{"id":51,"date":"2023-09-18T12:43:52","date_gmt":"2023-09-18T04:43:52","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=51"},"modified":"2023-09-18T12:43:53","modified_gmt":"2023-09-18T04:43:53","slug":"%e8%82%ba%e7%99%8cegfr%e7%aa%81%e5%8f%98%ef%bc%8c%e8%82%bf%e7%98%a4%e7%aa%81%e5%8f%98%e8%b4%9f%e8%8d%b7tmb%e5%be%88%e9%ab%98%e6%80%8e%e4%b9%88%e5%8a%9e%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=51","title":{"rendered":"\u80ba\u764c\u201cEGFR\u7a81\u53d8\u201d\uff0c\u80bf\u7624\u7a81\u53d8\u8d1f\u8377TMB\u5f88\u9ad8\u600e\u4e48\u529e\uff1f"},"content":{"rendered":"\n

\u80ba\u764c\u4e2d\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u817a\u764c\u6709\u8f83\u9ad8\u7684\u6bd4\u4f8b\u662fEGFR\u57fa\u56e0\u7a81\u53d8\uff0c<\/strong>\u5f53\u51fa\u73b0\u8fd9\u4e2a\u57fa\u56e0\u7a81\u53d8\u4e4b\u540e\u75c5\u4eba\u53ef\u4ee5\u4f7f\u7528\u9776\u5411\u836f\u7269\u5982\u7279\u7f57\u51ef\u3001\u6613\u745e\u6c99\u7b49\u8fdb\u884c\u9776\u5411\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u76ee\u524d\u5927\u70ed\u7684PD-1\u7c7b\u836f\u7269\u5982O\u836f\u548cK\u836f\u4e5f\u5df2\u7ecf\u76f8\u7ee7\u83b7\u6279\u4e0a\u5e02\uff0c\u9884\u6d4bPD-1\u7c7b\u836f\u7269\u7684\u751f\u7269\u6807\u5fd7\u7269\u6709PD-L1\u8868\u8fbe\uff0c\u80bf\u7624\u7a81\u53d8\u8d1f\u8377TMB\u548c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027MSI\u3002<\/p>\n\n\n\n

\u901a\u5e38\u6765\u8bf4\uff0c\u5982\u679c\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u9ad8\uff08\u226550%\uff09\uff0c\u80bf\u7624\u7a81\u53d8\u8d1f\u8377TMB\u9ad8\uff0c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff08MSI-H\uff09\uff0c\u5219\u75c5\u4eba\u4f7f\u7528PD-1\u6548\u679c\u4f1a\u597d\u3002<\/p>\n\n\n\n

\u4e4b\u524d\u5df2\u7ecf\u7ed9\u5927\u5bb6\u79d1\u666e\u8fc7\uff0c\u5bf9\u4e8eEGFR\u7a81\u53d8\u800c\u8a00\uff0c\u4f7f\u7528PD-1\u7684\u6548\u679c\u4e0d\u597d\uff0c\u4e00\u822c\u662f\u4e0d\u63a8\u8350\u4f7f\u7528PD-1\u7c7b\u836f\u7269\u8fdb\u884c\u6cbb\u7597\u7684\u3002<\/p>\n\n\n\n

\u4f46\u5982\u679c\u662fEGFR\u7a81\u53d8\uff0c\u80bf\u7624\u7a81\u53d8\u8d1f\u8377TMB\u5374\u5f88\u9ad8\u7684\u60c5\u51b5\u5462\uff1f<\/strong><\/p>\n\n\n\n

\u8fd9\u79cd\u60c5\u51b5\u4e0bPD-1\u4f1a\u6709\u6548\u5417\uff1f<\/p>\n\n\n\n

\u7b54\u6848\u662f\u5426\u5b9a\u7684\u3002<\/p>\n\n\n\n

\u6587\u732e\u7814\u7a76\u8868\u660e\uff0cEGFR\u57fa\u56e0\u7a81\u53d8\u548c\u9ad8TMB\u8fd9\u4e24\u4e2a\u6307\u6807\u5982\u679c\u78b0\u5230\u4e00\u8d77\uff0c\u75c5\u4eba\u4f7f\u7528EGFR\u9776\u70b9\u9776\u5411\u836f\u7269\u7597\u6548\u5f80\u5f80\u8f83\u5dee\uff0cTP53\u57fa\u56e0\u7a81\u53d8\u5f80\u5f80\u53d1\u751f\u5728\u9ad8TMB\u7684\u75c5\u4eba\u4e2d\u3002<\/p>\n\n\n\n

\u76f8\u6bd4\u9776\u5411\u836f\u7269\u4f7f\u7528\u524d\uff0c\u75c5\u4ebaEGFR\u9776\u5411\u836f\u7269\u8010\u836f\u4e4b\u540e\u7684TMB\u8981\u9ad8\u5f88\u591a\uff0c\u4e5f\u5c31\u662f\u9ad8TMB\u5728EGFR\u9776\u5411\u836f\u7269\u6cbb\u7597\u4e2d\u751a\u81f3\u626e\u6f14\u4e86\u8d1f\u9762\u89d2\u8272\u3002<\/p>\n\n\n\n

\u6211\u4eec\u4e00\u8d77\u6765\u770b\u4e0b\u8fd9\u7bc7\u7814\u7a76\u6587\u732e\uff1a<\/p>\n\n\n\n

\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u9ad8\u5219\u9776\u5411\u6cbb\u7597\u6548\u679c\u5dee<\/strong><\/p>\n\n\n\n

2010\u5e741\u6708\u81f32017\u5e749\u6708\uff0c\u4e00\u51713077\u540d\u80ba\u764c\u60a3\u8005\u7684\u57fa\u56e0\u68c0\u6d4b\u7b5b\u51fa\u4e86783\u540d\uff0c\u8fd9\u4e9b\u75c5\u4eba\u5177\u6709EGFR\u57fa\u56e0\u7a81\u53d8\uff0c\u5176\u4e2d153\u540d\u75c5\u4eba\u7b26\u5408\u8bd5\u9a8c\u8981\u6c42\uff08\u4ece\u57fa\u56e0\u7a81\u53d8\u548c\u7528\u836f\u7b56\u7565\u6765\u8bc4\u4f30\uff09\u3002<\/p>\n\n\n\n

\u8fd9153\u540d\u75c5\u4eba\u4e2d\u768462%\u662f\u4e0d\u5438\u70df\u7684\uff0c39%\u662fL858R\u7a81\u53d8\uff0c92%\u7684\u75c5\u4eba\u4f7f\u7528\u7279\u7f57\u51ef\u4f5c\u4e3a\u7b2c\u4e00\u6b21\u9776\u5411\u6cbb\u7597\u836f\u7269\u3002<\/p>\n\n\n\n

1\uff09<\/strong>\u4e0eEGFR\u91ce\u751f\u578b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u75c5\u4eba\u76f8\u6bd4\uff0cEGFR\u7a81\u53d8\u7684\u75c5\u4ebaTMB\u8f83\u4f4e\u3002<\/p>\n\n\n\n

2\uff09<\/strong>EGFR\u57fa\u56e0L858R\u7a81\u53d8\u7684\u75c5\u4eba\u6bd419del\u75c5\u4eba\u7684TMB\u66f4\u9ad8\u3002<\/p>\n\n\n\n

3\uff09<\/strong>EGFR\u7a81\u53d8\u80ba\u764c\u75c5\u4eba\u7684TMB\u9ad8\u4f4e\u4e0d\u540c\uff0c\u5448\u73b0\u4e00\u4e2a\u8f83\u5927\u7684\u8303\u56f4\uff080.82-17.9\u7a81\u53d8\/Mb\uff09<\/p>\n\n\n\n

\u4e3a\u4e86\u8bc4\u4f30TMB\u5bf9EGFR\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4f7f\u7528\u9776\u5411\u836f\u7269\u7684\u5f71\u54cd\uff0c\u7814\u7a76\u8005\u6839\u636e\u75c5\u4eba\u7684TMB\u6570\u503c\uff0c\u5c06\u5176\u5206\u4e3a\u4f4eTMB\uff08\u22642.83\u7a81\u53d8\/Mb\uff09\u3001\u4e2dTMB\uff082.84-4.85\u7a81\u53d8\/Mb\uff09\u3001\u9ad8TMB\uff08\uff1e4.85\u7a81\u53d8\/Mb\uff09\u3002<\/p>\n\n\n\n

1\uff09<\/strong>\u505c\u836f\u524d\u6301\u7eed\u7528\u836f\u65f6\u95f4TTD\u8fd9\u4e2a\u6307\u6807\u770b\uff0c\u4e2d\u4f4eTMB\u7684\u75c5\u4eba\u663e\u8457\u957f\u4e8e\u9ad8TMB\u7684\u75c5\u4eba\u3002<\/p>\n\n\n\n

\u4e09\u7ec4\u75c5\u4eba\u7684\u505c\u836f\u524d\u6301\u7eed\u7528\u836f\u65f6\u95f4TTD\u5206\u522b\u4e3a\uff1a17\u4e2a\u6708\u300116\u4e2a\u6708\u548c10\u4e2a\u6708\u3002<\/p>\n\n\n\n

2\uff09<\/strong>\u4e0e\u9ad8TMB\u7684\u75c5\u4eba\u76f8\u6bd4\uff0c\u4f4e\u6216\u4e2d\u7b49TMB\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4f7f\u7528\u9776\u5411\u836f\u7269\u603b\u751f\u5b58\u65f6\u95f4OS\u597d\uff0c\u4e09\u7ec4\u75c5\u4eba\u7684OS\u5206\u522b\u4e3a41\u4e2a\u6708\uff08\u4f4eTMB\uff09\u300137\u4e2a\u6708\uff08\u4e2dTMB\uff09\u548c21\u4e2a\u6708\uff08\u9ad8TMB\uff09\u3002<\/p>\n\n\n\n

3\uff09<\/strong>TP53\u57fa\u56e0\u7a81\u53d8\u5219\u75c5\u4eba\u9776\u5411\u6cbb\u7597\u6548\u679c\u8f83\u5dee\uff0c\u4f46\u662f\u5728\u4f4eTMB\u3001\u4e2dTMB\u548c\u9ad8TMB\u75c5\u4eba\u4e2d\u89c2\u5bdfTP53\u7684\u57fa\u56e0\u7a81\u53d8\u72b6\u6001\u3002<\/p>\n\n\n\n

\u53d1\u73b0\u4e0d\u7ba1TP53\u7a81\u53d8\u4e0e\u5426\uff0cTMB\u9ad8\u4f4e\u5bf9\u4e8e\u9776\u5411\u836f\u7269\u6cbb\u7597\u7597\u6548\u7684\u5f71\u54cd\u90fd\u662f\u5b58\u5728\u7684\u3002<\/p>\n\n\n\n

4\uff09<\/strong>\u9ad8TMB\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u75c5\u4eba\u66f4\u5e38\u89c1TP53\u7a81\u53d8\uff0c\u53e6\u5916PIK3CA\u548cSMARCA4\u7a81\u53d8\u4e5f\u5e38\u89c1\u4e8e\u9ad8TMB\u7684\u80ba\u764c\u75c5\u4eba\u3002<\/p>\n\n\n\n

5\uff09<\/strong>30\u4e2a\u75c5\u4eba\u5728\u9776\u5411\u836f\u7269\u4f7f\u7528\u524d\u548c\u9776\u5411\u836f\u7269\u8010\u836f\u540e\u8fdb\u884c\u4e86TMB\u7684\u68c0\u6d4b\uff0c\u53d1\u73b0TMB\u5728\u9776\u5411\u836f\u7269\u8010\u836f\u4e4b\u540e\u663e\u8457\u5347\u9ad8\u3002\u9776\u5411\u836f\u7269\u4e4b\u524d\u7684TMB\u4e2d\u4f4d\u6570\u662f3.41\u7a81\u53d8\/Mb\uff0c\u800c\u9776\u5411\u836f\u7269\u8010\u836f\u4e4b\u540e\u662f6.56\u7a81\u53d8\/Mb\u3002<\/p>\n\n\n\n

TMB\u4e3a\u4f55\u5f71\u54cd\u9776\u5411\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n\n\n\n

TMB\u7684\u5b9a\u4e49\u5c31\u662f\u6bcf\u4e00\u6bb5\u80bf\u7624\u7ec6\u80de\u7684\u57fa\u56e0\u5e8f\u5217\u4e0a\u5e73\u5747\u7684\u7a81\u53d8\u6570\u76ee\uff0c\u4e5f\u5c31\u662f\u8d8a\u662f\u8fd9\u4e2a\u6570\u503c\u9ad8\uff0c\u5219\u8bf4\u660e\u80bf\u7624\u7ec6\u80de\u7684\u57fa\u56e0\u5e8f\u5217\u91cc\u8d8a\u662f\u7a81\u53d8\u591a\uff0c\u53ef\u80fd\u5c31\u88ab\u8fd9\u4e9b\u574f\u86cb\u4eec\u6478\u5230\u4e00\u4e2a\u7a81\u53d8\uff0c\u53ef\u4ee5\u5bf9\u9776\u5411\u836f\u7269\u8010\u836f\uff0c\u6bd4\u5982EGFR\u57fa\u56e0\u7684T790M\u7a81\u53d8\u3002<\/p>\n\n\n\n

\u6240\u4ee5\u9ad8TMB\u7684\u75c5\u4eba\u4f7f\u7528\u9776\u5411\u836f\u7269\u7684\u7597\u6548\u65f6\u95f4\u77ed\uff0c\u8fd9\u4e2a\u4ece\u7406\u8bba\u4e0a\u662f\u5408\u4e4e\u903b\u8f91\u7684\u3002\u5f53\u672c\u7bc7\u7814\u7a76\u4e2d\u4e5f\u8bc1\u660e\u5b9e\u9645\u6cbb\u7597\u786e\u5b9e\u5982\u6b64\u3002<\/p>\n\n\n\n

\u7ec6\u5fc3\u7684\u8bfb\u8005\u53ef\u80fd\u4f1a\u6ce8\u610f\u5230\u4e86\uff0cEGFR\u9776\u5411\u836f\u7269\u8010\u836f\u4e4b\u540e\u80bf\u7624\u7a81\u53d8\u8d1f\u8377TMB\u589e\u52a0\u4e86\uff0c\u800c\u9ad8TMB\u7684\u75c5\u4eba\u5f80\u5f80\u53ef\u4ee5\u4ecePD-1\u6cbb\u7597\u83b7\u76ca\u3002<\/p>\n\n\n\n

\u90a3\u4e48\u662f\u4e0d\u662f\u8bf4\u660eEGFR\u57fa\u56e0\u7a81\u53d8\u7684\u75c5\u4eba\u5728\u9776\u5411\u836f\u7269\u8010\u836f\u4e4b\u540e\uff0c\u53ef\u4ee5\u4f7f\u7528PD-1\u836f\u7269\u6cbb\u7597\u4e86\u5462\uff1f<\/p>\n\n\n\n

\u5bf9\u4e8e\u8fd9\u4e2a\u95ee\u9898\uff0c\u7814\u7a76\u8005\u63a8\u7406\u8fd9\u4e00\u7b56\u7565\u53ef\u80fd\u4e0d\u5927\u7ba1\u7528\u3002<\/p>\n\n\n\n

\u9776\u5411\u836f\u7269\u4f7f\u7528\u4e4b\u524d\uff0c\u5c31\u5b58\u5728\u4e00\u4e9b\u8010\u836f\u7684\u764c\u7ec6\u80de\u4e9a\u514b\u9686\uff0c\u9776\u5411\u836f\u7269\u4f7f\u7528\u65f6\u5019\u8fd9\u4e9b\u4e9a\u514b\u9686\u6570\u91cf\u589e\u591a\uff0c\u8fd9\u5bfc\u81f4TMB\u6570\u503c\u53d8\u9ad8\uff0c\u8fd9\u4e9b\u539f\u672c\u5c31\u5b58\u5728\u7684\u764c\u7ec6\u80de\u4e9a\u514b\u9686\u6570\u76ee\u589e\u52a0\u5e76\u4e0d\u4f1a\u589e\u52a0\u6709\u6548\u7684\u514d\u75ab\u6297\u539f\u3002<\/p>\n\n\n\n

\u4e5f\u5c31\u662f\u9776\u5411\u836f\u7269\u6cbb\u7597\u4e4b\u524d\u7684\u9ad8TMB\u662f\u8868\u660e\u764c\u7ec6\u80de\u7684\u57fa\u56e0\u7a81\u53d8\u771f\u662f\u4e71\uff0c\u6709\u5f88\u591a\u7684\u514d\u75ab\u539f\u88ab\u514d\u75abT\u7ec6\u80de\u8bc6\u522b\u3002<\/p>\n\n\n\n

\u800c\u9776\u5411\u836f\u7269\u8010\u836f\u589e\u52a0\u7684TMB\u5e76\u4e0d\u662f\u771f\u6b63\u589e\u52a0\u8fd9\u79cd\u514d\u75ab\u539f\uff0c\u53ea\u662f\u5c06\u539f\u672c\u5b58\u5728\u7684\u591a\u79cd\u8010\u836f\u764c\u7ec6\u80de\u7684\u6570\u76ee\u589e\u52a0\u4e86\u800c\u5df2\u3002<\/p>\n\n\n\n

\u8fd9\u4e2a\u8bf4\u6cd5\u4e0d\u662f\u5f88\u597d\u7406\u89e3\uff0c\u5f53\u7136\u4e5f\u662f\u7814\u7a76\u8005\u81ea\u5df1\u4e00\u5bb6\u4e4b\u8a00\uff0c\u4e0d\u4e00\u5b9a\u6b63\u786e\uff0c\u5b9e\u9645\u60c5\u51b5\u5982\u4f55\u9700\u8981\u53c2\u8003\u771f\u6b63\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u624d\u80fd\u77e5\u6653\u3002<\/p>\n\n\n\n

\u5f53EGFR\u7a81\u53d8\u9047\u5230\u9ad8TMB\uff0c\u6211\u4eec\u600e\u4e48\u529e\uff1f<\/strong><\/p>\n\n\n\n

\u8bf4\u5b8c\u4e86\u4e0a\u9762\u7684\u4e00\u4e9b\u7814\u7a76\u5185\u5bb9\uff0c\u90a3\u4e48\u6211\u4eec\u63a8\u7406\u5982\u679cEGFR\u662f\u7a81\u53d8\u4e86\u3002\u800c\u4e14TMB\u662f\u9ad8\u7684\uff0c\u90a3\u4e48\u7a76\u7adf\u8be5\u600e\u4e48\u529e\uff1f<\/p>\n\n\n\n

\u6709\u4e0b\u9762\u4e24\u4e2a\u6ce8\u610f\u4e8b\u9879\u3002<\/p>\n\n\n\n

1\uff09<\/strong>\u4ece\u6cbb\u7597\u7b56\u7565\u770b\uff0c\u7814\u7a76\u8005\u7684\u7ed3\u8bba\u662f\u6839\u636eEGFR\u7a81\u53d8\u9009\u62e9\u9776\u5411\u6cbb\u7597\uff0c\u5373\u4fbf\u662f\u9776\u5411\u836f\u7269\u8010\u836f\u4e4b\u540eTMB\u9ad8\u4e86\uff0c\u4e5f\u4e0d\u652f\u6301\u9009\u62e9\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n\n\n\n

2\uff09<\/strong>\u5f53EGFR\u57fa\u56e0\u7a81\u53d8\uff0c\u800c\u4e14TMB\u8fd8\u662f\u9ad8\u7684\u8be5\u600e\u4e48\u529e\uff1f<\/p>\n\n\n\n

\u8fd9\u91cc\u6ca1\u6709\u66f4\u660e\u786e\u7684\u6307\u5bfc\u7b56\u7565\uff0c\u5012\u662f\u6709\u7814\u7a76\u8005\u8bc4\u8bba\u672c\u7814\u7a76\u7ed9\u51fa\u9776\u5411\u836f\u7269\u8054\u5408\u5316\u7597\u7684\u6cbb\u7597\u7b56\u7565\u3002\u5173\u4e8e\u8fd9\u4e2a\u8bfb\u8005\u53ef\u4e0e\u4e3b\u6cbb\u533b\u751f\u6c9f\u901a\u786e\u5b9a\u3002<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n

1\u3001Cheng ML ,et al., Does TMB impact the effectiveness of TKIs in EGFR-mutant NSCLC? Clin Cancer Res. 2018 Sep 6.<\/p>\n\n\n\n

2\u3001Offin M, et al., Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Lung Cancers.Clin Cancer Res. 2018 Jul 25<\/p>\n","protected":false},"excerpt":{"rendered":"

\u80ba\u764c\u4e2d\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u817a\u764c\u6709\u8f83\u9ad8\u7684\u6bd4\u4f8b\u662fEGFR\u57fa\u56e0\u7a81\u53d8\uff0c\u5f53\u51fa\u73b0\u8fd9\u4e2a\u57fa\u56e0\u7a81\u53d8\u4e4b\u540e\u75c5\u4eba\u53ef\u4ee5\u4f7f\u7528\u9776\u5411\u836f\u7269\u5982\u7279\u7f57\u51ef\u3001\u6613\u745e\u6c99\u7b49\u8fdb\u884c\u9776\u5411\u6cbb\u7597\u3002 \u76ee\u524d\u5927\u70ed\u7684PD-1\u7c7b\u836f\u7269\u5982O\u836f\u548cK\u836f\u4e5f\u5df2\u7ecf\u76f8\u7ee7\u83b7\u6279\u4e0a\u5e02\uff0c\u9884\u6d4bPD-1\u7c7b\u836f\u7269\u7684\u751f\u7269\u6807\u5fd7\u7269\u6709PD-L1\u8868\u8fbe\uff0c\u80bf\u7624\u7a81 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"topic":[],"class_list":["post-51","post","type-post","status-publish","format-standard","hentry","category-zuixinfangan"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/51","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51"}],"version-history":[{"count":1,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/51\/revisions"}],"predecessor-version":[{"id":52,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/51\/revisions\/52"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=51"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}