{"id":49,"date":"2023-09-18T12:39:21","date_gmt":"2023-09-18T04:39:21","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=49"},"modified":"2023-09-18T12:39:22","modified_gmt":"2023-09-18T04:39:22","slug":"%e9%92%88%e5%af%b9%e5%ae%9e%e4%bd%93%e8%82%bf%e7%98%a4-%e7%a5%9e%e5%a5%87%e7%9a%84bcl-2%e6%8a%91%e5%88%b6%e5%89%82%e8%83%bd%e5%90%a6%e5%86%8d%e6%8e%80%e6%b3%a2%e6%be%9c%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=49","title":{"rendered":"\u9488\u5bf9\u5b9e\u4f53\u80bf\u7624 \u795e\u5947\u7684BCL-2\u6291\u5236\u5242\u80fd\u5426\u518d\u6380\u6ce2\u6f9c\uff1f"},"content":{"rendered":"\n

\u7528\u4e8e\u81f3\u5c11\u7ecf\u8fc7\u4e00\u79cdEGFR\u9776\u5411\u836f\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80ba\u764c\u60a3\u8005\uff0c\u6297\u764c\u6709\u6548\u7387\u9ad8\u8fbe100%\uff0c\u4e2d\u4f4d\u65e0\u75be\u75c5\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\uff08mPFS\uff09\u4e3a16.8\u4e2a\u6708\u3002<\/p>\n\n\n\n

\u521b\u9020\u8fd9\u9879\u4f18\u5f02\u6570\u636e\u7684\u836f\u7269\u5e76\u975e\u795e\u79d8\u7684\u5728\u7814\u65b0\u836f\uff0c\u800c\u662f\u4e00\u79cd\u7528\u4e8e\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u6025\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08AML\uff09\u7b49\u8840\u6db2\u80bf\u7624\u7684\u836f\u7269\u3002\u6ca1\u9519\uff0c\u5b83\u8fde\u80ba\u764c\u836f\u90fd\u4e0d\u662f\uff01\u90a3\u4e48\u7a76\u7adf\u662f\u4f55\u65b9\u201c\u795e\u5723\u201d\u53ef\u4ee5\u6709\u5982\u6b64\u5a01\u529b\u5462\uff1f<\/p>\n\n\n\n

BCL-2\u6291\u5236\u5242<\/strong><\/p>\n\n\n\n

B\u7ec6\u80de\u6dcb\u5df4\u7624\/\u767d\u8840\u75c5-2\u57fa\u56e0\uff08B-cell lymphoma-2\uff0cBCL-2\uff09\u662f\u7ec6\u80de\u51cb\u4ea1\u7814\u7a76\u4e2d\u6700\u53d7\u91cd\u89c6\u7684\u764c\u57fa\u56e0\u4e4b\u4e00\uff0c\u5b83\u5177\u6709\u660e\u663e\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\u7684\u4f5c\u7528\u3002\u5728\u8be5\u57fa\u56e0\u88ab\u53d1\u73b0\u540e\u4e0d\u4e45\uff0c\u836f\u7269\u5f00\u53d1\u8005\u5c31\u8fc5\u901f\u610f\u8bc6\u5230BCL-2\u6291\u5236\u5242\u6cbb\u7597\u764c\u75c7\u7684\u6f5c\u5728\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n

\u4f46\u7531\u4e8e\u5f00\u53d1\u96be\u5ea6\u5927\uff0c\u5728BCL-2\u88ab\u53d1\u73b0\u768430\u591a\u5e74\u5185\u90fd\u4e0d\u66fe\u6709\u76f8\u5e94\u7684\u9776\u5411\u836f\uff0c\u76f4\u52302016\u5e74FDA\u6279\u51c6\u4e86\u9996\u6b3eBCL-2\u6291\u5236\u5242\u7ef4\u5948\u6258\u514b(venetoclax)\u4e0a\u5e02\u624d\u8ba9\u8be5\u9776\u70b9\u83b7\u5f97\u4e86\u4ef7\u503c\u3002\u5728\u4e0a\u5e02\u4e4b\u540e\uff0c\u7ef4\u5948\u6258\u514b\u51ed\u501f\u5176\u4f18\u5f02\u7684\u6cbb\u7597\u6548\u679c\u4e0e\u5f88\u5f3a\u7684\u836f\u7269\u8f85\u52a9\u4f5c\u7528\uff0c\u63a5\u8fde\u65a9\u4e0b3\u9879\u9002\u5e94\u75c7\u3002<\/p>\n\n\n\n

\u7ef4\u5948\u6258\u514b\u83b7\u6279\u9002\u5e94\u75c7\u5305\u62ec\uff1a<\/strong><\/p>\n\n\n\n

    \n
  1.  \u4e8c\u7ebf\u6cbb\u7597\u67d3\u8272\u4f5317p\u7f3a\u5931\u5f02\u5e38\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(CLL);<\/li>\n\n\n\n
  2. \u8054\u5408\u5229\u59a5\u6614\u5355\u6297\u4e8c\u7ebf\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624(SLL);<\/li>\n\n\n\n
  3. \u8054\u5408\u963f\u624e\u80de\u82f7\/\u5730\u897f\u4ed6\u6ee8\/\u963f\u7cd6\u80de\u82f7\u4e00\u7ebf\u6cbb\u7597\u4e0d\u9002\u5408\u6807\u51c6\u8bf1\u5bfc\u6cbb\u7597\u7684\u6025\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/li>\n<\/ol>\n\n\n\n

    \u4e0d\u96be\u53d1\u73b0\uff0c\u4e09\u9879\u83b7\u6279\u9002\u5e94\u75c7\u4e2d\u6709\u4e24\u9879\u662f\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u5408\u4f7f\u7528\u7684\u3002\u8fd9\u662f\u7531\u4e8eBCL-2\u6291\u5236\u5242\u7684\u836f\u7269\u7279\u6027\u51b3\u5b9a\u7684\uff0c\u5b83\u4e0d\u4ec5\u53ef\u4ee5\u5355\u72ec\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u8fd8\u53ef\u4ee5\u4e0e\u5176\u4ed6\u6297\u764c\u836f\u8054\u5408\u4f7f\u7528\u589e\u5f3a\u764c\u7ec6\u80de\u5bf9\u836f\u7269\u7684\u654f\u611f\u6027\u3002<\/p>\n\n\n\n

    BCL-2\u57fa\u56e0\u9664\u4e86\u5728\u8840\u6db2\u80bf\u7624\u4e2d\u6709\u53d1\u73b0\uff0c\u5728\u5982\u80ba\u764c\u3001\u98df\u7ba1\u764c\u3001\u80c3\u764c\u3001\u809d\u764c\u3001\u80f0\u817a\u764c\u7b49\u5b9e\u4f53\u7624\u4e5f\u53d1\u73b0\u4e86\u5176\u8eab\u5f71\u3002\u56e0\u6b64\uff0c\u5c06BCL-2\u6291\u5236\u5242\u7528\u4e8e\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u4e5f\u5c31\u987a\u7406\u6210\u7ae0\u3002\u4f46BCL-2\u6291\u5236\u5242\u7684\u201c\u8de8\u754c\u201d\u4e4b\u8def\u5e76\u4e0d\u987a\u5229\uff0c\u4e4b\u524d\u5355\u836f\u7528\u4e8e\u80ba\u764c\u3001\u98df\u7ba1\u764c\u7b49\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u672a\u6536\u5230\u4ee4\u4eba\u6ee1\u610f\u7684\u6210\u679c\u3002\u4e8e\u662f\u5927\u5bb6\u5f00\u59cb\u628a\u76ee\u5149\u8f6c\u5411BCL-2\u6291\u5236\u5242\u8054\u5408\u5176\u4ed6\u6297\u764c\u836f\u7269\u6765\u5bf9\u6297\u5b9e\u4f53\u80bf\u7624\u3002\u8fd9\u6b21\uff0c\u7ec8\u4e8e\u6536\u83b7\u4e86\u4e00\u4e9b\u632f\u594b\u4eba\u5fc3\u7684\u6d88\u606f\u3002<\/p>\n\n\n\n

    BCL-2\u6291\u5236\u5242\u4e0e\u5965\u5e0c\u66ff\u5c3c\u8054\u7528<\/strong><\/p>\n\n\n\n

    \u65e5\u524d\uff0c\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u9644\u5c5e\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u4e2d\u5fc3\u7684PasiA. Janne\u6559\u6388\u5f00\u5c55\u4e86\u4e00\u9879BCL-2\u6291\u5236\u5242Navitoclax\uff08\u5c5e\u4e8e\u7ef4\u5948\u6258\u514b\u7684\u524d\u8eab\uff09\u4e0e\u7b2c\u4e09\u4ee3EGFR\u9776\u5411\u6291\u5236\u5242\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u4f7f\u7528\u7528\u4e8e\u6cbb\u7597\u665a\u671fEGFR\u7a81\u53d8\u7684\u80ba\u764c\u60a3\u8005\u7684\u8bd5\u9a8c\u3002<\/p>\n\n\n\n

    \u8be5\u7814\u7a76\u5171\u7eb3\u516527\u540d\u81f3\u5c11\u7ecf\u8fc7\u4e00\u79cdEGFR\u9776\u5411\u836f\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80ba\u764c\u60a3\u8005\uff08\u5916\u663e\u5b5019 del 48%\uff0cL858R 37%\uff09\uff0c\u5176\u4e2d24\u4eba\u63a5\u53d7\u8fc7\u7279\u7f57\u51ef\u6cbb\u7597\uff0c6\u4eba\u63a5\u53d7\u8fc7\u6cf0\u745e\u6c99\u6cbb\u7597\uff0c10\u4eba\u5df2\u7ecf\u63a5\u53d7\u8fc7\u5316\u7597\uff0c2\u4eba\u8fd8\u5c1d\u8bd5\u8fc7\u514d\u75ab\u6cbb\u7597\uff0c\u4f46\u90fd\u4ee5\u5931\u8d25\u544a\u7ec8\u3002\u5bf9\u4ed6\u4eec\u4f7f\u752840-80mg\u5965\u5e0c\u66ff\u5c3c\u548c150-325mg\u7684Navitoclax\uff0c\u5171\u5206\u4e3a5\u4e2a\u5242\u91cf\u6c34\u5e73\u3002<\/p>\n\n\n\n

    \u7ed3\u679c\u663e\u793a\uff1a\u5728\u6700\u521d\u7684\u5242\u91cf\u722c\u5761\u9636\u6bb5\u768418\u4eba\u4e2d\uff0c\u6297\u764c\u63a7\u5236\u7387\u4e3a78%\uff0c\u4e2d\u4f4d\u65e0\u75be\u75c5\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\u4e3a7.6\u4e2a\u6708\uff1b\u5728\u540e\u7eed\u7684\u5242\u91cf\u62d3\u5c55\u76849\u4eba\u4e2d\uff0c1\u4eba\u80bf\u7624\u5b8c\u5168\u6d88\u5931\u30018\u4eba\u80bf\u7624\u660e\u663e\u7f29\u5c0f\uff0c\u6297\u764c\u6709\u6548\u7387\u9ad8\u8fbe100%\uff0c\u4e2d\u4f4d\u65e0\u75be\u75c5\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\u4e3a16.8\u4e2a\u6708\u3002<\/p>\n\n\n\n

    \u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\uff0837%\uff09\uff0c\u75b2\u52b3\uff0822%\uff09\uff0c\u6076\u5fc3\uff0822%\uff09\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0837%\uff09\u3002\u65e9\u53d1\u6027\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u7684\u51fa\u73b0\u8bc1\u660e\u4e86navitoclax\u5177\u6709\u4fc3\u7ec6\u80de\u51cb\u4ea1\u4f5c\u7528\u3002\u4f46\u4e5f\u9700\u8981\u6ce8\u610f\u5965\u5e0c\u66ff\u5c3c\u4e5f\u540c\u6837\u5177\u6709\u8840\u5c0f\u677f\u51cf\u5c11\u7684\u526f\u4f5c\u7528\uff0c\u4e8c\u8005\u53e0\u52a0\u53ef\u80fd\u4f1a\u5e26\u6765\u6bd4\u8f83\u4e25\u91cd\u7684\u8840\u5c0f\u677f\u7f3a\u4e4f\uff0c\u9700\u8981\u53ca\u65f6\u670d\u7528\u5347\u767d\u836f\u7269\u6216\u6ce8\u5c04\u5347\u767d\u9488\u3002<\/p>\n\n\n\n

    \u7ed3\u8bba\uff1anavitoclax\u548c\u5965\u5e0c\u66ff\u5c3c\u8054\u5408\u4f7f\u7528\u5b89\u5168\u53ef\u884c\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u4e34\u5e8a\u7597\u6548\u3002<\/p>\n\n\n\n

    BCL-2\u6291\u5236\u5242\u4e0e\u5316\u7597\u8054\u7528<\/strong><\/p>\n\n\n\n

    \u65e0\u72ec\u6709\u5076\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684Shumei Song\u535a\u58eb\u548c\u5176\u56e2\u961f\u5728\u80c3\u80a0\u80bf\u7624\u9886\u57df\u9876\u5c16\u5b66\u672f\u6742\u5fd7\u300aGut\u300b\u520a\u8f7d\u4e86\u4e00\u9879\u5173\u4e8eBCL-2\u6291\u5236\u5242\u4e0e\u5316\u7597\u8054\u5408\u7528\u4e8e\u98df\u9053\u764c\u60a3\u8005\u7684\u7814\u7a76\u3002\u8be5\u7814\u7a76\u540c\u6837\u8bc1\u5b9e\u4e86BCL-2\u6291\u5236\u5242\u5728\u5b9e\u4f53\u80bf\u7624\u6cbb\u7597\u7684\u53ef\u80fd\u3002<\/p>\n\n\n\n

    \u8be5\u7814\u7a76\u524d\u671f\u5148\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\u89c2\u5bdf\u5230\u4e86BCL-2\u6291\u5236\u5242AT-101\u51cf\u5c11\u4e86\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u5e76\u4e14\u53ef\u589e\u5f3a\u591a\u897f\u4ed6\u8d5b\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u7684\u4f5c\u7528\u3002\u4e4b\u540e\u5171\u53ec\u96c613\u4f8b\u98df\u9053\u764c\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u653e\u7597\u7684\u540c\u65f6\u53e3\u670dAT-101\u3002\u5176\u4e2d6\u540d\u60a3\u8005\u63a5\u53d7\u7684\u662f10mg\u6bcf\u5929\u4e00\u6b21\u7684\u4f4e\u5242\u91cf\uff0c\u672a\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff1b\u53e6\u59167\u540d\u60a3\u8005\u63a5\u53d720mg\u6bcf\u5929\u4e00\u6b21\u7684\u9ad8\u5242\u91cf\uff0c\u9ad8\u5242\u91cf\u7ec4\u51fa\u73b0\u4e86\u4e00\u5b9a\u7a0b\u5ea6\u7684\u5fc3\u810f\u6bd2\u6027\uff0c\u4e0d\u8fc7\u5c1a\u5728\u53ef\u63a7\u5236\u7684\u8303\u56f4\u5185\u3002<\/p>\n\n\n\n

    \u517111\u540d\u53d7\u8bd5\u8005\u5b8c\u6574\u5730\u63a5\u53d7\u4e86\u65e2\u5b9a\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u8fd911\u4f4d\u60a3\u8005\u5747\u5b9e\u73b0\u4e86\u4e34\u5e8a\u5b66\u8bca\u65ad\u7684\u80bf\u7624\u5b8c\u5168\u6d88\u5931\uff08CR\uff09\uff0c\u6297\u764c\u6709\u6548\u7387\u540c\u6837\u9ad8\u8fbe100%\uff0c\u5df2\u6709\u60a3\u8005\u7597\u6548\u6301\u7eed\u65f6\u95f4\u8d85\u8fc75\u5e74\u3002<\/p>\n\n\n\n

    \u4e24\u4f8b\u63a5\u53d7AT-101\u4e0e\u5316\u7597\u8054\u5408\u6cbb\u7597\u80bf\u7624\u5b8c\u5168\u6d88\u5931\u7684\u6848\u4f8b<\/p>\n\n\n\n

    \u7ed3\u8bba\uff1aBCL-2\u6291\u5236\u5242\u53ef\u901a\u8fc7\u764c\u75c7\u5e72\u7ec6\u80de\u7684\u9014\u5f84\u514b\u670d\u8010\u836f\u6027\uff0c\u5728\u98df\u9053\u764c\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u79ef\u6781\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n\n\n\n

    \u603b\u7ed3<\/strong><\/p>\n\n\n\n

    \u4e0a\u8ff0\u7684\u4e24\u9879\u8bd5\u9a8c\u867d\u90fd\u4e3a\u524d\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e14\u89c4\u6a21\u8f83\u5c0f\uff0c\u8bd5\u9a8c\u53c2\u4e0e\u4eba\u6570\u8f83\u5c11\uff0c\u4f46\u90fd\u8bc1\u5b9e\u4e86BCL-2\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u5408\u7528\u4e8e\u5b9e\u4f53\u80bf\u7624\u6cbb\u7597\u7684\u53ef\u884c\u6027\u3002\u4e3a\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u4ee5\u53ca\u836f\u7269\u7684\u589e\u654f\u548c\u8010\u836f\u5904\u7406\u63d0\u4f9b\u4e86\u5207\u5b9e\u53ef\u884c\u7684\u601d\u8def\u3002<\/p>\n\n\n\n

    \u76f8\u4fe1\u672a\u6765BCL-2\u6291\u5236\u5242\u4f1a\u5728\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u4e0a\u53d1\u6325\u66f4\u591a\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

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    [1] Bertino E M , Gentzler R D , Clifford S E , et al. Phase IB study of osimertinib in combination with navitoclax in EGFR-mutant NSCLC following resistance to initial EGFR therapy (ETCTN 9903)[J]. Clinical Cancer Research, 2020:clincanres.4084.2020.<\/p>\n\n\n\n

    [2] Song S , Chen Q , Li Y , et al. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma[J]. Gut, 2021:gutjnl-2020-321175.<\/p>\n","protected":false},"excerpt":{"rendered":"

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