{"id":176,"date":"2023-09-19T20:43:43","date_gmt":"2023-09-19T12:43:43","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=176"},"modified":"2023-10-19T18:44:49","modified_gmt":"2023-10-19T10:44:49","slug":"%e4%be%9d%e7%bb%b4%e8%8e%ab%e5%8f%b8%ef%bc%88everolimus%ef%bc%89","status":"publish","type":"post","link":"http:\/\/www.yaozhiyou.com\/?p=176","title":{"rendered":"\u4f9d\u7ef4\u83ab\u53f8\uff08Everolimus\uff09"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"424\" height=\"335\" src=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u5fae\u4fe1\u56fe\u7247_20230919204036.jpg\" alt=\"\u4f9d\u7ef4\u83ab\u53f8\uff08Everolimus\uff09\" class=\"wp-image-177\" srcset=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u5fae\u4fe1\u56fe\u7247_20230919204036.jpg 424w, http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u5fae\u4fe1\u56fe\u7247_20230919204036-300x237.jpg 300w\" sizes=\"auto, (max-width: 424px) 100vw, 424px\" \/><\/figure>\n\n\n\n<p><strong>\u3010\u836f\u54c1\u5c5e\u6027\u3011&nbsp;<\/strong><\/p>\n\n\n\n<p><strong>mTOR\u6291\u5236\u5242<\/strong><strong>\u4e73\u817a\u764c<\/strong><strong>\u80be\u7ec6\u80de\u764c<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th><strong>\u3010\u836f\u54c1\u7b80\u4ecb\u3011<\/strong><br><br><\/th><td>\u4f9d\u7ef4\u83ab\u53f8\u662f\u4e00\u79cdmTOR\u7684\u6291\u5236\u5242\uff0cPI3K\/AKT\u901a\u8def\u4e0b\u6e38\u7684\u4e00\u79cd\u4e1d\u6c28\u9178\u82cf\u6c28\u9178\u6fc0\u9176\u3002\u5728\u51e0\u79cd\u4eba\u764c\u75c7\u4e2dmTOR\u5931\u8c03\u63a7\uff0c\u4f9d\u7ef4\u83ab\u53f8\u7ed3\u5408\u81f3\u7ec6\u80de\u5185\u86cb\u767d\uff0cFKBP-12\uff0c\u5bfc\u81f4\u4e00\u79cd\u6291\u5236\u5242\u6027\u590d\u5408\u7269\u5f62\u6210\u548cmTOR\u6fc0\u9176\u6d3b\u6027\u7684\u6291\u5236\u3002\u4f9d\u7ef4\u83ab\u53f8\u51cf\u4f4eS6\u6838\u7cd6\u4f53\u86cb\u767d\u6fc0\u9176(S6K1)\u7684\u6d3b\u6027\u548c\u771f\u6838\u751f\u7269\u5ef6\u4f38\u56e0\u5b504E-\u7ed3\u5408\u86cb\u767d(4E-BP)\uff0cmTOR\u7684\u4e0b\u6e38\u6548\u5e94\u5668\uff0c\u6d89\u53ca\u86cb\u767d\u8d28\u5408\u6210\u3002\u6b64\u5916\uff0c\u4f9d\u7ef4\u83ab\u53f8\u6291\u5236\u7f3a\u6c27-\u53ef\u8bf1\u5bfc\u56e0\u5b50\u7684\u8868\u8fbe(\u5982\uff0cHIF-1)\u548c\u51cf\u4f4e\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50(VEGF)\u7684\u8868\u8fbe\u3002<\/td><\/tr><tr><th><strong>\u3010\u836f\u54c1\u7279\u8272\u3011<\/strong><\/th><td>\u5728\u4f53\u5916\u548c\u6216\u4f53\u5185\u7814\u7a76\u4e2d\u901a\u8fc7\u4f9d\u7ef4\u83ab\u53f8mTOR\u7684\u6291\u5236\u4f5c\u7528\u663e\u793a\u51cf\u4f4e\u7ec6\u80de\u589e\u6b96\uff0c\u6291\u5236\u8840\u7ba1\u751f\u6210\u548c\u8461\u8404\u7cd6\u6444\u53d6\u3002\u4f9d\u7ef4\u83ab\u53f8\u9002\u7528\u4e8e\u7528\u8212\u5c3c\u66ff\u5c3c\u6216\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u5931\u8d25\u540e\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>\u3010\u9002\u5e94\u75c7\u3011<\/strong><\/p>\n\n\n\n<p>\u3000\u30001)&nbsp; 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