{"id":557,"date":"2023-10-30T12:08:18","date_gmt":"2023-10-30T04:08:18","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=557"},"modified":"2023-11-01T10:14:14","modified_gmt":"2023-11-01T02:14:14","slug":"%e5%8e%84%e6%b4%9b%e6%9b%bf%e5%b0%bc%e8%87%b4%e7%9a%ae%e7%96%b9%ef%bc%8c%e4%bd%a0%e7%9f%a5%e5%a4%9a%e5%b0%91%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=557","title":{"rendered":"\u5384\u6d1b\u66ff\u5c3c\u81f4\u76ae\u75b9\uff0c\u4f60\u77e5\u591a\u5c11\uff1f"},"content":{"rendered":"

\"\u5384\u6d1b\u66ff\u5c3c\"1.\u00a0\u5384\u6d1b\u66ff\u5c3c<\/strong>\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u2014\u2014\u76ae\u75b9<\/strong><\/p>\n

\u76d0\u9178\u5384\u6d1b\u66ff\u5c3c\u7247\u662f\u4e00\u79cd\u5206\u5b50\u9776\u5411\u6cbb\u7597\u836f\u7269\uff0c\u9002\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002\u5c3d\u7ba1\u5176\u4e34\u5e8a\u7597\u6548\u660e\u663e\uff0c\u4f46\u5176\u526f\u4f5c\u7528\u4ecd\u4e0d\u5bb9\u5ffd\u89c6\u3002\u5176\u4e2d\uff0c\u76ae\u75b9\u662f\u5384\u6d1b\u66ff\u5c3c\u6700\u5e38\u89c1\u7684\u526f\u4f5c\u7528\uff0c\u4ea6\u662fEGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff0c\u5176\u76ae\u75b9\u53d1\u751f\u7387\u5728\u6b64\u7c7b\u836f\u7269\u4e2d\u8f83\u9ad8\uff08>\u00a030%\uff09\uff0c\u4e00\u9879\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u7684EGFR\u9633\u6027\u665a\u671f\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764cIII\u671f\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u4f7f\u7528\u5384\u6d1b\u66ff\u5c3c\u7684\u60a3\u8005\u4e2d\u670987%\u51fa\u73b0\u76ae\u75b9\uff0c\u5176\u4e2d3~4\u7ea7\u76ae\u75b9\u7684\u53d1\u751f\u7387\u4e3a21%\u3002<\/p>\n

\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u76ae\u75b9\u5728\u6cbb\u7597\u7684\u7b2c1-3\u5468\u5f00\u59cb\u51fa\u73b0\uff0c\u5728\u6cbb\u7597\u76843-5\u5468\u8fbe\u5230\u9ad8\u5cf0\uff0c\u5728\u6cbb\u7597\u505c\u6b624\u5468\u5185\u9010\u6e10\u6d88\u9000\uff0c\u4f46\u5728\u4e0d\u505c\u6b62\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u76ae\u75b9\u53ef\u80fd\u81ea\u53d1\u6027\u589e\u5927\u6216\u7f29\u5c0f\u3001\u8fdb\u5c55\u6216\u8005\u7f13\u89e3\u3002\u4e3b\u8981\u51fa\u73b0\u5728\u5934\u76ae\u3001\u9762\u90e8\u3001\u9888\u90e8\u3001\u80f8\u90e8\u3001\u80cc\u90e8\u7b49\uff0c\u8868\u73b0\u4e3a\u8113\u75b1\u6837\u76ae\u75b9\u6216\u7ea2\u8272\u5c0f\u4e18\u75b9\uff0c\u4f34\u6709\u7619\u75d2\u6216\u89e6\u75db\uff0c\u90e8\u5206\u76ae\u635f\u7834\u6e83\u6e17\u6db2\uff0c\u6d78\u6e0d\u7cdc\u70c2\uff0c\u91cd\u8005\u5168\u8eab\u6027\u5265\u8131\u6027\u76ae\u708e\uff0c\u4ece\u800c\u5bf9\u8eab\u5fc3\u5065\u5eb7\u53ca\u6b63\u5e38\u751f\u6d3b\u4ea7\u751f\u5f71\u54cd\u3002\u56e0\u6b64\u5bf9\u5384\u6d1b\u66ff\u5c3c\u5f15\u53d1\u7684\u76ae\u75b9\u8fdb\u884c\u9488\u5bf9\u6027\u7684\u9632\u62a4\u548c\u6cbb\u7597\uff0c\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n

2.\u00a0\u6b64\u7c7bEGFR<\/strong>-TK<\/strong>I\u76f8\u5173\u76ae\u75b9\u5982\u4f55\u5206\u7ea7\uff1f<\/strong><\/p>\n

\u7f8e\u56fd\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u6240\u4e0d\u826f\u4e8b\u4ef6\u8bc4\u4ef7\u6807\u51c6\uff08NCI-CTCAE\uff095.0\u7248\u5bf9\u7531EGFR-TKI\u6cbb\u7597\u5f15\u8d77\u7684\u75e4\u75ae\u6837\u76ae\u75b9\u4f5c\u4e86\u5177\u4f53\u5206\u7ea7\uff0c\u5177\u4f53\u5982\u4e0b\u8868\uff1a<\/p>\n\n\n\n\n\n\n\n\n
\u5206\u7ea7<\/td>\nNCI-CTCAE\u6807\u51c6<\/td>\n<\/tr>\n
1\u7ea7<\/td>\n\u4e18\u75b9\u548c\/\u6216\u8113\u75b1\uff1c10%\u4f53\u8868\u9762\u79ef\uff0c\u4f34\u6216\u4e0d\u4f34\u6709\u7619\u75d2\u6216\u538b\u75db\u75c7\u72b6<\/td>\n<\/tr>\n
2\u7ea7<\/td>\n\u4e18\u75b9\u548c\/\u6216\u8113\u75b1\u8986\u76d610%~30%\u7684\u4f53\u8868\u9762\u79ef\uff0c\u53ef\u80fd\u4f34\u6709\/\u4e0d\u4f34\u6709\u7619\u75d2\u548c\u538b\u75db\uff1b\u4f34\u5fc3\u7406\u5f71\u54cd\uff1b\u5f71\u54cd\u5de5\u5177\u6027\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8<\/td>\n<\/tr>\n
3\u7ea7<\/td>\n\u4e18\u75b9\u548c\/\u6216\u8113\u75b1\u8986\u76d6\u5927\u4e8e30%\u4f53\u8868\u9762\u79ef\uff0c\u4f34\u6709\u4e2d\u5230\u4e2d\u5ea6\u75c7\u72b6\uff1b\u5f71\u54cd\u81ea\u7406\u6027\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\uff1b\u4f34\u5c40\u90e8\u4e8c\u91cd\u611f\u67d3\uff0c\u9700\u8981\u53e3\u670d\u6297\u751f\u7d20\u6cbb\u7597<\/td>\n<\/tr>\n
4\u7ea7<\/td>\n\u5371\u53ca\u751f\u547d\uff1b\u4e18\u75b9\u548c\/\u6216\u8113\u75b1\u904d\u5e03\u5168\u8eab\u8868\u9762\uff0c\u53ef\u80fd\u4f34\u6709\/\u4e0d\u4f34\u6709\u7619\u75d2\u548c\u538b\u75db\uff1b\u4f34\u5e7f\u6cdb\u7684\u4e8c\u91cd\u611f\u67d3\uff0c\u9700\u8981\u9759\u8109\u7ed9\u4e88\u6297\u751f\u7d20\u6cbb\u7597<\/td>\n<\/tr>\n
5\u7ea7<\/td>\n\u6b7b\u4ea1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

1.\u00a0\u51fa\u73b0\u76ae\u75b9\u540e\u662f\u5426\u53ef\u4ee5\u7ee7\u7eed\u7528\u836f\uff1f<\/strong><\/p>\n

\u5bf9\u4e8e\u76d0\u9178\u5384\u6d1b\u66ff\u5c3c\u7247\u7684\u4f7f\u7528\uff0c\u51fa\u73b0\u76ae\u75b9\u540e\uff0c\u5e94\u5728\u533b\u751f\u6216\u836f\u5e08\u7684\u6307\u5bfc\u4e0b\u6839\u636e\u76ae\u75b9\u7684\u4e25\u91cd\u7a0b\u5ea6\u8fdb\u884c\u76f8\u5e94\u8c03\u6574\uff1a1\u7ea7\u76ae\u75b9\uff0c\u4e00\u822c\u91c7\u7528\u5e38\u89c4\u9632\u62a4\u63aa\u65bd\u53ca\u8fdb\u884c\u5fc3\u7406\u4e0a\u7684\u652f\u6301\u5373\u53ef\uff0c\u65e0\u9700\u8c03\u6574\u5384\u6d1b\u66ff\u5c3c\u7684\u7528\u91cf\uff1b2\u7ea7\u76ae\u75b9\uff0c\u53ef\u8fdb\u884c\u5fc3\u7406\u652f\u6301\u7597\u6cd5\uff0c\u82e5\u56e0\u76ae\u75b9\u800c\u5bfc\u81f4\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u7684\u4e0b\u964d\uff0c\u53ef\u505c\u836f3-5\u5929\u540e\u518d\u7ee7\u7eed\u53e3\u670d\u5384\u6d1b\u66ff\u5c3c\uff0c\u5982\u82e5\u518d\u6b21\u53d1\u751f\u76ae\u75b9\uff0c\u5e76\u5f71\u54cd\u751f\u6d3b\u8d28\u91cf\uff0c\u53ef\u51cf\u5c11\u5384\u6d1b\u66ff\u5c3c\u7684\u7528\u91cf\uff1b3\u7ea7\u76ae\u75b9\uff0c\u9664\u5fc3\u7406\u652f\u6301\u5916\uff0c\u8fd8\u5e94\u4e2d\u65ad\u670d\u7528\u5384\u6d1b\u66ff\u5c3c\uff0c\u76f4\u81f3\u76ae\u75b9\u6539\u5584\u81f3\u5c11\u4e00\u7ea7\u53ca\u4ee5\u4e0a\uff0c\u5f85\u75c7\u72b6\u6539\u5584\u540e\u53ef\u518d\u6b21\u670d\u7528\u5384\u6d1b\u66ff\u5c3c\uff0c\u6b64\u65f6\u5384\u6d1b\u66ff\u5c3c\u5e94\u51cf\u91cf\uff0c\u82e5\u51cf\u91cf\u540e\u76ae\u75b9\u52a0\u91cd\uff0c\u5219\u505c\u6b62\u4f7f\u7528\u5384\u6d1b\u66ff\u5c3c\uff1b4\u7ea7\u76ae\u75b9\uff0c\u5fc5\u987b\u505c\u7528\u5384\u6d1b\u66ff\u5c3c\uff0c\u9759\u8109\u4f7f\u7528\u9488\u5bf9\u6027\u7684\u5e7f\u8c31\u6297\u751f\u7d20\uff0c\u75c5\u60c5\u5371\u91cd\u8005\uff0c\u751a\u81f3\u8fdb\u5165\u91cd\u75c7\u76d1\u62a4\u5ba4\u6cbb\u7597\u3002<\/p>\n

2.\u00a0\u6b64\u7c7b\u76ae\u75b9\u5982\u4f55\u5904\u7406\uff1f<\/strong><\/p>\n

\u5bf9\u4e8e\u76ae\u75b9\uff0c\u6839\u636e\u5176\u4e25\u91cd\u7a0b\u5ea6\u8fdb\u884c\u6cbb\u7597\uff1a1\u7ea7\u8f7b\u5ea6\u76ae\u75b9\uff0c\u53ef\u5916\u75282.5%\u6c22\u5316\u53ef\u7684\u677e\u971c\u5242\u53ca\u6297\u751f\u7d20\uff0c\u53ef\u9009\u62e9\u7684\u6297\u751f\u7d20\u6709\uff1a1%\u514b\u6797\u9709\u7d20\u51dd\u80f6\u3001\u786b\u9178\u65b0\u9709\u7d20\u30011%\u7532\u785d\u5511\u6216\u6839\u636e\u7ecf\u9a8c\u4f7f\u7528\u592b\u897f\u5730\u9178\u8f6f\u818f\uff0c\u5982\u679c\u4f34\u6709\u7619\u75d2\uff0c\u53ef\u914c\u60c5\u4f7f\u7528\u6251\u5c14\u654f\u3001\u916e\u66ff\u82ac\u3001\u8d5b\u5e9a\u5576\u7b49\u6297\u8fc7\u654f\u836f\uff1b2\u7ea7\u4e2d\u5ea6\u76ae\u75b9\uff0c\u53ef\u57281\u7ea7\u6cbb\u7597\u63aa\u65bd\u7684\u57fa\u7840\u4e0a\uff0c\u52a0\u7528\u4ed6\u514b\u83ab\u53f8\u8f6f\u818f\uff0c\u53e3\u670d\u591a\u897f\u73af\u7d20\u6216\u7c73\u8bfa\u73af\u7d20\uff08100 mg\uff0c\u6bcf\u65e5\u4e24\u6b21\uff09\uff0c\u8fd8\u53ef\u4f7f\u7528\u7089\u7518\u77f3\u6d17\u5242\u6216\u6b62\u75d2\u914a\u5bf9\u672a\u7834\u6e83\u7684\u8113\u75b1\u72b6\u76ae\u75b9\u8fdb\u884c\u64e6\u62ed\uff1b3-4\u7ea7\u91cd\u5ea6\u76ae\u75b9\u5408\u5e76\u611f\u67d3\u65f6\uff0c\u5e94\u53ca\u65f6\u5c31\u533b\uff0c\u5fc5\u987b\u9009\u62e9\u5e7f\u8c31\u3001\u654f\u611f\u7684\u6297\u751f\u7d20\u8fdb\u884c\u6cbb\u7597\uff0c\u540c\u65f6\u6839\u636e\u60c5\u51b5\u6682\u65f6\u505c\u6b62\u4f7f\u7528\u5384\u6d1b\u66ff\u5c3c\u751a\u81f3\u7ec8\u6b62\u4f7f\u7528\u3002<\/p>\n

3.\u00a0\u5982\u4f55\u9884\u9632\uff1f<\/strong><\/p>\n

\u4e3a\u9884\u9632\u76ae\u75b9\u7684\u53d1\u751f\uff0c\u60a3\u8005\u5e94\u91c7\u53d6\u4ee5\u4e0b\u5982\u4e0b\u63aa\u65bd\uff1a\u996e\u98df\u6e05\u6de1\uff0c\u5fcc\u8f9b\u8fa3\u523a\u6fc0\u6cb9\u8364\uff1b\u5efa\u8bae\u4f7f\u7528\u9632\u6652\u7cfb\u6570\u226530\u7684\u9632\u6652\u7528\u54c1\uff1b\u6bcf\u5929\u4fdd\u6301\u76ae\u80a4\u7684\u6e05\u6d01\u4e0e\u6e7f\u6da6\uff0c\u6e29\u6c34\u6d17\u6d74\u540e\u9002\u5f53\u6d82\u62b9\u4fdd\u6e7f\u4e73\u971c\uff1b\u7a7f\u5bbd\u677e\u3001\u900f\u6c14\u7684\u978b\u5b50\u7b49\u3002<\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

1.\u00a0\u5384\u6d1b\u66ff\u5c3c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u2014\u2014\u76ae\u75b9 \u76d0\u9178\u5384\u6d1b\u66ff\u5c3c\u7247\u662f\u4e00\u79cd\u5206\u5b50\u9776\u5411\u6cbb\u7597\u836f\u7269\uff0c\u9002\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u5177\u6709\u654f\u611f\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002\u5c3d\u7ba1\u5176\u4e34\u5e8a\u7597\u6548\u660e\u663e\uff0c\u4f46\u5176\u526f\u4f5c\u7528\u4ecd\u4e0d\u5bb9\u5ffd\u89c6\u3002\u5176\u4e2d\uff0c\u76ae\u75b9\u662f\u5384\u6d1b\u66ff […]<\/p>\n","protected":false},"author":1,"featured_media":584,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[176,188],"topic":[],"class_list":["post-557","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-changjianwenti","tag-176","tag-188"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=557"}],"version-history":[{"count":3,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/557\/revisions"}],"predecessor-version":[{"id":586,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/557\/revisions\/586"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/584"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=557"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}