{"id":547,"date":"2023-10-28T21:22:18","date_gmt":"2023-10-28T13:22:18","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=547"},"modified":"2023-10-28T21:22:18","modified_gmt":"2023-10-28T13:22:18","slug":"%e5%a1%9e%e5%b0%94%e5%b8%95%e6%9b%bf%e5%b0%bc%ef%bc%88loxo-292%ef%bc%89","status":"publish","type":"post","link":"http:\/\/www.yaozhiyou.com\/?p=547","title":{"rendered":"\u585e\u5c14\u5e15\u66ff\u5c3c\uff08LOXO-292\uff09"},"content":{"rendered":"

\"\u585e\u5c14\u5e15\u66ff\u5c3c\uff08LOXO-292\uff09\"<\/p>\n

\u585e\u5c14\u5e15\u66ff\u5c3c\uff08selpercatinib\uff09LOXO-292 \u662f\u4e00\u79cdRET\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u963b\u65adRET\u7684\u6d3b\u6027\uff0c\u5e2e\u52a9\u963b\u6b62\u764c\u7ec6\u80de\u751f\u957f\u30022020\u5e745\u67088\u65e5\u7f8e\u56fdFDA\u6279\u51c6\u585e\u5c14\u5e15\u66ff\u5c3c\u4e0a\u5e02\u3002\u7528\u4e8e\u6cbb\u75973\u79cd\u764c\u75c7\uff1a\u6210\u4eba\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff1b\u9700\u8981\u7cfb\u7edf\u6cbb\u7597\u7684\u6210\u4eba\u53ca12\u5c81\u4ee5\u4e0a\u513f\u79d1\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8\u9633\u6027\u9ad3\u6837\u7532\u72b6\u817a\u764c\uff08MTC\uff09\u60a3\u8005\uff1b\u653e\u5c04\u6027\u7898\u96be\u6cbb\u7684\u9700\u8981\u7cfb\u7edf\u6cbb\u7597\u7684\u6210\u4eba\u53ca12\u5c81\u4ee5\u4e0a\u513f\u79d1\u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\u60a3\u8005\u3002\u585e\u5c14\u5e15\u66ff\u5c3c\u662f\u7b2c\u4e00\u4e2a\u4e13\u95e8\u6279\u51c6\u7528\u4e8e\u5177\u6709RET\u57fa\u56e0\u6539\u53d8\u7684\u764c\u75c7\u60a3\u8005\u7684\u7597\u6cd5\u3002<\/p>\n

\u3010\u9002\u5e94\u75c7\u3011<\/p>\n

1, \u7528\u4e8e\u6cbb\u7597\u665a\u671fRET\u878d\u5408\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\uff1b<\/p>\n

2, \u665a\u671f\u6216\u8f6c\u79fb\u6027RET\u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c\u6210\u4eba\u60a3\u8005\u3002<\/p>\n

3. RET\u9633\u6027\u7532\u72b6\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002<\/p>\n

\u3010\u89c4\u683c\u301140mg\uff0c60\u7c92\/\u76d2\uff1b<\/p>\n

80mg\uff0c60\u7c92\/\u76d2\uff1b<\/p>\n

\u3010\u53c2\u8003\u7528\u91cf\u3011<\/p>\n

\u5bf9\u4e8e\u4f53\u91cd\u4f4e\u4e8e50 kg\u7684\u60a3\u8005,\u63a8\u8350\u5242\u91cf\u4e3a 120 mg;\u5bf9\u4e8e\u4f53\u91cd\u4e3a50 kg\u6216\u4ee5\u4e0a\u7684\u60a3\u8005,\u63a8\u8350\u5242\u91cf\u4e3a160 mg \u3002<\/p>\n

\u541e\u4e0b\u6574\u4e2a\u80f6\u56ca\uff0c\u4e0d\u53ef\u78be\u788e\u6216\u5480\u56bc\u80f6\u56ca\u3002\u5982\u679c\u6f0f\u670d\uff0c\u53d1\u73b0\u65f6\u82e5\u79bb\u4e0b\u6b21\u670d\u836f 6\u5c0f\u65f6\u4ee5\u4e0a\uff0c\u53ef\u4ee5\u6309\u91cf\u8865\u670d\uff0c\u4e0b\u6b21\u670d\u836f\u4ecd\u6309\u7167\u539f\u95f4\u9694\u65f6\u95f4\u3002\u5982\u679c\u670d\u836f\u540e\u53d1\u751f\u5455\u5410\uff0c\u4e0d\u53ef\u8865\u670d\uff0c\u4e0b\u6b21\u670d\u836f\u4ecd\u6309\u7167\u539f\u95f4\u9694\u65f6\u95f4\u3002<\/p>\n

\u3010\u526f\u4f5c\u7528\u3011\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a<\/p>\n

1\u3001\u5b9e\u9a8c\u5ba4\u5f02\u5e38\uff0c\uff08\u226525%\uff09\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\uff08AST\uff09\u5347\u9ad8\uff0c\u4e19\u6c28\u9178\u8f6c\u6c28\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u8461\u8404\u7cd6\u5347\u9ad8<\/p>\n

2\u3001\u767d\u7ec6\u80de\u51cf\u5c11\uff0c\u767d\u86cb\u767d\u964d\u4f4e\uff0c\u9499\u51cf\u5c11<\/p>\n

3\u3001\u53e3\u5e72\uff0c\u8179\u6cfb\uff0c\u808c\u9150\u5347\u9ad8\uff0c\u78b1\u6027\u78f7\u9178\u9176\u5347\u9ad8<\/p>\n

4\u3001\u9ad8\u8840\u538b\uff0c\u75b2\u52b3\uff0c\u6c34\u80bf\uff0c\u8840\u5c0f\u677f\u51cf\u5c11<\/p>\n

5\u3001\u603b\u80c6\u56fa\u9187\u5347\u9ad8\uff0c\u76ae\u75b9\uff0c\u94a0\u51cf\u5c11\uff0c\u4fbf\u79d8<\/p>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\u76ee\u524d\u585e\u5c14\u5e15\u66ff\u5c3c\u7684\u4eff\u5236\u836f\u5206\u522b\u6709\u8001\u631d\u7b2c\u4e8c\u5236\u836f\u5382\u3001\u7f05\u7538\u4ef0\u5149\u5236\u836f\u5382\u3001\u7f05\u7538\u52d0\u62c9\u5236\u836f\u5382\u548c\u5b5f\u52a0\u62c9\u73e0\u5cf0\u5236\u836f\u5382\u751f\u4ea7\u3002\u4eff\u5236\u836f\u7684\u4ef7\u683c\u53ea\u6709\u539f\u7814\u836f\u7684\u4e8c\u5341\u5206\u4e4b\u4e00\uff0c\u5927\u5927\u51cf\u8f7b\u4e86\u60a3\u8005\u7684\u7ecf\u6d4e\u8d1f\u62c5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u585e\u5c14\u5e15\u66ff\u5c3c\uff08selpercatinib\uff09LOXO-292 \u662f\u4e00\u79cdRET\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u963b\u65adRET\u7684\u6d3b\u6027\uff0c\u5e2e\u52a9\u963b\u6b62\u764c\u7ec6\u80de\u751f\u957f\u30022020\u5e745\u67088\u65e5\u7f8e\u56fdFDA\u6279\u51c6\u585e\u5c14\u5e15\u66ff\u5c3c\u4e0a\u5e02\u3002\u7528\u4e8e\u6cbb\u75973\u79cd\u764c\u75c7\uff1a\u6210\u4eba\u8f6c\u79fb\u6027RET\u878d\u5408\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09 […]<\/p>\n","protected":false},"author":1,"featured_media":548,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[169,171,172,170,168,67],"topic":[],"class_list":{"0":"post-547","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","6":"hentry","7":"category-feiaiyaoping","8":"tag-loxo-292","9":"tag-ret","11":"tag-selpercatinib","12":"tag-168","13":"tag-67"},"_links":{"self":[{"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=547"}],"version-history":[{"count":1,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/547\/revisions"}],"predecessor-version":[{"id":549,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/posts\/547\/revisions\/549"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=\/wp\/v2\/media\/548"}],"wp:attachment":[{"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=547"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=547"},{"taxonomy":"topic","embeddable":true,"href":"http:\/\/www.yaozhiyou.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftopic&post=547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}