{"id":141,"date":"2023-09-19T12:34:25","date_gmt":"2023-09-19T04:34:25","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=141"},"modified":"2023-10-19T18:40:36","modified_gmt":"2023-10-19T10:40:36","slug":"%e5%a5%a5%e8%b4%9d%e8%83%86%e9%85%b8obeticholic","status":"publish","type":"post","link":"https:\/\/www.yaozhiyou.com\/?p=141","title":{"rendered":"\u5965\u8d1d\u80c6\u9178(obeticholic)"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"266\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/t017a214810dea5b341.jpg\" alt=\"\u5965\u8d1d\u80c6\u9178(obeticholic)\" class=\"wp-image-142\" srcset=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/t017a214810dea5b341.jpg 400w, https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/t017a214810dea5b341-300x200.jpg 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n\n\n\n<p><strong>\u5b5f\u52a0\u62c9\u78a7\u5eb7\u5236\u836f\u5965\u8d1d\u80c6\u9178(obeticholic) -\u8bf4\u660e\u4e66-\u9002\u5e94\u75c7-\u7528\u6cd5\u7528\u91cf-\u526f\u4f5c\u7528\u7b49<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u578b<\/h3>\n\n\n\n<p>\u7247\u5242 5\u6beb\u514b\u548c10\u6beb\u514b<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u53e3\u670d\u7ba1\u7406<\/h3>\n\n\n\n<p>\u53ef\u5e26\u6216\u4e0d\u5e26\u98df\u7269<\/p>\n\n\n\n<p>\u4f34\u968f\u7684\u80c6\u6c41\u9178\u7ed3\u5408\u6811\u8102\uff1a\u5c06\u5bf9\u7f9f\u57fa\u82ef\u7532\u9178\u5242\u91cf\u5206\u5f00\u81f3\u5c114\u5c0f\u65f6<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5b58\u50a8<\/h3>\n\n\n\n<p>\u50a8\u5b58\u572820-25\u00baC\uff0868-77\u00baF\uff09;&nbsp;\u77ed\u9014\u65c5\u884c\u5141\u8bb815-30\u00baC\uff0859-86\u00baF\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e<\/h3>\n\n\n\n<p>\u5965\u8d1d\u80c6\u9178\u9002\u7528\u4e8e\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\uff08PBC\uff09\u8054\u5408\u718a\u53bb\u6c27\u80c6\u9178\uff08UDCA\uff09\uff0c\u6210\u4eba\u5bf9UDCA\u7684\u53cd\u5e94\u81f3\u5c111\u5e74\uff0c\u6216\u8005\u6210\u4eba\u5355\u836f\u6cbb\u7597\u65e0\u6cd5\u8010\u53d7UDCA<\/p>\n\n\n\n<p>\u5728\u6000\u7591\u60a3\u6709\u809d\u786c\u5316\u7684\u60a3\u8005\u4e2d\u5f00\u59cb\u4f7f\u7528obeticholic acid\u4e4b\u524d\uff0c\u4f7f\u7528\u8bfa\u6a21\u56fe\uff08\u4e0b\u6587\u63d0\u4f9b\uff09\u786e\u5b9a\u60a3\u8005\u7684Child-Pugh\u5206\u7c7b\uff08A\uff0cB\u6216C\uff09\uff0c\u5e76\u786e\u5b9a\u5408\u9002\u7684\u8d77\u59cb\u5242\u91cf<\/p>\n\n\n\n<p>Child-Pugh\u8bfa\u6a21\u56fe<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5728\u5f00\u59cb\u4e4b\u524d\u8ba1\u7b97Child-Pugh\u7c7b<\/li>\n\n\n\n<li>\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5e38\u89c4\u76d1\u6d4b\u751f\u5316\u53cd\u5e94\uff0c\u8010\u53d7\u6027\uff0cPBC\u75be\u75c5\u7684\u8fdb\u5c55\uff0c\u5e76\u91cd\u65b0\u8bc4\u4f30Child-Pugh\u5206\u7c7b\uff0c\u4ee5\u786e\u5b9a\u662f\u5426\u9700\u8981\u8c03\u6574\u5242\u91cf<\/li>\n\n\n\n<li>\u9002\u7528\u4e8e\u8fdb\u5c55\u4e3a\u665a\u671f\u75be\u75c5\u7684\u60a3\u8005\uff08\u5373\u4eceChild-Pugh A\u7ea7\u5230Child-Pugh B\u7ea7\u6216C\u7ea7\uff09\uff0c\u6bcf\u65e5\u4e00\u6b21\u81f3\u6bcf\u5468\u4e00\u6b21\u7684\u5242\u91cf\u9891\u7387\u964d\u4f4e<\/li>\n\n\n\n<li>\u8111\u75c5\u7b49\u7ea7\n<ul class=\"wp-block-list\">\n<li>0\u7ea7\uff1a1\u5206<\/li>\n\n\n\n<li>1\u5e74\u7ea7\u62162\u5e74\u7ea7\uff1a2\u5206<\/li>\n\n\n\n<li>3\u62164\u5e74\u7ea7\uff1a3\u5206<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u8179\u6c34\n<ul class=\"wp-block-list\">\n<li>\u7f3a\u5e2d\uff1a1\u5206<\/li>\n\n\n\n<li>\u8f7b\u5fae\uff1a2\u5206<\/li>\n\n\n\n<li>\u4e2d\u7b49\uff1a3\u5206<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u8840\u6e05\u80c6\u7ea2\u7d20\uff08mg \/ dL\uff09\n<ul class=\"wp-block-list\">\n<li>&lt;2\uff1a1\u5206<\/li>\n\n\n\n<li>2-3\uff1a2\u5206<\/li>\n\n\n\n<li>&gt; 3\uff1a3\u5206<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u8840\u6e05\u767d\u86cb\u767d\uff08g \/ dL\uff09\n<ul class=\"wp-block-list\">\n<li>&gt; 3.5\uff1a1\u5206<\/li>\n\n\n\n<li>2.8-3.5\uff1a2\u5206<\/li>\n\n\n\n<li>&lt;2.8\uff1a3\u5206<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>INR\n<ul class=\"wp-block-list\">\n<li>&lt;1.7\uff1a1\u5206<\/li>\n\n\n\n<li>1.7-2.2\uff1a2\u5206<\/li>\n\n\n\n<li>&gt; 2.2\uff1a3\u5206<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Child-Pugh\u7c7b\uff08\u6240\u6709\u79ef\u5206\u7684\u603b\u548c\uff09\n<ul class=\"wp-block-list\">\n<li>\u901a\u8fc7\u6dfb\u52a0\u6765\u81ea\u6240\u67095\u4e2a\u53c2\u6570\u7684\u70b9\u6765\u83b7\u5f97Child-Pugh\u7c7b\u4ee5\u5f97\u51fa\u603b\u5206\uff0c\u5176\u53ef\u4ee5\u57285-15\u4e2a\u70b9\u7684\u8303\u56f4\u5185<\/li>\n\n\n\n<li>Child-Pugh A\u7ea7\uff1a5-6\u5206<\/li>\n\n\n\n<li>Child-Pugh B\u7ea7\uff1a7-9\u5206<\/li>\n\n\n\n<li>Child-Pugh C\u7ea7\uff1a10-15\u5206<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u8d77\u59cb\u5242\u91cf\u548c\u6ef4\u5b9a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u975e\u809d\u786c\u5316\u6216\u8865\u507fChild-Pugh A\u7ea7\n<ul class=\"wp-block-list\">\n<li>\u8d77\u59cb\u5242\u91cf\uff1a5mg \u6bcf\u5929<\/li>\n\n\n\n<li>\u5242\u91cf\u6ef4\u5b9a\uff1a\u5982\u679c\u57285\u6beb\u514b\/\u59293\u4e2a\u6708\u540e\u4ecd\u672a\u8fbe\u5230\u8db3\u591f\u7684\u53cd\u5e94\uff0c\u5e76\u4e14\u8010\u53d7\u78b1\u66ff\u5361\u7f57\u916e\uff0c\u5219\u5c06\u5242\u91cf\u589e\u52a0\u81f310\u6beb\u514b\u6bcf\u5929<\/li>\n\n\n\n<li>\u4e0d\u8d85\u8fc710\u6beb\u514b\/\u5929<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Child-Pugh B\u7ea7\u6216C\u7ea7\uff0c\u6216\u4e4b\u524d\u7684\u5931\u4ee3\u507f\u4e8b\u4ef6\n<ul class=\"wp-block-list\">\n<li>\u8d77\u59cb\u5242\u91cf\uff1a\u6bcf\u5468\u4e00\u6b215mg<\/li>\n\n\n\n<li>\u5242\u91cf\u6ef4\u5b9a\uff1a\u5982\u679c\u5728\u6bcf\u5468\u4e00\u6b215\u6beb\u514b3\u4e2a\u6708\u540e\u6ca1\u6709\u8fbe\u5230\u8db3\u591f\u7684\u53cd\u5e94\uff0c\u5e76\u4e14\u8010\u53d7\u78b1\u66ff\u5361\u7f57\u916e\uff0c\u5219\u6bcf\u5468\u4e24\u6b21\u589e\u52a0\u5242\u91cf\u81f35\u6beb\u514b\uff08\u81f3\u5c11\u95f4\u96943\u5929\uff09<\/li>\n\n\n\n<li>\u6839\u636e\u53cd\u5e94\u548c\u8010\u53d7\u6027\uff0c\u6bcf\u5468\u4e24\u6b21\uff08\u81f3\u5c11\u95f4\u96943\u5929\uff09\u6ef4\u5b9a\u81f310 mg<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u91cf\u4fee\u6539<\/h3>\n\n\n\n<p>\u96be\u4ee5\u5fcd\u53d7\u7684\u7619\u75d2\u75c7<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8003\u8651\u4ee5\u4e0b\u4e00\u4e2a\u6216\u591a\u4e2a\u9009\u9879\uff1a<\/li>\n\n\n\n<li>\u975e\u809d\u786c\u5316\u6216\u8865\u507f\u6027\u809d\u786c\u5316Child-Pugh A\u7ea7\n<ul class=\"wp-block-list\">\n<li>\u52a0\u5165\u6297\u7ec4\u80fa\u836f\u6216\u80c6\u6c41\u9178\u7ed3\u5408\u6811\u8102<\/li>\n\n\n\n<li>\u6682\u65f6\u4e2d\u65ad\u6cbb\u7597\u957f\u8fbe2\u5468\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u5242\u91cf\u91cd\u65b0\u5f00\u59cb<\/li>\n\n\n\n<li>\u5982\u679c\u4e0d\u8010\u53d75\u6beb\u514b\/\u5929\uff0c\u6bcf\u9694\u4e00\u5929\u51cf\u5c11\u52305\u6beb\u514b<\/li>\n\n\n\n<li>\u5982\u679c\u4e0d\u8010\u53d710\u6beb\u514b\/\u5929\uff0c\u51cf\u5c11\u52305\u6beb\u514b\/\u5929<\/li>\n\n\n\n<li>\u5bf9\u4e8e\u5242\u91cf\u51cf\u5c11\u6216\u4e2d\u65ad\u7684\u60a3\u8005\uff0c\u6839\u636e\u751f\u5316\u53cd\u5e94\uff0c\u8010\u53d7\u6027\u6ef4\u5b9a\u5242\u91cf\uff0c\u5e76\u6839\u636eChild-Pugh\u5206\u7c7b\u8fdb\u884c\u8c03\u6574<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Child-Pugh B\u7ea7\u6216C\u7ea7\u6216\u4e4b\u524d\u7684\u5931\u4ee3\u507f\u4e8b\u4ef6\n<ul class=\"wp-block-list\">\n<li>\u52a0\u5165\u6297\u7ec4\u80fa\u836f\u6216\u80c6\u6c41\u9178\u7ed3\u5408\u6811\u8102<\/li>\n\n\n\n<li>\u6682\u65f6\u4e2d\u65ad\u6cbb\u7597\u957f\u8fbe2\u5468\uff0c\u7136\u540e\u5728\u9002\u5f53\u7684\u60c5\u51b5\u4e0b\u4ee5\u51cf\u5c11\u5242\u91cf\u91cd\u65b0\u5f00\u59cb;&nbsp;\u6839\u636e\u751f\u5316\u53cd\u5e94\uff0c\u8010\u53d7\u6027\u6ef4\u5b9a\u5242\u91cf\uff0c\u5e76\u6839\u636eChild-Pugh\u5206\u7c7b\u8fdb\u884c\u8c03\u6574<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u6cbb\u7597\u4e2d\u6b62\n<ul class=\"wp-block-list\">\n<li>\u8003\u8651\u5728\u7ee7\u7eed\u7ecf\u5386\u65e0\u6cd5\u5fcd\u53d7\u7684\u7619\u75d2\u75c7\u7684\u60a3\u8005\u4e2d\u505c\u6b62\u6cbb\u7597<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u809d\u529f\u80fd\u635f\u5bb3<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6839\u636eChild-Pugh\u7c7b\uff0c\u53c2\u89c1\u6210\u4eba\u5242\u91cf\u7ed9\u836f\u5242\u91cf\u5efa\u8bae<\/li>\n\n\n\n<li>\u7981\u7528\u5b8c\u5168\u6027\u80c6\u9053\u6897\u963b<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u91cf\u6ce8\u610f\u4e8b\u9879<\/h3>\n\n\n\n<p>\u57fa\u4e8e\u78b1\u6027\u78f7\u9178\u9176\u7684\u51cf\u5c11\uff0c\u5728\u52a0\u901f\u6279\u51c6\u4e0b\u6279\u51c6\u6307\u793a;&nbsp;\u7ee7\u7eed\u6279\u51c6\u8be5\u9002\u5e94\u75c7\u53ef\u80fd\u53d6\u51b3\u4e8e\u786e\u8ba4\u8bd5\u9a8c\u4e2d\u7684\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0<\/p>\n\n\n\n<p>\u5bc6\u5207\u76d1\u6d4b\u809d\u529f\u80fd\u5931\u4ee3\u507f\u98ce\u9669\u589e\u52a0\u7684\u60a3\u8005\uff0c\u5305\u62ec\u809d\u529f\u80fd\u6076\u5316\u7684\u5b9e\u9a8c\u5ba4\u8bc1\u636e\uff08\u5373\u603b\u80c6\u7ea2\u7d20\uff0cINR\uff0c\u767d\u86cb\u767d\uff09\u548c\/\u6216\u8fdb\u5c55\u4e3a\u809d\u786c\u5316\u7684\u60a3\u8005<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u5176\u4ed6\u836f\u7269\u5f71\u54cd<\/h4>\n\n\n\n<p><strong>\u5bc6\u5207\u5173\u6ce8\uff086\uff09<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\" id=\"draglist3\">\n<li>\u6d88\u80c6\u80fa<\/li>\n\n\n\n<li>\u8003\u6765\u7ef4\u4ed1<\/li>\n\n\n\n<li>\u8003\u6765\u66ff\u6cca<\/li>\n\n\n\n<li>\u8336\u78b1<\/li>\n\n\n\n<li>\u66ff\u624e\u5c3c\u5b9a<\/li>\n\n\n\n<li>\u534e\u6cd5\u6797<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e0d\u826f\u53cd\u5e94<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">&gt; 10\uff05\u7684<\/h3>\n\n\n\n<p>\u7619\u75d2\u75c7\uff0856-70\uff05\uff09<\/p>\n\n\n\n<p>\u75b2\u52b3\uff0819-25\uff05\uff09<\/p>\n\n\n\n<p>\u4e25\u91cd\u7619\u75d2\u75c7\uff0819-23\uff05\uff09<\/p>\n\n\n\n<p>\u964d\u4f4eHDL-C\uff089-20\uff05\uff09<\/p>\n\n\n\n<p>\u8179\u75db\u548c\u4e0d\u9002\uff0810-19\uff05\uff09<\/p>\n\n\n\n<h3 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