eba\u300b\u4e00\u4e66\u5f15\u6765\u5173\u6ce8\uff1b\u540c\u5e7411\u6708\uff0c\u7c73\u6258\u5766\u7247\u88ab\u56fd\u836f\u76d1\u7ba1\u5c40\u7eb3\u5165\u201c\u62df\u4f18\u5148\u5ba1\u8bc4\u201d\u3002<\/section>\n<section><span class=\"wx_text_underline\">2. \u00a0\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u662f\u4e00\u79cd\u7f55\u89c1\u6076\u6027\u80bf\u7624\uff0c\u5e38\u89c1\u4e8e\u5e7c\u513f\u548c\u4e2d\u8001\u5e74\u4eba\u7fa4\u4f53\uff0c\u6cbb\u7597\u65b9\u6cd5\u901a\u5e38\u4e3a\u624b\u672f\u5207\u9664\u548c\u670d\u7528\u7c73\u6258\u5766\u7247\u3002<\/span>\u7c73\u6258\u5766\u7247\u6700\u521d\u662f\u6cbb\u866b\u5bb3\u548c\u9f20\u5bb3\u7684\u519c\u836f\uff0c\u540e\u6765\u88ab\u7f8e\u56fd\u7814\u7a76\u8005\u7528\u4f5c\u72d7\u836f\u3002\u6539\u826f\u540e\u4e8e1960\u5e74\u5f00\u5c55\u4e34\u5e8a\u5e94\u7528\uff0c\u6210\u529f\u4f7f\u60a3\u8005\u80bf\u7624\u6d88\u9000\u3002<\/section>\n<section>3. \u00a0\u4e2d\u56fd\u6ccc\u5c3f\u5916\u79d1\u6559\u6388\u4e8e1961\u5e74\u62a5\u544a\u5185\u5730\u9996\u4f8b\u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff0c\u5e76\u63d0\u4f9b\u8bca\u65ad\u4e0e\u6cbb\u7597\u65b9\u6cd5\u30022019\u5e74\uff0c\u534f\u548c\u533b\u9662\u901a\u8fc7\u8fdb\u53e3\u91c7\u8d2d\u7c73\u6258\u5766\uff0c\u867d\u672a\u80fd\u89e3\u51b3\u7528\u836f\u96be\u95ee\u9898\uff0c\u4f46\u4e3a\u6b64\u540e\u6279\u51c6\u505a\u597d\u524d\u671f\u51c6\u5907\uff1b2020\u5e74\uff0c\u6211\u56fd\u5efa\u7acb\u4e86\u80be\u4e0a\u817a\u6fc0\u7d20\u6c34\u5e73\u68c0\u6d4b\u65b9\u6cd5\u3002<\/section>\n<section>4. \u00a0\u636e\u4e86\u89e3\uff0c\u7c73\u6258\u5766\u7247\u5728\u5185\u5730\u4e0a\u5e02\u5e76\u8d2d\u4e70\u5230\u6700\u5feb\u9700\u89813-4\u4e2a\u6708\u7684\u65f6\u95f4\u3002\u5728\u7f8e\u56fd\uff0c500\u6beb\u514b\u7c73\u6258\u5766\u4ef7\u683c\u4e3a1359\u7f8e\u5143\uff08\u7ea6\u4eba\u6c11\u5e019980\u5143\uff09\uff0c\u9999\u6e2f\u836f\u623f\u4ef7\u683c\u8d85\u8fc79000\u6e2f\u5143\uff08\u7ea6\u4eba\u6c11\u5e018430\u5143\uff09\u3002\u76ee\u524d\u552e\u836f\u516c\u53f8\u5c1a\u672a\u6572\u5b9a\u4ef7\u683c\uff0c\u4f46\u4e89\u53d6\u5728\u660e\u5e74\u8fdb\u5165\u533b\u4fdd\u3002<\/section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-563\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/10\/76.png\" alt=\"\" width=\"428\" height=\"337\" \/><\/section>\n<section>\n<section><strong>\u7f55\u89c1\u75c5\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u836f\u7269\u7c73\u6258\u5766\uff0c\u5728\u6b27\u7f8e\u591a\u56fd\u4e0a\u5e0253\u5e74\u540e\uff0c\u5728\u4e2d\u56fd\u6b63\u5f0f\u83b7\u5f97\u6279\u51c6<\/strong><\/section>\n<section>9\u67088\u65e5\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5b98\u7f51\u6700\u65b0\u516c\u793a\uff0c<strong>HRA Pharma Rare Diseases\u516c\u53f8\u7684\u7c73\u6258\u5766\u7247\uff08mitotane\uff09\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02<\/strong>\u3002\u6839\u636e\u4f18\u5148\u5ba1\u8bc4\u516c\u793a\u4fe1\u606f\uff0c<strong>\u8be5\u836f\u672c\u6b21\u83b7\u6279\u7684\u9002\u5e94\u75c7\u4e3a\u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff08ACC\uff09\u3002<\/strong><\/section>\n<section>\u80be\u4e0a\u817a\u4f4d\u4e8e\u80be\u810f\u4e0a\u65b9\uff0c\u53ef\u4ea7\u751f\u6fc0\u7d20\uff0c\u5305\u62ec\u76ae\u8d28\u9187\u3001\u919b\u56fa\u916e\u548c\u7537\u6027\u6027\u6fc0\u7d20\u3002\u8fd9\u4e9b\u817a\u4f53\u4e2d\u7684\u80bf\u7624\u5f88\u5e38\u89c1\uff0c\u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff08adrenocortical carcinoma\uff0cACC\uff09\u662f\u4e00\u79cd\u9884\u540e\u5dee\u7684\u7f55\u89c1\u6076\u6027\u80bf\u7624\uff0c\u5176\u5e74\u53d1\u75c5\u7387\u7ea6\u4e3a1-2\/100\u4e07\uff0c\u7ea6\u5360\u6240\u6709\u6076\u6027\u80bf\u7624\u76840.12%\u3002\u5728\u5e74\u9f84\u5206\u5e03\u4e0a\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u6709\u4e24\u4e2a\u9ad8\u53d1\u5e74\u9f84\u6bb5\uff1a<strong>\u4e00\u662f\u5c0f\u4e8e5\u5c81\u7684\u5e7c\u513f\uff0c\u4e8c\u662f40-69\u5c81\u5e74\u9f84\u6bb5\u7684\u6210\u5e74\u4eba\u3002<\/strong><\/section>\n<section><strong>\u7c73\u6258\u5766\u662f\u4e00\u79cd\u80be\u4e0a\u817a\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u7269\u8d28\uff0c\u53ef\u6291\u5236\u80be\u4e0a\u817a\u76ae\u8d28\u4ea7\u751f\u76ae\u8d28\u7c7b\u56fa\u9187\u6fc0\u7d20\u3002<\/strong>\u5bf9\u7c73\u6258\u5766\u4f5c\u7528\u65b9\u5f0f\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8be5\u836f\u6709\u4e24\u4e2a\u4e3b\u8981\u7684\u751f\u7269\u5b66\u6548\u5e94\uff1a\u4e00\u662f\u901a\u8fc7\u7ebf\u7c92\u4f53\u6539\u53d8\u548c\u6291\u5236\u753e\u9187-O-\u9170\u57fa\u8f6c\u79fb\u91761\uff08SOAT1\uff09\u7684\u6d3b\u6027\uff0c\u7c73\u6258\u5766<strong>\u53ef\u5bf9\u80be\u4e0a\u817a\u76ae\u8d28\u7ec6\u80de\u4ea7\u751f\u76f4\u63a5\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528<\/strong>\uff1b\u4e8c\u662f\u901a\u8fc7\u6539\u53d8\u76ae\u8d28\u9187\u7684\u5916\u5468\u4ee3\u8c22\u5e76\u76f4\u63a5\u6291\u5236\u80be\u4e0a\u817a\u76ae\u8d28\u5206\u6ccc\u76ae\u8d28\u7c7b\u56fa\u9187\uff0c<strong>\u6765\u6291\u5236\u76ae\u8d28\u7c7b\u56fa\u9187\u7684\u5408\u6210\u3002<\/strong><\/section>\n<section>\n<section><strong>\u8fd9\u6b3e\u836f\u7269\u4e8e1964\u5e74\u4e0a\u5e02\uff0c\u7f8e\u56fdFDA\u4e8e1970\u5e74\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u3002<\/strong><strong>2018\u5e74\u30012019\u5e74<\/strong>\u4e2d\u56fd\u66fe\u901a\u8fc7\u4e34\u65f6\u8fdb\u53e3\u9014\u5f84\uff08\u4e0d\u7528\u4e34\u5e8a\u8bd5\u9a8c\uff09\u8fdb\u53e3\u4e86\u90e8\u5206\u836f\u54c1\uff0c<strong>\u4f46\u5e76\u672a\u80fd\u89e3\u51b3\u56fd\u5185\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u75c5\u4eba\u7684\u7528\u836f\u96be\u95ee\u9898\u3002<\/strong><\/section>\n<section>\u636e\u4f30\u8ba1\uff0c\u5728\u4e2d\u56fd<strong>\u53ef\u80fd\u670910000\u540d\u5de6\u53f3\u7684\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u75c5\u4eba\u3002<\/strong><\/section>\n<section>\n<section>2012\u5e749\u6708\uff0c\u4f5c\u5bb6\u5e08\u6c38\u521a\u786e\u8bca\u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff0c\u4e3a\u5bfb\u627e\u7c73\u6258\u5766\uff0c\u53bb\u7f8e\u56fdMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u6cbb\u7597\u3002<strong>2022\u5e748\u6708\uff0c\u64b0\u5199\u51fa\u7248\u4e86\u8bb0\u5f55\u6cbb\u7597\u7f55\u89c1\u75c5\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u516b\u5e74\u5386\u7a0b\u7684\u300a\u65e0\u56fd\u754c\u75c5\u4eba\u300b\u4e00\u4e66\uff0c<\/strong>\u8fd9\u672c\u4e66\u62ab\u9732\u4e86\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7279\u6548\u836f\u7c73\u6258\u5766<strong>\u5728\u6b27\u7f8e\u4e0a\u5e0250\u591a\u5e74\uff0c\u672a\u80fd\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\uff0c\u5f15\u53d1\u4e86\u5a92\u4f53\u4e0e\u76f8\u5173\u65b9\u9762\u7684\u5173\u6ce8\u3002<\/strong><\/section>\n<section>2022\u5e7411\u670810\u65e5\uff0c\u7c73\u6258\u5766\u7247\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u7eb3\u5165\u201c\u62df\u4f18\u5148\u5ba1\u8bc4\u201d\u516c\u793a\u3002<strong>10\u4e2a\u6708\u5373\u83b7\u5f97\u5feb\u901f\u6279\u51c6\u3002<\/strong><\/section>\n<section><strong>\u636e\u4e86\u89e3\uff0c\u7c73\u6258\u5766\u7247\u5728\u56fd\u5185\u5ba1\u6279\u4f7f\u7528\u4e86\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u6570\u636e\uff0c\u672a\u518d\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c<\/strong>\u8fd9\u5f97\u76ca\u4e8e\u8fd1\u5e74\u6765\u56fd\u5bb6\u5bf9\u4e8e\u7f55\u89c1\u75c5\u836f\u68b0\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u5236\u5ea6\u3002<\/section>\n<section>\u7c73\u6258\u5766\u662f\u4e00\u79cd\u4ec0\u4e48\u836f\u7269\uff1f<strong>\u4e3a\u4f55\u8bf4\u5b83\u662f\u519c\u836f\u6ef4\u6ef4\u6ef4\u7684\u7247\u5242\uff1f\u4e3a\u4f5553\u5e74\u540e\u624d\u5728\u4e2d\u56fd\u5185\u5730\u4e0a\u5e02\uff1f<\/strong><\/section>\n<section>\n<section><strong>Mitotane\uff08\u7c73\u6258\u5766\uff09\u662f\u519c\u836f\u6ef4\u6ef4\u6ef4\u7684\u7247\u5242\uff1f\u66fe\u662f\u8457\u540d\u72d7\u836f\uff0c1970\u5e74\u83b7FDA\u6279\u51c6<\/strong><\/section>\n<section>Mitotane\uff08\u7c73\u6258\u5766\uff09\u4e25\u683c\u610f\u4e49\u4e0a\u6765\u8bf4\uff0c<strong>\u662f\u4e00\u79cd\u5267\u6bd2\u6740\u866b\u5242<\/strong>\u3002<\/section>\n<section>\u8fd9\u6b3e\u836f\u7269\u7684\u4e2d\u6587\u540d\u53eb\u505a\u6ef4\u6ef4\u6ef4\uff0c\u662f\u53e6\u4e00\u6b3e\u519c\u836f\u6ef4\u6ef4\u6d95\u7684\u540c\u7c7b\u5316\u5408\u7269\u3002DDT\u5728\u56fd\u5185\u4e00\u5ea6\u5bb6\u55bb\u6237\u6653\u3002<strong>\u5b83\u572880\u5e74\u4ee3\uff0c\u662f\u519c\u6751\u7528\u4e8e\u6740\u6b7b\u8001\u9f20\u4e0e\u5176\u4ed6\u5bb3\u866b\u7684\u4e3b\u6d41\u519c\u836f\u3002<\/strong>\u5173\u4e8e\u7c73\u6258\u5766\u7684\u901a\u4fd7\u89e3\u91ca\u662f\uff0c<strong>\u5b83\u662f\u7ec6\u80de\u6291\u5236\u5242\u548c\u6740\u866b\u5242\u3002<\/strong>\u4f5c\u4e3a\u80bf\u7624\u836f\u7269\uff0c\u5b83\u7684\u57fa\u672c\u6210\u5206\u201c\u662f\u4e00\u79cd\u7c7b\u56fa\u9187\u6fc0\u7d20\u5408\u6210\u6291\u5236\u5242\u548c\u6291\u5236\u7ec6\u80de\u751f\u957f\u7684\u6297\u80bf\u7624\u836f\u7269\u201d\u3002<\/section>\n<section>\u662f\u4e0d\u662f\u6bd4\u6ef4\u6ef4\u6ef4\u663e\u5f97\u9ad8\u7ea7\u4e9b\uff1f<\/section>\n<section>1945\u5e74\uff0c\u5316\u5b66\u5bb6Haller\u7b49\u4eceDDT\u7684\u914d\u65b9\u4e2d\uff0c\u53d1\u73b0\u5e76\u5408\u6210\u4e86DDD\uff08\u6ef4\u6ef4\u6ef4\uff0c\u4e8c\u6c2f\u4e8c\u82ef\u4e8c\u6c2f\u4e59\u70f7\uff09\uff0c\u6027\u8d28\u4e0eDDT\u7c7b\u4f3c\uff0c\u4f46\u6bd2\u6027\u4f4e\u4e8eDDT\u3002\u5b83\u7684\u81f4\u6bd2\u539f\u7406\u5f15\u8d77\u4e86\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240Bergenstal\u53ca\u5176\u540c\u4e8b\u7684\u6ce8\u610f\u3002<strong>\u4ed6\u4eec\u53d1\u73b0\u7ed9\u72d7\u53e3\u670d\u4f7f\u7528DDD\u6216Rothan\u8fd9\u4e24\u6b3e\u6df7\u5408\u6740\u866b\u5242\uff0c\u4f1a\u5f15\u8d77\u80be\u4e0a\u817a\u76ae\u8d28\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u840e\u7f29\uff0c\u5305\u62ec\u809d\u635f\u5bb3\u3002<\/strong>\u8fd9\u4e24\u79cd\u519c\u836f\u6df7\u5408\u540e\u51fa\u73b0\u7684\u6f5c\u5728\u6cbb\u7597\u4f5c\u7528\u4e8e1949\u5e74\u9996\u6b21\u5f97\u5230\u8ba4\u53ef\uff0c\u5f53\u65f6\u7684\u4e00\u4f4d\u533b\u751fNelson\u5728\u62a5\u544a\u4e2d\u8bf4\uff0c<strong>\u8fd9\u79cd\u519c\u836f\u5728\u72d7\u8eab\u4e0a\u7684\u4f5c\u7528\u8f83\u4e3a\u5f3a\u70c8\uff0c\u5728\u4eba\u8eab\u4e0a\u7684\u4f5c\u7528\u4e00\u822c\u3002\u5f53\u65f6\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\u8fd9\u662f\u4e00\u79cd\u72d7\u836f\u3002<\/strong><\/section>\n<section>\n<section>1960\u5e74\uff0cBergenstal\u53ca\u5176\u540c\u4e8b\u5728\u7f8e\u56fd\u5185\u79d1\u533b\u5e08\u5b66\u4f1a\u7b2c41\u5c4a\u5e74\u4f1a\u4e0a\u63d0\u51fa\u4e86\u5bf9\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u5316\u5b66\u6cbb\u7597\u7684\u65b9\u6cd5\uff0c\u5e76\u5c06\u8fd9\u79cd\u6539\u826f\u540e\u7684\u201c\u519c\u836f\u201d\uff0c\u7387\u5148\u5728\u8f6c\u79fb\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff08ACC\uff09\u60a3\u8005\u4e2d\u4e34\u5e8a\u5e94\u7528\uff0c\u5e76\u4f7f\u80bf\u7624\u6d88\u9000\u3002\u968f\u540e\u7684\u62a5\u544a\u652f\u6301\u4e86\u8fd9\u6b3e\u201c\u519c\u836f\u201d\u5728\u65e0\u6cd5\u5207\u9664\u7684ACC\u4e2d\u7684\u4f5c\u7528\uff1b<strong>\u8fd9\u53ef\u80fd\u662f\u4eba\u7c7b\u5386\u53f2\u4e0a\u7b2c\u4e00\u6b21\u4f7f\u7528\u519c\u836f\u201cDDD\u201d\u6cbb\u7597\u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff0c\u8fd9\u4e5f\u662f\u81ea\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u4e8e1886\u5e74\u53d1\u73b0\u540e\uff0c\u9996\u6b21\u6709\u4e00\u4e2a\u9488\u5bf9\u6027\u7684\u836f\u7269\u3002<\/strong><\/section>\n<section>\u6b64\u6b3e\u201c\u519c\u836f\u201d\u7684\u6539\u826f\u7248\u968f\u540e\u4e8e1964\u5e74\u9996\u6b21\u4ee5\u201cMitotane\u201d\uff08\u7c73\u6258\u5766\uff09\u7684\u540d\u5b57\u4e0a\u5e02\u3002\u7c73\u6258\u5766\u7247\u56e0\u5176\u201c\u6cbb\u7597\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u6709\u6548\u6027\uff0c\u9002\u7528\u4e8e\u672f\u540e\u9884\u9632\u590d\u53d1\u53ca\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u60a3\u8005\u201d\uff0c\u4e8e1970\u5e74\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff0c\u5e76\u4e8e2002\u5e74\u88ab\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u5217\u4e3a\u7f55\u89c1\u75c5\u836f\u7269\u3002\u968f\u540e\uff0c\u7c73\u6258\u5766\u7247\u5728\u52a0\u62ff\u5927\uff081978\u5e74\uff09\u3001\u5df4\u897f\uff081988\u5e74\uff09\u3001\u4e2d\u56fd\u9999\u6e2f\uff081989\u5e74\uff09\u3001\u97e9\u56fd\uff082001\u5e74\uff09\u7b49\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u6279\u51c6\u4e0a\u5e02\u3002<strong>\u76ee\u524d\u6cd5\u56fdLaboratoire HRA\u516c\u53f8\u662f\u7c73\u6258\u5766\u7247\u7684\u5168\u7403\u552f\u4e00\u751f\u4ea7\u6301\u8bc1\u5546\u3002<\/strong><\/section>\n<section>&nbsp;<\/p>\n<section><strong>100\u5e74\u524d\u53d1\u73b0\u80be\u4e0a\u817a\u8fd9\u4e2a\u795e\u79d8\u5668\u5b98\uff0c53\u5e74\u95f4\uff0c\u4ec5\u6709\u7c73\u6258\u5766\u8fd9\u4e00\u6b3e\u836f\u7269\u5f97\u5230\u4e86\u6279\u51c6<\/strong><\/section>\n<section>\u4efb\u4f55\u4e00\u79cd\u7f55\u89c1\u75c5\u7684\u53d1\u73b0\uff0c\u4ece\u6765\u90fd\u4e0d\u662f\u4e00\u4ef6\u5bb9\u6613\u7684\u4e8b\u3002\u6709\u7684\u53ef\u80fd\u9700\u8981\u81f3\u5c11\u4e00\u767e\u591a\u5e74\uff0c\u80be\u4e0a\u817a\u8fd9\u4e2a\u5668\u5b98\u4ece\u88ab\u53d1\u73b0\u5230\u76ae\u8d28\u764c\u88ab\u786e\u8bca\u7684\u8fc7\u7a0b\uff0c\u5219\u7ecf\u5386\u4e86\u4e09\u4e2a\u4e16\u7eaa\u3002<\/section>\n<section><strong>\u80be\u4e0a\u817a\u5f88\u5bb9\u6613\u88ab\u5ffd\u89c6\u3002\u8fd9\u662f\u4e00\u4e2a\u5dee\u70b9\u88ab\u9057\u5fd8\u7684\u6ccc\u5c3f\u5668\u5b98\u3002<\/strong>\u5b83\u662f\u4f4d\u4e8e\u4e24\u4e2a\u80be\u810f\u4e0a\u7684\u4e09\u89d2\u5f62\u5e3d\u5b50\u5f0f\u7684\u817a\u4f53\u3002\u8fd9\u4e2a\u975e\u5e38\u5c0f\u7684\u5668\u5b98\uff0c\u8d1f\u8d23\u5236\u9020\u51e0\u79cd\u91cd\u8981\u7684\u6fc0\u7d20\u3002\u8fd9\u4e9b\u6fc0\u7d20\u6709\u52a9\u4e8e\u8eab\u4f53\u5e94\u5bf9\u538b\u529b\uff08\u76ae\u8d28\u9187\uff09\uff0c\u63a7\u5236\u8840\u538b\uff08\u919b\u56fa\u916e\uff09\uff0c\u5e76\u4fdd\u6301\u94a0\uff0c\u94be\u548c\u6c34\u7684\u9002\u5f53\u5e73\u8861\u3002\u5176\u4ed6\u6fc0\u7d20\uff0c\u79f0\u4e3a\u6027\u7c7b\u56fa\u9187\u6216\u6027\u6fc0\u7d20\uff0c\u7531\u80be\u4e0a\u817a\u7684\u4e00\u90e8\u5206\u4ea7\u751f\uff0c\u79f0\u4e3a\u80be\u4e0a\u817a\u76ae\u8d28\u3002\u4e5f\u5c31\u662f\u8377\u5c14\u8499\u3002<strong>\u5b83\u662f\u4eba\u4eec\u529b\u91cf\u7684\u6765\u6e90\u4e0e\u5f00\u5173\u3002<\/strong><\/section>\n<section>\n<section><strong>\u572816\u4e16\u7eaa\u524d\uff0c\u4eba\u4eec\u5e76\u4e0d\u77e5\u9053\u8fd9\u4e2a\u5668\u5b98\u7684\u5b58\u5728\u4e0e\u91cd\u8981\u6027\u3002<\/strong>\u76f4\u5230\u4e00\u4f4d\u610f\u5927\u5229\u89e3\u5256\u5b66\u5bb6\u5728\u63cf\u8ff0\u8179\u819c\u540e\u9057\u75c7\u4e2d\u53d1\u73b0\u80be\u4e0a\u817a\u7684\u5b58\u5728\uff0c\u5e76\u5c06\u5b83\u51c6\u786e\u5730\u753b\u4e86\u51fa\u6765\u3002<strong>\u8fd9\u4e00\u8fc7\u7a0b\u6301\u7eed\u523020\u4e16\u7eaa\u521d\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u7684\u53d1\u73b0\uff0c\u65f6\u95f4\u7adf\u957f\u8fbe3\u4e2a\u591a\u4e16\u7eaa\u3002<\/strong><\/section>\n<section>\u8d77\u521d\uff0c\u4eba\u4eec\u4e0d\u77e5\u9053\u80be\u4e0a\u817a\u5728\u8eab\u4f53\u4e2d\u53d1\u6325\u4ec0\u4e48\u4f5c\u7528\uff0c\u540e\u6765\u501f\u52a9\u663e\u5fae\u955c\uff0c\u624d\u77e5\u9053\u80be\u4e0a\u817a\u5206\u4e3a\u76ae\u8d28\u548c\u9ad3\u8d28\uff0c\u4ece\u5f62\u6001\u4e0a\u770b\uff0c\u5e94\u8be5\u662f\u4e00\u79cd\u5185\u5206\u6ccc\u817a\u3002\u8fd9\u5bfc\u81f4\u572820\u4e16\u7eaa30\u5e74\u4ee3\u548c50\u5e74\u4ee3\uff0c\u5185\u5206\u6ccc\u79d1\u7684\u533b\u5b66\u5bb6\u4eec\u53d1\u73b0\u548c\u5206\u79bb\u51fa\u4e86\u80be\u4e0a\u817a\u7d20\uff0c\u76ae\u8d28\u9187\u548c\u968f\u540e\u7684\u919b\u56fa\u916e\uff0c<strong>\u800c\u5b83\u4eec\u7684\u53d1\u73b0\u4f7f1950\u5e74\u7684\u8bfa\u8d1d\u5c14\u5956\u9881\u53d1\u7ed9\u4e86\u5316\u5b66\u5bb6Edward C. Kendall\uff0cPhilip S. Hench\u548cTadeus Reichstein\u3002<\/strong><\/section>\n<section>\u4f46\u76f4\u81f31969\u5e74\uff0c\u624d\u786e\u7acb\u4e86\u5173\u4e8e\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u68c0\u6d4b\u65b9\u6cd5\u4e0e\u624b\u6bb5\uff0c\u540c\u65f6\u627e\u5230\u4e86\u5b83\u7684\u7b2c\u4e00\u6b3e\u836f\uff0c\u7c73\u6258\u5766\u3002\u800c\u8fd9\u4e2d\u95f4\uff0c<strong>\u53d1\u73b0\u80be\u4e0a\u817a\u8fd9\u4e2a\u5668\u5b98\uff0c\u7528\u65f6\u5c06\u8fd1\u767e\u5e74<\/strong>\uff1b\u53d1\u73b0\u80be\u4e0a\u817a\u7684\u6fc0\u7d20\u529f\u80fd\uff0c\u7528\u65f620\u591a\u5e74\uff1b<strong>\u53d1\u73b0\u80be\u4e0a\u817a\u76ae\u8d28\u80bf\u7624\uff0c\u5219\u662f\u5728\u8fd9\u4e2a\u5668\u5b98\u88ab\u53d1\u73b0100\u591a\u5e74\u540e<\/strong>\uff1b\u53d1\u73b0\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u68c0\u6d4b\u65b9\u6cd5\u4e0e\u6cbb\u7597\u624b\u6bb5\uff0c<strong>\u5219\u4ece1959\u5e74\u81f3\u4eca\uff0c\u7528\u4e86\u5c06\u8fd140\u5e74\u300240\u5e74\u95f4\uff0c\u53ea\u6709\u7c73\u6258\u5766\u8fd9\u4e00\u6b3e\u836f\u7269\u5f97\u5230\u4e86\u6279\u51c6\u3002<\/strong><\/section>\n<section><strong>\u4e2d\u56fd\u5185\u5730\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\u65b9\u6cd5\uff0c\u5219\u8fdf\u81f31961\u5e74\u624d\u7531\u8457\u540d\u6ccc\u5c3f\u5916\u79d1\u5434\u9636\u5e73\u6559\u6388\u62a5\u544a\u9996\u4f8b\uff0c<\/strong>\u4f46\u4ed6\u6700\u5927\u7684\u8d21\u732e\u5219\u662f\u53d1\u73b0\u4e86\u80be\u4e0a\u817a\u9ad3\u8d28\u589e\u751f\u8fd9\u79cd\u65b0\u7684\u75be\u75c5\uff0c\u8fd9\u79cd\u6bd4\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u66f4\u4e3a\u7f55\u89c1\u7684\u75be\u75c5\uff0c\u53d7\u5230\u56fd\u9645\u4e0a\u7684\u91cd\u89c6\u548c\u627f\u8ba4\u3002\u5e76\u8ba4\u5b9a\u4e3a\u4e00\u4e2a\u65b0\u7684\u75c5\u75c7\uff0c\u8fdb\u884c\u6cbb\u7597\u3002<strong>\u76ee\u524d\u6536\u6cbb\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u4e0e\u80be\u4e0a\u817a\u75c5\u4eba\u6700\u591a\u7684\u533b\u9662\uff0c\u662f\u5317\u4eac\u7684\u534f\u548c\u533b\u9662\u548c\u4e0a\u6d77\u7684\u745e\u91d1\u533b\u9662\u3002<\/strong><strong>\u5176\u4e2d\u80be\u4e0a\u817a\u6fc0\u7d20\u6c34\u5e73\u7684\u68c0\u6d4b\u65b9\u6cd5\uff0c\u5219\u52302020\u5e74\u624d\u5efa\u7acb\u3002<\/strong><\/section>\n<section><strong>2019\u5e74\uff0c\u4e3a\u89e3\u51b3\u56fd\u5185\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u60a3\u8005\u7528\u836f\u9700\u6c42\u548c\u4fdd\u969c\u7528\u836f\u5b89\u5168\uff0c\u5317\u4eac\u534f\u548c\u533b\u9662\u901a\u8fc7\u4e00\u6b21\u6027\u8fdb\u53e3\u7684\u9014\u5f84\uff0c<\/strong>\u5206\u4e24\u6279\u901a\u8fc7\u7279\u6b8a\u91c7\u8d2d\u65b9\u5f0f\u8fdb\u5165\u534f\u548c\u533b\u9662\uff0c\u5e76\u5728\u5317\u4eac\u534f\u548c\u533b\u9662\u5f20\u6292\u6768\u9662\u957f\u4e3b\u5bfc\u4e0b\u5236\u5b9a\u4e86\u300a\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u8bca\u6cbb\u4e13\u5bb6\u5171\u8bc6\u300b\u548c\u300a\u7c73\u6258\u5766\u6cbb\u7597\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u4e13\u5bb6\u5171\u8bc6\u300b\u3002\u8fd9\u4e5f\u4e3a\u6b63\u5f0f\u6279\u51c6\u7c73\u6258\u5766\uff0c\u63d0\u4f9b\u4e86\u524d\u671f\u51c6\u5907\u3002<\/section>\n<section>\n<section><strong>\u7c73\u6258\u5766\u7684\u5b9a\u4ef7\u5982\u4f55\uff0c\u4f55\u65f6\u6b63\u5f0f\u4e0a\u5e02\u53ef\u4ee5\u8d2d\u4e70\u5230\uff0c\u4e5f\u6210\u4e3a\u60a3\u8005\u5173\u6ce8\u7684\u7126\u70b9\uff01<\/strong><\/section>\n<section>8\u67088\u65e5\uff0c\u51e4\u51f0\u7f51\u300aCC\u60c5\u62a5\u5c40\u300b\u91c7\u8bbf\u4e86\u6770\u8c1b\u533b\u836f\u8d1f\u8d23\u4eba\u9648\u601d\u701a\uff0c\u4ed6\u62ab\u9732\uff0c<strong>\u7c73\u6258\u5766\u7247\u5728\u5185\u5730\u6b63\u5f0f\u4e0a\u5e02\u5e76\u8d2d\u4e70\u5230\uff0c\u6700\u5feb\u9700\u89813-4\u4e2a\u6708\u3002<\/strong>\u8fd9\u4e9b\u836f\u7269\u5c06\u7531\u610f\u5927\u5229\u7684\u4e00\u95f4\u836f\u5382\u751f\u4ea7\u3002\u5728\u95ee\u5230\u8fd9\u6b3e\u836f\u7269\u7684\u5b9a\u4ef7\u65f6\uff0c<strong>\u4ed6\u8bf4\u76ee\u524dHRA\u8fd8\u6ca1\u6709\u6700\u540e\u6572\u5b9a\u4ef7\u683c\uff0c\u4f46\u516c\u53f8\u7684\u76ee\u6807\u662f\u660e\u5e74\u4e89\u53d6\u8fdb\u5165\u533b\u4fdd\u3002<\/strong><\/section>\n<section>\u636e\u4e86\u89e3\uff0c\u8fd9\u6b3e\u836f\u7269\u5728\u7f8e\u56fd500\u6beb\u514b\u7684\u4ef7\u683c\uff0c\u7ea6\u4e3a1,359\u7f8e\u5143\uff08100\u7247\uff09\u3002\u9999\u6e2f\u836f\u623f\u4ef7\u683c\u5219\u4e3a9000\u591a\u6e2f\u5143\u3002\u60a3\u8005\u82e5\u6309\u6700\u5927\u5242\u91cf\u670d\u7528\uff0c\u53ef\u80fd\u6bcf\u6708\u9700\u8981\u670d\u75283\u74f6\u5de6\u53f3\uff0c\u5e73\u5747\u6bcf\u6708\u9700\u82b1\u8d394000\u7f8e\u5143\u5de6\u53f3\u3002<\/section>\n<section><strong>\u671f\u5f85\u7c73\u6258\u5766\u8fd9\u4e00\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7279\u6548\u836f\u7269\uff0c\u4e0d\u662f\u5929\u4ef7\u3002<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>1. \u00a02023\u5e749\u67088\u65e5\uff0c\u4e2d\u56fd\u56fd\u836f\u76d1\u7ba1\u5c40\u5b98\u7f51\u663e\u793a\uff0c\u7528\u4e8e\u6cbb\u7597\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u7c73\u6258\u5766\u7247\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u3002\u8be5\u836f\u7269\u9996\u6b21\u4e0a\u5e02\u4e8e1964\u5e74\u30022022\u5e748\u6708\uff0c\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u60a3\u8005\u5e08\u6c38\u521a\u51fa\u7248\u300a\u65e0\u56fd\u754c\u75c5\u4eba\u300b\u4e00\u4e66\u5f15\u6765\u5173\u6ce8\uff1b\u540c\u5e7411\u6708\uff0c\u7c73\u6258\u5766\u7247\u88ab\u56fd\u836f\u76d1\u7ba1\u5c40\u7eb3\u5165\u201c\u62df\u4f18 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":563,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[177],"topic":[],"class_list":["post-562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zuixinfangan","tag-177"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=562"}],"version-history":[{"count":1,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/562\/revisions"}],"predecessor-version":[{"id":564,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/562\/revisions\/564"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/563"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=562"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}