{"id":264,"date":"2023-10-08T15:54:26","date_gmt":"2023-10-08T07:54:26","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=264"},"modified":"2023-10-19T18:49:16","modified_gmt":"2023-10-19T10:49:16","slug":"%e5%a4%9a%e5%a5%88%e5%93%8c%e9%bd%90donepezil","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=264","title":{"rendered":"\u591a\u5948\u54cc\u9f50(Donepezil)"},"content":{"rendered":"\n
\"\u591a\u5948\u54cc\u9f50\"<\/figure>\n\n\n\n

\u3010\u836f\u54c1\u540d\u79f0\u3011<\/p>\n\n\n\n

  \u901a\u7528\u540d\u79f0\uff1a\u76d0\u9178\u591a\u5948\u54cc\u9f50\u7247<\/p>\n\n\n\n

  \u5546\u54c1\u540d\u79f0\uff1a\u76d0\u9178\u591a\u5948\u54cc\u9f50\u7247(\u963f\u745e\u65af) \u56fd\u5185\u540d\u79f0\uff1a\u5b89\u7406\u7533<\/p>\n\n\n\n

  \u82f1\u6587\u540d\u79f0\uff1aDonepezil Hydrochloride Tablets<\/p>\n\n\n\n

  \u62fc\u97f3\u5168\u7801\uff1aYanSuanDuoNaiPaiQiPian(ARuiSi)<\/p>\n\n\n\n

\u3010\u4e3b\u8981\u6210\u4efd\u3011 \u672c\u54c1\u4e3b\u8981\u6210\u4efd\u4e3a\uff1a\u76d0\u9178\u591a\u5948\u54cc\u9f50\u3002<\/p>\n\n\n\n

\u3010\u6210 \u4efd\u3011<\/p>\n\n\n\n

  \u5316\u5b66\u540d\uff1a(\u00b1)-2-[(l-benzylpiperidin-4-yl)methyl]-5\uff0c6-dimethoxyindan-1-one monohydrochloride<\/p>\n\n\n\n

   \u5206\u5b50\u91cf\uff1aC24H29NO3\u00b7HCl<\/p>\n\n\n\n

\u3010\u6027 \u72b6\u3011 \u672c\u54c1\u4e3a\u8584\u819c\u8863\u7247\uff0c\u9664\u53bb\u5305\u8863\u540e\u663e\u767d\u8272\u6216\u7c7b\u767d\u8272\u3002<\/p>\n\n\n\n

\u3010\u9002\u5e94\u75c7\/\u529f\u80fd\u4e3b\u6cbb\u3011 \u8f7b\u5ea6\u6216\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u578b\u75f4\u5446\u75c7\u72b6\u7684\u6cbb\u7597\u3002<\/p>\n\n\n\n

\u3010\u89c4\u683c\u578b\u53f7\u3011 10mg*100(\u963f\u745e\u65af)<\/p>\n\n\n\n

\u3010\u7528\u6cd5\u7528\u91cf\u3011 \u53e3\u670d\u3002\u521d\u59cb\u7528\u91cf\u6bcf\u6b215mg\uff081\u7247\uff09\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u7761\u524d\u670d\u7528\uff1b\u5e76\u81f3\u5c11\u5c06\u521d\u59cb\u5242\u91cf\u7ef4\u63011\u4e2a\u6708\u4ee5\u4e0a\uff0c\u624d\u53ef\u6839\u636e\u6cbb\u7597\u6548\u679c\u589e\u52a0\u5242\u91cf\u81f3\u6bcf\u6b2110mg\uff082\u7247\uff09\uff0c\u4ecd\u6bcf\u65e5\u4e00\u6b21\u3002\u6700\u5927\u63a8\u8350\u5242\u91cf\u4e3a\u6bcf\u65e510mg\u3002\u5927\u4e8e\u6bcf\u65e510mg\u7684\u5242\u91cf\u672a\u8fdb\u884c\u8fc7\u4e34\u5e8a\u7814\u7a76\u3002\u505c\u6b62\u6cbb\u7597\u540e\uff0c\u76d0\u9178\u591a\u5948\u54cc\u9f50\u7684\u7597\u6548\u9010\u6e10\u51cf\u9000\uff0c\u4e2d\u6b62\u6cbb\u7597\u65e0\u53cd\u8df3\u73b0\u8c61\u3002\u5bf9\u4e8e\u80be\u529f\u80fd\u4e0d\u5168\u53ca\u8f7b\u81f3\u4e2d\u5ea6\u809d\u529f\u80fd\u4e0d\u5168\u8005\uff0c\u76d0\u9178\u591a\u5948\u54cc\u9f50\u7684\u6d88\u9664\u4e0d\u53d7\u5f71\u54cd\uff0c\u56e0\u6b64\u8fd9\u4e9b\u75c5\u4eba\u53ef\u4f7f\u7528\u76f8\u4f3c\u5242\u91cf\u65b9\u6848\u3002\u6216\u9075\u533b\u5631\u3002<\/p>\n\n\n\n

\u3010\u4e0d\u826f\u53cd\u5e94\u3011 \u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265(greaterthanorequalto)5%\uff0c\u5e76\u4e14\u662f\u5b89\u6170\u5242\u7ec4\u76842\u500d\uff09\u4e3a\u8179\u6cfb\u3001\u808c\u8089\u75c9\u631b\u3001\u4e4f\u529b\u3001\u6076\u5fc3\u3001\u5455\u5410\u548c\u5931\u7720\u3002\u5176\u5b83\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265(greaterthanorequalto)5%\u5e76\u4e14\u2265(greaterthanorequalto)\u5b89\u6170\u5242\u7ec4\uff09\u4e3a\u5934\u75db\u3001\u75bc\u75db\u3001\u610f\u5916\u4f24\u5bb3\u3001\u666e\u901a\u611f\u5192\u3001\u8179\u90e8\u5668\u5b98\u673a\u80fd\u7d0a\u4e71\u548c\u5934\u6655\u3002\u6655\u53a5\u3001\u5fc3\u52a8\u8fc7\u7f13\u548c\u5c11\u89c1\u7684\u7aa6\u623f\u4f20\u5bfc\u963b\u6ede\u3001\u623f\u5ba4\u4f20\u5bfc\u963b\u6ede\u548c\u766b\u75eb\u4e5f\u6709\u62a5\u9053\u3002<\/p>\n\n\n\n

\u3010\u7981 \u5fcc\u3011 \u7981\u7528\u4e8e\u5bf9\u76d0\u9178\u591a\u5948\u54cc\u9f50\u3001\u54cc\u5576\u884d\u751f\u7269\u6216\u5236\u5242\u4e2d\u8d4b\u5f62\u5242\u6709\u8fc7\u654f\u53f2\u7684\u75c5\u4eba\u3002\u7981\u7528\u4e8e\u598a\u5a20\u53ca\u54fa\u4e73\u671f\u5987\u5973\u3002<\/p>\n\n\n\n

\u3010\u6ce8\u610f\u4e8b\u9879\u3011 \u5e94\u5f53\u7531\u4e00\u4e2a\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u578b\u75f4\u5446\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u6709\u7ecf\u9a8c\u7684\u533b\u5e08\u5f00\u59cb\u5e76\u76d1\u7763\u76d0\u9178\u591a\u5948\u54cc\u9f50\u7684\u6cbb\u7597\u3002\u901a\u8fc7\u516c\u8ba4\u7684\u6807\u51c6\uff08\u5982DSM IV\uff0cICD10\uff09\u6765\u8bca\u65ad\uff0c\u53ea\u6709\u5f53\u60a3\u8005\u6709\u53ef\u9760\u7684\u7167\u6599\u8005\u5e76\u4e14\u80fd\u591f\u7ecf\u5e38\u76d1\u63a7\u75c5\u4eba\u670d\u7528\u836f\u7269\u65f6\u624d\u80fd\u5f00\u59cb\u591a\u5948\u54cc\u9f50\u7684\u6cbb\u7597\u3002\u6cbb\u7597\u53ef\u4ee5\u4e00\u76f4\u6301\u7eed\uff0c\u53ea\u8981\u5bf9\u75c5\u4eba\u6cbb\u7597\u7684\u76ca\u5904\u4e00\u76f4\u5b58\u5728\u3002\u56e0\u6b64\uff0c\u591a\u5948\u54cc\u9f50\u7684\u4e34\u5e8a\u7597\u6548\u5e94\u5f53\u5b9a\u671f\u88ab\u91cd\u65b0\u8bc4\u4f30\u3002\u5f53\u6cbb\u7597\u7684\u76ca\u5904\u4e0d\u518d\u5b58\u5728\u65f6\uff0c\u5e94\u5f53\u8003\u8651\u4e2d\u6b62\u6cbb\u7597\u3002\u6bcf\u4e2a\u75c5\u4eba\u5bf9\u4e8e\u591a\u5948\u54cc\u9f50\u7684\u53cd\u5e94\u662f\u4e0d\u80fd\u88ab\u9884\u4f30\u7684\u3002\u5bf9\u4e8e\u90a3\u4e9b\u4e25\u91cd\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u578b\u75f4\u5446\u75c5\u4eba\uff0c\u5176\u5b83\u7c7b\u578b\u7684\u75f4\u5446\u6216\u5176\u5b83\u7c7b\u578b\u7684\u8bb0\u5fc6\u635f\u4f24(\u4f8b\u5982\uff1a\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u8ba4\u77e5\u529f\u80fd\u51cf\u9000)\u75c5\u4eba\u5e94\u7528\u76d0\u9178\u591a\u5948\u54cc\u9f50\u7684\u6548\u679c\u8fd8\u672a\u5168\u9762\u89c2\u5bdf\u3002\u8bf7\u4ed4\u7ec6\u9605\u8bfb\u8bf4\u660e\u4e66\u5e76\u9075\u533b\u5631\u4f7f\u7528\u3002<\/p>\n\n\n\n

\u3010\u513f\u7ae5\u7528\u836f\u3011 \u76d0\u9178\u591a\u5948\u54cc\u9f50\u4e0d\u63a8\u8350\u7528\u4e8e\u513f\u7ae5\u3002<\/p>\n\n\n\n

\u3010\u8001\u5e74\u60a3\u8005\u7528\u836f\u3011 \u6309\u63a8\u8350\u5242\u91cf\u5e94\u7528\u3002<\/p>\n\n\n\n

\u3010\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7528\u836f\u3011 1.\u598a\u5a20\uff1a\u4ee5\u7ea680\u500d\u4eba\u7528\u5242\u91cf\u5728\u598a\u5a20\u5927\u9f20\u548c50\u500d\u4eba\u7528\u5242\u91cf\u5728\u5bb6\u5154\u4e2d\u505a\u7684\u81f4\u7578\u5b9e\u9a8c\u7ed3\u679c\u672a\u53d1\u73b0\u6709\u81f4\u7578\u6027\u3002\u4f46\u4ee550\u500d\u4eba\u7528\u5242\u91cf\u5728\u598a\u5a20\u5927\u9f20\u6240\u505a\u7684\u5b9e\u9a8c\u4e2d\uff0c\u4ece\u5b5517\u5929\u81f3\u4ea7\u540e20\u5929\u7ed9\u836f\uff0c\u6b7b\u4ea7\u8f7b\u5fae\u589e\u591a\uff0c\u5e76\u4e14\u4ea7\u540e4\u5929\u4ed4\u9f20\u5b58\u6d3b\u7387\u8f7b\u5ea6\u4e0b\u964d\u3002\u4f46\u5728\u7ea615\u500d\u4eba\u7528\u5242\u91cf\u7684\u4e0b\u4e00\u4e2a\u4f4e\u5242\u91cf\u65f6\uff0c\u672a\u53d1\u73b0\u5f02\u5e38\u4f5c\u7528\u3002\u76ee\u524d\u5c1a\u65e0\u5c06\u591a\u5948\u54cc\u9f50\u7528\u4e8e\u5b55\u5987\u7684\u4e34\u5e8a\u8d44\u6599\u3002\u56e0\u6b64\uff0c\u672c\u54c1\u5b55\u5987\u7981\u7528\u3002 2.\u5c1a\u65e0\u54fa\u4e73\u671f\u5987\u5973\u7528\u836f\u7684\u5b89\u5168\u6709\u6548\u6027\u7814\u7a76\u8d44\u6599\uff0c\u6545\u670d\u7528\u672c\u54c1\u5987\u5973\u4e0d\u80fd\u54fa\u4e73\u3002<\/p>\n\n\n\n

\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011 1.CYP3A4\u548cCYP2D6\u540c\u5de5\u9176\u7684\u8bf1\u5bfc\u5242\u82ef\u59a5\u82f1\u94a0\u3001\u5361\u9a6c\u897f\u5e73\u3001\u5730\u585e\u7c73\u677e\u3001\u5229\u798f\u5e73\u3001\u82ef\u5df4\u6bd4\u59a5\u53ef\u63d0\u9ad8\u672c\u54c1\u7684\u6e05\u9664\u7387\u3002 2.CYP3A4\u548cCYP2D6\u540c\u5de5\u9176\u7684\u6291\u5236\u5242\u916e\u5eb7\u5511\u548c\u594e\u5c3c\u4e01\u6291\u5236\u672c\u54c1\u7684\u4ee3\u8c22\u3002 3.\u672c\u54c1\u5bf9\u8336\u78b1\u3001\u897f\u54aa\u66ff\u4e01\u3001\u534e\u6cd5\u6797\u3001\u5730\u9ad8\u8f9b\u7684\u4ee3\u8c22\u672a\u53d1\u73b0\u5e72\u6270\u3002 4.\u672c\u54c1\u53ef\u80fd\u4f1a\u5f71\u54cd\u6709\u6297\u80c6\u78b1\u6d3b\u6027\u7684\u836f\u7269\u3002<\/p>\n\n\n\n

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\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265(greaterthanorequalto)5%\uff0c\u5e76\u4e14\u662f\u5b89\u6170\u5242\u7ec4\u76842\u500d\uff09\u4e3a\u8179\u6cfb\u3001\u808c\u8089\u75c9\u631b\u3001\u4e4f\u529b\u3001\u6076\u5fc3\u3001\u5455\u5410\u548c\u5931\u7720\u3002\u5176\u5b83\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u53d1\u751f\u7387\u2265(greaterthanorequalto)5%\u5e76\u4e14\u2265(greaterthanorequalto)\u5b89\u6170\u5242\u7ec4\uff09\u4e3a\u5934\u75db\u3001\u75bc\u75db\u3001\u610f\u5916\u4f24\u5bb3\u3001\u666e\u901a\u611f\u5192\u3001\u8179\u90e8\u5668\u5b98\u673a\u80fd\u7d0a\u4e71\u548c\u5934\u6655\u3002\u6655\u53a5\u3001\u5fc3\u52a8\u8fc7\u7f13\u548c\u5c11\u89c1\u7684\u7aa6\u623f\u4f20\u5bfc\u963b\u6ede\u3001\u623f\u5ba4\u4f20\u5bfc\u963b\u6ede\u548c\u766b\u75eb\u4e5f\u6709\u62a5\u9053\u3002\u6682\u65e0\u7981\u7528\u4e8e\u5bf9\u76d0\u9178\u591a\u5948\u54cc\u9f50\u3001\u54cc\u5576\u884d\u751f\u7269\u6216\u5236\u5242\u4e2d\u8d4b\u5f62\u5242\u6709\u8fc7\u654f\u53f2\u7684\u75c5\u4eba\u3002\u7981\u7528\u4e8e\u598a\u5a20\u53ca\u54fa\u4e73\u671f\u5987\u5973\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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