{"id":267,"date":"2023-10-08T16:06:03","date_gmt":"2023-10-08T08:06:03","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=267"},"modified":"2023-10-19T19:00:49","modified_gmt":"2023-10-19T11:00:49","slug":"%e6%b3%8a%e9%a9%ac%e5%ba%a6%e8%83%bapomalidomide","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=267","title":{"rendered":"\u6cca\u9a6c\u5ea6\u80fa(pomalidomide)"},"content":{"rendered":"\n
\"\u6cca\u9a6c\u5ea6\u80fa(pomalidomide)\"<\/figure>\n\n\n\n

\u836f\u54c1\u7c7b\u522b\uff1a\u8840\u6db2\u9aa8\u9ad3<\/a> \u9002\u7528\u75c5\u75c7\uff1a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624 \u751f\u4ea7\u5382\u5bb6\uff1aNATCO\u516c\u53f8 \u89c4\u683c\uff1a4mg*21\u7c92<\/p>\n\n\n\n

\u6cca\u9a6c\u5ea6\u80faPomalidomide\uff08\u5728\u7f8e\u56fd\u54c1\u724c\u540d\u4e3aPomalyst \uff0c\u5728\u6b27\u76df\u548c\u4fc4\u7f57\u65af\u54c1\u724c\u540dImnovid\uff09\u662f\u7531Celgene\u9500\u552e\u7684\u6c99\u5229\u5ea6\u80fa\u7684\u884d\u751f\u7269\u3002\u5b83\u5177\u6709\u6297\u8840\u7ba1\u751f\u6210\u4f5c\u7528\uff0c\u4e5f\u53ef\u4f5c\u4e3a\u514d\u75ab\u8c03\u8282\u5242\u30022013\u5e742\u6708\uff0cPomalidomide\u88ab\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u548c\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002\u5b83\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u5df2\u7ecf\u63a5\u53d7\u81f3\u5c11\u4e24\u79cd\u5148\u524d\u7597\u6cd5\u7684\u4eba\uff0c\u5305\u62ec\u6765\u90a3\u5ea6\u80fa\u548c\u787c\u66ff\u4f50\u7c73\uff0c\u5e76\u4e14\u5728\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u5b8c\u6210\u540e60\u5929\u6216\u4e4b\u5185\u8bc1\u5b9e\u4e86\u75be\u75c5\u8fdb\u5c55\u3002\u5b83\u4e8e2013\u5e748\u6708\u83b7\u5f97\u4e86\u6b27\u76df\u59d4\u5458\u4f1a\u7684\u7c7b\u4f3c\u6279\u51c6\u3002<\/p>\n\n\n\n

\u53e3\u670d\u7ba1\u7406
\u7528\u6c34\u541e\u4e0b\u6574\u4e2a\u80f6\u56ca; \u4e0d\u8981\u7834\u788e\uff0c\u5480\u56bc\u6216\u6253\u5f00\u80f6\u56ca<\/p>\n\n\n\n

\u996d\u524d\u81f3\u5c112\u5c0f\u65f6\u6216\u996d\u540e2\u5c0f\u65f6\u670d\u7528<\/p>\n\n\n\n

\u9002\u5e94\u75c7\uff1a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/p>\n\n\n\n

\u6c99\u5229\u5ea6\u80fa\u7c7b\u4f3c\u7269\u4e0e\u5730\u585e\u7c73\u677e\u8054\u5408\u5e94\u7528\u4e8e\u63a5\u53d7\u8fc7\u81f3\u5c112\u79cd\u65e2\u5f80\u6cbb\u7597\uff08\u5305\u62ec\u6765\u90a3\u5ea6\u80fa\u548c\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff09\u7684\u60a3\u8005\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff0c\u5e76\u4e14\u5728\u6700\u540e\u4e00\u6b21\u6cbb\u7597\u5b8c\u6210\u540e60\u5929\u6216\u4e4b\u5185\u6709\u75be\u75c5\u8fdb\u5c55<\/p>\n\n\n\n

\u5728\u91cd\u590d\u768428\u5929\u5468\u671f\u7684\u7b2c1-21\u5929\uff0c4mg \u53e3\u670d \u6bcf\u59291\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55;<\/p>\n\n\n\n

\u4e0e\u4f4e\u5242\u91cf\u5730\u585e\u7c73\u677e\u8054\u5408\u4f7f\u7528<\/p>\n\n\n\n

\u4f4e\u5242\u91cf\u5730\u585e\u7c73\u677e<\/p>\n\n\n\n

\u4ec5\u5728\u6bcf\u4e2a28\u5929\u5468\u671f\u7684\u7b2c1,8,15\u548c22\u5929\u7ed9\u4e88\u53e3\u670d
\u226475\u5c81\uff1a40\u6beb\u514b\/\u5929
> 75\u5c81\uff1a20\u6beb\u514b\/\u5929
\u5242\u91cf\u8c03\u6574
\u5982\u679c\u5242\u91cf\u51cf\u5c11\u81f31 mg\u540e\u7ee7\u7eed\u53d1\u751f\u6bd2\u6027\uff0c\u5219\u505c\u6b62\u6cbb\u7597<\/p>\n\n\n\n

\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11<\/p>\n\n\n\n

ANC <500 \/ mcL\u6216\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff08\u5373\u53d1\u70ed\u226438.5\u00b0C\u4e14ANC <1,000 \/ mcL\uff09\uff1a\u5982\u679cANC\u6062\u590d\u81f3\u2265500\/ mcL\uff0c\u4e2d\u65ad\u6cbb\u7597\u5e76\u6bcf\u5468\u9075\u5faaCBC\uff0c\u53ef\u6062\u590d3 mg \/\u5929
\u5bf9\u4e8e\u6bcf\u6b21\u968f\u540e\u7684\u4e0b\u964d<500 \/ mcL\uff1a\u4e2d\u65ad\u6cbb\u7597\uff0c\u5982\u679cANC\u6062\u590d\u5230\u2265500\/ mcL\uff0c\u53ef\u4ee5\u6062\u590d\u6bd4\u5148\u524d\u5242\u91cf\u5c111 mg
\u8840\u5c0f\u677f\u51cf\u5c11<\/p>\n\n\n\n

\u8840\u5c0f\u677f<25,000 \/ mcL\uff1a\u4e2d\u65ad\u6cbb\u7597\u5e76\u6bcf\u5468\u9075\u5faaCBC\uff0c\u5982\u679c\u8840\u5c0f\u677f\u6062\u590d\u81f3\u226550,000\/ mcL\uff0c\u53ef\u6062\u590d3 mg \/\u5929
\u5bf9\u4e8e\u6bcf\u6b21\u968f\u540e\u7684\u4e0b\u964d<25,000 \/ mcL\uff1a\u4e2d\u65ad\u6cbb\u7597\uff0c\u5982\u679c\u8840\u5c0f\u677f\u6062\u590d\u5230\u226550,000\/ mcL\uff0c\u53ef\u4ee5\u6062\u590d\u6bd4\u5148\u524d\u5242\u91cf\u5c111 mg
\u5176\u4ed6<\/p>\n\n\n\n

\u6c38\u4e45\u505c\u6b62\u8840\u7ba1\u6027\u6c34\u80bf\uff0c\u76ae\u80a4\u53bb\u89d2\u8d28\uff0c\u5927\u75b1\u6216\u4efb\u4f55\u5176\u4ed6\u4e25\u91cd\u7684\u76ae\u80a4\u75c5\u53cd\u5e94
\u5bf9\u4e8e\u5176\u4ed63\u7ea7\u62164\u7ea7\u6bd2\u6027\uff0c\u5f53\u533b\u751f\u914c\u60c5\u51b3\u5b9a\u6bd2\u6027\u5df2\u89e3\u51b3\u81f3\u5c0f\u4e8e\u6216\u7b49\u4e8e2\u7ea7\u65f6\uff0c\u4fdd\u6301\u6cbb\u7597\u5e76\u91cd\u65b0\u5f00\u59cb\u6cbb\u7597\uff0c\u6bd4\u4e4b\u524d\u7684\u5242\u91cf\u51cf\u5c111 mg
\u80be\u810f\u548c\u809d\u810f\u635f\u5bb3<\/p>\n\n\n\n

\u5982\u679c\u8840\u6e05\u808c\u9150> 3 mg \/ dL\uff0c\u8bf7\u907f\u514d\u4f7f\u7528
\u5982\u679c\u8840\u6e05\u80c6\u7ea2\u7d20> 2 mg \/ dL\u4e14AST \/ ALT> 3x ULN\uff0c\u8bf7\u907f\u514d\u4f7f\u7528
\u5242\u91cf\u6ce8\u610f\u4e8b\u9879
\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\u5fc5\u987b\u5728\u5f00\u59cb\u524d\u8fdb\u884c\u9634\u6027\u598a\u5a20\u8bd5\u9a8c\u5e76\u4f7f\u7528\u907f\u5b55\u65b9\u6cd5<\/p>\n\n\n\n

\u8981\u5f00\u59cb\u65b0\u7684\u5468\u671f\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u5fc5\u987b\u2265500\/ mcL\uff0c\u8840\u5c0f\u677f\u8ba1\u6570\u5fc5\u987b\u226550,000\/ mcL<\/p>\n\n\n\n

\u5b64\u513f\u75c5\u5e94\u7528
\u7cfb\u7edf\u6027\u786c\u5316\u75c7
\u5361\u6ce2\u897f\u8089\u7624
\u4e0d\u826f\u53cd\u5e94
> 10\uff05
\u75b2\u52b3\u548c\u865a\u5f31\uff0855-63\uff05\uff09
\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0847-52\uff05\uff09
\u547c\u5438\u56f0\u96be\uff0834-45\uff05\uff09
\u8d2b\u8840\uff0838-39\uff05\uff09
\u4fbf\u79d8\uff0835-36\uff05\uff09
\u6076\u5fc3\uff0822-36\uff05\uff09
\u8179\u6cfb\uff0833-34\uff05\uff09
\u80cc\u75db\uff0830-32\uff05\uff09
\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0825-32\uff05\uff09
\u53d1\u706b\uff0819-30\uff05\uff09
\u80ba\u708e\uff0823-29\uff05\uff09
\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0823-25\uff05\uff09
\u5468\u56f4\u6c34\u80bf\uff0816-23\uff05\uff09
\u808c\u8089\u9aa8\u9abc\u80f8\u75db\uff0820-22\uff05\uff09
\u98df\u6b32\u4e0b\u964d\uff0818-22\uff05\uff09
\u76ae\u75b9\uff0816-22\uff05\uff09
\u54b3\u55fd\uff0814-21\uff05\uff09
\u9ad8\u9499\u8840\u75c7\uff0812-21\uff05\uff09
\u5934\u6655\uff0817-20\uff05\uff09
\u808c\u8089\u75c9\u631b\uff0819\uff05\uff09
\u767d\u7ec6\u80de\u51cf\u5c11\u75c7\uff0811-18\uff05\uff09
\u5173\u8282\u75db\uff0815-16\uff05\uff09
\u5c3f\u8def\u611f\u67d3\uff088-16\uff05\uff09
\u591a\u6c57\u75c7\uff086-16\uff05\uff09
\u9ad8\u8840\u7cd6\uff0812-15\uff05\uff09
\u808c\u8089\u9aa8\u9abc\u75bc\u75db\uff0811-15\uff05\uff09
\u9f3b\u51fa\u8840\uff0811-15\uff05\uff09
\u7619\u75d2\u75c7\uff0811-15\uff05\uff09
\u8840\u808c\u9150\u589e\u52a0\uff0811-15\uff05\uff09
\u80be\u529f\u80fd\u8870\u7aed\uff0810-15\uff05\uff09
\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\uff084-15\uff05\uff09
\u5455\u5410\uff0813-14\uff05\uff09
\u51cf\u91cd\uff088-14\uff05\uff09
\u5931\u7720\uff087-14\uff05\uff09
\u80a2\u4f53\u75bc\u75db\uff085-14\uff05\uff09
\u4f4e\u94a0\u8840\u75c7\uff0810-13\uff05\uff09
\u6df7\u4e71\u72b6\u6001\uff0810-13\uff05\uff09
\u9707\u98a4\uff089-13\uff05\uff09
\u5934\u75db\uff088-13\uff05\uff09
\u76d7\u6c57\uff085-13\uff05\uff09
\u808c\u8089\u65e0\u529b\uff0812\uff05\uff09
\u4f4e\u9499\u8840\u75c7\uff086-12\uff05\uff09
\u9aa8\u75db\uff085-12\uff05\uff09
\u4f4e\u94be\u8840\u75c7\uff0811\uff05\uff09
\u76ae\u80a4\u5e72\u71e5\uff089-11\uff05\uff09
\u5bd2\u6218\uff089-11\uff05\uff09
\u7126\u8651\uff087-11\uff05\uff09
\u4f53\u91cd\u589e\u52a0\uff081-11\uff05\uff09
1-10\uff05
\u795e\u7ecf\u75c5\u53d8\uff0c\u5916\u5468\uff087-10\uff05\uff09
\u75bc\u75db\uff085-6\uff05\uff09
\u8840\u6813\u6813\u585e\uff083\uff05\uff09
\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff083\uff05\uff09
\u4e0a\u5e02\u540e\u62a5\u544a
\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u75c7
\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u518d\u6fc0\u6d3b
\u5e26\u72b6\u75b1\u75b9
\u80c3\u80a0\u9053\u51fa\u8840
\u57fa\u5e95\u7ec6\u80de\u764c
\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c
\u8840\u6db2\u548c\u6dcb\u5df4\u7cfb\u7edf\u75be\u75c5\uff1aPancytopenia
\u80c3\u80a0\u9053\u75be\u75c5\uff1a\u80c3\u80a0\u9053\u51fa\u8840
\u809d\u80c6\u75be\u75c5\uff1a\u809d\u529f\u80fd\u8870\u7aed\uff08\u5305\u62ec\u81f4\u547d\u75c5\u4f8b\uff09\uff0c\u809d\u9176\u5347\u9ad8
\u514d\u75ab\u7cfb\u7edf\u75be\u75c5\uff1a\u8fc7\u654f\u53cd\u5e94\uff08\u5982\u8840\u7ba1\u795e\u7ecf\u6027\u6c34\u80bf\uff0c\u8368\u9ebb\u75b9\uff09
\u611f\u67d3\u548c\u611f\u67d3\uff1a\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u518d\u6fc0\u6d3b\uff0c\u5e26\u72b6\u75b1\u75b9
\u826f\u6027\uff0c\u6076\u6027\u548c\u672a\u6307\u5b9a\u7684\u80bf\u7624\uff08\u5305\u62ec\u56ca\u80bf\u548c\u606f\u8089\uff09\uff1a\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u75c7\uff0c\u57fa\u5e95\u7ec6\u80de\u764c\u548c\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c
\u76ae\u80a4\u548c\u76ae\u4e0b\u7ec4\u7ec7\u75be\u75c5\uff1a\u53f2\u8482\u6587\u65af \u2013 \u7ea6\u7ff0\u900a\u7efc\u5408\u75c7\uff0c\u4e2d\u6bd2\u6027\u8868\u76ae\u574f\u6b7b\u677e\u89e3\u75c7\uff0c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u75c7\u548c\u5168\u8eab\u75c7\u72b6\u7684\u836f\u7269\u53cd\u5e94\uff08DRESS\uff09
\u9ed1\u5323\u5b50\u8b66\u544a
\u80da\u80ce \u2013 \u80ce\u513f\u6bd2\u6027<\/p>\n\n\n\n

\u6000\u5b55\u671f\u95f4\u7981\u5fcc
Pomalidomide\u662f\u4e00\u79cd\u6c99\u5229\u5ea6\u80fa\u7c7b\u4f3c\u7269\uff0c\u662f\u4e00\u79cd\u5df2\u77e5\u7684\u4eba\u7c7b\u81f4\u7578\u539f\uff0c\u53ef\u5bfc\u81f4\u4e25\u91cd\u7684\u5148\u5929\u6027\u7f3a\u9677\u6216\u80da\u80ce \u2013 \u80ce\u513f\u6b7b\u4ea1
\u5728\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\u4e2d\uff0c\u5728\u5f00\u59cb\u6cbb\u7597\u524d\u83b7\u5f972\u6b21\u9634\u6027\u598a\u5a20\u8bd5\u9a8c
\u544a\u77e5\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\uff0c\u5979\u4eec\u5fc5\u987b\u5728\u6cbb\u7597\u524d4\u5468\u907f\u514d\u6000\u5b55
\u5177\u6709\u751f\u6b96\u6f5c\u529b\u7684\u5987\u5973\u5fc5\u987b\u4f7f\u75282\u79cd\u907f\u5b55\u65b9\u6cd5\uff0c\u6216\u5728\u505c\u6b62\u4f7f\u7528pomalidomide\u540e4\u5468\u5185\u7ee7\u7eed\u907f\u514d\u5f02\u6027\u6027\u884c\u4e3a
\u51fa\u73b0\u5728\u7cbe\u6db2\u4e2d; \u7537\u6027\u5fc5\u987b\u59cb\u7ec8\u4f7f\u7528\u4e73\u80f6\u6216\u5408\u6210\u907f\u5b55\u5957\uff0c\u5728\u4e0e\u751f\u6b96\u6f5c\u529b\u7684\u5973\u6027\u53d1\u751f\u4efb\u4f55\u6027\u63a5\u89e6\u65f6\u670d\u7528pomalidomide\uff0c\u505c\u6b62\u6cbb\u7597\u540e4\u5468
\u7537\u6027\u60a3\u8005\u5728\u505c\u836f\u540e4\u5468\u5185\u4e0d\u5f97\u6350\u732e\u7cbe\u5b50
\u7537\u6027\u548c\u5973\u6027\u60a3\u8005\u5728\u6cbb\u7597\u671f\u95f4\u548c\u505c\u836f\u540e4\u5468\u5185\u4e0d\u5f97\u732e\u8840
\u9759\u8109\u548c\u8840\u6813\u6813\u585e<\/p>\n\n\n\n

\u7528pomalidomide\u6cbb\u7597\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u53d1\u751f\u6df1\u9759\u8109\u8840\u6813\u5f62\u6210\uff08DVT\uff09\uff0c\u80ba\u6813\u585e\uff08PE\uff09\uff0c\u5fc3\u808c\u6897\u6b7b\u548c\u4e2d\u98ce; \u63a8\u8350\u6297\u8840\u6813\u9884\u9632
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