{"id":555,"date":"2023-10-30T12:04:03","date_gmt":"2023-10-30T04:04:03","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=555"},"modified":"2023-10-30T12:04:03","modified_gmt":"2023-10-30T04:04:03","slug":"%e6%96%b0%e4%b8%80%e4%bb%a3%e5%b9%bf%e8%b0%b1%e9%9d%b6%e5%90%91%e8%8d%af%e7%89%a9%ef%bc%8c%e6%b3%9bfgfr%e6%8a%91%e5%88%b6%e5%89%82%e5%8e%84%e8%be%be%e6%9b%bf%e5%b0%bc%ef%bc%88erdafit","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=555","title":{"rendered":"\u65b0\u4e00\u4ee3\u201c\u5e7f\u8c31\u201d\u9776\u5411\u836f\u7269\uff0c\u6cdbFGFR\u6291\u5236\u5242\u5384\u8fbe\u66ff\u5c3c\uff08Erdafitinib\uff09\u5f15\u9886\u6297\u764c\u65b0\u7a81\u7834"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-509\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/10\/\u5384\u8fbe\u66ff\u5c3c.png\" alt=\"\" width=\"332\" height=\"390\" 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growth \u00a0factor\uff0cFGF\uff09\u5bb6\u65cf\u81f3\u5c11\u670928\u4e2a\u4e0d\u540c\u7684\u6210\u5458\uff0c\u4e3b\u8981\u5206\u5e03\u4e8e\u4e0a\u76ae\u6216\u5185\u76ae\u7ec6\u80de\u3002\u5b83\u4eec\u901a\u8fc7\u7ed3\u5408\u5176\u53d7\u4f53\uff08fibroblast growth factor \u00a0receptors\uff0cFGFRs\uff09\uff0c\u6fc0\u6d3b\u5176\u8c03\u63a7\u7684\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff0c\u5728\u4fc3\u5206\u88c2\uff08\u80da\u80ce\u53d1\u751f\u3001\u751f\u957f\u53d1\u80b2\u7b49\uff09\u548c\u975e\u4fc3\u5206\u88c2\uff08\u795e\u7ecf\u8c03\u8282\u3001\u4ee3\u8c22\u8c03\u8282\u7b49\uff09\u7b49\u751f\u7269\u5b66\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p>FGFRs\u662f\u4e00\u7c7b\u5178\u578b\u7684\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff08receptor tyrosine kinases\uff0cRTKs\uff09\uff0c\u5176\u5bb6\u65cf\u5305\u62ecFGFR1\u3001FGFR2\u3001FGFR3\u548cFGFR4\u56db\u79cd\u53d7\u4f53\u3002\u8fd9\u4e9b\u53d7\u4f53\u5177\u6709\u91cd\u53e0\u8bc6\u522b\u7684\u7279\u70b9\uff0c\u5373\u4e00\u4e2aFGFR\u53d7\u4f53\u80fd\u591f\u4ee5\u76f8\u4f3c\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u4e0e\u4e0d\u540c\u7684FGFs\u7ed3\u5408\uff1b\u540c\u6837\uff0c\u6bcf\u4e2aFGF\u80fd\u591f\u4e0e\u4e0d\u540c\u7684FGFRs\u7ed3\u5408\u3002\u8fd1\u5e74\u6765\uff0c\u4e0d\u5c11\u7814\u7a76\u8868\u660e<strong>FGFR\u7684\u9ad8\u8868\u8fbe\u3001\u7a81\u53d8\u7b49\u5bfc\u81f4\u5176\u4fe1\u53f7\u901a\u8def\u5f02\u5e38\u6fc0\u6d3b\uff0c\u5f02\u5e38\u6fc0\u6d3b\u4f7f\u80bf\u7624\u7ec6\u80de\u4ee5&#8221;\u81ea\u7ed9\u81ea\u8db3&#8221;\u7684\u65b9\u5f0f\u7ef4\u6301\u751f\u957f<\/strong>\uff0c\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\u3001\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\u548c\u8840\u7ba1\u751f\u6210\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\u7684\u4fb5\u88ad\u3001\u8f6c\u79fb\u548c\u5bf9\u6cbb\u7597\u7684\u8010\u53d7\uff0c\u4e0e\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u3001\u5375\u5de2\u764c\u7b49\u591a\u79cd\u75be\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n<p>2016\u5e741\u6708\u5728Clinical Cancer Research\u671f\u520a\u4e2d\u53d1\u8868\u7684\u6587\u7ae0\uff0c\u7528\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u63cf\u8ff0\u4e86\u6765\u81ea\u5404\u79cd\u764c\u75c7\u76844853\u4e2a\u60a3\u8005\u6837\u54c1\u4e2dFGFR\u7684\u7a81\u53d8\u60c5\u51b5\uff0c\u5305\u62ec\u6269\u589e\uff0c\u7a81\u53d8\u548c\u91cd\u6392\u3002\u5728\u6d4b\u5e8f\u76844853\u79cd\u764c\u75c7\u4e2d\uff0c\u8be5\u7814\u7a76\u89c2\u5bdf\u5230FGFR\u7a81\u53d8\u603b\u53d1\u751f\u7387\u4e3a7.1\uff05\uff0817\u4e2a\u764c\u75c7\u5177\u6709\u591a\u4e2aFGFR\u6539\u53d8\uff09\u3002<\/p>\n<p>2020\u5e74\uff0c\u4e2d\u56fd\u5b66\u8005\u5bf9\u4e2d\u56fd\u7684\u80bf\u7624\u60a3\u8005\u4e2d\u4e5f\u8fdb\u884c\u4e86\u5728\u591a\u764c\u79cd\u4e2dFGFR\u6539\u53d8\u60c5\u51b5\u7684\u5206\u6790\u3002\u53d1\u73b0\u5728745\u4f8b\u60a3\u8005\u4e2d\uff0c\u8868\u8fbe\u6539\u53d8\u7684\u53d1\u751f\u7387\u4e3a7%\u3002\u5176\u4e2d8.5%\u7684\u7a81\u53d8\u60a3\u8005\u6709\u4e0d\u5c11\u4e8e1\u79cdFGFR\u4e9a\u578b\u7684\u57fa\u56e0\u6539\u53d8\u3002\u5728\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\uff08\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\u301031%\u3011\u3001\u80c3\u764c\u301016.8%\u3011\u548c\u98df\u7ba1\u764c\u301012.7%\u3011\uff09\u548c\u4e73\u817a\u764c\u4e2d\u7684\u53d1\u751f\u7387\u5747\u8f83\u9ad8\u3002<\/p>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<section><strong>FGFR\u6210\u4e3a\u5e7f\u53d7\u5173\u6ce8\u7684\u6cbb\u7597\u9776\u70b9\uff0c<\/strong><\/p>\n<p><strong>\u66f4\u6210\u4e3a\u6cdb\u764c\u79cd\u6cbb\u7597\u7684\u65b0\u5e0c\u671b<\/strong><\/p>\n<\/section>\n<\/section>\n<section>\n<section>2019\u5e744\u670812\u65e5\uff0c\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\u4e86\u53e3\u670d<strong>\u5c0f\u5206\u5b50\u6cdbFGFR\u6291\u5236\u5242\u5384\u8fbe\u66ff\u5c3c\uff08\u5546\u54c1\u540dBalversa\uff09<\/strong>\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26FGFR2\/3\u7a81\u53d8\uff0c\u5728\u94c2\u7c7b\u5316\u7597\u671f\u95f4\u6216\u5316\u7597\u540e\uff08\u5305\u62ec\u5728\u65b0\u8f85\u52a9\u5316\u7597\u6216\u8f85\u52a9\u5316\u7597\u4e00\u5e74\u5185\uff09\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\uff08mUC\uff09\u6210\u4eba\u60a3\u8005\u3002<strong>\u8fd9\u662f\u5168\u7403\u9996\u6b3e\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\u7684FGFR\u6291\u5236\u5242\uff0c\u4e5f\u662fFDA\u6279\u51c6\u7684\u7b2c\u4e00\u4e2a\u9488\u5bf9\u8f6c\u79fb\u6027\u8180\u80f1\u764c\u7684\u9776\u5411\u6cbb\u7597\u7597\u6cd5\u3002<\/strong><\/p>\n<p>\u8be5\u6279\u51c6\u662f\u57fa\u4e8e\u4e00\u9879\u540d\u79f0\u4e3aBLC2001\u7684\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5355\u81c2\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8be5\u7814\u7a76\u7eb3\u5165\u53d7\u8bd5\u60a3\u800587\u4eba\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u81f3\u5c11\u4e00\u6b21\u5316\u7597\u4e4b\u524d\u6216\u4e4b\u540e\u53d1\u751f\u4e86\u8fdb\u5c55\uff0c\u5e76\u4e14\u81f3\u5c11\u6709\u4e00\u4e2a\u4ee5\u4e0b\u7684\u57fa\u56e0\u6539\u53d8\uff1a\u5728\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u7684CTA\u68c0\u6d4b\u53d1\u73b0FGFR3\u57fa\u56e0\u7a81\u53d8\u6216FGFR\u57fa\u56e0\u878d\u5408\u3002\u6240\u6709\u60a3\u8005\u63a5\u53d7\u5384\u8fbe\u66ff\u5c3c\u6bcf\u5929\u4e00\u6b218mg\uff0c\u5728\u8840\u6e05\u78f7\u9178\u76d0\u7b26\u5408\u6c34\u5e73\uff08\u7ea6\u7b2c14-17\u5929\u65f6\uff09\u4e4b\u540e\uff0c\u589e\u52a0\u81f3\u6bcf\u5929\u4e00\u6b219mg\uff0c\u6cbb\u7597\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n<p>\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\u51fa\uff0c\u5728\u6240\u6709\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a32.2%\uff0c\u5176\u4e2d\u5b8c\u5168\u7f13\u89e3\u4e3a2.3%\uff0c\u90e8\u5206\u7f13\u89e3\u4e3a29.9%\uff1b\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u4e3a5.4\u4e2a\u6708\u3002\u5176\u4e2d\uff0c\u5bf9\u4e8eFGFR\u7a81\u53d8\u768464\u4f4d\u60a3\u8005\u6765\u8bf4\uff0cORR\u4e3a40.6%\uff1b\u5bf9\u4e8eFGFR\u878d\u5408\u768418\u4f4d\u60a3\u8005\u6765\u8bf4\uff0cORR\u4e3a11.1%\u3002<\/p>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<section><strong>\u6cdb\u764c\u79cd\u7684\u5c1d\u8bd5\u4e0d\u65ad\u63a8\u8fdb<\/strong><\/p>\n<\/section>\n<\/section>\n<section>\n<section>2022\u5e746\u6708\u4e3e\u529e\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u4e00\u9879\u5173\u952e\u6027II\u671fRAGNAR\u8bd5\u9a8c\u7684\u521d\u6b65\u6210\u679c\uff0c\u4e3b\u8981\u8bc4\u4f30\u4e86\u5384\u8fbe\u66ff\u5c3c\u5728\u60a3\u6709FGFR\u7a81\u53d8\u7684\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8be5\u8bd5\u9a8c\u4e0d\u533a\u5206\u5176\u80bf\u7624\u4f4d\u7f6e\u6216\u7ec4\u7ec7\u5b66\u5f62\u6001\u3002\u4e2d\u671f\u5206\u6790\u662f\u57fa\u4e8e178\u4f4d\u5e26\u670932\u79cd\u4e0d\u540c\u7ec4\u7ec7\u5b66\u5f62\u6001\u80bf\u7624\u75c5\u60a3\u7684\u7ed3\u679c\u3002\u5176\u4e2d\u53d7\u8bd5\u8005\u4e2d74.7%\u90fd\u66fe\u63a5\u53d7\u8fc7\u4e0d\u5c11\u4e8e2\u6b21\u7684\u7597\u6cd5\u3002\u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class=\"list-paddingleft-1\">\n<li><strong>\u773c\u90e8\u75be\u75c5\uff1a<\/strong>Balversa\u53ef\u5f15\u8d77\u4e2d\u592e\u6027\u6d46\u6db2\u6027\u89c6\u7f51\u819c\u75c5\u53d8\/\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u8131\u79bb\uff08CSR\/RPED\uff09\u3002\u5e94\u5728\u6cbb\u7597\u7684\u5934\u56db\u4e2a\u6708\u7684\u6bcf\u6708\u3001\u4ee5\u540e\u6bcf\u4e09\u4e2a\u6708\u4ee5\u53ca\u5728\u51fa\u73b0\u4efb\u4f55\u89c6\u89c9\u75c7\u72b6\u65f6\u5019\u8fdb\u884c\u773c\u79d1\u68c0\u67e5\u3002\u53d1\u751fCSR\/RPED\u65f6\u5e94\u505c\u7528Balversa\uff0c\u5982\u679c4\u5468\u5185\u4ecd\u672a\u89e3\u51b3\u6216\u4e25\u91cd\u6027\u4e3a4\u7ea7\uff0c\u5219\u6c38\u4e45\u505c\u7528Balversa\u3002<\/li>\n<li><strong>\u9ad8\u78f7\u9178\u76d0\u8840\u75c7\uff1a<\/strong>\u78f7\u9178\u76d0\u6c34\u5e73\u5347\u9ad8\u662fBalversa\u7684\u836f\u6548\u5b66\u4f5c\u7528\u3002\u5e94\u76d1\u6d4b\u9ad8\u78f7\u8840\u75c7\u5e76\u5728\u9700\u8981\u65f6\u8c03\u6574\u5242\u91cf\u3002<\/li>\n<li><strong>\u80da\u80ce-\u80ce\u513f\u6bd2\u6027\uff1a<\/strong>\u53ef\u5f15\u8d77\u80ce\u513f\u4f24\u5bb3\u3002\u5e94\u63d0\u793a\u60a3\u8005\u836f\u7269\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u98ce\u9669\u5e76\u5efa\u8bae\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3002<\/li>\n<\/ul>\n<\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<section><strong>\u4e0d\u826f\u53cd\u5e94<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u53ca\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u5f02\u5e38\uff08\u226520\uff05\uff09\u4e3a\u78f7\u9178\u76d0\u5347\u9ad8\uff0c\u53e3\u8154\u708e\uff0c\u75b2\u52b3\uff0c\u808c\u9150\u5347\u9ad8\uff0c\u8179\u6cfb\uff0c\u53e3\u5e72\uff0c\u7532\u5265\u79bb\u75c7\uff0cALT\u5347\u9ad8\uff0c\u78b1\u6027\u78f7\u9178\u9176\u5347\u9ad8\uff0c\u4f4e\u94a0\uff0c\u98df\u6b32\u4e0b\u964d\uff0c\u767d\u86cb\u767d\u51cf\u5c11\uff0c\u5473\u89c9\u5f02\u5e38\uff0c\u8840\u7ea2\u86cb\u767d\u51cf\u5c11\uff0c\u76ae\u80a4\u5e72\u71e5\uff0cAST\u5347\u9ad8\uff0c\u4f4e\u9541\uff0c\u5e72\u773c\u75c7\uff0c\u8131\u53d1\uff0c\u638c\u8db3\u7ea2\u80bf\u89e6\u75db\uff08PPE\uff09\u7efc\u5408\u5f81\uff0c\u4fbf\u79d8\uff0c\u78f7\u9178\u76d0\u51cf\u5c11\uff0c\u8179\u75db\uff0c\u9499\u5347\u9ad8\uff0c\u6076\u5fc3\u548c\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u3002<\/p>\n<p>\u5f53\u53d1\u751f\u9ad8\u78f7\u9178\u8840\u75c7\u3001CSR\/RPED\u6216\u5176\u4ed6\u4e09\u56db\u7ea7\u4e0d\u826f\u53cd\u5e94\u65f6\uff0c\u53ef\u4ee5\u6839\u636e\u4e0d\u826f\u53cd\u5e94\u7c7b\u578b\u548c\u7a0b\u5ea6\u6682\u505c\u7528\u836f\u3001\u8c03\u6574\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528Balversa\u3002\u5242\u91cf\u964d\u4f4e\u81f34mg\u4ecd\u65e0\u6cd5\u8010\u53d7\u5219\u9700\u505c\u7528Balversa\u3002<\/p>\n<\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<section><strong>\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<ul 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