{"id":320,"date":"2023-10-09T13:33:49","date_gmt":"2023-10-09T05:33:49","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=320"},"modified":"2023-10-19T17:34:28","modified_gmt":"2023-10-19T09:34:28","slug":"%e8%8e%ab%e5%8d%9a%e6%9b%bf%e5%b0%bc%ef%bc%88-mobocertinib%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=320","title":{"rendered":"\u83ab\u535a\u66ff\u5c3c\uff08 Mobocertinib\uff09"},"content":{"rendered":"\n
\"\u83ab\u535a\u66ff\u5c3c\"<\/figure>\n\n\n\n

\u83ab\u535a\u66ff\u5c3c(mobocertinib)<\/p>\n\n\n\n

\u901a\u7528\u540d\uff1amobocertinib<\/p>\n\n\n\n

\u5546\u54c1\u540d(\u82f1\u6587)\uff1aExkivity<\/p>\n\n\n\n

\u5546\u54c1\u540d(\u4e2d\u6587)\uff1a\u5b89\u536b\u529b<\/p>\n\n\n\n

\u56fd\u5185\u540d\uff1a\u7425\u73c0\u9178\u83ab\u535a\u8d5b\u66ff\u5c3c\u80f6\u56ca<\/p>\n\n\n\n

\u5168\u90e8\u540d\u79f0\uff1a\u83ab\u535a\u66ff\u5c3c\uff0c\u7425\u73c0\u9178\u83ab\u535a\u8d5b\u66ff\u5c3c\u80f6\u56ca\uff0c\u5b89\u536b\u529b\uff0cExkivity\uff0cTAK-788\uff0cmobocertinib<\/p>\n\n\n\n

\u9002\u5e94\u75c7<\/p>\n\n\n\n

EXKIVITY\u662f\u4e00\u79cd\u6fc0\u9176\u6291\u5236\u5242\uff0c\u9002\u7528\u4e8e\u6cbb\u7597\u5177\u6709\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u6210\u4eba\u60a3\u8005\uff0c\u7ecfFDA\u6279\u51c6\u7684\u6d4b\u8bd5\u68c0\u6d4b\u5230\uff0c\u5176\u75be\u75c5\u5728\u94c2\u7c7b\u5316\u7597\u671f\u95f4\u6216\u4e4b\u540e\u8fdb\u5c55\u3002<\/p>\n\n\n\n

\u7528\u6cd5\u7528\u91cf<\/p>\n\n\n\n

\u63a8\u8350\u5242\u91cf\uff1a160mg\u6bcf\u5929\u4e00\u6b21\u53e3\u670d\uff0c\u6709\u6216\u6ca1\u6709\u98df\u7269\u3002<\/p>\n\n\n\n

\u89c4\u683c<\/p>\n\n\n\n

40mg\uff08112\u7c92\/\u76d2\uff0c14\u7c92\/\u677f\uff0c8\u677f\/\u76d2\uff09<\/p>\n\n\n\n

\u4e0d\u826f\u53cd\u5e94<\/p>\n\n\n\n

\u6700\u5e38\u89c1\uff08>20%\uff09\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u6076\u5fc3\u3001\u53e3\u8154\u708e\u3001\u5455\u5410\u3001\u98df\u6b32\u4e0b\u964d\u3001\u7532\u6c9f\u708e\u3001\u75b2\u52b3\u3001\u76ae\u80a4\u5e72\u71e5\u548c\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u3002<\/p>\n\n\n\n

\u6700\u5e38\u89c1\u7684(\u22652%)3\u62164\u7ea7\u5b9e\u9a8c\u5ba4\u5f02\u5e38\u662f\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff0c\u6dcb\u5df4\u7ec6\u80de\u589e\u52a0\u6dc0\u7c89\u9176\u3001\u8102\u80aa\u9176\u589e\u52a0\u3001\u94be\u51cf\u5c11\u3001\u8840\u7ea2\u86cb\u767d\u51cf\u5c11\u3001\u808c\u9150\u589e\u52a0\u548c\u9541\u51cf\u5c11\u3002<\/p>\n\n\n\n

\u7981\u5fcc<\/p>\n\n\n\n

\u65e0\u3002<\/p>\n\n\n\n

\u6ce8\u610f\u4e8b\u9879<\/p>\n\n\n\n

EXKIVITY\u53ef\u5bfc\u81f4\u5371\u53ca\u751f\u547d\u7684\u5fc3\u7387\u6821\u6b63QT(QTc)\u5ef6\u957f\uff0c\u5305\u62ec\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\uff0c\u8fd9\u53ef\u80fd\u662f\u81f4\u547d\u7684\uff0c\u9700\u8981\u76d1\u6d4bQTc\u548c\u5728\u57fa\u7ebf\u548c\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u68c0\u67e5\u7535\u89e3\u8d28\u3002<\/p>\n\n\n\n

\u589e\u52a0\u6709QTc\u5ef6\u957f\u5371\u9669\u56e0\u7d20\u7684\u60a3\u8005\u7684\u76d1\u6d4b\u9891\u7387\u3002<\/p>\n\n\n\n

\u907f\u514d\u4f7f\u7528\u5df2\u77e5\u4f1a\u5ef6\u957fQTc\u95f4\u671f\u7684\u4f34\u968f\u836f\u7269\uff0c\u4ee5\u53ca\u4f7f\u7528\u5f3a\u6216\u4e2d\u5ea6CYP3A\u6291\u5236\u5242\u4e0eEXKIVITY\uff0c\u8fd9\u53ef\u80fd\u4f1a\u8fdb\u4e00\u6b65\u5ef6\u957fQTc\u3002<\/p>\n\n\n\n

\u6839\u636eQTc\u5ef6\u957f\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e0d\u7ed9\u3001\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u7ec8\u6b62EXKIVITY\u3002<\/p>\n\n\n\n

\u95f4\u8d28\u6027\u80ba\u75c5(ILD)\/\u80ba\u708e\uff1a\u76d1\u6d4b\u60a3\u8005\u662f\u5426\u51fa\u73b0\u65b0\u7684\u6216\u6076\u5316\u7684\u8868\u660eILD\/\u80ba\u708e\u7684\u80ba\u90e8\u75c7\u72b6\u3002\u5bf9\u7591\u4f3cILD\/\u80ba\u708e\u60a3\u8005\u7acb\u5373\u505c\u7528EXKIVITY\uff0c\u5982\u679c\u786e\u8ba4ILD\/\u80ba\u708e\uff0c\u5219\u6c38\u4e45\u7ec8\u6b62EXKIVITY\u3002<\/p>\n\n\n\n

\u5fc3\u810f\u6bd2\u6027\uff1a\u5728\u57fa\u7ebf\u548c\u6cbb\u7597\u671f\u95f4\u76d1\u6d4b\u5fc3\u810f\u529f\u80fd\uff0c\u5305\u62ec\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\u3002\u6263\u7559\u3001\u51cf\u4f4e\u5242\u91cf\u6062\u590d\u6216\u6839\u636e\u4e25\u91cd\u7a0b\u5ea6\u6c38\u4e45\u505c\u836f\u3002<\/p>\n\n\n\n

\u8179\u6cfb\uff1a\u8179\u6cfb\u53ef\u80fd\u5bfc\u81f4\u8131\u6c34\u6216\u7535\u89e3\u8d28\u5931\u8861\uff0c\u65e0\u8bba\u6709\u65e0\u80be\u529f\u80fd\u635f\u5bb3\u3002\u76d1\u6d4b\u7535\u89e3\u8d28\u5e76\u5efa\u8bae\u60a3\u8005\u5728\u8179\u6cfb\u7b2c\u4e00\u6b21\u53d1\u4f5c\u65f6\u5f00\u59cb\u4f7f\u7528\u6b62\u6cfb\u836f\u5e76\u589e\u52a0\u6db2\u4f53\u548c\u7535\u89e3\u8d28\u7684\u6444\u5165\u91cf\u3002\u6839\u636e\u4e25\u91cd\u7a0b\u5ea6\u6263\u7559\u3001\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u7ec8\u6b62 EXKIVITY\u3002<\/p>\n\n\n\n

\u80da\u80ce-\u80ce\u513f\u6bd2\u6027\uff1a\u53ef\u80fd\u5bf9\u80ce\u513f\u9020\u6210\u4f24\u5bb3\u3002\u5fe0\u544a\u6709\u751f\u80b2\u6f5c\u529b\u7684\u5973\u6027\u5bf9\u80ce\u513f\u7684\u6f5c\u5728\u98ce\u9669\u5e76\u4f7f\u7528\u6709\u6548\u7684\u975e\u6fc0\u7d20\u907f\u5b55\u836f\u3002<\/p>\n\n\n\n

\u8d2e\u85cf<\/p>\n\n\n\n

\u6700\u5e38\u89c1\uff08>20%\uff09\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u8179\u6cfb\u3001\u76ae\u75b9\u3001\u6076\u5fc3\u3001\u53e3\u8154\u708e\u3001\u5455\u5410\u3001\u98df\u6b32\u4e0b\u964d\u3001\u7532\u6c9f\u708e\u3001\u75b2\u52b3\u3001\u76ae\u80a4\u5e72\u71e5\u548c\u808c\u8089\u9aa8\u9abc\u75bc\u75db\u3002\u6700\u5e38\u89c1\u7684(\u22652%)3\u62164\u7ea7\u5b9e\u9a8c\u5ba4\u5f02\u5e38\u662f\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff0c\u6dcb\u5df4\u7ec6\u80de\u589e\u52a0\u6dc0\u7c89\u9176\u3001\u8102\u80aa\u9176\u589e\u52a0\u3001\u94be\u51cf\u5c11\u3001\u8840\u7ea2\u86cb\u767d\u51cf\u5c11\u3001\u808c\u9150\u589e\u52a0\u548c\u9541\u51cf\u5c11\u3002<\/p>\n\n\n\n

\u4f5c\u7528\u673a\u5236<\/p>\n\n\n\n

Mobocertinib\u662f\u4e00\u79cd\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5728\u4f4e\u4e8e\u91ce\u751f\u578b(WT)EGFR\u7684\u6d53\u5ea6\u4e0b\u4e0d\u53ef\u9006\u5730\u7ed3\u5408\u5e76\u6291\u5236EGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u3002\u4e24\u79cd\u836f\u7406\u6d3b\u6027\u4ee3\u8c22\u7269\uff08AP32960\u548cAP32914\uff09\u4e0emobocertinib\u5177\u6709\u76f8\u4f3c\u7684\u6291\u5236\u7279\u6027 \u5df2\u5728\u53e3\u670d\u83ab\u535a\u585e\u66ff\u5c3c\u540e\u7684\u8840\u6d46\u4e2d\u53d1\u73b0\u3002<\/p>\n\n\n\n

\u5728\u4f53\u5916\uff0cmobocertinib\u8fd8\u5728\u4e34\u5e8a\u76f8\u5173\u6d53\u5ea6\uff08IC50\u503c<2nM\uff09\u4e0b\u6291\u5236\u5176\u4ed6EGFR\u5bb6\u65cf\u6210\u5458\uff08HER2\u548cHER4\uff09\u548c\u4e00\u79cd\u989d\u5916\u6fc0\u9176(BLK)\u7684\u6d3b\u6027\u3002<\/p>\n\n\n\n

\u5728\u57f9\u517b\u7684\u7ec6\u80de\u6a21\u578b\u4e2d\uff0cmobocertinib\u4ee5\u6bd4WT-EGFR\u4fe1\u53f7\u4f20\u5bfc\u6291\u5236\u4f4e1.5\u81f310\u500d\u7684\u6d53\u5ea6\u6291\u5236\u7531\u4e0d\u540cEGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u53d8\u4f53\u9a71\u52a8\u7684\u7ec6\u80de\u589e\u6b96\u3002<\/p>\n\n\n\n

\u5728\u52a8\u7269\u80bf\u7624\u690d\u5165\u6a21\u578b\u4e2d\uff0cmobocertinib\u5bf9EGFR\u5916\u663e\u5b5020\u63d2\u5165NPH\u6216ASV\u7684\u5f02\u79cd\u79fb\u690d\u7269\u8868\u73b0\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n\n\n\n

\u5b89\u5168\u4e0e\u7597\u6548<\/p>\n\n\n\n

Mobocertinib\u662f\u7f8e\u56fd\u6279\u51c6\u7684\u9996\u4e2a\u9488\u5bf9EGFR Exon20\u63d2\u5165\u7a81\u53d8\u7684\u53e3\u670d\u7597\u6cd5\u3002\u7f8e\u56fdFDA\u7684\u6279\u51c6\u662f\u57fa\u4e8e\u57281\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u66fe\u63a5\u53d7\u8fc7\u542b\u94c2\u5316\u7597\u6cbb\u7597\u7684\u60a3\u8005\u7fa4\u4f53\u3002<\/p>\n\n\n\n

\u57282021\u5e74ASCO\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0c\u6839\u636e\u72ec\u7acb\u6570\u636e\u76d1\u63a7\u4e2d\u5fc3\u7684\u8bc4\u4f30\uff0c\u63a5\u53d7mobocertinib\uff08160mg\uff09\u6bcf\u65e51\u6b21\u6cbb\u7597\u60a3\u8005\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a28%\uff08\u7814\u7a76\u8005\u8bc4\u4f30\u4e3a35%\uff09\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08mDoR\uff09\u4e3a17.5\u4e2a\u6708\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u4e3a7.3\u4e2a\u6708\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a78%\u3002<\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c\uff08 Mobocertinib\uff09\u7684\u6210\u5206\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n\n\n\n

\u6d3b\u6027\u6210\u5206\uff1a\u83ab\u535a\u897f\u66ff\u5c3c<\/p>\n\n\n\n

\u975e\u6d3b\u6027\u6210\u5206\uff1a\u6ca1\u6709<\/p>\n\n\n\n

\u80f6\u56ca\u58f3\uff1a\u660e\u80f6\u548c\u4e8c\u6c27\u5316\u949b\u3002\u5370\u5237\u6cb9\u58a8\u542b\u6709\u866b\u80f6\uff0c\u8131\u6c34\u9187\uff0c\u5f02\u4e19\u9187\uff0c\u4e01\u9187\uff0c\u4e19\u4e8c\u9187\uff0c\u5f3a\u6c28\u6eb6\u6db2\uff0c\u9ed1\u8272\u6c27\u5316\u94c1\uff0c\u6c22\u6c27\u5316\u94be\u548c\u7eaf\u51c0\u6c34\u3002<\/p>\n\n\n\n

\u4ec0\u4e48\u662f\u83ab\u535a\u897f\u66ff\u5c3c\uff08 Mobocertinib\uff09\uff1f<\/strong><\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c\u662f\u4e00\u79cd\u79f0\u4e3a\u6fc0\u9176\u6291\u5236\u5242\u7684\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u4e00\u79cd\u7f55\u89c1\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002<\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u7531\u7279\u5b9a\u7c7b\u578b\u7684\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684NSCLC\uff0c\u79f0\u4e3a\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u3002\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u53ea\u6709\u5927\u7ea62000\u81f34000\u4eba\u88ab\u8bca\u65ad\u51fa\u60a3\u6709\u8fd9\u79cd\u7c7b\u578b\u7684\u764c\u75c7\u3002<\/p>\n\n\n\n

EGFR\u662f\u4e00\u79cd\u5e2e\u52a9\u7ec6\u80de\u751f\u957f\u548c\u5206\u88c2\u7684\u86cb\u767d\u8d28\u3002\u5f53\u53d1\u751f\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u65f6\uff0c\u5b83\u9a71\u52a8\u7ec6\u80de\u5f02\u5e38\u751f\u957f\u548c\u5206\u88c2\uff0c\u5bfc\u81f4EGFR\u9633\u6027\u764c\u75c7\u3002<\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c\u901a\u8fc7\u7ed3\u5408\u548c\u963b\u65adEGFR\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u8d77\u4f5c\u7528\uff0c\u8fd9\u6709\u52a9\u4e8e\u51cf\u7f13\u764c\u7ec6\u80de\u7684\u751f\u957f\u3002<\/p>\n\n\n\n

Mobocertinib\u4e8e2021\u5e74\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u52a0\u901f\u6279\u51c6\u3002\u5b83\u4e0eOncomine Dx\u9776\u6807\u4e00\u8d77\u4f7f\u7528\uff0c\u8be5\u8bd5\u9a8c\u53ef\u8bc6\u522b\u5177\u6709\u5916\u663e\u5b5020\u63d2\u5165\u7a81\u53d8\u7684\u60a3\u8005\u3002<\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c(Mobocertinib)\u7684\u7528\u9014\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u6210\u4ebaNSCLC\u7684\u5904\u65b9\u836f\uff1a\u5c40\u90e8\u665a\u671f\u6216\u5df2\u6269\u6563\u5230\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\uff08\u8f6c\u79fb\u6027\uff09\u4e14\u65e0\u6cd5\u901a\u8fc7\u624b\u672f\u5207\u9664\uff0c\u4ee5\u53ca\u5177\u6709\u7531\u5916\u663e\u5b50 20 \u63d2\u5165\u7a81\u53d8\u5f15\u8d77\u7684\u5f02\u5e38 EGFR \u57fa\u56e0\u3002<\/p>\n\n\n\n

\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u5c06\u8fdb\u884c\u6d4b\u8bd5\uff0c\u4ee5\u786e\u4fdd\u83ab\u535a\u897f\u66ff\u5c3c\u9002\u5408\u60a8\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u83ab\u535a\u897f\u66ff\u5c3c\u5bf9\u513f\u7ae5\u662f\u5426\u5b89\u5168\u6709\u6548\u3002<\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c(Mobocertinib)<\/strong>\u91cd\u8981\u4fe1\u606f<\/strong><\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c\u53ef\u80fd\u4f1a\u5f15\u8d77\u4e25\u91cd\u7684\u526f\u4f5c\u7528\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n

 \u5fc3\u810f\u7535\u6d3b\u52a8\u7684\u53d8\u5316\u79f0\u4e3aQTc\u5ef6\u957f\u548c\u5c16\u7aef\u626d\u8f6c\u578b\u5ba4\u6027\u5fc3\u52a8\u8fc7\u901f\u3002QTc\u5ef6\u957f\u53ef\u5bfc\u81f4\u5fc3\u8df3\u4e0d\u89c4\u5219\uff0c\u53ef\u80fd\u5371\u53ca\u751f\u547d\u5e76\u53ef\u80fd\u5bfc\u81f4\u6b7b\u4ea1\u3002\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u5c06\u901a\u8fc7\u79f0\u4e3a\u5fc3\u7535\u56fe\uff08ECG\uff09\u7684\u6d4b\u8bd5\u6765\u68c0\u67e5\u60a8\u5fc3\u810f\u7684\u7535\u6d3b\u52a8\uff0c\u5e76\u5728\u5f00\u59cb\u4f7f\u7528\u83ab\u535a\u897f\u66ff\u5c3c\u6cbb\u7597\u4e4b\u524d\u548c\u6cbb\u7597\u671f\u95f4\u8fdb\u884c\u8840\u6db2\u68c0\u67e5\u4ee5\u68c0\u67e5\u60a8\u7684\u7535\u89e3\u8d28\u3002\u5982\u679c\u60a8\u611f\u5230\u5934\u6655\uff0c\u5934\u6655\uff0c\u6655\u7729\u6216\u5fc3\u8df3\u4e0d\u89c4\u5219\uff0c\u8bf7\u7acb\u5373\u544a\u8bc9\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u3002<\/p>\n\n\n\n

\u5728\u670d\u7528\u83ab\u535a\u897f\u66ff\u5c3c\u4e4b\u524d\uff0c\u6211\u5e94\u8be5\u544a\u8bc9\u6211\u7684\u533b\u751f\u4ec0\u4e48\uff1f<\/strong><\/p>\n\n\n\n

\u5728\u670d\u7528\u83ab\u535a\u897f\u66ff\u5c3c\u4e4b\u524d\uff0c\u8bf7\u544a\u8bc9\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u60a8\u7684\u6240\u6709\u533b\u7597\u72b6\u51b5\uff0c\u5305\u62ec\u5982\u679c\u60a8\uff1a\u6709\u5fc3\u810f\u95ee\u9898\uff0c\u5305\u62ec\u4e00\u79cd\u79f0\u4e3a\u957fQTc\u7efc\u5408\u5f81\u7684\u75be\u75c5\uff1b\u60a8\u7684\u7535\u89e3\u8d28\u6709\u95ee\u9898\uff0c\u5982\u94a0\u3001\u94be\u3001\u9499\u6216\u9541\uff1b\u6709\u80ba\u764c\u4ee5\u5916\u7684\u80ba\u90e8\u6216\u547c\u5438\u95ee\u9898<\/p>\n\n\n\n

   \u5e94\u8be5\u5982\u4f55\u670d\u7528\u83ab\u535a\u897f\u66ff\u5c3c\uff1f<\/strong><\/p>\n\n\n\n

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\u5982\u679c\u9519\u8fc7\u4e86\u5242\u91cf\u600e\u4e48\u529e<\/strong>\uff1f<\/strong><\/p>\n\n\n\n

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\u914d\u6599\u4fe1\u606f<\/strong><\/p>\n\n\n\n

\u83ab\u535a\u897f\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u4e3a160mg\u53e3\u670d\uff0c\u6bcf\u5929\u4e00\u6b21\u3002\u83ab\u535a\u897f\u66ff\u5c3c\u53ef\u4ee5\u4e0e\u98df\u7269\u4e00\u8d77\u6216\u4e0d\u4e0e\u98df\u7269\u4e00\u8d77\u670d\u7528\u3002<\/p>\n\n\n\n

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\u83ab\u535a\u897f\u66ff\u5c3c\u7684\u526f\u4f5c\u7528\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n\n\n\n

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    \u8179\u6cfb\u5728\u7528\u83ab\u535a\u897f\u66ff\u5c3c\u6cbb\u7597\u671f\u95f4\u5f88\u5e38\u89c1\uff0c\u6709\u65f6\u53ef\u80fd\u5f88\u4e25\u91cd\u3002\u8179\u6cfb\u4f1a\u5bfc\u81f4\u60a8\u5931\u53bb\u8fc7\u591a\u7684\u4f53\u6db2\uff08\u8131\u6c34\uff09\u548c\u80be\u810f\u95ee\u9898\u3002\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u53ef\u80fd\u4f1a\u544a\u8bc9\u60a8\u5f00\u59cb\u591a\u559d\u6db2\u4f53\u548c\u7535\u89e3\u8d28\u4ee5\u4ee3\u66ff\u4f53\u76d0\u6216\u5f00\u59cb\u670d\u7528\u6b62\u6cfb\u836f\u3002\u5982\u679c\u60a8\u6709\u4efb\u4f55\u7a00\u4fbf\u6216\u5927\u4fbf\u9891\u7387\u9ad8\u4e8e\u6b63\u5e38\u60c5\u51b5\uff0c\u8bf7\u7acb\u5373\u544a\u8bc9\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u3002<\/p>\n\n\n\n

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\uff1b\u75b2\u52b3\uff1b\u76ae\u80a4\u5e72\u71e5\uff1b\u808c\u8089\u6216\u9aa8\u9abc\u75bc\u75db<\/p>\n\n\n\n

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\u76f8\u4e92 \u4f5c\u7528<\/strong><\/p>\n\n\n\n

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\u6000\u5b55\u548c\u54fa\u4e73<\/strong><\/p>\n\n\n\n

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\u80fd\u591f\u6000\u5b55\u7684\u5973\u6027\uff1a<\/p>\n\n\n\n

\u5728\u60a8\u5f00\u59cb\u4f7f\u7528\u83ab\u535a\u897f\u66ff\u5c3c\u6cbb\u7597\u4e4b\u524d\uff0c\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u5e94\u8fdb\u884c\u598a\u5a20\u8bd5\u9a8c\u3002<\/p>\n\n\n\n

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\u907f\u5b55\u836f\uff08\u53e3\u670d\u907f\u5b55\u836f\uff09\u548c\u5176\u4ed6\u6fc0\u7d20\u5f62\u5f0f\u7684\u8282\u80b2\u63aa\u65bd\u5728\u7528\u83ab\u535a\u897f\u66ff\u5c3c\u6cbb\u7597\u671f\u95f4\u53ef\u80fd\u4e0d\u8d77\u4f5c\u7528\u3002<\/p>\n\n\n\n

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