{"id":94,"date":"2023-09-18T15:22:13","date_gmt":"2023-09-18T07:22:13","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=94"},"modified":"2023-09-18T15:22:13","modified_gmt":"2023-09-18T07:22:13","slug":"%e5%85%8b%e5%94%91%e6%9b%bf%e5%b0%bccrizocent%e7%99%bd%e7%9b%92%e4%bc%8a%e6%80%9d%e8%be%beincepta%e4%bb%8b%e7%bb%8d","status":"publish","type":"post","link":"http:\/\/www.yaozhiyou.com\/?p=94","title":{"rendered":"\u514b\u5511\u66ff\u5c3ccrizocent|\u767d\u76d2\u4f0a\u601d\u8fbeincepta\u4ecb\u7ecd"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"358\" height=\"365\" src=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u767d\u514b.jpg\" alt=\"\" class=\"wp-image-95\" srcset=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u767d\u514b.jpg 358w, http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u767d\u514b-294x300.jpg 294w\" sizes=\"auto, (max-width: 358px) 100vw, 358px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/h3>\n\n\n\n<p>\u514b\u5511\u66ff\u5c3c\u9002\u7528\u4e8e\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u5373\u7ecfFDA\u6279\u51c6\u7684\u68c0\u6d4b\u6240\u68c0\u6d4b\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\u9633\u6027\u3002\u4e5f\u9002\u7528\u4e8eROS1\u9633\u6027\u7684\u8f6c\u79fb\u6027NSCLC\u80bf\u7624\u3002<\/p>\n\n\n\n<p>\u6839\u636e\u80bf\u7624\u6807\u672c\u4e2dALK\u6216ROS1\u9633\u6027\u7684\u5b58\u5728\uff0c\u9009\u62e9\u6cbb\u7597\u8f6c\u79fb\u6027NSCLC\u7684\u60a3\u8005\u3002<\/p>\n\n\n\n<p>\u6bcf12\u5c0f\u65f6\u53e3\u670d250\u6beb\u514b\u514b\u5511\u66ff\u5c3c\uff0c\u53ea\u8981\u60a3\u8005\u4ece\u6cbb\u7597\u4e2d\u83b7\u5f97\u4e34\u5e8a\u76ca\u5904\uff0c\u5c31\u7ee7\u7eed\u6cbb\u7597\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u578b\uff1a\u80f6\u56ca<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>200mg \u548c 250mg 2\u79cd\u89c4\u683c<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5242\u91cf\u8c03\u6574<\/strong><\/p>\n\n\n\n<p>\u6839\u636e\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u53ef\u80fd\u9700\u8981\u7ed9\u836f\u4e2d\u65ad\u548c\/\u6216\u5242\u91cf\u51cf\u5c11\u81f3200 mg \/12\u5c0f\u65f6; \u5982\u679c\u9700\u8981\u8fdb\u4e00\u6b65\u51cf\u5c11\uff0c\u5219\u51cf\u5c11\u81f3250 mg \/\u6bcf\u5929<\/p>\n\n\n\n<p>NCI\u4e0d\u826f\u4e8b\u4ef6\u5e38\u7528\u672f\u8bed\u6807\u51c6\u8bc4\u5b9a\u7684\u4e34\u5e8a\u4e0d\u826f\u4e8b\u4ef6\u7684\u5f3a\u5ea6<\/p>\n\n\n\n<p><strong>\u8840\u6db2\u5b66\u6bd2\u6027<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5242\u91cf\u8c03\u6574\u9002\u7528\u4e8e\u9664\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u5916\u7684\u6240\u6709\u8840\u6db2\u5b66\u6bd2\u6027\uff08\u9664\u975e\u4e0e\u4e34\u5e8a\u4e8b\u4ef6\u76f8\u5173\uff0c\u4f8b\u5982\u673a\u4f1a\u6027\u611f\u67d3\uff09<\/li>\n\n\n\n<li>3\u7ea7AE\uff1a\u6263\u7559\u81f3\u6062\u590d\u81f3\u22642\u7ea7\uff0c\u7136\u540e\u4ee5\u76f8\u540c\u7684\u5242\u91cf\u65f6\u95f4\u8868\u6062\u590d<\/li>\n\n\n\n<li>4\u7ea7AE\uff1a\u505c\u7559\u81f3\u6062\u590d\u81f3\u22642\u7ea7\uff0c\u7136\u540e\u6062\u590d\u81f3200 mg PO q12hr\uff08\u5982\u679c\u590d\u53d1\uff0c\u4fdd\u7559\u81f3\u6062\u590d\u81f3\u22642\u7ea7\uff0c\u5219\u6062\u590d\u81f3250 mg PO qDay;\u57284\u7ea7\u590d\u53d1\u65f6\u6c38\u4e45\u505c\u6b62\uff09<\/li>\n<\/ul>\n\n\n\n<p><strong>\u975e\u8840\u6db2\u5b66\u6bd2\u6027<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>3\u7ea7\u62164\u7ea7\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u6216\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u5347\u9ad8\uff0c\u22641\u7ea7\u603b\u80c6\u7ea2\u7d20\uff1a\u505c\u7559\u81f3\u6062\u590d\u81f3\u22641\u7ea7\u6216\u57fa\u7ebf\uff0c\u7136\u540e\u6062\u590d\u81f3200 mg PO q12hr\uff08\u5982\u679c\u590d\u53d1\uff0c\u505c\u7559\u81f3\u6062\u590d\u81f3\u7b49\u7ea7\u22641\uff0c\u7136\u540e\u6062\u590d\u4e3a250 mg PO qDay;\u5982\u679c\u518d\u6b21\u8fdb\u51653\u7ea7\u62164\u7ea7\uff0c\u5219\u6c38\u4e45\u505c\u6b62\uff09<\/li>\n\n\n\n<li>2\u7ea7\uff0c3\u7ea7\u62164\u7ea7ALT\u6216AST\u5347\u9ad8\uff0c\u540c\u65f6\u53d1\u751f2\u7ea7\uff0c3\u7ea7\u62164\u7ea7\u80c6\u7ea2\u7d20\u5347\u9ad8\uff08\u65e0\u80c6\u6c41\u6de4\u79ef\u6216\u6eb6\u8840\uff09\uff1a\u6c38\u4e45\u505c\u836f<\/li>\n\n\n\n<li>\u4efb\u4f55\u7ea7\u522b\u80ba\u708e\uff1a\u6c38\u4e45\u505c\u836f<\/li>\n\n\n\n<li>3\u7ea7QTc\u5ef6\u957f\uff1a\u4fdd\u6301\u81f3\u6062\u590d\u81f3\u22641\u7ea7\uff0c\u7136\u540e\u6062\u590d\u81f3200mg PO q12hr<\/li>\n\n\n\n<li>4\u7ea7QTc\u5ef6\u957f\uff1a\u6c38\u4e45\u505c\u6b62<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5fc3\u52a8\u8fc7\u7f13<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\uff1a\u505c\u6b62\u76f4\u81f3\u6062\u590d\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216HR\u226560bpm;&nbsp;\u5982\u679c\u60a3\u8005\u670d\u7528\u5176\u4ed6\u5f15\u8d77\u5fc3\u52a8\u8fc7\u7f13\u7684\u836f\u7269\uff0c\u8bf7\u8c03\u6574\u5242\u91cf\uff08\u6216\u8005\u5982\u679c\u53ef\u80fd\u7684\u8bdd\uff0c\u505c\u836f\uff09;&nbsp;\u5982\u679c\u60a3\u8005\u6ca1\u6709\u670d\u7528\u5176\u4ed6\u5f15\u8d77\u5fc3\u52a8\u8fc7\u7f13\u7684\u836f\u7269<\/li>\n\n\n\n<li>\u5371\u53ca\u751f\u547d\u7684\u5fc3\u52a8\u8fc7\u7f13\uff1a\u5982\u679c\u6ca1\u6709\u786e\u5b9a\u7684\u4f34\u968f\u836f\u7269\uff0c\u5219\u6c38\u4e45\u505c\u836f;&nbsp;\u5982\u679c\u786e\u5b9a\u5e76\u505c\u7528\u5176\u4ed6\u836f\u7269\uff0c\u6216\u8c03\u6574\u5176\u5242\u91cf\uff0c\u6062\u590d\u81f3\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560\u6b21\/\u5206\u65f6\uff0c\u6bcf\u65e5\u4e00\u6b21\u6062\u590d\u514b\u5511\u66ff\u5c3c250 mg\uff0c\u5e76\u7ecf\u5e38\u76d1\u6d4b<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u80be\u810f\u548c\u809d\u810f\u635f\u4f24<\/h3>\n\n\n\n<p><strong>\u809d\u529f\u80fd\u635f\u5bb3<\/strong>\uff1a\u5efa\u8bae\u8c28\u614e<\/p>\n\n\n\n<p><strong>\u80be\u529f\u80fd\u4e0d\u5168<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\uff08CrCl 30-90 mL \/ min\uff09\uff1a\u65e0\u9700\u8c03\u6574\u8d77\u59cb\u5242\u91cf;&nbsp;\u8fd9\u4e24\u7ec4\u7684\u7a33\u6001\u8c37\u6d53\u5ea6\u4e0e\u80be\u529f\u80fd\u6b63\u5e38\u8005\u76f8\u4f3c\uff08\u5373CrCl&gt; 90 mL \/ min\uff09<\/li>\n\n\n\n<li>\u4e25\u91cd\uff08CrCl &lt;30 mL \/ min\uff09\u6216\u7ec8\u672b\u671f\u80be\u75c5\uff1a\u5efa\u8bae\u8c28\u614e<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e0e\u5176\u4ed6\u836f\u7269\u7684\u4e92\u52a8<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">\u7981\u5fcc\uff086\uff09<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u897f\u6c99\u5fc5\u5229\/\u51b3\u5948\u8fbe\u9686\/\u6c1f\u73ed\u8272\u6797\/lomitapide\/\u5339\u83ab\u9f50\u7279\/\u786b\u5229\u8fbe\u55ea<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u4e25\u91cd \u2013 \u4f7f\u7528\u66ff\u4ee3\u54c1\uff0835\uff09<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>apalutamide\/\u6ce2\u8212\/cobimetinib\/\u4e19\u5421\u80fa\/edoxaban\/eliglustat\/encorafenib<\/li>\n\n\n\n<li>eslicarbazepine acetate\/\u82ac\u592a\u5c3c\/\u82ac\u592a\u5c3c\u9f3b\u5185\/\u82ac\u592a\u5c3c\u79bb\u5b50\u7535\u6e17\u900f\u76ae\u7cfb\u7edf<\/li>\n\n\n\n<li>\u82ac\u592a\u5c3c\u900f\u76ae\/\u82ac\u592a\u5c3c\u900f\u7c98\u819c\/glasdegib\/idelalisib\/inotuzumab\/\u4f0a\u7acb\u66ff\u5eb7<\/li>\n\n\n\n<li>\u4f0a\u7acb\u66ff\u5eb7\u8102\u8d28\u4f53\/\u4f0a\u66f2\u5eb7\u5511\/\u4f0a\u4f10\u5e03\u96f7\u5b9a\/ivosidenib\/macimorelin\/naloxegol<\/li>\n\n\n\n<li>\u90a3\u66ff\u5c3c\/\u5965\u62c9\u5e15\u5c3c\/\u6602\u4e39\u53f8\u743c\/\u5e15\u5229\u592b\u660e\/\u5e15\u6bd4\u53f8\u4ed6\/\u594e\u5c3c\u4e01\/siponimod\/\u4ed6\u514b\u83ab\u53f8<\/li>\n\n\n\n<li>\u62d3\u6251\u66ff\u5eb7\/\u5438\u5165umeclidinium bromide \/ vilanterol\/venetoclax<\/li>\n\n\n\n<li>\u5438\u5165vilanterol \/\u6c1f\u66ff\u5361\u677e\u7ce0\u9178\u916f\/<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u5bc6\u5207\u76d1\u89c6\uff08270\uff09<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u963f\u6bd4\u7279\u9f99\/acalabrutinib\/\u963f\u82ac\u592a\u5c3c\/\u963f\u592b\u5511\u55ea\/\u963f\u5229\u5409\u4ed1\/\u963f\u666e\u5511\u4ed1\/\u6c22\u6c27\u5316\u94dd<\/li>\n\n\n\n<li>\u80fa\u7898\u916e\/\u963f\u7c73\u66ff\u6797\/\u6c28\u6c2f\u5730\u5e73\/\u963f\u83ab\u6c99\/\u963f\u6734\u5417\u5561\/\u963f\u745e\/\u963f\u7acb\u54cc\u5511\/\u963f\u83ab\u8fbe\u975e\u5c3c<\/li>\n\n\n\n<li>\u4e09\u6c27\u5316\u4e8c\u7837\/\u84bf\u7532\u919a\/\u82ef\u82b4\u9187\/\u963f\u585e\u90a3\u5e73\/\u963f\u624e\u90a3\u97e6\/\u963f\u6258\u4f10\u4ed6\u6c40\/avanafil<\/li>\n\n\n\n<li>\u963f\u5947\u9709\u7d20\/bedaquiline\/\u8d1d\u66f2\u897f\u73ed\/\u6bd4\u5361\u9c81\u80fa\/\u787c\u66ff\u4f50\u7c73\/\u6ce2\u751f\u5766\/brexpiprazole<\/li>\n\n\n\n<li>\u6eb4\u9690\u4ead\/\u5e03\u5730\u5948\u5fb7\/\u4e01\u4e19\u8bfa\u5561\/\u4e01\u4e19\u8bfa\u5561\u53e3\u8154\/\u4e01\u4e19\u8bfa\u5561\u76ae\u4e0b\u690d\u5165\u7269\/\u5927\u9ebb<\/li>\n\n\n\n<li>\u4e01\u4e19\u8bfa\u5561\u957f\u6548\u6ce8\u5c04\u5242\/\u4e01\u87ba\u73af\u916e\/\u5361\u5df4\u4ed6\u8d5b\/\u5361\u535a\u66ff\u5c3c\/\u78b3\u9178\u9499\/\u5361\u9a6c\u897f\u5e73<\/li>\n\n\n\n<li>\u5361\u7ef4\u5730\u6d1b\/ceritinib\/\u897f\u66ff\u5229\u55ea\/\u6c2f\u55b9\/\u6c2f\u4e19\u55ea\/\u5438\u5165ciclesonide\/\u897f\u6d1b\u4ed6\u5511<\/li>\n\n\n\n<li>\u897f\u54aa\u66ff\u4e01\/\u897f\u90a3\u5361\u585e\/\u73af\u4e19\u6c99\u661f\/\u897f\u915e\u666e\u5170\/\u514b\u62c9\u9709\u7d20\/\u6c2f\u7c73\u5e15\u660e\/\u6c2f\u785d\u897f\u6cee<\/li>\n\n\n\n<li>\u8003\u5c3c\u4f10\u5766\/Crofelemer\/\u73af\u82ef\u624e\u6797\/\u73af\u5b62\u7d20\/\u8fbe\u6bd4\u52a0\u7fa4\/dabrafenib\/\u6c28\u82ef\u781c<\/li>\n\n\n\n<li>\u8fbe\u975e\u90a3\u65b0\/\u8fbe\u82a6\u90a3\u97e6\/\u8fbe\u6c99\u66ff\u5c3c\/\u67d4\u7ea2\u9709\u7d20\/\u5730\u592b\u53ef\/\u52a0\u745e\u514b\/\u62c9\u97e6\u5b9a\/\u5730\u6614\u5e15\u660e<\/li>\n\n\n\n<li>\u6c2f\u96f7\u4ed6\u5b9a\/\u5730\u585e\u7c73\u677e\/\u5170\u7d22\u62c9\u5511\/\u5730\u897f\u6cee\/\u53cc\u6c2f\/\u5730\u9ad8\u8f9b\/\u4e8c\u6c22\u9ea6\u89d2\u80fa\/\u5730\u5c14\u786b\u5353<\/li>\n\n\n\n<li>\u53cc\u6c22\u9ea6\u89d2\u80fa\u9f3b\u5185\/\u591a\u897f\u4ed6\u8d5b\/\u591a\u975e\u5229\u7279\/\u591a\u62c9\u53f8\u743c\/\u591a\u67d4\u6bd4\u661f\/\u591a\u67d4\u6bd4\u661f\u8102\u8d28\u4f53<\/li>\n\n\n\n<li>\u6c1f\u54cc\u5229\u591a\/duvelisib\/\u4f9d\u975e\u97e6\u4f26\/\u66f2\u666e\u5766\/elvitegravir \/ cobicistat\/encorafenib<\/li>\n\n\n\n<li>emtricitabine \/ tenofovir df\/\u9ea6\u89d2\u80fa\/\u5384\u6d1b\u66ff\u5c3c\/\u7ea2\u9709\u7d20\u78b1\/\u4e73\u7cd6\u9178\u7ea2\u9709\u7d20<\/li>\n\n\n\n<li>\u7ea2\u9709\u7d20\u4e59\u57fa\u7425\u73c0\u9178\u76d0\/\u7ea2\u9709\u7d20\u786c\u8102\u9178\u916f\/\u827e\u53f8\u897f\u915e\u666e\u5170\/\u57c3\u7d22\u7f8e\u62c9\u5511\/\u4e59\u7425\u80fa<\/li>\n\n\n\n<li>\u5de6\u65cb\u4f50\u5339\u514b\u9686\/\u4f9d\u6258\u6cca\u82f7\/\u4f9d\u7ef4\u83ab\u53f8\/\u6cd5\u83ab\u66ff\u4e01\/\u975e\u6d1b\u5730\u5e73\/\u975e\u7d22\u7f57\u5b9a\/\u975e\u7d22\u975e\u90a3\u5b9a<\/li>\n\n\n\n<li>\u6c1f\u5361\u5c3c\/\u6c1f\u5eb7\u5511\/\u6c1f\u897f\u6c40\/\u6c1f\u897f\u6cee\/\u798f\u6c99\/\u81a6\u7532\u9178\u94a0\/\u78f7\u82ef\u59a5\u82f1\/\u5409\u7c73\u6c99\u661f\/\u5409\u59a5\u5355\u6297<\/li>\n\n\n\n<li>glecaprevir \/ pibrentasvir\/\u6208\u820d\u745e\u6797\/\u8461\u8404\u67da\/\u80cd\u6cd5\u8f9b\/\u6c1f\u54cc\u5576\u9187\/\u6942\/\u4f0a\u62c9<\/li>\n\n\n\n<li>\u7ec4\u6c28\u745e\u6797\/\u5df1\u9178\u7f9f\u5b55\u916e\/\u4f9d\u7f57\u66ff\u5c3c\/\u5e03\u6d1b\u82ac\/\u6cd5\u83ab\u66ff\u4e01\/\u4f0a\u5e03\u5229\u7279\/\u5f02\u73af\u78f7\u9170\u80fa<\/li>\n\n\n\n<li>\u4f0a\u6f58\u7acb\u916e\/\u4f0a\u9a6c\u66ff\u5c3c\/\u5432\u8fbe\u5e15\u80fa\/\u831a\u5730\u90a3\u97e6\/\u4f0a\u7acb\u66ff\u5eb7\/\u4f0a\u7acb\u66ff\u5eb7\u8102\u8d28\u4f53\/\u5f02\u70df\u80bc<\/li>\n\n\n\n<li>ivosidenib\/\u4f0a\u6c99\u5339\u9686\/\u916e\u5eb7\u5511\/\u5170\u7d22\u62c9\u5511\/\u62c9\u5e15\u66ff\u5c3c\/lenvatinib\/\u918b\u9178\u4eae\u4e19\u745e\u6797<\/li>\n\n\n\n<li>\u5de6\u6c27\u6c1f\u6c99\u661f\/\u6d1b\u54cc\u4e01\u80fa\/\u6d1b\u5339\u90a3\u97e6\/\u6c2f\u96f7\u4ed6\u5b9a\/\u6d1b\u4f10\u4ed6\u6c40\/\u672c\u82b4\u9187\/\u6c22\u6c27\u5316\u9541\/\u6c27\u5316\u9541<\/li>\n\n\n\n<li>\u9a6c\u666e\u66ff\u6797\/\u9a6c\u62c9\u97e6\u7f57\/\u7532\u6c1f\u55b9\/\u7f8e\u6c99\u916e\/methylergonovine\/\u54aa\u8fbe\u5511\u4ed1\/\u7c73\u975e\u53f8\u916e<\/li>\n\n\n\n<li>\u7c73\u6c2e\u5e73\/\u4e1d\u88c2\u9709\u7d20\/\u7c73\u6258\u5766\/\u83ab\u8fbe\u975e\u5c3c\/\u83ab\u897f\u6c99\u661f\/\u90a3\u6cd5\u745e\u6797\/naldemedine<\/li>\n\n\n\n<li>\u5948\u6cd5\u5511\u916e\/\u5948\u975e\u90a3\u97e6\/\u5c3c\u5361\u5730\u5e73\/\u785d\u82ef\u5730\u5e73\/\u5c3c\u6d1b\u66ff\u5c3c\/\u5c3c\u83ab\u5730\u5e73\/\u5c3c\u8fbe\u5c3c\u5e03\/\u5e15\u745e<\/li>\n\n\n\n<li>\u5c3c\u7d22\u5730\u5e73\/\u5c3c\u624e\u66ff\u4e01\/\u53bb\u7532\u66ff\u6797\/\u5965\u66f2\u80bd\/\u6c27\u6c1f\u6c99\u661f\/\u5965\u7f8e\u62c9\u5511\/\u6602\u4e39\u53f8\u743c\/\u7d2b\u6749\u9187<\/li>\n\n\n\n<li>osimertinib\/\u5965\u6c99\u5229\u94c2\/\u5965\u5361\u897f\u5e73\/\u7f9f\u8003\u916e\/\u7d2b\u6749\u9187\u86cb\u767d\u7ed3\u5408\/palbociclib<\/li>\n\n\n\n<li>\u5e15\u6f58\/\u6cee\u6258\u62c9\u5511\/\u5e15\u5511\u5e15\u5c3c\/\u55b7\u4ed6\u8112\/\u82ef\u5df4\u6bd4\u59a5\/\u82ef\u59a5\u82f1\u94a0\/\u6cca\u6c99\u5eb7\u5511\/\u666e\u4f10\u4ed6\u6c40<\/li>\n\n\n\n<li>\u5421\u55b9\u916e\/\u666e\u9c81\u5361\u56e0\u80fa\/\u666e\u7f57\u5e15\u916e\/\u666e\u7f57\/\u55b9\u786b\u5e73\/\u594e\u5b81\/\u96f7\u8d1d\u62c9\u5511\/\u96f7\u5c3c\u66ff\u4e01\/\u96f7\u8bfa\u55ea<\/li>\n\n\n\n<li>\u745e\u683c\u5217\u5948\/\u5229\u798f\u5e03\u4e01\/\u5229\u798f\u5e73\/\u5229\u798f\u55b7\u4e01\/\u5229\u798f\u6614\u660e\/\u5229\u5339\u97e6\u6797\/\u5229\u57f9\u916e\/\u5229\u6258\u90a3\u97e6<\/li>\n\n\n\n<li>\u5229\u4f10\u6c99\u73ed\/\u7f57\u7c73\u5730\/\u6c99\u594e\u90a3\u97e6\/sarecycline\/\u6c99\u683c\u5217\u6c40\/\u897f\u5730\u90a3\u975e\/\u897f\u6d1b\u591a\u8f9b<\/li>\n\n\n\n<li>\u8f9b\u4f10\u4ed6\u6c40\/siponimod\/\u897f\u7f57\u83ab\u53f8\/\u897f\u4ed6\u5217\u6c40\/\u78b3\u9178\u6c22\u94a0\/\u73af\u7845\u9178\u9506\u94a0\/\u7d22\u5229\u90a3\u65b0<\/li>\n\n\n\n<li>sonidegib\/\u7d22\u62c9\u975e\u5c3c\/\u7d22\u4ed6\u6d1b\u5c14\/\u5723\u7ea6\u7ff0\u9ea6\u6c41\/\u53f8\u66ff\u620a\u9187\/\u8212\u82ac\u592a\u5c3c\/\u8212\u82ac\u592a\u5c3c<\/li>\n\n\n\n<li>\u8212\u5c3c\u66ff\u5c3c\/\u4e86suvorexant\/\u4ed6\u514b\u83ab\u53f8\/\u4ed6\u8fbe\u62c9\u975e\/\u4ed6\u83ab\u6614\u82ac\/\u5766\u7d22\u7f57\u8f9b\/tecovirimat<\/li>\n\n\n\n<li>\u7279\u62c9\u4e07\u661f\/\u897f\u7f57\u83ab\u53f8\/\u66ff\u5c3c\u6cca\u82f7\/tezacaftor\/\u8336\u78b1\/\u66ff\u6c83\u567b\u5428\/\u567b\u52a0\u5bbe\/\u66ff\u785d\u5511\/\u66f2\u8d1d<\/li>\n\n\n\n<li>\u66ff\u62c9\u90a3\u97e6\/\u6258\u6cd5\u66ff\u5c3c\/\u6258\u7279\u7f57\u5b9a\/\u6258\u4f10\u666e\u5766\/\u6258\u745e\u7c73\u82ac\/\u66f2\u9a6c\u591a\/\u66f2\u5511\u916e\/\u4e09\u5511\u4ed1<\/li>\n\n\n\n<li>\u7c73\u5e15\u660e\/\u66f2\u666e\u745e\u6797\/\u51e1\u5fb7\u4ed6\u5c3c\/\u4f10\u5730\u90a3\u975e\/\u5a01\u7f57\u83f2\u5c3c\/\u7ef4\u62c9\u5e15\u7c73\/\u957f\u6625\u78b1\/\u957f\u6625\u65b0\u78b1<\/li>\n\n\n\n<li>\u957f\u6625\u65b0\u78b1\u8102\u8d28\u4f53\/\u957f\u6625\u745e\u6ee8\/\u4f0f\u7acb\u5eb7\u5511\/\u4f0f\u7acb\u8bfa\u4ed6\/\u9f50\u62c9\u897f\u916e\/\u5511\u5421\u5766\/\u5511\u5c3c\u6c99\u80fa<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u6b21\u8981\uff081\uff09<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u96cc\u4e8c\u9187\u9634\u9053<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e0d\u826f\u53cd\u5e94<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">&gt; 10\uff05\u7684<\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>ALT\u5347\u9ad8\uff0876\uff05\uff09<\/li>\n\n\n\n<li>AST\u5347\u9ad8\uff0861\uff05\uff09<\/li>\n\n\n\n<li>\u89c6\u529b\u969c\u788d\uff0860\uff05\uff09<\/li>\n\n\n\n<li>\u8179\u6cfb\uff0860\uff05\uff09<\/li>\n\n\n\n<li>\u6076\u5fc3\uff0855\uff05\uff09<\/li>\n\n\n\n<li>\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff0851\uff05\uff09<\/li>\n\n\n\n<li>\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0849\uff05\uff09<\/li>\n\n\n\n<li>\u5455\u5410\uff0847\uff05\uff09<\/li>\n\n\n\n<li>\u4fbf\u79d8\uff0842\uff05\uff09<\/li>\n\n\n\n<li>\u6c34\u80bf\uff0831\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u78f7\u8840\u75c7\uff0828\uff05\uff09<\/li>\n\n\n\n<li>\u98df\u6b32\u4e0b\u964d\uff0827\uff05\uff09<\/li>\n\n\n\n<li>\u75b2\u52b3\uff0827\uff05\uff09<\/li>\n\n\n\n<li>Dysgeusia\uff0826\uff05\uff09<\/li>\n\n\n\n<li>\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0826\uff05\uff09<\/li>\n\n\n\n<li>\u5934\u6655\uff0822\uff05\uff09<\/li>\n\n\n\n<li>\u795e\u7ecf\u75c5\u53d8\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u611f\u89c9\u8fdf\u949d\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u6b65\u6001\u7d0a\u4e71\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u611f\u89c9\u8fdf\u949d\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u808c\u8089\u65e0\u529b\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u795e\u7ecf\u75db\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u611f\u89c9\u5f02\u5e38\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u5468\u56f4\u611f\u89c9\u795e\u7ecf\u75c5\u53d8\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u591a\u53d1\u6027\u795e\u7ecf\u75c5\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u76ae\u80a4\u707c\u70e7\u611f\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94be\u8840\u75c7\uff0818\uff05\uff09<\/li>\n<\/ol>\n\n\n\n<h3 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class=\"wp-block-list\">\n<li>\u89c6\u529b\u4e27\u5931\uff0c4\u7ea7\uff080.2\uff05\uff09<\/li>\n\n\n\n<li>\u6027\u817a\u529f\u80fd\u4f4e\u4e0b;&nbsp;\u8840\u777e\u916e\u51cf\u5c11\uff081\uff05\uff09<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\">\u6ce8\u610f\u4e8b\u9879<\/h3>\n\n\n\n<p>\u62a5\u544a\u4e86\u4e25\u91cd\u7684\uff0c\u5305\u62ec\u81f4\u547d\u7684\u6cbb\u7597\u76f8\u5173\u6027\u80ba\u708e;&nbsp;\u76d1\u6d4b\u6307\u793a\u80ba\u708e\u7684\u80ba\u90e8\u75c7\u72b6\uff0c\u5982\u679c\u786e\u8bca\u5219\u6c38\u4e45\u505c\u836f<\/p>\n\n\n\n<p>\u62a5\u544a\u4e86\u809d\u6bd2\u6027;&nbsp;\u62a5\u544aALT\u5347\u9ad8\u548c\u603b\u80c6\u7ea2\u7d20\u5347\u9ad8;&nbsp;\u76d1\u6d4bq2wk 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