{"id":41,"date":"2023-09-18T12:09:35","date_gmt":"2023-09-18T04:09:35","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=41"},"modified":"2023-09-18T12:09:36","modified_gmt":"2023-09-18T04:09:36","slug":"%e8%89%be%e6%bb%8b%e7%97%85hiv%e6%8a%97%e7%97%85%e6%af%92%e6%b2%bb%e7%96%97%e7%9a%84%e8%8d%af%e7%89%a9%e8%80%90%e8%8d%af%e8%a7%a3%e5%86%b3%e6%96%b9%e6%a1%88","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=41","title":{"rendered":"\u827e\u6ecb\u75c5HIV\u6297\u75c5\u6bd2\u6cbb\u7597\u7684\u836f\u7269\u8010\u836f\u89e3\u51b3\u65b9\u6848"},"content":{"rendered":"\n

\u968f\u7740\u9ad8\u6548\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\uff08HAART\uff09\u7684\u5e7f\u6cdb\u5f00\u5c55\uff0c\u827e\u6ecb\u75c5\u75c5\u6bd2\uff08HIV\uff09\u8010\u836f\u6027\u53d8\u5f02\u7684\u51fa\u73b0\u53ca\u8010\u836f\u682a\u7684\u4f20\u64ad\uff0c\u4ece\u800c\u5bfc\u81f4HAART\u5931\u8d25\u7684\u95ee\u9898\uff0c\u8fd1\u5e74\u6765\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002\u5728\u8010\u836f\u7a81\u53d8\u7684\u9010\u6e10\u7d2f\u79ef\u4ee5\u53ca\u836f\u7269\u9009\u62e9\u538b\u529b\u7684\u53cc\u91cd\u4f5c\u7528\u4e0b\uff0cHIV\u6700\u7ec8\u53ef\u4ee5\u53d1\u5c55\u4e3a\u5bf9\u540c\u4e00\u7c7b\u522b\u4e2d\u4e0d\u540c\u836f\u7269\uff0c\u751a\u81f3\u4e0d\u540c\u7c7b\u522b\u836f\u7269\u7684\u4ea4\u53c9\u8010\u836f\uff0c\u5bf9HIV\u8010\u836f\u673a\u5236\u7684\u9610\u660e\u4ee5\u53ca\u8010\u836f\u68c0\u6d4b\u65b9\u6cd5\u7684\u6539\u8fdb\uff0c\u5bf9\u4e8e\u6307\u5bfc\u4e34\u5e8a\u6cbb\u7597\u51cf\u5c11\u8010\u836f\u53d1\u751f\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n\n\n\n

1\u3001HIV\uff0fAIDS\u836f\u7269\u6cbb\u7597\u65b9\u6848<\/h3>\n\n\n\n

\u76ee\u524d\u7528\u6765\u6cbb\u7597HIV\u611f\u67d3\u7684\u836f\u7269\u4e3b\u8981\u6709\u516d\u7c7b\uff1a\u6838\u82f7\u7c7b\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\uff08NRTIs\uff09\uff1b\u975e\u6838\u82f7\u7c7b\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\uff08NNRTIs\uff09\uff1b\u86cb\u767d\u9176\u6291\u5236\u5242\uff08PIs\uff09\uff1b\u6574\u5408\u9176\u6291\u5236\u5242\uff1b\u8fdb\u5165\u6291\u5236\u5242\uff08EIs\uff09\uff1bCCR5\u6291\u5236\u5242\u3002<\/p>\n\n\n\n

\u4e34\u5e8a\u4e0a\u901a\u5e38\u91c7\u7528\u8054\u5408\u7528\u836f\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u4e24\u79cdNRTIs\u548c\u4e00\u79cdPIs\u6216\u8005\u4e00\u79cdNNRTIs\u3002\u6297\u75c5\u6bd2\u836f\u7269\u5728\u7814\u5236\u4e2d\u5b58\u5728\u91cd\u5927\u6280\u672f\u969c\u788d\uff0cHIV\u8010\u836f\u682a\u5df2\u6210\u4e3a\u533b\u5b66\u754c\u9762\u4e34\u7684\u4e00\u4e2a\u65b0\u6311\u6218\u3002\u7531\u4e8eHIV\u7e41\u6b96\u5b58\u5728\u9519\u8bef\u7387\u9ad8\u7684\u9006\u8f6c\u5f55\u8fd9\u4e00\u72ec\u7279\u7684\u590d\u5236\u8fc7\u7a0b\uff0c\u56e0\u6b64\uff0c\u5728\u836f\u7269\u6cbb\u7597\u4e2d\u4e5f\u6700\u6613\u51fa\u73b0\u8010\u836f\u6027\u3002\u968f\u7740\u7528\u836f\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u8010\u836f\u6bd2\u682a\u4e5f\u4f1a\u4ece\u6297\u4e00\u79cd\u836f\u7269\u53d1\u5c55\u5230\u6297\u591a\u79cd\u836f\u7269\u3002<\/p>\n\n\n\n

2\u3001HIV\u8010\u836f\u7c7b\u578b<\/h3>\n\n\n\n

2.1\u539f\u53d1\u6027\u8010\u836f<\/strong> \u539f\u53d1\u6027\u8010\u836f\u6307\u4ece\u672a\u63a5\u53d7\u8fc7\u6297\u827e\u6ecb\u75c5\u75c5\u6bd2\u836f\u7269\u7684\u827e\u6ecb\u75c5\u75c5\u4eba\uff0cHIV\u6bd2\u682a\u682a\u5bf91\u79cd\u6216\u591a\u79cd\u6297HIV\u836f\u7269\u8010\u836f\uff0c\u4e00\u822c\u662f\u7531\u8010\u836fHIV\u4f20\u64ad\u5f15\u8d77\u3002\u7814\u7a76\u663e\u793a\uff0c\u4e0d\u540c\u5730\u533a\u6d41\u884c\u7684\u4e3b\u8981HIV-1\u8010\u836f\u682a\u5448\u73b0\u5f88\u5927\u7684\u53d8\u5f02\u6027\uff0c\u800c\u4e14\u8fd9\u79cd\u53d8\u5f02\u6027\u6709\u5347\u9ad8\u7684\u8d8b\u52bf\u3002\u867d\u7136\u539f\u53d1\u611f\u67d3\u7684\u8010\u836f\u682a\u5927\u591a\u6765\u81ea\u5931\u8d25\u7684HAART\u6cbb\u7597\uff0c\u4f46\u662f\u4e00\u4e9bHIV\u6bd2\u682a\u5929\u751f\u5c31\u5bf9\u4e00\u79cd\u6216\u591a\u79cd\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u4ea7\u751f\u8010\u836f\u3002<\/p>\n\n\n\n

2.2\u8bf1\u5bfc\u578b\u8010\u836f<\/strong>\uff08\u4e5f\u79f0\u7ee7\u53d1\u6027\u8010\u836f<\/strong>\uff09\u8bf1\u5bfc\u578b\u8010\u836f\u7684\u53d1\u751f\u53d1\u5c55\u4e0eHIV\u5728\u5bbf\u4e3b\u4f53\u5185\u7684\u590d\u5236\u548c\u611f\u67d3\u7279\u5f81\u6709\u5173\u3002\u8054\u5408\u7528\u836f\u53ef\u4ee5\u963b\u6b62HIV\u8bf1\u5bfc\u578b\u8010\u836f\u7684\u9009\u62e9\u8fc7\u7a0b\u4e3b\u8981\u6709\u4e24\u65b9\u9762\u539f\u56e0\uff1a\u7b2c\u4e00\uff0cHIV\u5bf9\u6240\u6709\u6cbb\u7597\u836f\u7269\u5747\u8010\u836f\u9700\u8981\u591a\u91cd\u673a\u5236\uff08\u9488\u5bf9\u6bcf\u79cd\u836f\u7269\u8010\u836f\u9700\u8981\u4e0d\u540c\u7684\u7a81\u53d8\uff09\uff0c\u5373\u4f7f\u6cbb\u7597\u524d\u5b58\u5728\u5c11\u91cf\u5bf9\u4e2a\u522b\u836f\u7269\u7684\u6f5c\u5728\u8010\u836f\u7a81\u53d8\uff0c\u8fd9\u4e9b\u7a81\u53d8\u4e5f\u4e0d\u53ef\u80fd\u5bf9\u6240\u6709\u836f\u7269\u5747\u8010\u836f\u3002\u7b2c\u4e8c\uff0c\u8054\u5408\u7528\u836f\u6bd4\u5355\u72ec\u7528\u836f\u53ef\u4ee5\u66f4\u6709\u6548\u5730\u6291\u5236HIV\u590d\u5236\uff0c\u963b\u6b62\u65b0\u7a81\u53d8\u7684\u4ea7\u751f\u3002\u5728\u63a5\u53d7HAART\u4f5c\u4e3a\u9996\u9009\u6cbb\u7597\u7684\u75c5\u4eba\u5f53\u4e2d\uff0c\u53ea\u6709\u5f53HIV\u80fd\u591f\u6301\u7eed\u590d\u5236\uff0c\u800c\u4e14\u73b0\u6709\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u6c34\u5e73\u53c8\u4e0d\u80fd\u5b8c\u5168\u963b\u6b62HIV\u590d\u5236\uff0c\u4f46\u5bf9\u8010\u836f\u7a81\u53d8\u53c8\u8db3\u4ee5\u53d1\u6325\u9633\u6027\u9009\u62e9\u4f5c\u7528\u65f6\uff0c\u5bf9\u6240\u6709\u6cbb\u7597\u836f\u7269\u8010\u836f\u7684\u6bd2\u682a\u624d\u4f1a\u9010\u6e10\u51fa\u73b0\u3002\u503c\u5f97\u6211\u4eec\u5f3a\u8c03\u7684\u662f\uff0c\u76ee\u524d\u7edd\u5927\u591a\u6570\u8010\u836f\u662fHAART\u6cbb\u7597\u7684\u4e00\u4e2a\u7ed3\u679c\uff0c\u800c\u975e\u6cbb\u7597\u5931\u8d25\u3002<\/p>\n\n\n\n

3\u3001\u4ea4\u53c9\u8010\u836f\uff08Cross resistance\uff09<\/h3>\n\n\n\n

\u7531\u4e00\u79cd\u836f\u7269\u6240\u9009\u62e9\u7684\u8010\u836f\u7a81\u53d8\u5bfc\u81f4HIV\u5bf9\u4ece\u672a\u4f7f\u7528\u8fc7\u7684\u4e00\u79cd\u6216\u8005\u4e00\u4e9b\u836f\u7269\u4ea7\u751f\u7684\u8010\u836f\u79f0\u4e3a\u4ea4\u53c9\u8010\u836f\u3002\u4ea4\u53c9\u8010\u836f\u901a\u5e38\u4ec5\u9650\u4e8e\u540c\u4e00\u7c7b\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u4e4b\u95f4\uff0c\u4f46\u6240\u6709\u4e09\u7c7b\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u90fd\u53ef\u53d7\u5f71\u54cd\u3002\u5728NRTIs\u6216PIs\u8010\u836f\u8fdb\u5c55\u65e9\u671f\uff0cHIV\u53ef\u80fd\u53ea\u5bf9\u8fd9\u4e24\u7c7b\u836f\u7269\u4e2d\u7684\u4e24\u79cd\u836f\u7269\u4f4e\u6c34\u5e73\u4ea4\u53c9\u8010\u836f\uff0c\u4f46\u5728\u6b64\u57fa\u7840\u4e0a\u53ea\u9700\u6dfb\u52a0\u4e00\u4e2a\u6216\u4e00\u4e9b\u989d\u5916\u7a81\u53d8\uff0c\u5373\u53ef\u53d1\u5c55\u4e3a\u9ad8\u5ea6\u4ea4\u53c9\u8010\u836f\u3002\u56e0\u6b64\uff0c\u5728\u66f4\u6362\u4e3a\u770b\u4f3c\u6709\u6548\u7684\u53e6\u4e00\u79cd\u836f\u7269\u65f6\uff0c\u4f4e\u5ea6\u4ea4\u53c9\u8010\u836f\u6bd2\u682a\u53ea\u9700\u6700\u5c0f\u7684\u8fdb\u5316\u6539\u53d8\uff0c\u5c31\u53ef\u8fc5\u901f\u5bf9\u9ad8\u8010\u836f\u53d8\u79cd\u4f5c\u51fa\u9009\u62e9\u3002<\/p>\n\n\n\n

4 \u3001HIV\u8010\u836f\u7684\u53d1\u5c55\u8fdb\u7a0b<\/h3>\n\n\n\n

\u81ea\u5b9e\u884cHAART\u4ee5\u6765\uff0cHIV\u5bf9\u8d8a\u6765\u8d8a\u591a\u7684\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u8010\u836f\u3002HIV-1\u5bf9\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242\u548cPIs\u8010\u836f\u901a\u5e38\u662f\u4e00\u4e2a\u9010\u6e10\u589e\u5f3a\u7684\u8fc7\u7a0b\uff0c\u5e76\u53ef\u4ee5\u7528\u7a81\u53d8\u79ef\u7d2f\u7684\u6570\u91cf\u9884\u6d4bPIs\u6cbb\u7597\u7684\u53cd\u5e94\u6027\u3002\u867d\u7136\u5982\u6b64\uff0c\u5373\u4f7fHIV\u86cb\u767d\u9176\u548c\u9006\u8f6c\u5f55\u9176\u5df2\u7ecf\u79ef\u7d2f\u4e86\u51e0\u4e2a\u8db3\u591f\u5bfc\u81f4\u6cbb\u7597\u5931\u8d25\u7684\u7a81\u53d8\uff0c\u8010\u836f\u4e5f\u53ef\u80fd\u6ca1\u6709\u8fbe\u5230\u6700\u9ad8\u6c34\u5e73\uff0c\u5728\u4e0d\u6539\u53d8\u6cbb\u7597\u65b9\u6848\u7684\u60c5\u51b5\u4e0b\u4e5f\u53ef\u53d1\u751f\u63d0\u9ad8\u8010\u836f\u7a0b\u5ea6\u7684\u9644\u52a0\u7a81\u53d8\u3002\u56e0\u6b64\uff0c\u5728\u8bc4\u4f30\u5355\u4e2a\u836f\u7269\u4ecd\u7136\u5177\u6709\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u65f6\uff0c\u5bf9\u8010\u836f\u53d1\u5c55\u8fdb\u7a0b\u7684\u8ba4\u8bc6\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u5bf9\u611f\u67d3\u591a\u91cd\u8010\u836f\u6bd2\u682a\u75c5\u4eba\u5b9e\u65bd\u6cbb\u7597\u3002<\/p>\n\n\n\n

5\u3001\u8010\u836f\u7a81\u53d8\u5bf9HIV\u590d\u5236\u548c\u81f4\u75c5\u80fd\u529b\u7684\u5f71\u54cd<\/h3>\n\n\n\n

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