{"id":335,"date":"2023-10-09T16:15:42","date_gmt":"2023-10-09T08:15:42","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=335"},"modified":"2023-10-22T16:52:54","modified_gmt":"2023-10-22T08:52:54","slug":"%e5%b8%95%e5%94%91%e5%b8%95%e5%b0%bcpazopani","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=335","title":{"rendered":"\u5e15\u5511\u5e15\u5c3c(Pazopani)"},"content":{"rendered":"\n
\"\u5e15\u5511\u5e15\u5c3c(Pazopani)\"<\/figure>\n\n\n\n

\u5e15\u5511\u5e15\u5c3c(Pazopani)\u3010\u9002\u5e94\u75c7\u3011<\/p>\n\n\n\n

\u3000\u3000\uff081\uff09\u96be\u6cbb\u6216\u8f6c\u79fb\u6027\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08\u4e00\u79cd\u5728\u80be\u5c0f\u7ba1\u4e2d\u53d1\u73b0\u764c\u7ec6\u80de\u7684\u80be\u764c\u7c7b\u578b\uff09\uff1b<\/p>\n\n\n\n

\u3000\u3000\uff082\uff09\u65e2\u5f80\u63a5\u53d7\u5316\u7597\u7684\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624(STS)\u60a3\u8005\uff1b<\/p>\n\n\n\n

\u3000\u3000\uff083\uff09\u94c2\u7c7b\u8010\u836f\u6216\u94c2\u7c7b\u96be\u6cbb\u7684\u4e0a\u76ae\u6027\u5375\u5de2\u764c\uff1b<\/p>\n\n\n\n

\u3000\u3000\uff084\uff09\u4e00\u7ebf\u5316\u7597\u540e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u7ef4\u6301\u6cbb\u7597\uff1b<\/p>\n\n\n\n

\u3000\u3000\u3010\u5242\u91cf\u548c\u7ed9\u836f\u65b9\u6cd5\u3011<\/p>\n\n\n\n

\u3000\u3000800 mg\u53e3\u670d\u6bcf\u59291\u6b21\u4e0d\u548c\u98df\u7269\u4e00\u8d77\u670d\u836f(\u81f3\u5c11\u5728\u8fdb\u9910\u524d1\u5c0f\u65f6\u6216\u540e2\u5c0f\u65f6)\u3002\u57fa\u7ebf\u4e2d\u5ea6\u809d\u635f\u4f24 \u2013 \u53e3\u670d200 mg\u6bcf\u59291\u6b21\u3002\u4e25\u91cd\u809d\u635f\u4f24\u60a3\u8005\u4e0d\u5efa\u8bae\u4f7f\u7528\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u6ce8\u610f\u4e8b\u9879\u3011<\/p>\n\n\n\n

\u3000\u3000\uff081\uff09\u89c2\u5bdf\u5230\u589e\u52a0\u8840\u6e05\u8f6c\u6c28\u9176\u6c34\u5e73\u548c\u80c6\u7ea2\u7d20\u3002\u66fe\u53d1\u751f\u4e25\u91cd\u81f4\u6b7b\u6027\u809d\u6bd2\u6027\u3002\u5f00\u59cb\u6cbb\u7597\u524d\u548c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u6d4b\u5b9a\u809d\u5316\u5b66\u3002<\/p>\n\n\n\n

\u3000\u30002\uff09\u66fe\u89c2\u5bdf\u5230QT\u95f4\u9694\u5ef6\u957f\u548c\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u901f(torsades de pointes)\u3002\u8f83\u9ad8\u5371\u53d1\u751fQT\u95f4\u9694\u5ef6\u957f\u60a3\u8005\u614e\u7528\u3002 \u5e94\u8003\u8651\u76d1\u67e5\u5fc3\u7535\u56fe\u548c\u7535\u89e3\u8d28\u3002<\/p>\n\n\n\n

\u3000\u30003) \u66fe\u62a5\u9053\u81f4\u6b7b\u6027\u51fa\u8840\u4e8b\u4ef6\u3002\u5c1a\u672a\u5728\u65e2\u5f806\u4e2a\u6708\u5185\u6709\u54af\u8840\u3001\u8111\u3001\u6216\u6709\u4e34\u5e8a\u610f\u4e49\u80c3\u80a0\u9053\u51fa\u8840\u53f2\u7684\u60a3\u8005\u7814\u7a76VOTRIENT\u800c\u4e0d\u5e94\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u4f7f\u7528\u3002<\/p>\n\n\n\n

\u3000\u30004) \u66fe\u89c2\u5bdf\u5230\u52a8\u8109\u8840\u6813\u5f62\u6210\u4e8b\u4ef6\u548c\u53ef\u80fd\u81f4\u6b7b\u3002\u5bf9\u8fd9\u4e9b\u4e8b\u4ef6\u98ce\u9669\u589e\u52a0\u60a3\u8005\u4e2d\u614e\u7528\u3002<\/p>\n\n\n\n

\u3000\u30005) \u66fe\u53d1\u751f\u80c3\u80a0\u9053\u7a7f\u5b54\u6216\u7618\u7ba1\u3002\u66fe\u53d1\u751f\u81f4\u6b7b\u6027\u7a7f\u5b54\u4e8b\u4ef6\u3002\u80c3\u80a0\u9053\u7a7f\u5b54\u6216\u7618\u7ba1\u98ce\u9669\u589e\u52a0\u60a3\u8005\u4e2d\u614e\u7528\u3002<\/p>\n\n\n\n

\u3000\u30006) \u66fe\u89c2\u5bdf\u5230\u9ad8\u8840\u538b\u3002\u5f00\u59cb\u7528VOTRIENT\u5e94\u5145\u5206\u63a7\u5236\u8840\u538b\u3002\u9700\u8981\u65f6\u76d1\u67e5\u548c\u6cbb\u7597\u9ad8\u8840\u538b\u3002<\/p>\n\n\n\n

\u3000\u30007) \u5728\u8fdb\u884c\u624b\u672f\u60a3\u8005\u4e2d\u5efa\u8bae\u4e2d\u65adVOTRIENT\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u3000\u30008) \u53ef\u80fd\u53d1\u751f\u7532\u72b6\u817a\u673a\u80fd\u51cf\u9000\u3002\u5efa\u8bae\u76d1\u67e5\u7532\u72b6\u817a\u529f\u80fd\u3002<\/p>\n\n\n\n

\u3000\u30009\uff09\u86cb\u767d\u5c3f\uff1a\u76d1\u67e5\u5c3f\u86cb\u767d\u3002\u5bf94\u7ea7\u86cb\u767d\u5c3f\u4e2d\u65ad\u836f\u7269\u3002<\/p>\n\n\n\n

\u3000\u300010) \u5f53\u598a\u5a20\u5987\u5973\u7ed9\u4e88VOTRIENT\u53ef\u80fd\u5371\u5bb3\u80ce\u513f\u3002\u6000\u5b55\u6f5c\u80fd\u5987\u5973\u5e94\u5fe0\u544a\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u5371\u5bb3\u548c\u670d\u7528\u662f\u907f\u514d\u53d7\u5b55\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/p>\n\n\n\n

\u3000\u3000\u8179\u6cfb\u3001\u9ad8\u8840\u538b\u3001\u6bdb\u53d1\u989c\u8272\u6539\u53d8\u3001\u6076\u5fc3\u3001\u98df\u6b32\u4e0d\u632f\u3001\u5455\u5410\u3001\u75b2\u52b3\u3001\u865a\u5f31\u3001\u8179\u75db\u53ca\u5934\u75db\u7b49\u3002 \u5f15\u8d77\u4e25\u91cd\u7684\u809d\u810f\u95ee\u9898\uff0c\u56e0\u6b64\u533b\u62a4\u4eba\u5458\u5e94\u5728\u60a3\u8005\u4f7f\u7528\u8be5\u836f\u7269\u6cbb\u7597\u524d\u548c\u6cbb\u7597\u671f\u95f4\u5bf9\u60a3\u8005\u8fdb\u884c\u8840\u6db2\u68c0\u9a8c\uff0c \u76d1\u6d4b\u60a3\u8005\u809d\u529f\u80fd \u5bf9\u80ce\u513f\u6709\u5371\u5bb3\uff0c\u598a\u5a20\u671f\u5e94\u7981\u7528\u6b64\u836f\u3002 \u5e15\u5511\u5e15\u5c3c\u8fd8\u53ef\u5bfc\u81f4\u5fc3\u5f8b\u4e0d\u9f50\uff0c\u60a3\u8005\u5728\u7528\u836f\u671f\u95f4\u5e94\u5b9a\u671f\u505a\u5fc3\u7535\u56fe\u6d4b\u91cf\u5fc3\u7387\uff0c\u5e76\u5b9a\u671f\u8fdb\u884c\u8840\u6db2\u68c0\u9a8c\u76d1\u6d4b \u7535\u89e3\u8d28\u6c34\u5e73\uff0c\u56e0\u4e3a\u7535\u89e3\u8d28\u5931\u8861\u4e5f\u4f1a\u4e5f\u8d77\u5fc3\u5f8b\u4e0d\u9f50\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011<\/p>\n\n\n\n

\u3000\u3000CYP3A4\u6291\u5236\u5242\uff1a\u907f\u514d\u4f7f\u7528\u5f3a\u6291\u5236\u5242\u3002VOTRIENT\u5f53\u4e0e\u5f3aCYP3A4\u6291\u5236\u5242\u4f7f\u7528\u8003\u8651\u51cf\u4f4e\u5242\u91cf\u3002<\/p>\n\n\n\n

\u3000\u3000CYP3A4\u8bf1\u5bfc\u5242\uff1a\u8003\u7387\u53e6\u4e00\u79cd\u540c\u65f6\u836f\u7269\u65e0\u6216\u5c0f\u9176\u8bf1\u5bfc\u6f5c\u80fd\u6216\u907f\u514dVOTRIENT\u3002<\/p>\n\n\n\n

\u3000\u3000CYP\u5e95\u7269\uff1a\u4e0d\u5efa\u8baeVOTRIENT\u7684\u540c\u65f6\u4f7f\u7528\u6cbb\u7597\u7a97\u72ed\u7a84\u88abCYP3A4, CYP2D6,\u6216CYP2C8\u4ee3\u8c22\u836f\u7269\u3002<\/p>\n\n\n\n

\u3000\u3000\u3010\u8d2e\u85cf\u3011<\/p>\n\n\n\n

\u3000\u3000\u8d2e\u5b58\u572825\u00b0\u4ee5\u4e0b,\u5bc6\u5c01<\/p>\n\n\n\n

\u3000\u3000\u3010\u5e15\u5511\u5e15\u5c3c\u6548\u679c\u3011<\/p>\n\n\n\n

\u3000\u3000\u665a\u671f\u80be\u7ec6\u80de\u764c\uff1a<\/p>\n\n\n\n

\u3000\u3000\u5728\u4e00\u9879\u6cbb\u7597\u80be\u7ec6\u80de\u764cA\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4f30\u4e86225\u4f8b\u60a3\u8005\u3002\u8fd9\u4e9b\u60a3\u8005\u5177\u6709\u660e\u786e\u7ec6\u80de\u7c7b\u578b\u7684\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u3002\u7ed3\u679c\u663e\u793a\u670d\u7528\u5e15\u5511\u5e15\u5c3c\u7684\u60a3\u8005\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a51.7\u5468\u3002\u5728\u53e6\u4e00\u4e2a55\u4f8b\u5bf9\u8212\u5c3c\u66ff\u8010\u836f\u6216\u8d1d\u4f10\u5355\u6297\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u80be\u900f\u660e\u7ec6\u80de\u764c\u60a3\u8005,\u670d\u7528\u5e15\u5511\u5e15\u5c3c\u5176\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u65f6\u95f4\u662f7.5\u4e2a\u6708\u3002\u8fd9\u4e9b\u4e8c\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c\u8bc1\u5b9e\u4e86\u5e15\u5511\u5e15\u5c3c\u7684\u6709\u6548\u6027\u3002\u6b64\u5916\uff0c\u8ba4\u4e3a\u5e15\u4f50\u5e15\u5c3c\u7684\u5b89\u5168\u6982\u51b5\u662f\u53ef\u4ee5\u63a5\u53d7\u7684\uff0c\u5e76\u8bc1\u5b9e\u4e86\u5176\u8010\u53d7\u6027\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5e15\u5511\u5e15\u5c3c(Pazopani)\u3010\u9002\u5e94\u75c7\u3011 \u3000\u3000\uff081\uff09\u96be\u6cbb\u6216\u8f6c\u79fb\u6027\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08\u4e00\u79cd\u5728\u80be\u5c0f\u7ba1\u4e2d\u53d1\u73b0\u764c\u7ec6\u80de\u7684\u80be\u764c\u7c7b\u578b\uff09\uff1b \u3000\u3000\uff082\uff09\u65e2\u5f80\u63a5\u53d7\u5316\u7597\u7684\u665a\u671f\u8f6f\u7ec4\u7ec7\u8089\u7624(STS)\u60a3\u8005\uff1b \u3000\u3000\uff083\uff09\u94c2\u7c7b\u8010\u836f\u6216\u94c2\u7c7b\u96be\u6cbb\u7684\u4e0a\u76ae\u6027\u5375\u5de2\u764c\uff1b \u3000\u3000\uff084\uff09\u4e00\u7ebf\u5316\u7597\u540e\u975e […]<\/p>\n","protected":false},"author":1,"featured_media":336,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,20],"tags":[119,116,117,118],"topic":[],"class_list":["post-335","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-feiaiyaoping","category-shenbingyaoping","tag-119","tag-116","tag-117","tag-sts"],"_links":{"self":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=335"}],"version-history":[{"count":2,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/335\/revisions"}],"predecessor-version":[{"id":419,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/335\/revisions\/419"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/336"}],"wp:attachment":[{"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=335"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}