{"id":687,"date":"2023-11-21T10:16:08","date_gmt":"2023-11-21T02:16:08","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=687"},"modified":"2023-11-21T10:16:08","modified_gmt":"2023-11-21T02:16:08","slug":"%e6%9b%bf%e8%8e%ab%e5%94%91%e8%83%ba-%e6%b3%b0%e9%81%93%e5%8d%b0%e5%ba%a6%e4%bb%bf%e5%88%b6%e8%8d%af%e8%af%a6%e7%bb%86%e8%af%b4%e6%98%8e%e4%b9%a6","status":"publish","type":"post","link":"http:\/\/www.yaozhiyou.com\/?p=687","title":{"rendered":"\u66ff\u83ab\u5511\u80fa\/\u6cf0\u9053\u5370\u5ea6\u4eff\u5236\u836f\u8be6\u7ec6\u8bf4\u660e\u4e66"},"content":{"rendered":"

\u66ff\u83ab\u5511\u80fa(Temozolomide)<\/h2>\n

\u901a\u7528\u540d\uff1a\u66ff\u83ab\u5511\u80fa<\/p>\n

\u5546\u54c1\u540d\uff1a\u8482\u6e05<\/p>\n

\u5168\u90e8\u540d\u79f0\uff1a\u66ff\u83ab\u5511\u80fa\uff0c\u8482\u6e05\uff0cTemozolomide\uff0ctemodar,TZM\uff0cTemozolamide,temosolomide<\/p>\n

\u9002\u5e94\u75c7<\/h2>\n

\u672c\u54c1\u7528\u4e8e\u6cbb\u7597\uff1a\u65b0\u8bca\u65ad\u7684\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff0c\u5f00\u59cb\u5148\u4e0e\u653e\u7597\u8054\u6cbb\u7597\uff0c\u968f\u540e\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n

\u5e38\u89c4\u6cbb\u7597\u540e\u590d\u53d1\u6216\u8fdb\u5c55\u7684\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6216\u95f4\u53d8\u6027\u661f\u5f62\u7ec6\u80de\u7624\u3002<\/p>\n

\u7528\u6cd5\u7528\u91cf<\/h2>\n

\u4e00\u3001\u65b0\u8bca\u65ad\u7684\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u6210\u4eba\u60a3\u8005\uff1a<\/p>\n

1\u3001\u540c\u6b65\u653e\u5316\u7597\u671f\uff1a\u53e3\u670d\u672c\u54c1\uff0c\u6bcf\u65e5\u5242\u91cf\u4e3a75mg\/m\uff0c\u517142\u5929\uff0c\u540c\u65f6\u63a5\u53d7\u653e\u7597\uff0860 Gy \u520630\u6b21\uff09\uff1b\u968f\u540e\u63a5\u53d76\u4e2a\u5468\u671f\u7684\u672c\u54c1\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n

\u6839\u636e\u60a3\u8005\u8010\u53d7\u7a0b\u5ea6\u53ef\u6682\u505c\u7528\u836f\uff0c\u4f46\u65e0\u9700\u964d\u4f4e\u5242\u91cf\u3002\u540c\u6b65\u653e\u5316\u7597\u671f\u5982\u679c\u7b26\u5408\u4ee5\u4e0b\u6761\u4ef6\uff1a\u7edd\u5bf9\u767d\u7ec6\u80de\u8ba1\u6570\u22651.5\u00d710\/L\uff0c\u8840\u5c0f\u677f\u8ba1\u6570\u22651.5\u00d710\/L\uff0c\u666e\u901a\u6bd2\u6027\u6807\u51c6\uff08CTC\uff09-\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u22641\u7ea7\uff08\u9664\u5916\u8131\u53d1\u3001\u6076\u5fc3\u548c\u5455\u5410\uff09\uff0c\u672c\u54c1\u53ef\u8fde\u7eed\u4f7f\u752842\u5929\uff0c\u76f4\u81f349\u5929\u3002\u6cbb\u7597\u671f\u95f4\u6bcf\u5468\u5e94\u8fdb\u884c\u5168\u8840\u7ec6\u80de\u8ba1\u6570\u3002<\/p>\n

2\u3001\u8f85\u52a9\u6cbb\u7597\u671f\uff1a\u672c\u54c1\u540c\u6b65\u653e\u5316\u7597\u671f\u7ed3\u675f\u540e4\u5468\uff0c\u8fdb\u884c6\u4e2a\u5468\u671f\u7684\u672c\u54c1\u8f85\u52a9\u6cbb\u7597\u3002\u7b2c1\u5468\u671f\u7684\u672c\u54c1\u5242\u91cf\u662f150mg\/m\/\u65e5\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u51715\u5929\uff0c\u7136\u540e\u505c\u836f23\u5929\u3002<\/p>\n

\u7b2c2\u5468\u671f\u5f00\u59cb\u65f6\uff0c\u5982\u679c\u7b2c1\u5468\u671fCTC\u7684\u975e\u8840\u6db2\u5b66\u6bd2\u6027\u22642\u7ea7\uff08\u9664\u5916\u8131\u53d1\u3001\u6076\u5fc3\u548c\u5455\u5410\uff09\u3001\u7edd\u5bf9\u767d\u7ec6\u80de\u8ba1\u6570\uff08ANC\uff09\u22651.5 \u00d710\/L\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u2265100\u00d710\/L\uff0c\u5219\u5242\u91cf\u53ef\u589e\u81f3200mg\/m\/\u65e5\u3002<\/p>\n

\u5982\u679c\u7b2c2\u5468\u671f\u7684\u5242\u91cf\u6ca1\u6709\u589e\u52a0\uff0c\u5728\u4ee5\u540e\u7684\u5468\u671f\u4e2d\u4e5f\u4e0d\u5e94\u589e\u52a0\u5242\u91cf\u3002\u9664\u51fa\u73b0\u6bd2\u6027\u5916\uff0c\u4ee5\u540e\u5404\u5468\u671f\u7684\u5242\u91cf\u7ef4\u6301\u5728\u6bcf\u65e5200mg\/m\u3002<\/p>\n

\u4e8c\u3001\u5e38\u89c4\u6cbb\u7597\u540e\u590d\u53d1\u6216\u8fdb\u5c55\u7684\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6216\u95f4\u53d8\u6027\u661f\u5f62\u7ec6\u80de\u7624\u60a3\u8005\uff1a<\/p>\n

1\u3001\u6210\u4eba\u60a3\u8005\uff1a\u4ee5\u524d\u66fe\u63a5\u53d7\u8fc7\u5316\u7597\u60a3\u8005\u7684\u672c\u54c1\u8d77\u59cb\u5242\u91cf\u662f150 mg\/m\/\u65e5\uff0c\u51715\u5929.\u5982\u679c\u4e0b\u4e2a\u5468\u671f\u7b2c\u4e00\u5929\u7684ANC\u22651.5\u00d710\/L \u548c\u8840\u5c0f\u677f\u8ba1\u6570\u2265100\u00d710\/L\uff0c\u5219\u7b2c2\u5468\u671f\u7684\u5242\u91cf\u589e\u4e3a200 mg\/m\/\u65e5\u3002\u5e94\u6839\u636eANC\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u6700\u4f4e\u503c\u8c03\u6574\u672c\u54c1\u7684\u5242\u91cf\u3002<\/p>\n

2\u3001\u513f\u7ae5\u60a3\u8005\uff1a\u5728\u4ee5\u524d\u66fe\u63a5\u53d7\u8fc7\u5316\u75973\u5c81\u62163\u5c81\u4ee5\u4e0a\u7684\u60a3\u513f\u4e2d\uff0c\u6bcf28\u5929\u5468\u671f\u4e2d\u672c\u54c1\u53e3\u670d\u8d77\u59cb\u5242\u91cf\u662f150 mg\/m\/\u65e5\uff0c\u51715\u5929\uff1b\u5982\u679c\u6ca1\u6709\u51fa\u73b0\u6bd2\u6027\uff0c\u4e0b\u4e2a\u5468\u671f\u7684\u5242\u91cf\u589e\u81f3200 mg\/m\/\u65e5\u3002<\/p>\n

\u4e09\u3001\u5168\u90e8\u60a3\u8005\uff1a<\/p>\n

1\u3001\u5e94\u7a7a\u8179\uff08\u8fdb\u9910\u524d\u81f3\u5c11\u4e00\u5c0f\u65f6\uff09\u670d\u7528\u672c\u54c1\u3002\u670d\u7528\u672c\u54c1\u524d\u540e\u53ef\u4f7f\u7528\u6b62\u5410\u836f\u3002\u5982\u679c\u670d\u836f\u540e\u51fa\u73b0\u5455\u5410\uff0c\u5f53\u5929\u4e0d\u80fd\u670d\u7528\u7b2c2\u5242\u3002<\/p>\n

2\u3001\u4e0d\u80fd\u6253\u5f00\u6216\u5480\u56bc\u672c\u54c1\uff0c\u5e94\u7528\u4e00\u676f\u6c34\u6574\u7c92\u541e\u670d\u3002\u5982\u679c\u80f6\u56ca\u6709\u7834\u635f\uff0c\u5e94\u907f\u514d\u76ae\u80a4\u6216\u7c98\u819c\u4e0e\u80f6\u56ca\u5185\u7c89\u72b6\u5185\u5bb9\u7269\u63a5\u89e6\u3002<\/p>\n

\u4e0d\u826f\u53cd\u5e94<\/h2>\n

1\u3001\u4e3b\u8981\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u6076\u5fc3\u3001\u5455\u5410\u3001\u5026\u6020\u548c\u8840\u6db2\u5b66\u53cd\u5e94\u3002<\/p>\n

2\u3001\u5176\u4ed6\u7ecf\u5e38\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u75b2\u4e4f\u3001\u4fbf\u79d8\u548c\u5934\u75db\u3002<\/p>\n

3\u3001\u8fd8\u62a5\u544a\u98df\u6b32\u51cf\u9000\u3001\u8179\u6cfb\uff0c\u76ae\u75b9\u3001\u53d1\u70ed\u3001\u65e0\u529b\u548c\u778c\u7761\u3002<\/p>\n

4\u3001\u4e0d\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8179\u75db\u3001\u75bc\u75db\u3001\u5934\u6655\u3001\u4f53\u91cd\u4e0b\u964d\u3001\u4e0d\u9002\u3001\u547c\u5438\u56f0\u96be\u3001\u8131\u53d1\u3001\u50f5\u76f4\u3001\u7619\u75d2\u3001\u6d88\u5316\u4e0d\u826f\u3001\u5473\u89c9\u5f02\u5e38\uff0c\u611f\u89c9\u5f02\u5e38\u548c\u7600\u70b9\u3002<\/p>\n

\u7981\u5fcc<\/h2>\n

1\u3001\u5bf9\u66ff\u83ab\u5511\u80fa\u80f6\u56ca\u6216\u8fbe\u5361\u5df4\u55ea\uff08DTIC\uff09\u8fc7\u654f\u8005\u7981\u7528\u3002<\/p>\n

2\u3001\u598a\u5a20\u671f\u7981\u7528\uff08\u89c1\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7528\u836f\uff09\u3002<\/p>\n

3\u3001\u7981\u7528\u4e8e\u4e25\u91cd\u9aa8\u9ad3\u6291\u5236\u7684\u60a3\u8005\u3002<\/p>\n

\u6ce8\u610f\u4e8b\u9879<\/h2>\n

1\u3001\u5728\u4e00\u9879\u6cbb\u7597\u65f6\u95f4\u5ef6\u957f\u523042\u5929\u7684\u5c0f\u89c4\u6a21\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7\u672c\u54c1\u548c\u653e\u7597\u5408\u5e76\u6cbb\u7597\u7684\u60a3\u8005\u662f\u5361\u6c0f\u80ba\u56ca\u866b\u6027\u80ba\u708e\u7684\u9ad8\u5371\u8005\u3002\u56e0\u6b64\u5bf9\u4e8e\u63a5\u53d742\u5929\uff08\u6700\u591a\u4e3a49\u5929\uff09\u5408\u5e76\u6cbb\u7597\u7684\u5168\u90e8\u60a3\u8005\u9700\u8981\u9884\u9632\u5361\u6c0f\u80ba\u56ca\u866b\u6027\u80ba\u708e\u53d1\u751f\u3002<\/p>\n

2\u3001\u5728\u8f83\u957f\u671f\u7684\u7ed9\u836f\u65b9\u6848\u6cbb\u7597\u671f\u95f4\uff0c\u63a5\u53d7\u66ff\u83ab\u5511\u80fa\u6cbb\u7597\u671f\u95f4\u5361\u6c0f\u80ba\u56ca\u866b\u6027\u80ba\u708e\u53d1\u751f\u7387\u53ef\u80fd\u8f83\u9ad8\u3002\u4e0d\u7ba1\u4f55\u79cd\u6cbb\u7597\u65b9\u6848\uff0c\u90fd\u5e94\u5bc6\u5207\u89c2\u5bdf\u66ff\u83ab\u5511\u80fa\u6cbb\u7597\u7684\u5168\u90e8\u60a3\u8005\uff08\u7279\u522b\u662f\u63a5\u53d7\u7c7b\u56fa\u9187\u6cbb\u7597\u60a3\u8005\uff09\u53d1\u751f\u5361\u6c0f\u80ba\u56ca\u866b\u6027\u80ba\u708e\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

3\u3001\u6b62\u5410\u6cbb\u7597\uff1a\u6076\u5fc3\u548c\u5455\u5410\u5e38\u4e0e\u672c\u54c1\u76f8\u5173\uff0c\u670d\u7528\u672c\u54c1\u524d\u540e\u53ef\u4f7f\u7528\u6b62\u5410\u836f\u3002<\/p>\n

\u6307\u5bfc\u539f\u5219\u4e3a\uff1a<\/p>\n

1\uff09\u65b0\u8bca\u65ad\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u60a3\u8005\uff1a\u5728\u5f00\u59cb\u63a5\u53d7\u66ff\u83ab\u5511\u80fa\u5408\u5e76\u6cbb\u7597\u524d\uff0c\u5efa\u8bae\u91c7\u7528\u6b62\u5410\u836f\u9884\u9632\uff0c\u5728\u8f85\u52a9\u6cbb\u7597\u671f\u95f4\uff0c\u6781\u529b\u5efa\u8bae\u91c7\u7528\u6b62\u5410\u836f\u9884\u9632\u3002<\/p>\n

2\uff09\u795e\u7ecf\u80f6\u8d28\u7624\u590d\u53d1\u6216\u8fdb\u5c55\u7684\u60a3\u8005\uff1a\u5728\u4ee5\u524d\u6cbb\u7597\u5468\u671f\u4e2d\u51fa\u73b0\u8fc7\u91cd\u5ea6\uff083\u62164\u7ea7\uff09\u5455\u5410\u7684\u60a3\u8005\u9700\u8981\u6b62\u5410\u836f\u6cbb\u7597\u3002<\/p>\n

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3\uff09\u7537\u6027\u60a3\u8005\uff1a\u670d\u7528\u66ff\u83ab\u5511\u80fa\u7684\u7537\u6027\u60a3\u8005\u5e94\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3002\u66ff\u83ab\u5511\u80fa\u5177\u6709\u9057\u4f20\u6bd2\u6027\uff0c\u56e0\u6b64\u5728\u6cbb\u7597\u8fc7\u7a0b\u53ca\u6cbb\u7597\u7ed3\u675f\u540e6\u4e2a\u6708\u4e4b\u5185\uff0c\u7537\u6027\u5e94\u907f\u5b55\u3002\u7531\u4e8e\u63a5\u53d7\u66ff\u83ab\u5511\u80fa\u6cbb\u7597\u6709\u5bfc\u81f4\u4e0d\u53ef\u9006\u4e0d\u80b2\u7684\u53ef\u80fd\uff0c\u5728\u63a5\u53d7\u8be5\u6cbb\u7597\u4e4b\u524d\u5e94\u51b0\u51bb\u4fdd\u5b58\u7cbe\u5b50\u3002<\/p>\n

4\uff09\u809d\u80be\u529f\u80fd\u635f\u5bb3\u8005\uff1a\u809d\u529f\u80fd\u6b63\u5e38\u7684\u75c5\u4eba\u4e0e\u809d\u529f\u80fd\u8f7b\u4e2d\u5ea6\u5f02\u5e38\u7684\u75c5\u4eba\u836f\u4ee3\u52a8\u529b\u5b66\u7ed3\u679c\u76f8\u4f3c\uff1b\u4e25\u91cd\u809d\u529f\u80fd\u5f02\u5e38\uff08Child\u2019s Class III\uff09\u6216\u80be\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\u5c1a\u65e0\u670d\u7528\u66ff\u83ab\u5511\u80fa\u7684\u8d44\u6599\u3002\u6839\u636e\u66ff\u83ab\u5511\u80fa\u80f6\u56ca\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u5bf9\u4e8e\u4e25\u91cd\u809d\u80be\u529f\u80fd\u4e0d\u5168\u7684\u75c5\u4eba\u4e0d\u5fc5\u964d\u4f4e\u66ff\u83ab\u5511\u80fa\u7528\u91cf\uff0c\u4f46\u5e94\u7528\u65f6\u9700\u500d\u52a0\u5c0f\u5fc3\u3002<\/p>\n

5\uff09\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u7528\u836f\uff1a\u5bf9\u598a\u5a20\u671f\u5987\u5973\u4f7f\u7528\u8be5\u836f\u5c1a\u672a\u8fdb\u884c\u7814\u7a76\u3002\u5728\u7528\u5927\u9f20\u548c\u5154\u6240\u8fdb\u884c\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u7ed9\u836f150mg\/m\u66fe\u6709\u81f4\u7578\u548c\/\u6216\u80ce\u513f\u6bd2\u6027\u7684\u62a5\u9053\u3002<\/p>\n

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